108 research outputs found
Rancang Bangun Troller dengan Menggunakan Sistem Remote Kontrol RF YS-1020
No full textTroller merupakan sebuah alat bantu pemindah barang dalam skala cukup banyak dan berat ke tempat yang dituju dengan menggunakan tenaga manusia dengan cara didorong. Pada tulisan ini dijelaskan rancang bangun troller yang dikendalikan oleh mikrokontroler ATMega 16 melalui sistem kendali pulse width modulation (pwm), yang dilengkapi dengan sistem Komunikasi data remote control RF Transceiver YS-1020 agar pengguna (manusia) lebih mudah dalam memindahkan barang.
Evolution of BL Lacertae host galaxies
No full textWe present and discuss deep, high-resolution I-band images of 24 BL Lac
objects between and 1.3 taken with the Nordic Optical
Telescope (NOT) and the ESO-NTT and VLT telescopes.
In addition, new redshifts for the BL Lac objects PKS 0406+121, PKS 0426–380
and PKS 1519–273 are reported.
In 17/24 (71%) of the BL Lac objects, we detected an
underlying nebulosity, in 11/17 for the first time. We assigned the underlying
nebulosity to the BL Lac host galaxy in 11 cases spanning the redshift range . The remaining 6 BL Lac objects have either intervening galaxies (S4
0218+35, PKS 0426–380), no redshift (MH 2133–449) or are probably
misidentified (Q 0230+3429, B2 0937+26, MS 2347.4+1924).
Restricting ourselves to the 11 BL Lac objects ( ),
where a core and host galaxy was
detected, we find that their host galaxies are luminous ()
and large ( kpc). They are on average about 0.6 mag brighter
than BL Lac host galaxies at indicative of evolution,
whereas their half-light radii are similar.
By combining our data with literature data at low-redshift and applying
evolutionary models to them, we show that the properties of the host galaxies
of BL Lac objects up to are compatible with passively evolving
elliptical galaxies formed at a redshift of
(13 Gyrs ago in our adopted cosmology).
Our results, however, are affected by an unavoidable luminosity bias and need
to be confirmed. Future prospects are described.
If they could be confirmed, host galaxies of low-luminosity radio-loud
AGN (BL Lac/FR I) have very similar properties
to the hosts of radio-quiet QSOs and high-luminosity radio-loud AGN
(radio-loud QSO/FR II) over a wide redshift range.
This supports the picture of the “Grand Unification”
in which AGN activity is a transient phenomenon in galaxy evolution
Salivary antibodies directed against outer membrane proteins of Moraxella catarrhalis in healthy adults
No full textMoraxella catarrhalis is a major mucosal pathogen of the human respiratory tract, but the mucosal immune response directed against surface components of this organism has not been characterized in detail. The aim of this study was to investigate the salivary immunoglobulin A (IgA) response toward outer membrane proteins (OMP) of M. catarrhalis in healthy adults, the group of individuals least likely to be colonized and thus most likely to display mucosal immunity. Unstimulated saliva samples collected from 14 healthy adult volunteers were subjected to IgA immunoblot analysis with OMP preparations of M. catarrhalis strain O35E. Immunoblot analysis revealed a consistent pattern of IgA reactivity, with the appearance of five major bands located at >250, 200, 120, 80, and 60 kDa. Eleven (79%) of 14 saliva samples elicited reactivity to all five bands. Immunoblot analysis with a set of isogenic knockout mutants lacking the expression of individual OMP was used to determine the identities of OMP giving rise to IgA bands. Human saliva was shown consistently to exhibit IgA-binding activity for oligomeric UspA2 (>250 kDa), hemagglutinin (200 kDa), monomeric UspA1 (120 kDa), transferrin-binding protein B (TbpB), monomeric UspA2, CopB, and presumably OMP CD. TbpB, oligomeric UspA2, and CopB formed a cluster of bands at about 80 kDa. These data indicate that the human salivary IgA response is directed consistently against a small number of major OMP, some of which are presently considered vaccine candidates. The functional properties of these mucosal antibodies remain to be elucidated
Accuracy-enhancing methods for balancing-related frequency-weighted model and controller reduction
