43,941 research outputs found
On isomorphism of the space of continuous functions with finite p-th variation along a partition sequence
No full textWe study the concept of (generalized) p-th variation of a real-valued continuous function along a general class of refining sequence of partitions. We show that the finiteness of the p-th variation of a given function is closely related to the finiteness of p-norm pound of the coefficients along a Schauder basis, similar to the fact that H & ouml;lder coefficient of the function is connected to B infinity-norm of the Schauder coefficients. This result provides an isomorphism between the space of ca-H & ouml;lder continuous functions with finite (generalized) p-th variation along a given partition sequence and a subclass of infinite-dimensional matrices equipped with an appropriate norm, in the spirit of Ciesielski.
Pola Penyebaran Nilai Tahanan Jenis Lapisan Batuan Gunungapi Purba Sapaya di DAS Jenelata Sulawesi Selatan
No full textPenelitian peranan geolistrik tahanan jenis untuk mengetahui pola penyebaran vertikal nilai tahanan jenis lapisan batuan di Daerah Aliran Sungai (DAS) Jenelata dilatarbelakangi oleh kondisi geologi di daerah tersebut. Geologi daerah tersebut didominasi batuan plutonik dan rempah-rempah gunungapi. DAS Jenelata merupakan tempat aliran material letusan Gunungapi purba Sapaya. Tahanan jenis material dari beberapa jenis batuan yang mengendap ini perlu diketahui dengan menggunakan kajian geofisika-geolistrik. Metode geolistrik tahanan jenis konfigurasi Wenner yang digunakan dalam penelitian ini bertujuan untuk memetakan secara vertikal lapisan batuan di DAS Jenelata. Hasil yang diperoleh dari 4 lintasan dengan masing-masing panjang 150 meter menunjukkan nilai tahanan jenis rata-rata di DAS Jenelata sekitar 5 ??? 2000 ??m. Nilai tahanan jenis ini dapat dikelompokkan menjadi 2 bagian yaitu 5 ??? 300 ??m dan 301 ??? 2000 ??m Hasil yang terakhir ini menunjukkan nilai tahanan jenis batuan plutonik. Di sekitar hilir DAS Jenelata nilai tahanan jenis relatif rendah, yaitu dibawah 300 ??m. Nilai ini menandakan bahwa di hilir DAS mengendap batuan yang telah mengalami pelapukan
New species for the avifauna of adjoining coastal areas of Purba Medinipur district, West Bengal, India
No full textTo upgrade the known avifaunal assemblages of adjoining coastal areas of Purba Medinipur district, West Bengal, India, opportunistic survey were carried out during January 2020 to August 2022. The survey yielded additions of 36 bird species in 10 orders and 17 families to the coastal area of Purba Medinipur district, based on photographic evidences. Among these recorded birds, 30 species were classified as Least Concern, two species were Near Threatened (Aythya nyroca, Calidris canutus), one species was Vulnerable (Aythya ferina), two species were Endangered (Calidris tenuirostris, Rynchops albicollis) and one species was Not Assessed (Porphyrio poliocephalus). Details of all the records are given here
Seminário sobre aquacultura 14 a 16 de dezembro de 1983
No full textA necessidade de desenvolver a aquacultura em Portugal obriga à escolha das espécies mais indicadas para tal finalidade. A propósito o autor chama a atenção para as graves consequências que podem advir das introduções e/ou transferências de animais aquáticos, quer para as espécies locais e meio ambiente, como para a para a saúde pública.Concerning the need to choose the most convenient species to cultivate in order to implement aquaculture in Portugal, the author draws the attention to the deleterious consequences of introductions and transfers of aquatic animals.Caixa Geral de Depósito
SARS-CoV-2 spike fusion peptide trans interaction with phosphatidylserine lipid triggers membrane fusion for viral entry
No full textSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the fusion machine for host cell entry. Still, the mechanism by which spike protein interacts with the target lipid membrane to facilitate membrane fusion during entry is not fully understood. Here, using steady-state membrane fusion and single-molecule fluorescence resonance energy transfer imaging of spike trimers on the surface of SARS-CoV-2 pseudovirion, we directly show that spike protein interacts with phosphatidylserine (PS) lipid in the target membrane for mediating fusion. We observed that the fusion peptide of the spike S2 domain interacts with the PS lipid of the target membrane. Low pH and Ca2+ trigger the spike conformational change and bring fusion peptide in close proximity to the PS lipid of the membrane. The binding of the spike with PS lipid of its viral membrane (cis interaction) impedes the fusion activation. PS on the target membrane promotes spike binding via trans interaction, prevents the cis interaction, and accelerates fusion. Sequestering or absence of PS lipid abrogates the spike-mediated fusion process and restricts SARS-CoV-2 infectivity. We found that PS-dependent interaction for fusion is conserved across all the SARS-CoV-2 spike variants of concern (D614G, Alpha, Beta, Delta, and Omicron). Our study suggests that PS lipid is indispensable for SARS-CoV-2 spike-mediated virus and target membrane fusion for entry, and restricting PS interaction with spike inhibits the SARS-CoV-2 spike-mediated entry. Therefore, PS is an important cofactor and acts as a molecular beacon in the target membrane for SARS-CoV-2 entry
Cross-section across the Manu River at Purba Ratachhara (a) t1 (b) t2.
