5,330 research outputs found
Replication Data for: Flow and Transport of Methane from Leaking Underground Pipelines: Effects of Soil Surface Conditions and Implications for Natural Gas Leak Classification
No full textReplication Data for: Jayarathne, J. R. R. N., R. S. Kolodziej, S. N. Riddick, D. J. Zimmerle, and K. M. Smits. 2023. Flow and Transport of Methane from Leaking Underground Pipelines: Effects of Soil Surface Conditions and Implications for Natural Gas Leak Classification. Env. Sci. Tech. Letters, In revie
Colmjon (Gerben). R. C. Bakhuizen van den Brink. Een markante persoonlijkheid
No full textSmits Frans. Colmjon (Gerben). R. C. Bakhuizen van den Brink. Een markante persoonlijkheid. In: Revue belge de philologie et d'histoire, tome 30, fasc. 3-4, 1952. pp. 989-993
Cryptus subspinosus SMITS VAN BURGST 1913
No full textCryptus subspinosus SMITS VAN BURGST 1913 M a t e r i a l: West Azarbaijan province: Khoy, 1, 26 September 2006. D i s t r i b u t i o n o u t s i d e I r a n Tunisia, Algeria, Spain, France, Italia, Bulgaria, Israel.Published as part of Ghahari, H., Jussila, R. & I, Northwestern, 2011, A contribution to the knowledge of Ichneumon wasps (Hymenoptera: Ichneumonoidea: Ichneumonidae) from West Azarbaijan Province, Northwestern Iran, pp. 1277-1284 in Linzer biologische Beiträge 43 (2) on page 1279, DOI: 10.5281/zenodo.532633
Introduction to Sustainable Finance and Climate Change: Law and Regulation
No full textThis chapter provides a road map to the substantive chapters contained in the book and summarises their main contents
The ECB’s mandate in the face of climate change and biodiversity loss
No full textThis chapter delves into the mandate of the European Central Bank in relation to climate change and biodiversity loss. It reflects on the history of the interpretation of the ECB’s mandate and discusses the international developments on climate change on central banking and financial-sector supervision (NGFS, TCFD, BIS) and interprets the ECB’s primary mandate of maintaining price stability and its secondary mandate (to support the general economic policies in the Union with a view to contributing to the achievement of the objectives of the EU which include climate change-related objectives). The chapter sees strong arguments to read the primary and secondary mandates as not only permitting but requiring the ECB to take full account of climate change and biodiversity loss, while additional arguments can be derived from the integration provisions of the TFEU and the binding nature of the Paris Agreement. The chapter refutes that the open market principle forms an obstacle to its reading and discusses the operational consequences of this interpretation, also in the field of prudential supervision of banks and against the background of the EU taxonomy
A local search algorithm for the optimization of the stochastic economic lot scheduling problem
No full textA local search algorithm for the optimization of the stochastic economic lot scheduling problem / M. Wagner, S. R. Smits. - In: International journal of production economics. 90. 2004. S. 391-40
Effects of the H4 receptor antagonist JNJ7777120 in mice: focus on strain-related differenes
No full textThe histamine H4 receptor (H4R)has been identified in immune/inflammatory cells of different species and has been proposed as a new target for anti-inflammatory/antiallergic drugs (Smits et al., 2009). In the present study, the effect of the selective H4R antagonist JNJ7777120 was investigated in different experimental models from the mouse, focusing on possible strain-related differences.
The anti-inflammatory activity of JNJ7777120 was tested, in comparison with dexamethasone, in the ear edema assay by application of 2.5% croton oil (CO). Ear weight and histological tissue damage were investigated at different times (2-4 h) after CO administration. Gastric lesions were evaluated in fasted mice, 4 h after indomethacin (30 mg/kg sc) + bethanechol (5 mg/kg ip) (Rainsford KD, 1987).
JNJ7777120 (30-100 mg/kg sc) significantly reduced both ear weight and histological damage at 2 h (maximum inhibition 40-50%, n=6-8), but not at 4 h (n=8). This effect was observed in CD1, but not in C57BL/6J or NMRI mice. Moreover, in CD1 and NMRI strains, but not in the C57BL/6J, dexamethasone (2 mg/kg sc) displayed anti-inflammatory effects (65% inhibition on ear weight, n=6-9) at any time point considered. JNJ7777120 (3-30 mg/kg sc) did not damage the gastric mucosa and, actually, reduced the gastric lesions induced by concomitant administration of indomethacin (30 mg/kg sc) + bethanechol (5 mg/kg ip) (maximum inhibition 50% at 10 mg/kg sc, n=8). The gastroprotective effect was observed in CD1, NMRI and BALBc, but not in C57BL/6J mice.
In conclusion,present data evidence the anti-inflammatory activity of JNJ7777120 in a mouse model of skin inflammation developing at 2 h, whereas the inflammatory response at 4 h was not affected. The effect of JNJ7777120 was associated to protective effects in the gastric mucosa, suggesting a new treatment of inflammation combined with gastric safety. The different effects of the H4R antagonist in various mouse strains have to be carefully considered in the pharmacological characterization of H4R functions and evaluation of new H4R ligands.
Rainsford KD (1987). J. Pharm. Pharmacol. 39, 669-672
Smits et al. (2009). Drug Discov Today.14, 745-753
The Authors acknowledge support from the EU-KP7 COST programme BM0806 (Histamine H4receptor network)
Ten legal gaps Europe’s regulators must close
No full textRené Smits idenitifies ten key issues that European financial legislators must consider when constructing the post-crisis regulatory framework
Β. L. Humans Jr., R. Th. van der Paardt, E. R. Smits, R. E. H. Westendorp Boerma, A. G. Westerbrink, Apuleius Madaurensis. Metamorphoses. Book IV, 1-27. Text, Introduction and Commentary
No full textKnecht Daniel. Β. L. Humans Jr., R. Th. van der Paardt, E. R. Smits, R. E. H. Westendorp Boerma, A. G. Westerbrink, Apuleius Madaurensis. Metamorphoses. Book IV, 1-27. Text, Introduction and Commentary. In: L'antiquité classique, Tome 48, fasc. 2, 1979. pp. 697-698
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