No full textWe consider the solution of the balancing-related frequency-weighted model and controller reduction problems using accuracy enhanced numerical algorithms. We propose first new stability-enforcing choices of the frequency-weighted grammians which can guarantee the stability of reduced models for two-sided frequency weights. Then we show that for the frequency-weighted controller reduction problems with standard stability and performance-enforcing frequency weights the computation of the frequency-weighted grammians can be done by solving reduced order Lyapunov equations. For both frequency-weighted model and controller reduction problems we indicate how to compute the grammians directly in terms of their Cholesky factors. This allows the extension of the square-root and balancing-free accuracy-enhancing techniques to the frequency-weighted case
Rendez-Vous and Docking Position Tracking via Sliding Mode Control
No full textThis paper proposes a sliding mode strategy for the Chaser position tracking during the approaching maneuver to a passive vehicle (Target). The presented sliding mode control procedure considers different phases of the approaching maneuver, which are identified mainly based on the Chaser distance from the Target. The various stages correspond to different choices of the designed sliding mode control switching parameters (different frequencies, gains and desired velocity). The tracking performance of the proposed sliding mode con- troller is demonstrated by simulations. The obtained results are analyzed in order to evaluate the impact of the different choices on the overall performances (fuel consumption, precision of the docking and time required to complete the maneuver
Measurements of rotational energy transfer and quenching in OH A 2[Sigma]+, v'=0 at elevated temperature
No full textLee MP, Kienle R, Kohse-Höinghaus K. Measurements of rotational energy transfer and quenching in OH A 2[Sigma]+, v'=0 at elevated temperature. Applied Physics B. 1994;58(6):447-457.Total rotational energy transfer rates have been measured at 1330 K for specific rotational levels in the OH A 2[Sigma]+, v'=0 state in collisions with H 20. Rotational levels ranging from N'=0 to 15 were studied. Measurements were performed in the post-flame region of a stoichiometric H2/O2/He flame operating at 25 mbar. Quenching rates following excitation of individual upper rotational states were also measured. The RET and quenching rates both exhibit monotonic decreases with increasing rotational quantum number
Down-regulation of porin M35 in Moraxella catarrhalis by aminopenicillins and environmental factors and its potential contribution to the mechanism of resistance to aminopenicillins
No full textThe outer membrane protein M35 of Moraxella catarrhalis is an antigenically conserved porin. Knocking out M35 significantly increases the MICs of aminopenicillins. The aim of this study was to determine the biological mechanism of this potentially new antimicrobial resistance mechanism of M. catarrhalis and the behaviour of M35 in general stress situations
UA-R-GC-1914-01-01-1948-11-19_Page-002
No full textThe American University at Cairo
iviI NUTES OF THE THIRTIETH ANNUAL MEETING
of
The Board of Trustees
New York City November 19, 1948.
(References are to page numbers in the docket)
596.
ORGANIZATION
597.
PREVIOUS MINUTES
The meeting was held at the University Club, beginning at
10010 a.m. and opening with the Lord's Prayer led by
Dr. Horton.
Presents D. Horton, Chairman, R. G. Andrus, E. E. Calver-ly,
W. W. Cleland, E. M. Craig, H. Garrett, T. J. Gillespie,
Jr., R. W. Harbison, A. B. Lisle, G. D. Lockhart, R. W. Mc-
Clenahan, F. M. Potter, J. R. Sizoo, Mrs. W. E. Stevenson,
S. Thorne, F. K. Weyerhaeuser; also J. S. Badeau, R. S. Mc-
Clenahan, W. N. Madison, L. S. Kelley, and Anna Lister.
Absent: R. J. Dodds, C. P. Erdman, G. F. Jewett, and
J. M. Steele.
The Chairman called attention to the unusual fact that
more than two-thirds of the membership of the Board was
present.
The Chairman introduced Mrs . Stevenson, who was attending
her first meeting as trustee, and Miss Lister as Comp-troller,
and extended a welcome to Dr. McClenahan, Dean
Emeritus.
