85 research outputs found

    MMIC implementation of a new active pre-distortion scheme for Highly Linear Power Amplifier

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    This paper describes the complete design methodology used to implement a MMIC lineariser in 0.25um pHemt GaAs technology. Theoretical concepts and numerical simulations of a new pre-distorter prototype designed for a wide band and high linearity power amplifier are presented. Modeling and process variations sensitivity has been accurately taken into account during the implementation of the lineariser architecture allowing a time effective and safe design approach. Several parts of the main amplifier have been reused in the pre-distorter design reducing the total development lead-time and the risk of model inaccuracies. The implemented predistortion topology has been verified using Agilent ADS simulator showing an improvement up to 10 dBc in third order intermodulation distortion (IM3) over a relative bandwidth of 28%. These results are also confirmed by experimental characterizations that demonstrate the effectiveness of the new pre-distortion scheme and implementation methodology

    A New Active Predistortion Linearizer Suitable for MMIC Power Amplifier

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    A new predistortion scheme based on active devices is presented in this paper.Through a simplified theoretical analysis a preliminary dimensioning of the structure is first performed;then a circuit optimization, based on very accurate modeling of the various active and passive blocks,allows obtaining a significant reduction of intermodulation distortion (IM3)of the PA to be linearized. The proposed predistortion architecture has been verified using Agilent ADS simulator for accomplishing two-tone and 16QAM analyses,firstly by means of behavioral components;then a CAD implementation based on TriQuint Semiconductors library for GaAs MMIC process has been simulated,confirming the expected performances.Also a worst-case analysis has been performed,demonstrating the robustness of the proposed solution

    Efficacy and safety of 24-week pramipexole augmentation in patients with treatment resistant depression. A retrospective cohort study

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    Pramipexole is a dopamine agonist with potential antidepressant, neuroprotective, antioxidant and anti-inflammatory activity. In the present study we investigated the 24 weeks effect and safety of traditional AD augmentation with pramipexole for treatment-resistant depression. The study includes 116 patients, 37 (32%) with bipolar disorders and 79 (68%) with major depressive disorder, who failed to respond to at least 2 ADs trials of different classes and that were treated with AD augmented with pramipexole. Mood stabilizers and/or second-generation antipsychotics were added in patients with bipolar or mixed depression. Exclusion criteria were psychotic depression, rapid cycling bipolar course and previous unsuccessful treatment with pramipexole. After 24 weeks of pramipexole augmentation (median max dose 1.05 mg/day, IQR 0.72–1.08) 74.1% of patients responded (≥50% reduction of baseline Hamilton Depression Rating Scale21 total score) and 66.4% remitted (Hamilton Depression Rating Scale21 total score < 7). Global Assessment of Functioning score significantly increase from 53 (50–60) at baseline to 80 (71–81) at 24 weeks (Wilcoxon signed rank test = 8.174, p < 0.001]. Ten patients (8.6%) dropped out (8 due to side effects and 2 for lack of efficacy) and 1 experienced an induced hypomanic switch. No patient committed a suicide attempt, had suicidal ideation, needed hospitalization, reported lethargy, gambling, hypersexuality and compulsive shopping. The limitations of the study are the observational design, the lack of a control group, the inclusion of outpatients only, the unblinded outcomes assessment, and the flexibility of the add-on schedule. The findings of the present study showed that off-label use of pramipexole as augmentation of traditional AD is an effective and safe 24 weeks treatment of resistant unipolar and bipolar depression. These results need confirmation from randomized clinical trials on larger samples

    Intangible capital, innovation, and productivity à la Jorgenson evidence from Europe and the United States

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    This chapter focuses on intangible capital as source of economic growth in Europe and the United States. It (1) sets out a Jorgenson-like model for thinking about the role of knowledge investments and innovation in fostering economic growth; (2) uses standard growth accounting decompositions to illustrate the empirical relevance of intangible capital deepening as a source of growth, and (3) considers how knowledge spillovers from investments in both R&amp;D and non-R&amp;D intangible assets might contribute to productivity

    Sistemi e requisiti per il controllo ambientale negli scenari assistenziali e di intervento edilizio. In: PASS - Private Assisted House per la Longevità Attiva e Indipendente dell’Anziano.

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    Progetto di Ricerca “Private Assisted House per la Longevità Attiva e Indipendente dell’Anziano” - "Casa intelligente per una longevità attiva ed indipendente dell'anziano”. Progetto vincitore del Bando per la selezione di proposte progettuali finalizzate allo sviluppo di piattaforme di integrazione dedicate all'Active Aging e all'Ambient Assisted Living (DGR 1464 del 7/11/2011). Il progetto di ricerca ha l’obiettivo di definire in modo sistematico una ipotesi di approccio metodologico alla progettazione di componenti, sistemi , oggetti d’uso per l’ambiente domestico, che prevedano l’impiego e l’inserimento delle nuove tecnologie informatiche, domotiche e robotiche con livelli prestazionali di qualità architettonica e di design partendo dalle differenti tipologie di profili assistenziali individuati. Smart Object e Smart System. Responsabili gruppo di lavoro per Unicam, Scuola di Architettura e Design: prof. Giuseppe Losco (P.O.), prof. Andrea Lupacchini (R), prof. Luca Bradini (R.T.D.
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