1,709 research outputs found

    Increased mtDNA damage in KC corneas.

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    A, Representative agarose gels image of mtDNA damage in the KC patients and controls. B, Quantitation of smaller-sized bands per individual in normal and KC corneal LX-PCR mtDNA. The medians and the 25th and 75th percentiles of smaller-sized mtDNA bands of the KC and normal corneas are shown.</p

    Optimal design of building integrated energy systems by combining two-phase optimization and a data-driven model

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    By combining renewable energy systems (RESs) with buildings, building integrated energy systems (BIESs) reshape the building demand-supply relationship and contribute to both embodied and operational benefits. Their optimal designs, however, require consideration of various parameters and model complexity, making it challenging to solve multi-criteria problems and computationally intensive. This study aims to develop a datadriven two-phase optimization framework for exploring optimal BIES configurations. The novelties lie in 1) a co-simulation modelling and evaluation framework for BIES from both building and RES perspectives; 2) a twophase workflow to decouple the complex BIES model and solve multi-criteria decision problems and 3) an artificial neural network (ANN) surrogate model for rapid prediction. The proposed method is demonstrated using a prototype office building in a hot-summer and cold-winter area of China. The results show that RES-only optimization presents the lowest performances, necessitating the coordinated design for both building and RES sides. The simultaneous optimization method demonstrates the balanced quality for exploring both Pareto front and optimal solution, but encounters expensive computational costs (225 h) and convergence difficulty under 5000 optimization iterations. Comparatively, the proposed ANN-based two-phase optimization can achieve competitive solutions with half the computational time (90.6 h), which can be further reduced by efficient sampling methods. Overall, this study provides an optimization framework for holistically assessing and designing BIES that can approximate optimal configurations with significant computational savings

    Mekanisme Restrukturisasi Dalam Penyelesaian Pembiayaan Murabahah Bermasalah Pada Bank Sumut Syariah KC Medan Katamso

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    The purpose of this study is to understand the restructuring mechanism in solving problematic murabahah financing at Bank Sumut Syariah KC Medan Katamso. This research uses descriptive qualitative method. The source of the data obtained and used in this study was obtained directly at the research location at PT Bank Sumut Syariah KC Medan Katamso. This study uses primary data. In addition, in this study, raw data was also collected in the form of secondary data, such as evidence, documents or historical reports, documents, archives, whether published or not. The data collection that the writer did was through observation, interviews and document studies. Observations were made through direct observation at PT Bank Sumut Syariah KC Medan Katamso. Interviews were addressed directly to the Business or Marketing division of PT. Bank Sumut Syariah KC Medan Katamso according to the information needs by answering the questions raised by the author. Document research conducted by the author is in the form of written data or other documents needed by the author. After doing the research, it can be concluded that the North Sumatra Sharia KC Medan Katamso Bank in implementing the restructuring mechanism there are principles that must be followed in resolving problem financing contained in Bank Indonesia Regulations and can be said to be good. The principles applied by Bank Sumut Syariah KC Medan Katamso are in accordance with Bank Indonesia Regulation No. 13/9/PBI/2011 concerning amendments to Bank Indonesia Regulation Number 10/1/PBI/2008 concerning Financing Restructuring for Sharia Banks and UUS. Namely, rescheduling, reconditioning, and restructuring

    Reduced muscle weight in C26-bearing mice.

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    (A) Body weight (BW), Tibialis anterior (TA), gastrocnemius (GC), and quadriceps (Qu) muscle weights (mg) of #KC (black bar)- or colon26 (C26, white bar)-bearing mice 16 or 19 days after transplantation. (B) Relative tumor weights of #KC (black bar)- and C26 (white bar)- bearing mice 19 days after tumor transplantation. (C) The GC or Qu muscle weights (mg) per body weight (g) of #KC (black bar)- or colon26 (C26, white bar)-bearing mice 16 or 19 days after transplantation. (D) Fat weight (mg) of #KC (black bar)- or C26 (white bar)-bearing mice 19 days after tumor transplantation. *PP<0.01, NS: non-significant.</p

    Pelaksanaan Pembiayaan Modal Kerja Musyarakah Pada PT. Bank Syariah Indonesia KC Padang