Greetings were read from Dr. George L. Robinson, Honorary
Life Trustee, and from Dean Worth Howard, Acting President
at Cairo.
Minutes of the Twenty-Ninth Annual Meeting held on Novem-ber
17, 1947, and of the special meeting of March 18, 1948,
were approved as distributed.
598.
SPECIAL VISITS TO CAIRO Reports of these visits by Dr, Potter, Mr. Garrett, and
Mr. and Mrs. Madison had been sent earlier to all members.
599.
REPORT OF THE PRESIDENT Also distributed in advance, this report was presented
by Dr. Badeau who called attention to certain portions
that he read and amplified. These included, under General
Observations, the present Egyptian attitude toward Ameri-cans,
relationships with Government, comments on inter-views
with the Prime Minister and Minister of Education,
and paucity of staff. At this point the Chairman note
Manifestações neurológicas e neurofisiológicas, padrão de inativação do X e biomarcadores nas heterozigotas para Adrenoleucodistrofia ligada ao X.
No full textA Adrenoleucodistrofia ligada ao X (X-ALD) é uma doença hereditária dos peroxissomos causada por mutações no gene ABCD1 -ATP-binding cassete (ABC), subfamília D, membro 1- um meio transportador peroxissômico: a proteína da adrenoleucodistrofia (ALDP). Bioquimicamente, a X-ALD é caracterizada pelo acúmulo de ácidos graxos de cadeia muito longa (VLCFA) e pelo impedimento parcial da Q-oxidação destes lipídeos no peroxissomo. O espectro clínico masculino varia desde insuficiência adrenal isolada, mieloneuropatia lentamente progressiva (AMN) a desmilelinização cerebral generalizada. As heterozigotas sintomáticas desenvolvem um quadro degenerativo e lentamente progressivo similar a AMN masculina. Por apresentarem a forma “pura” AMN, as heterozigotas foram escolhidas como modelo de estudo da mieloneuropatia da X-ALD. Estudamos uma coorte de 33 heterozigotas em relação a suas manifestações neurológicas e neurofisiológicas e correlacionamos à idade, duração da doença, tipos e localização das mutações, padrão de inativação do cromossomo X e através de um marcador de dano neuronal: a Enolase (NSE). Métodos: 39 heterozigotas previamente diagnosticadas em nossa instituição foram convidadas a participar e, após o consentimento, 37 realizaram o screening inicial. Quatro foram excluídas por apresentarem outras possíveis causas de mieloneuropatia. Trinta e três foram incluídas no grupo final e avaliadas através de duas escalas clínicas para mielopatia (JOA e SSPROM), de estudos de neurocondução periférica (NCS) e de potenciais evocados somatossensitivos (SEP). O padrão de inativação foi estudado através do ensaio de metilação HUMARA e a NSE medida através de ensaio de eletroquimiluminescência. Os dados foram correlacionados com variáveis demográficas e tipo e posição da mutação. C26:0 e C26:0/C22:0 previamente coletados também foram analisados. Resultados: 33 mulheres (29 sintomáticas) foram avaliadas. Sintomáticas e assintomáticas tinham diferenças significativas (m±dp) em relação à idade (43.9 ± 10.2 VS 24.3 ± 4.6), JOA (14.5 ± 1.7 VS 16.6 ± 0.2) e SSPROM (86.6± 7.9 VS 98.4 ± 1.1) escores (p<0.05). Ambas, JOA (r = -0.68) e SSPROM (r = -0.65) correlacionaram-se com a idade independente do estado sintomático (p = 0.0001, Spearman). Não houve achados importantes nos NCS, exceto pela amplitude do nervo fibular superficial com a idade ao início dos sintomas (rs = 0.55, p = 0.015). De todas heterozigotas, 72% apresentaram latências prolongadas na condução central ascendente dos membros inferiores avaliadas através do P40. SSPROM e P40 foram significativamente correlacionados (rs = -0.47, p = 0.018). Os tipos e posições das mutações e o padrão de lyonização não foram associados ao estado da doença. Os valores de NSE foram diferentes entre as heterozigotas e controles (12.9 ± 7 e 7.2 ± 7 Zg/l p = 0.012, Mann-Whitney U). Os valores dos VLCFA eram diretamente proporcionais ao aumento da idade da paciente no momento da coleta. Discussão: manifestações neurológicas correlacionam-se claramente com a idade e foram bastante comuns na presente coorte. Não houve