178,506 research outputs found
Genetic Basis of Inherited Eye Diseases
No full textContains fulltext :
106926.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 18 april 2013Promotores : Cremers, F.P.M., Qamar, R. Co-promotor : Collin, R.W.J
Molecular Genetic Elucidation of Inherited Retinal Diseases
No full textContains fulltext :
106925.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 17 april 2013Promotores : Cremers, F.P.M., Qamar, R. Co-promotores : Collin, R.W.J., Hollander, A.I. de
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Genetics of glaucoma
No full textContains fulltext :
194336.pdf (Publisher’s version ) (Open Access)Glaucoma is a complex neurodegenerative disorder and the leading cause of irreversible blindness worldwide. The disease is genetically, physiologically, and phenotypically complex. Glaucoma is subdivided into primary and secondary types which may be associated with additional systemic anomalies causing different syndromic phenotypes. In this thesis, structure of the eye and related tissues involved in the pathogenesis of disease, different types of glaucoma, associated syndromes, genetic risk factors and their heritability have been explained. In addition, different techniques and approaches used in this thesis to identify genetic risk factors and novel candidate genes for glaucoma. In this thesis, we performed Candidate gene sequencing, using Sanger sequencing of genes previously associated with glaucoma and associated syndromes (CYP1B1, MYOC, OPTN, ASB10, FOXC1, PAX6, PITX2, FBN1) in families from Pakistan. Novel rare pathogenic variants were identified in the analyzed genes in Pakistani families with PCG, POAG, anterior segment dysgenesis and Marfan syndrome. Whole exome sequencing for identification of novel genes was performed. Using high-throughput sequencing technology rare variants in known glaucoma genes (LTBP2, PRDM5, PXDN) in consanguineous Pakistani families and a novel gene (TP53BP2) in a dominant Dutch POAG family have been identified. Homozygosity mapping together with WES identified a novel candidate gene, DBX2, in a large consanguineous family with JOAG, and rare variants in the PRDM5 gene in a family with brittle cornea syndrome. PRDM5 gene variants were also identified in Axenfeld Rieger’s syndrome. A novel genotype-phenotype association was found for variants in the PRPF8 gene in large Dutch and Pakistani families with glaucoma. In addition, past and present treatment strategies for glaucoma are explained. In future research, patient-specific induced pluripotent stem cells can be used to differentiate cells relevant to the disease site in the eye, which can help to understand the disease mechanisms and to design new treatment options.Radboud University, 26 september 2018Promotores : Hollander, A.I. den, Qamar, R
Adult burn survivors’ personal experiences of rehabilitation: An integrative review
No full textAbstract not availableR. Kornhaber, A. Wilson, M.Z. Abu-Qamar, L. McLea
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Letter from R. R. Zellick, Assistant Trust Officer, Anglo California National Bank of San Francisco, to Joseph R. Goodman, October 2, 1942
No full textLetter from R. R. Zellick, Assistant Trust Officer at The Anglo California National Bank of San Francisco, to Joseph R. Goodman, regarding property owned by Dave Tatsuno. Zellick mentions a dispute between current tenants and Tatsuno, and that Tatsuno has asked Goodman to help locate trustworthy tenants.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
Estimation of Distribution of Income in Pakistan, Using Micro Data
No full textIncome distribution entered the post war discussion of economic development fairly late. Until the 1960s much of the focus was on industrialisation and the need for capital accumulation. Pakistan was no exception as in the early 60s economic expansion became the main target and means to political identity. Rapid population growth associated with steep decline in mortality demanded acceleration of production to keep pace. Overall aggregate expansion was much faster than before but without benefit for the poor. In that context emerged a new professional interest in income distribution. Haq’s (1964) study was one of the oldest studies conducted to measure inequality in personal income distribution in the high income brackets in the urban areas of Pakistan. The main objective of the author was to present the income distribution pattern in terms of the relative shares of different income groups as well as in terms of Pareto coefficients and concentration ratio during the period 1948-49 to 1957-58 for which published tax data was available. While recognising the limitations of the data used, the author went on to calculate various measures of income inequality including Pareto coefficient and Lorenz curve. The author also made comparison of Pakistan’s income distribution with U.S.A. and U.K.
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
