323,202 research outputs found
ЭТИОЛОГИЯ, ПАТОГЕНЕЗ И МОРФОЛОГИЯ ЭФФЕКТА QUILTY
No full textDespite the fact that the study of endocardial infi ltrates (Quilty effect) in the transplanted heart has been going on for more than 30 years, the etiology, morphology and clinical signifi cance of this phenomenon are not yet fully understood. The article presents the facts of the available literature on the possible causes and mechanisms of the effect of Quilty, as well as on its impact on the function of the transplanted heartНесмотря на то что изучение эндокардиальных инфильтратов (Quilty effect) в трансплантированном сердце продолжается уже более 30 лет, этиология, морфология и клиническое значение этого феномена остаются до конца не выясненными. В статье приведены данные доступной литературы о возможных причинах и механизмах развития эффекта Quilty, а также о его влиянии на функцию трансплантированного сердца
СВЯЗЬ ЭФФЕКТА QUILTY С ОСТРЫМ ОТТОРЖЕНИЕМ ТРАНСПЛАНТИРОВАННОГО СЕРДЦА
No full textIntroduction. The Quilty Effect (lymphoid-cellular infiltration of the endocardium) is a frequent finding in biopsies of the transplanted heart. The role of this phenomenon in the rejection of the transplanted heart remains unclear. Aim. Retrospective analysis of endomyocardial biopsies of the transplanted heart and assessment of the relationship between acute cellular rejection and Quilty Effect. Methods and results. 112 endomyocardial biopsies with Quilty Effect were identified out of 883 studied biopsies during the period from January 2010 to June 2014. The frequency of Quilty damage occurrence in acute cellular rejection is significantly higher than in its absence (17.7% and 5.6%; р < 0.001). The combination of acute cellular rejection with acute antibodymediated rejection significantly increases the frequency of Quilty damage (р = 0.039). Isolated acute antibodymediated rejection of the transplanted heart does not affect the frequency of Quilty Effect occurrence and is not a direct etiologic and pathogenetic factor of this phenomenon. In the absence of acute cellular rejection, Quilty Effect is a predictor of its later development. Mild acute cellular rejection in conjunction with the Quilty Effect causes the risk of more severe degree of rejection. Quilty Effect type B occurs much less frequently than type A (1.9% and 10.8%; р = 0.001) and is observed primarily in acute cellular rejection of grade G2R (р = 0.001); the frequency of these morphological types at various periods after heart transplant was not significantly different (р > 0.05). Conclusion. The Quilty Effect is a kind of manifestation of acute cellular rejection of the transplanted heart when immunosuppressive therapy with calcineurin inhibitors is used. Введение. Эффект Quilty (лимфоидно-клеточная инфильтрация эндокарда) является нередкой находкой в биоптатах трансплантированного сердца. Остается неясным, какую роль играет этот феномен в отторжении трансплантированного сердца. Цель. Ретроспективный анализ эндомиокардиальных биоптатов трансплантированного сердца и оценка взаимосвязи острого клеточного отторжения с эффектом Quilty. Методы и результаты. В период с января 2010 г. по июнь 2014 г. было выявлено 112 эндомиокардиальных биоптатов с эффектом Quiltу из 883 изученных биоптатов. Установлено, что частота возникновения Quilty-повреждения при остром клеточном отторжении значительно выше, чем при его отсутствии (соответственно 17,7 и 5,6%; р < 0,001). Сочетание острого клеточного с острым антителоопосредованным отторжением существенно увеличивает частоту Quilty повреждения (р = 0,039). Изолированное острое антителоопосредованное отторжение трансплантированного сердца не влияет на частоту появления эффекта Quilty и не является непосредственным этиологическим и патогенетическим фактором этого феномена. При отсутствии острого клеточного отторжения эффект Quilty является предиктором его более позднего развития. При легкой степени острого клеточного отторжения в сочетании с эффектом Quilty существует риск более тяжелой степени отторжения. Эффект Quilty типа В встречается существенно реже типа А (1,9 и 10,8%; р = 0,001) и наблюдается преимущественно при остром клеточном отторжении степени G2R (р = 0,001); частота этих морфологических типов в различные сроки после трансплантации сердца значимо не отличается (р > 0,05). Заключение. Эффект Quilty является своеобразным проявлением острого клеточного отторжения трансплантированного сердца при иммуносупрессивной терапии ингибиторами кальциневрина.