explicações moleculares sobre porque algumas mulheres são mais afetadas que outras. Ambas, JOA e SSPROM foram capazes de discriminar as assintomáticas das sintomáticas. As escalas, o P40 e a NSE podem ser ferramentas úteis para acompanhar a progressão da doença em futuros estudos. Os achados neurofisiológicos reforçam a idéia prévia de que a doença neurológica nas mulheres acomete predominantemente as vias medulares com padrão ascendente e que o início dos sintomas possa ser simplesmente uma questão de tempo.X-linked adrenoleukodystrophy (X-ALD) is an inherited peroxisomal disorder caused by mutations in the ABCD1 gene - ATP-binding cassette (ABC) transporter ABCD1, subfamily D, member 1- a peroxisomal half transporter: the adrenoleukodystrophy protein (ALDP). Biochemically, X-ALD is characterized by accumulation of very longchain fatty acids (VLCFA) and partially impaired peroxisomal Q-oxidation. The clinical spectrum in males with X-ALD ranges from isolated adrenocortical insufficiency and slowly progressive myeloneuropathy (AMN) to devastating cerebral demyelination. The symptomatic heterozygotes develop a slowly progressive degenerative picture similar to the male AMN. Due to the “pure” AMN presentation of the heterozygotes, they were chosen as our model of X-ALD myeloneuropathy. We studied a cohort of 33 X-ALD heterozygotes in regards to their neurological and neurophysiological manifestations and correlated them with age, disease duration, types and position of mutations, X inactivation pattern, and the serum concentration of a neuron damage marker: Enolase (NSE). Methods: 39 heterozygotes previously diagnosed in our institution were invited to participate and, after consent, 37 went through the initial screening. Four were excluded due to the presence of other possible causes of myeloneuropathy. Thirty three were evaluated through two clinical scales for myelopathy (JOA and SSPROM); peripheral nerve conduction studies (NCS) and somatosensory evoked potentials (SEP). The inactivation pattern was tested by HUMARA methylation assay, and serum NSE was measured through eletrochemiluminescent assay. The data was correlated with demographic variables and type and position of the mutation. C26:0 and C26:0/C22:0 ratios were also analyzed. Results: 33 women (29 symptomatic) were analyzed. Symptomatic and asymptomatic women presented significantly different m±sd ages (43.9 ± 10.2 vs 24.3 ± 4.6), JOA (14.5 ± 1.7 vs 16.6 ± 0.2) and SSPROM (86.6± 7.9 vs 98.4 ± 1.1) scores (p<0.05). Both JOA (r = -0.68) and SSPROM (r = -0.65) correlated with age, irrespectively of the disease status (p = 0.0001, Spearman). There were no remarkable findings on NCS except for the fibular superficial nerve amplitudes that correlated with age at onset of symptoms among the heterozygotes (rs = 0.55, p = 0.015). Of all heterozygotes, 72% presented delayed latencies in the central ascending conduction studies from the lower limbs: P40. SSPROM and P40 latency were significantly correlated (rs = -0.47, p = 0.018). Types and positions of mutations and inactivation pattern were not associated with the disease status. NSE values were different between heterozygotes and controls (12.9 ± 7 and 7.2 ± 7 Zg/l p = 0.012, Mann-Whitney U). The higher the VLCFA levels and the more skewed the inactivation pattern as the older the women were at the time of the VLCFA sample collection. Discussion: neurologic manifestations clearly correlated to age and were quite common in the present cohort. There were no molecular clues to explain why some women were more affected than others. Both JOA and SSPROM scales were able to discriminate the asymptomatic from the symptomatic heterozygotes. Both scales plus P40 latency and NSE might be useful tools to follow the disease progression in future studies. The neurophysiologic findings supported the previous idea that the neuronal disease in the women has a predominant spinal cord involvement with an ascending pattern and that the beginning of symptoms might be a matter of time
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