No full textCross-section across the Manu River at Purba Ratachhara (a) t1 (b) t2.</p
Pola Penyebaran Nilai Tahanan Jenis Lapisan Batuan Gunung Api Purba Sapaya di DAS Jene???lata
No full textAbstrak. Pen3elitian peranan geolistrik tahanan jenis untuk mengetahui pola penyebaran vertikal nilai tahanan jenis lapisan batuan di Daerah Aliran Sungai (DAS) Jenelata dilatarbelakangi oleh kondisi geologi di daerah tersebut. Geologi daerah tersebut didomonasi batuan plutonik dan rempah-rempah gunungapi. DAS Jenelata merupakan tempat aliran material letusan gunungapi purba Sapaya. Tahanan jenis material dari beberapa jenis batuan yang mengendap ini perlu diketahui dengan menggunakan kajian geofisika-geolistrik. Metode geofisika tahanan jenis konfigurasi Wenner yang digunakan dalam penelitian ini bertujuan untuk memetakan secara vertikal lapisan batuan di DAS Jenelata. Hasil yang diperoleh dari 4 lintasan dengan masing-masing panjang 150 meter menunjukkan nilai tahanan jenis rata-rata di DAS Jenelata sekitar 5-2000 ???m. Nilai tahanan jenis ini dapat dikelompokkan menjadi 2 bagian yaitu 5-300 ???m dan 301-2000 ???m. Hasil yang terakhir ini menunjukkan nilai tahanan jenis batuan plutonik. Di sekitar hilir DAS Jenelata nilai tahanan jenis relatif rendah, yaitu di bawah 300 ???m. Nilai ini menendakan bahwa di hilir DAS Jenelata mengendap batuan yang telah mengalami pelapukan
Identify Marketing Channel & Marketing Efficiency, Marketing Margin, Marketing Cost, Price Spread of Gobindobhog Rice in Purba Bardhaman District of West Bengal, India
Get PDFThe present study entitled “IDENTIFY MARKETING CHANNEL & MARKETING EFFICIENCY, MARKETING MARGIN, MARKETING COST, PRICE SPREAD OF GOBINDOBHOG RICE IN PURBA BARDHAMAN DISTRICT OF WEST BENGAL, INDIA”. It was founded that there are two marketing channels involved in marketing of Gobindobhog in Purba Bardhaman district of West Bengal (Channel 1 – Producer/Rice mill-Wholesaler-Consumer), (Channel 2- Producer/Rice Mill- Wholesaler- Retailer-Consumer). The majorly preferred marketing channel by respondents in the study area is Channel 2. In channel 1, total marketing cost is Rs.25, total marketing margin is Rs 595, marketing efficiency of channel 1 is 2.58% and Price spread seen in channel 1 is Rs.550. In channel 2, total marketing cost is Rs.255, total marketing margin in channel 2 is Rs. 800, marketing efficiency of channel 2 is 1.71% and Price spread seen in channel 2 is Rs.755.00
Redox-Responsive Nanocapsules for the Spatiotemporal Release of Miltefosine in Lysosome: Protection against Leishmania
No full textLeishmaniasis, a vector-borne disease, is caused by intracellular parasite Leishmania donovani. Unlike most intracellular pathogens, Leishmania donovani are lodged in parasitophorous vacuoles and replicate within the phagolysosomes in macrophages. Effective vaccines against this disease are still under development, while the efficacy of the available drugs is being questioned owing to the toxicity for nonspecific distribution in human physiology and the reported drug-resistance developed by Leishmania donovani. Thus, a stimuli-responsive nanocarrier that allows specific localization and release of the drug in the lysosome has been highly sought after for addressing two crucial issues, lower drug toxicity and a higher drug efficacy. We report here a unique lysosome targeting polymeric nanocapsules, formed via inverse mini-emulsion technique, for stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line. A benign polymeric backbone, with a disulfide bonding susceptible to an oxidative cleavage, is utilized for the organelle-specific release of miltefosine. Oxidative rupture of the disulfide bond is induced by intracellular glutathione (GSH) as an endogenous stimulus. Such a stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line over a few hours helped in achieving an improved drug efficacy by 200 times as compared to pure miltefosine. Such a drug formulation could contribute to a new line of treatment for leishmaniasis.A. Das acknowledges SERB (India) Grants (CRG/2020/000492 and JCB/2017/000004) and DBT Grant (BT/PR22251/NNT/28/1274/2017) for supporting this research. N. Mukherjee acknowledges SERB (India) Grant PDF/2016/001437 and K. Das acknowledges the grant EMR/2015/001674 for supporting this research. Financial support from DST (DST/INSPIRE/03/2017/002477) is acknowledged by R.T. This manuscript bears CSMCRI registration no 7/2021.Pramanik, SK (corresponding author), CSIR Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India.
Mukherjee, N (corresponding author), CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, Kolkata 700032, India.
Chattopadhy, S (corresponding author), BITS Pilani, Pilani 403726, Goa, India.
Das, A (corresponding author), Indian Inst Sci Educ & Res Kolkata, Mohanpur 741246, W Bengal, India.
[email protected]; [email protected]; [email protected]
Interview with Indra Das
Get PDFIndra Das is most well-recognized as the author of The Devourers (2015), a novel that won the Lambda Literary Award for straddling the genres of sci-fi, speculative, and fantasy fiction alongside LGBT themes. Das’s short fiction is widely published is horror and sci-fi anthologies, as well as magazines like Tor.com, Strange Horizons, and Asimov’s Science Fiction. He spoke candidly with Alok Amatya over email about the current literary landscape, the work of writing transgressive genre fiction, and his own experiences as an upcoming global author
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