HISTOLOGICAL CHARACTERISTICS OF THE QUILTY EFFECT
No full textAim. Identifi cation of possible histological differences of the Quilty effect in acute rejection and its absence as well as studying the proliferation of blood and lymph vessels in the area of Quilty damage.Materials and methods. 883 endomyocardial biopsy materials from 352 patients were studied. Histological sections were stained with hematoxylin and eosin, Masson method; the endothelium of lymphatic vessels was stained with immunoperoxidase method using a marker D2-40.Results. The Quilty effect was observed both in acute rejection and inits absence. In the majority of cases the Quilty effect was of type «A» and it was combined with acute rejection. The Quilty effect of type «B» has been mostly in the G2R. Acute rejection is characterized by diffuse form of endocardium lymphoid infi ltration. Follicular form resembles lymphoid organ tissue. Different types and forms of the Quilty effect may be combined in the same biopsy. Proliferation of blood vessels presents in the area of the Quilty effect. Lymphatic vessels are missing in endocardium and in the area of the Quilty effect. They could be found only in the myocardium of endomiocardial biopsy.Conclusion. Diffuse lymphoid infi ltration of the endocardium is a characteristic feature of acute rejection of the transplanted heart. Follicular form of the Quilty effect is similar to lymphoid tissue whose role requires further study using immunohistochemical methods
Quilty, B T, NX30364
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/412056Surname: QUILTY. Given Name(s) or Initials: B T. Military Service Number or Last Known Location: NX30364. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 41770.228013
Item: [2016.0049.44320] "Quilty, B T, NX30364
ETIOLOGY, PATHOGENESIS AND MORPHOLOGY OF THE QUILTY EFFECT
No full textDespite the fact that the study of endocardial infi ltrates (Quilty effect) in the transplanted heart has been going on for more than 30 years, the etiology, morphology and clinical signifi cance of this phenomenon are not yet fully understood. The article presents the facts of the available literature on the possible causes and mechanisms of the effect of Quilty, as well as on its impact on the function of the transplanted hear
THE RELATIONSHIP OF QUILTY EFFECT TO ACUTE REJECTION OF THE TRANSPLANTED HEART
No full textIntroduction. The Quilty Effect (lymphoid-cellular infiltration of the endocardium) is a frequent finding in biopsies of the transplanted heart. The role of this phenomenon in the rejection of the transplanted heart remains unclear. Aim. Retrospective analysis of endomyocardial biopsies of the transplanted heart and assessment of the relationship between acute cellular rejection and Quilty Effect. Methods and results. 112 endomyocardial biopsies with Quilty Effect were identified out of 883 studied biopsies during the period from January 2010 to June 2014. The frequency of Quilty damage occurrence in acute cellular rejection is significantly higher than in its absence (17.7% and 5.6%; р < 0.001). The combination of acute cellular rejection with acute antibodymediated rejection significantly increases the frequency of Quilty damage (р = 0.039). Isolated acute antibodymediated rejection of the transplanted heart does not affect the frequency of Quilty Effect occurrence and is not a direct etiologic and pathogenetic factor of this phenomenon. In the absence of acute cellular rejection, Quilty Effect is a predictor of its later development. Mild acute cellular rejection in conjunction with the Quilty Effect causes the risk of more severe degree of rejection. Quilty Effect type B occurs much less frequently than type A (1.9% and 10.8%; р = 0.001) and is observed primarily in acute cellular rejection of grade G2R (р = 0.001); the frequency of these morphological types at various periods after heart transplant was not significantly different (р > 0.05). Conclusion. The Quilty Effect is a kind of manifestation of acute cellular rejection of the transplanted heart when immunosuppressive therapy with calcineurin inhibitors is used
A tale of two cancers: collision presentation of ovarian carcinoma and lymphoma
No full textSynchronous malignancies are rare diagnostic and treatment challenges. Here we present three cases of synchronous ovarian cancer and lymphoma. Both malignancies were recognised in the same histopathology sections. This report discusses diagnosis and management dilemmas with a brief literature review. The simultaneous presentation of ovarian cancer and lymphoma has not previously been reported.Nimit Singhal, Simon Quilty, Matthew George, Margaret Davy and Sid Selva Nayaga
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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