712 research outputs found
PARTICIPANCY AND THE CONTEMPORARY IN INDEPENDENT FILM PRODUCTION IN SLOVENIA
No full textV dobrem stoletju svojega obstoja je dokumentarni film doživel radikalne spremembe tako v svoji reprezentaciji kot v samem izgledu. Dandanes je dokumentarizem eno glavnih orodij za razumevanje globalnih kontekstov na nivoju širše javnosti. Tudi v Sloveniji je dokumentarna produkcija, predvsem neodvisna, v zelo hitrem razvoju, krog ustvarjalcev in tudi občinstva dokumentarnih filmov pa je širši kot kdajkoli prej. V diplomskem delu se, po pregledu trenutnega stanja neodvisne dokumentarne produkcije v Sloveniji, poglobimo v različne teorije dokumentarne reprezentacije. Nato pa preko pogovora z režiserko Anjo Medved in analizo njenih filmov skušamo raziskati, kakšne so značilnosti sodobnih dokumentarnih vsebin, v katero smer pelje njihov razvoj ter kakšni so cilji, ki si jih njihovi režiserji zastavljajo.In more than one hundred years of its history, the documentary film was marked by radical changes in representational and visual meanings. Nowadays, the main efforts of documentarism are focused toward the understanding of global contexts on a large public scale. The independent documentary in Slovenia is developing extremely fast. The consequences are fast growing production teams and audiences. We begin the following thesis with a short overview on documentary tradition and a structural research on some documentary theories. The core part is based on the director Anja Medved, starting with an interview and followed by an analysis of four of her films. The goal is to find some specifics of the contemporary documentary film and understand the meanings which today\u27s directors impose on documentarism
Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells
No full textArsenic trioxide (arsenite) was the first chemotherapeutic drug to be described and is now being rediscovered in cancer treatment, including glioblastoma multiforme. Arsenite toxicity triggers autophagy in cancer cells, although final stages of the process involve executive caspases, suggesting an interplay between autophagic and apoptotic pathways that awaits to be explained at a molecular level. We evaluated the contribution of the lysosomal cathepsins (Cat) L and B, which are upregulated in glioblastomas, in the mechanism of arsenite toxicity in human glioblastoma cells. Arsenite treatment induced autophagosome formation and permeabilization of mitochondria, followed by caspase 3/7-mediated apoptosis. The autophagy inhibitor 3-methyladenine protected from arsenite toxicity, whereas bafilomycin A1 did not. Furthermore, arsenite significantly decreased CatB levels and selectively inhibited its cellular and recombinant protein activity, while not affecting CatL. However, downregulation of CatL greatly enhanced apoptosis by arsenite. Our results show that arsenite toxicity involves a complex interplay between autophagy and apoptosis in human glioblastoma cells and is associated with inhibition of CatB, and that this toxicity is highly exacerbated by simultaneous CatL inhibition. The latter points to a synergy that could be used in clinical treatment to lower the therapeutic dose, thus avoiding the toxic side effects of arsenite in glioblastoma management
Resveratrol Reduces the Invasive Growth and Promotes the Acquisition of a Long-Lasting Differentiated Phenotype in Human Glioblastoma Cells
No full textMalignant glioblastoma represents a challenge in the chemotherapy of brain
tumors, because of its aggressive behavior characterized by chemoresistance,
infiltrative diffusion, and high rate of recurrence and death. In this study, we
used cultured human U87MG cells and primary human glioblastoma cultures to test
the anticancer properties of resveratrol (RV), a phytoalexin abundantly present
in a variety of dietary products. In U87MG cells, 100 μM RV elicited cell growth
arrest by 48 h and bax-mediated cell toxicity by 96 h and greatly limited cell
migration and invasion through matrigel. Both in U87MG cells and in primary
glioblastoma cultures, the chronic administration of RV (100 μM for up to 96 h)
decreased the expression of nestin (a brain (cancer) stem cells marker) but
increased that of glial acidic fibrillary protein (a mature glial cell marker)
and of βIII-tubulin (a neuronal differentiation marker). Chronic treatment with
RV increased the proportion of cells positive for senescence-associated
β-galactosidase activity. This is the first report showing the ability of RV to