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    The purpose of this research was to determine the implementation of Musyarakah working capital financing at PT. Bank Syariah Indonesia KC Padang. In analyzing the data, the author uses qualitative data analysis methods as a research method that describes descriptively the implementation of Musyarakah working capital financing at the PT. Bank Syariah Indonesia KC Padang. The results of this study there are several stages of procedures in the Implementation of Musyarakah Working Capital Financing at PT. Bank Syariah Indonesia KC Padang, namely submitting a financing application, financing feasibility analysis, the decision to grant Musyarakah working capital financing which is divided into two decisions, namely the financing decision is accepted and the decision is rejected. If the financing decision is accepted or rejected, it is submitted in writing by providing clear and thoughtful reasons. After the financing decision is approved, it will proceed to the stage of contract and disbursement of financing, supervision of financing and repayment of financing

    On the mountain pass lemma

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    MathematicsSCI(E)2ARTICLE203-208119

    Relative mtDNA content in 101 normal corneas and 193 KC corneas.

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    The medians and the 25th and 75th percentiles of relative mtDNA content in the KC and normal corneas are shown.</p

    Penyelesaian Pembiayaan Bermasalah Terhadap Perjanjian Kepemilikan Rumah Di Brk Syariah Kc Arifin Ahmad Pekanbaru

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    ABSTRACT Housing is a basic need besides food and clothing. The role of banking greatly affects the economic activities of a country. Providing housing financing is one of the most basic bank businesses, one of which is providing housing financing by BRK Syariah. Before providing financing the bank needs to assess customers who apply for financing. Because, not a few customers fail to fulfill their obligations in house payments which results in problematic financing. In resolving problematic financing, settlement is not always carried out through court channels, but also efforts to resolve problems carried out outside the court provided by BRK Syariah. The formulation of the problem in this research is how to review the law regarding the resolution of problematic home ownership financing at BRK Syariah KC Arifin Ahmad Pekanbaru and what factors cause problematic home ownership financing at BRK Syariah KC Arifin Ahmad Pekanbaru. The type of research used is included in the empirical group and the sample for this research is one part of the BRK Syariah bank KC Arifin Ahmad Pekanbaru, namely the Management Director and several customers who have been declared in default or failed to carry out their obligations. From the results of research that has been conducted by the author, that the settlement of problematic financing of home ownership in BRK Syariah KC Arifin Ahmad Pekanbaru is litigation and non-litigation, such as rescheduling, reconditioning and restructuring and there are 2 (two) factors causing the financing of problematic home ownership in BRK Syariah KC Arifin Ahmad Pekanbaru, namely internal factors originating from the bank that are not careful both from analyzing prospective customers, as well as in the calculation of home financing and ext from the bank that is not careful both from analyzing prospective customers, as well as in the calculation of rumaa financing and external factors from the customer, where there are some customers who do not make payments because there is an element of intentionality and an element of customer unintentionality. Keywords

    Test Record for Author Crosswalk FIG to ELE 20250807 KC

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    This test record is for the purpose of testing the FIG to ELE crosswalk for author Keely Chapman on 20250807. </p

    Transcriptome profile in Drosophila Kc and S2 embryonic cell lines

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    Drosophila melanogaster cell lines are an important resource for a range of studies spanning genomics, molecular genetics, and cell biology. Amongst these valuable lines are Kc167 (Kc) and Schneider 2 (S2) cells, which were originally isolated in the late 1960s from embryonic sources and have been used extensively to investigate a broad spectrum of biological activities including cell-cell signaling and immune system function. Whole-genome tiling microarray analysis of total RNA from these two cell types was performed as part of the modENCODE project over a decade ago and revealed that they share a number of gene expression features. Here, we expand on these earlier studies by using deep-coverage RNA-sequencing approaches to investigate the transcriptional profile in Kc and S2 cells in detail. Comparison of the transcriptomes reveals that ∼75% of the 13,919 annotated genes are expressed at a detectable level in at least one of the cell lines, with the majority of these genes expressed at high levels in both cell lines. Despite the overall similarity of the transcriptional landscape in the two cell types, 2,588 differentially expressed genes are identified. Many of the genes with the largest fold change are known only by their CG designations, indicating that the molecular control of Kc and S2 cell identity may be regulated in part by a cohort of relatively uncharacterized genes. Our data also indicate that both cell lines have distinct hemocyte-like identities, but share active signaling pathways and express a number of genes in the network responsible for dorsal-ventral patterning of the early embryo. © The Author(s) 2023. Published by Oxford University Press on behalf of the Genetics Society of America
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