142 research outputs found
A dataset of 9.896 single nuclear polymorphisms for 112 wild grapes, obtained with the GrapeReSeq 18K Vitis chip
No full textThe dataset, comprising 9.896 SNPs for 112 wild grapes (Vitis vinifera subsp. sylvestris), is made available here in support of the paper : Ramos-Madrigal J, Wiborg Runge AK, Bouby L, Lacombe T, Samaniego-Castruita JA, Adam-Blondon AF, Figueiral I, Hallavant C, Martínez-Zapater JM, Schaal C, Töpfer R, Petersen B, Sicheritz-Pontén T, This P, Bacilieri R, Gilbert MTP, Wales, 2019. Palaeogenomic insights into the origins of French grapevine diversity. Submitted to Nature Plants, 2019. These 9.869 SNPs are a subset of the 10.207 SNPs for cultivated grapes previously published by Le Paslier et al, 2018 (https://doi.org/10.15454/1.4861359557068474E12). Plant material was harvested in two grapevine collections (FAO WIEWS instcode FRA139 and DEU098), respectively: A) France, “INRA Domaine de Vassal, Marseillan-Plage” (http://www6.montpellier.inra.fr/vassal) ; and B) Germany, “JKI Geilweilerhof, Siebeldingen” (http://www.deutsche-genbank-reben.julius-kuehn.de/
“VENERE PRIVATA” DA SCERBANENCO A BACILIERI: LINGUA, STILE E RETORICA DALLA LETTERATURA AL FUMETTO
No full textIl romanzo Venere privata di Giorgio Scerbanenco (1966) è tra i capostipiti del giallo italiano contemporaneo e introduce il personaggio Duca Lamberti, medico radiato dall’ordine per aver praticato l’eutanasia su una paziente e diventato, una volta scontata la pena, consulente della polizia milanese. La narrazione, la lingua e lo stile dell’autore, già studiati da diversi interventi specialistici, sono ora oggetto dell’adattamento a fumetti di Paolo Bacilieri, apparso a puntate sulla rivista Linus a partire dall’agosto 2021. La pubblicazione dovrebbe concludersi in rivista entro l’anno, ed è prevista per l’autunno 2022 l’edizione integrale in volume per Oblomov. Il presente studio affronta le prime sei puntate dell’adattamento, ne studia la lingua e lo stile in relazione al testo originale, la raffigurazione di ambienti, personaggi e situazioni in relazione agli elementi diegetici del romanzo e a modelli esterni usati da Bacilieri, infine la configurazione degli elementi iconici e verbali nelle tavole in prospettiva retorica. Ciò consente di comprendere non solo il processo e il concetto di adattamento attuati dall’autore, ma anche la lettura e l’interpretazione che questi ha fatto del racconto, della lingua e dello stile del testo originario.
Venere privata from Scerbanenco and Bacilieri: language, style and rhetoric from literature to comics
Giorgio Scerbanenco’s novel Venere privata (1966) is among the progenitors of the contemporary Italian detective story and introduces the character Duca Lamberti, a doctor disbarred for practicing euthanasia on a patient and becoming, once he has served his sentence, a consultant to the Milanese police. The author’s narrative, language and style, which have already been studied by several specialist papers, are now the subject of Paolo Bacilieri\u27s comic book adaptation, appearing serialized in Linus magazine starting in August 2021. The publication is expected to be completed in the magazine within the year, and a full volume edition for Oblomov is planned for Fall 2022. The present study deals with the first six installments of the adaptation, studying the language and style in relation to the original text, the depiction of the environments, characters and situations in relation to the diegetic elements of the novel and external models used by Bacilieri, and finally the configuration of the iconic and verbal elements in the tables in rhetorical perspective. This allows us to understand not only the process and concept of adaptation implemented by the author, but also his reading and interpretation of the story, language and style of the original text
Autocorrelation of Molecular Electrostatic Potential Surface Properties Combined with Partial Least Squares Analysis as New Strategy for the Prediction of the Activity of Human A3 Adenosine Receptor Antagonists.