induce glial-like and neuronal-like differentiation in glioblastoma cells. The
beneficial effects of chronic RV supplementation lasted up to 96 h after its
withdrawal from the culture medium. The present findings support the introduction
of pulsed administration of this food-derived molecule in the chemotherapy
regimen of astrocytomas
Open Access
No full textGroup X secreted phospholipase A 2 induces lipid droplet formation and prolongs breast cancer cell surviva
Institutionalizing ASEAN: celebrating Europe through network governance
No full textThis article provides a new piece for two of the puzzles of institutionalized cooperation in Association of Southeast Asian Nations (ASEAN). First, with regard to the organization's four decades of existence, there has always been a marked gap between ASEAN's rhetorical goals of cooperation and its actual achievements. What explains these systematic failures of implementation? Second, from the outset, ASEAN was criticized for its light institutionalization, which failed to deliver the substantial cooperation goals. Despite selected institutional reforms, ASEAN's autonomy has not increased remarkably and it has not made any major institutional innovations. Why does ASEAN design institutions it does not use? Why does this transformation gap occur? The author suggests a sociological institutional explanation and argues that major impulses for cooperation have come from outside Southeast Asia, most importantly from Europe. By mimicking the European integration process, ASEAN member states have effectively created an isomorphic organization. The Association's institutional development reflects a concern for international legitimacy and less an objective functional demand arising from the specific interactions of member states. This copying process has led to network governance within the organization
The Vietnamese Theatrical Tradition in the Plot of Monsun, by Anja Hillin
No full textFrom the dramatic text Monsun by the German author Anja Hilling, this article analyzes the construction of a plot using elements of the Asian theater, in this specific case the Vietnamese tradition, identifying its presence inthe structure beyond the constant references to the context of that country, starting with the title of the play itself and the trip of one of the characters to Vietnam.A partir do texto dramático Monsun, da autora alemã Anja Hilling, este artigo analisa a construção de uma trama que se utiliza de elementos do teatro asiático, neste caso específico a tradição vietnamita, identi cando a sua presença na estrutura, além das men- ções constantes ao contexto daquele país, começando pelo próprio título da peça e pela viagem de uma das personagens ao Vietnam. 
Discussing Anja Štefan`s fairytales in the first year of primary school
No full textFairytales are an indispensable part in children's lives. They stimulate the development of imagination, fantasy; they help to enrich children’s vocabulary and with expressing feelings. There are different types of fairytales and it is very important that children get to know the variety of them. I firstly presented a youth author Anja Štefan and her literary works in my diploma paper. Later on I continued with the presentation of youth literature and I defined the theory of a fairytale, wrote about the origin, its meaning and classification of fairytales which I have also described in greater detail. I stated and described authorial prose work of Anja Štefan: picture book Lešniki, lešniki and classic fairytales Kotiček na koncu sveta, Melje, melje mlinček and Štiri črne mravljice, which can be defined as animal fairytales. I was interested in the receptive development of children in the period of intuitive intelligence, which I thoroughly described. In the empirical part of my diploma I wrote lesson plans for discussing and teaching three Anja Štefan’s animal fairytales in the first grade of primary school. 25 children took part in the research. I found out that pupils distinguish between real and unreal life (imaginative life), they are capable of identifying themselves with a literary person and they perceive animals as literary persons and they identify themselves with them
Correction to: Predicting the effectiveness of protected areas of Natura 2000 under climate change
No full textIn the original publication of this article (Nila & Hossain, 2019), co-authors ‘Carl Beierkuhnlein, Anja Jaeschke and Samuel Hoffmann’ need to be added to the author list
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