311 research outputs found
Innova Macerata
No full textIl progetto prende vita dalla intersezione tra industria delle ICT, formazione e musealizzazione e si struttura in due macro azioni complementari:
1 - attivazione di un Progetto di Ricerca industriale e sviluppo sperimentale;
2 – attivazione di un Progetto di Sperimentazione e Prototipazione in risposta ai fabbisogni del sistema urbano di riferimento
Role of nitric oxide and melanogenesis in the accomplishment of anticryptococcal activity by the BV-2 microglial cell line.
No full textJ Neuroimmunol. 1995 Apr;58(1):111-6.
Role of nitric oxide and melanogenesis in the accomplishment of anticryptococcal activity by the BV-2 microglial cell line.
Blasi E, Barluzzi R, Mazzolla R, Tancini B, Saleppico S, Puliti M, Pitzurra L, Bistoni F.
SourceDepartment of Biomedical Sciences, University of Modena, Italy.
Abstract
In the present paper, we investigated the involvement of cryptococcal melanogenesis and macrophage nitric oxide (NO) production in the accomplishment of anticryptococcal activity by microglial effector cells, using the murine cell line BV-2. We demonstrate that the constitutive levels of anticryptococcal activity exerted by BV-2 cells is significantly enhanced upon interferon gamma plus lipopolysaccharide treatment. The phenomenon, which occurs with no enhancement of phagocytic activity, is associated with the production of high levels of NO and is abolished by addition of NG-monomethyl-L-arginine. Comparable patterns of results are observed employing either unopsonized or opsonized microbial targets, the latter microorganisms being markedly more susceptible to BV-2 cell antimicrobial activity. Furthermore, melanization of Cryptococcus neoformans significantly reduces its susceptibility to BV-2 antimicrobial activity, regardless of the fact that activated macrophages or opsonized microorganisms have been employed. In conclusion, our results provide evidence that NO-dependent events are involved in the fulfillment of anticryptococcal activity by activated microglial cells and that fungal melanization is a precious escamotage through which C. neoformans overcomes host defenses.
PMID: 773044
Crystal structure of a new alpha-cyclodextrin hydrate form. Molecular geometry and packing features: disordered solvent contribution
No full textThe crystallog. study of a new hydrated form of α-cyclodextrin (cyclohexaamylose) is reported. C36H60O30.11H2O; space group P212121 with cell consts. a= 13.839(3), b=15.398(3), c=24.209(7) Å; final discrepancy index R=0.057 for the 5182 obsd. reflections and 632 refined parameters. Besides four ordered water mols. placed outside α-cyclodextrins, the structure shows regions of severely disordered solvent mainly confined in the oligosaccharide cavities. The contribution of the obsd. disorder has been computed via Fourier inversions of the residual electron d. and incorporated into the structure factors in further refinements of the ordered part. The α-cyclodextrin mol. assumes a relaxed round shape stabilized by a ring sequence of all the six possible O2...O3 intramol. hydrogen bonds. The four ordered water mols. take part in an extensive network of hydrogen bonds (infinite chains and loops) without modifying the scheme of intramol. H-bonds or the (-)gauche conformations of O-6-H hydroxyl groups. The structure shows a new mol. arrangement, for an "empty" hydrated α-cyclodextrin, like that "brick-type" obsd. for α-CD in the iodoanilide trihydrate complex crystg. in an isomorphous cell
Conformational stability of avarol-type molecules. Crystal structure of 3 ́-methylaminoavarone, a metabolite from Dysidea avara
No full textGiulio Puliti, Luigi Sturzo e la fiammata bibliotecaria
No full textIn the early years of the 20thcentury a tragic event broke in the history of Italian libraries: the violent and voluntary death of Giulio Puliti, librarian and director of the University Library of Catania, author of several essays. The main reason of Puliti’s death was a violent argument with Luigi Sturzo, a fellow member of the Commission for the reconstruction of the municipal library of Caltagirone, that was destroyed by a terrible fire in 1901. The paper recalls the main steps of the reconstruction of the library of Caltagirone between 1901 and 1904, analyzing the role of Puliti and Sturzo within the Commission and displaying several unpublished documents related to the events.Nei primi anni del XX secolo la storia bibliotecaria italiana è attraversata da una tragedia: la morte violenta e volontaria di Giulio Puliti, bibliotecario governativo e direttore della Biblioteca universitaria di Catania, già collaboratore di rilievo di Martini e Fumagalli e attivo nel panorama italiano con una serie di saggi di biblioteconomia. A portarlo all’estremo gesto, nel giugno 1904, fu uno scontro violento con Luigi Sturzo con cui condivideva la partecipazione alla Commissione per la ricostruzione della Biblioteca comunale di Caltagirone, distrutta da un disastroso incendio nella notte tra il 16 e il 17 febbraio 1901. Nell’articolo si ripercorrono le vicende legate alla ricostruzione della biblioteca calatina tra il 1901 e il 1904, si analizzano il ruolo di Puliti e quello di Sturzo all’interno della Commissione e si riportano una serie di documenti inediti relativi agli avvenimenti in questione
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