No full textThe combination of molecular electrostatic potential (MEP) surface properties (autocorrelation vectors) with the conventional partial least squares (PLS) analysis has been used for the prediction of the human A(3) receptor antagonist activities. Three-hundred-fifty-eight structurally diverse human A(3) receptor antagonists have been utilized to generate a novel ligand-based three-dimensional structure-activity relationship. Remarkably, our chemical library includes all 21 important chemical classes of human A(3) antagonists currently discovered, and it represents the largest molecular collection used to generate a general human A(3) antagonist structure-activity relationship. A robust quantitative model has been obtained as described by both cross-validated correlation coefficient (r(cv) = 0.81) and prediction capability (r(pred) = 0.82). The proposed MEP/PLS approach can be considered as an alternative hit identification tool in virtual screening applications
Carcinoma spinocellulare del letto ungueale: descrizione di due casi.
No full textvengono presentati due casi di carcinoma spinocellulare del letto ungueal
Prediction of the acqueous solvation free energy of organic compounds by using autocorrelation of molecular electrostatic potential surface properties combined with response surface analysis
No full textSeveral quantitative structure-property relationship (QSPR) approaches have been explored for the prediction of aqueous solubility or aqueous solvation free energies, DeltaG(sol), as crucial parameter affecting the pharmacokinetic profile and toxicity of chemical compounds. It is mostly accepted that aqueous solvation free energies can be expressed quantitatively in terms of properties of the molecular surface electrostatic potentials of the solutes. In the present study we have introduced autocorrelation molecular electrostatic potential (autoMEP) vectors in combination with nonlinear response surface analysis (RSA) as alternative 3D-QSPR strategy to evaluate the aqueous solvation free energy of organic compounds. A robust QSPR model (r(cv)=0.93) has been obtained by using a collection of 248 organic chemicals. An external test set based on 23 molecules confirmed the good predictivity of the autoMEP/RSA model suggesting its further applicability in the in silico prediction of water solubility of large organic compound libraries
Molecular survey of georgian traditional grapevine genetic resources
No full textThe South Caucasus area is considered one of the main centers of origin and domestication for the cultivated grapevine, Vitis vinifera L. ssp. sativa DC. The aim of this work is to study the genetic structure of the Georgian grapevine platform by analyzing 135 Georgian grapevine accessions using 20 SSR molecular markers and to verify the contribution of Georgian germplasm to European viticulture. Among the 135 selected samples, 112 were representatives of traditional Georgian wine and table grape cultivars and 23 were collected from several Georgian woodlands and, after visual inspection, were considered representatives of Vitis vinifera ssp. sylvestris subspecies. Molecular fingerprints (20 SSR loci) of all 135 accessions were compared with data from the 2,300 accessions conserved at the Institut National de la Recherche Agronomique (INRA) grape germplasm repository of Domaine de Vassal. Nei’s genetic distance was calculated among the Vassal and Georgian samples to verify the presence of synonyms and to have an overview of the structure of Georgian grapevine germplasm platform compared with the ones belonging to other countries. Results highlighted that most of Georgian viticulture is quite isolated from elsewhere. The results suggest that the Georgian viticulture is still strongly correlated to its geographic origin, allowing to clearly distinguish groups of accessions belonging to different regions of the country. Among wild samples, the molecular fingerprint has revealed very few mistakes or inter-specific crossings in the pool of collected samples and highlighted that, as already verified for other regions, there is diversification between the wild and cultivated forms. Yet this separation does not seem to be, in the case of Georgia, as robust as seen in other grape growing regions. These results seem to confirm that typical Georgian cultivars weren’t spread to other European countries and, on the other hand Georgian viticulture did not have contaminations from elsewhere. The apparent isolation of Georgian germplasm makes this viticulture particularly interesting for further investigation
Serological Protection Induced by Influenza Inactivated Vaccine Against Drifted Variants: The importance of Adjuvant MF-59
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Comparison between a conventional subunit vaccine and the MF59-adjuvanted subunit vaccine in the ederly: an evaluation of the safety, tolerability and immunogenicity.
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