97,341 research outputs found

    Semibiotic Persistence

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    From observation, we find four different strategies to successfully enable structures to persist over extended periods of time. If functionally relevant features are very large compared to the changes that can be effectuated by entropy, the functional structure itself has a high enough probability to erode only slowly over time. If the functionally relevant features are protected from environmental influence by sacrificial layers that absorb the impinging of the environment,deterioration can be avoided or slowed. Loss of functionality can be delayed, even for complex systems, by keeping alternate options for all required components available. Biological systems also apply information processing to actively counter the impact of entropy. The latter strategy increases the overall persistence of living systems and enables them to maintain a highly complex functional organisation during their lifetime and over generations. In contrast to the other strategies, information processing has only low material overhead. While at present engineered technology is far from achieving the self-repair of evolved systems, the semibiotic combination of biological components with conventionally engineered systems may open a path to long-term persistence of functional devices in harsh environments. We review nature’s strategies for persistence, and consider early steps taken in the laboratory to import such capabilities into engineered architectures.<br/

    Joshua Davis: Author of Spare Parts

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    Citation: K-State First (2016). Joshua Davis: Author of Spare Parts [Flier]. Manhattan, Kansas: K-State First.Flyer advertising Joshua Davis's author talk at Kansas State University

    Steven Johnson Author Talk Poster

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    K-State Book NetworkA poster advertising an author talk by Steven Johnson at Kansas State University on September 3, 2014. Steven Johnson's book "The Ghost Map" was the 2014-2015 common book

    Interviews | 'African Cities' - 3 chapters explained by their authors : George Owusu, Sebastian Prothmann and Florian Stoll

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    Watch the videos https://youtu.be/B8suWj4cdtM George Owusu, professor at the Institute of Statistical, Social and Economic Research (ISSER University of Ghana) and the Director of the Centre of Urban Management Studies (CUMS) at the University of Ghana, elaborates on the challenges of rapid population growth in many African Cities. Read his article here: https://journals.openedition.org/poldev/2719 https://youtu.be/8jpa__Gfq-k Sebastian Prothmann, independent researcher based in Nurem..

    Measurement of branching ratios and CP asymmetries for the decays B0->pi+pi- B0->K+pi- B0->K+K-

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    Diese Doktorarbeit stellt eine Messung der Verzweigungsverhältnisse und CP Parameter der Zerfallskanäle B0->pi+pi-, B0->K+pi- und B0->K+K- vor. Der gesamte Belle Datensatz mit 772 Millionen BB Paaren wird untersucht. Die BB Paare wurden am KEKB e+e- Speicherring bei einer Schwerpunktsenergie, die der Masse der Y(4S) Resonanz entspricht, erzeugt. Die Analyse liefert folgende Ergebnisse für die Verzweigungsverhältnisse B(B0->pi+pi-) = (5,63 +- 0,16(stat) +- 0,16(syst)) x 10^-6 , B(B0->K+pi-) = (18,71 +- 0,25(stat) +- 0,37(syst)) x 10^-6 , B(B0->K+K-) < 14 x 10^-8 at 90% CL. Für die CP-Asymmetrien ergeben sich folgende Werte ACP (B0->pi+pi-) = 0,33 +- 0,06 (stat) +- 0,03 (syst), SCP (B0->K+pi-) = -0,64 +- 0,08 (stat) +- 0,03 (syst), ACP (B0->K+K-) = -0,061 +- 0,014 (stat) +- 0,008 (syst), wobei die Parameter ACP und SCP jeweils die direkte und die durch Mischung induzierte CP Verletzung messen. Unsere Ergebnisse schließen eine Winkel phi_2 des Unitaritätsdreiecks zwischen 23,8 und 66,8 Grad mit einer Signifikanz von 1 Sigma aus. Eine Modell unabhängige Suche nach neuer Physik beim Zerfall von B0->K+pi- zeigt eine kleine Abweichung vom Standardmodel von -0,289 +- 0,139(stat) +- 0,064(syst) mit einer Signifikanz von 1,9 Sigma.We present measurements of the branching fractions and CP violation parameters for the decay channels B0->pi+pi-, B0->K+pi- and B0->K+K-. The final Belle dataset of 772 million BB pairs produced at the Y(4S) resonance at the KEKB asymmetric-energy e+e- collider is used. For the branching fractions, we obtain B(B0->pi+pi-) = (5.63 +- 0.16(stat) +- 0.16(syst)) x 10^-6, B(B0->K+pi-) = (18.71 +- 0.25(stat) +- 0.37(syst)) x 10^-6, B(B0->K+K-) < 14 x 10^-8 at 90% CL. For the CP-asymmetries, we obtain following values: ACP (B0->pi+pi-) = 0.33 +- 0.06 (stat) +- 0.03 (syst), SCP (B0->pi+pi-) = -0.64 +- 0.08 (stat) +- 0.03 (syst), ACP (B0->K+K-) = -0.061 +- 0.014 (stat) +- 0.008 (syst), where ACP and SCP represent direct and mixing-induced CP violation, respectively. For the CP-violating weak phase phi_2 we exclude the region 23.8 < phi_2 < 66.8 degree at the 1 sigma level. A model independent test of new physics using a sum rule in the Kpi system yields a mild deviation from the standard model of -0.289 +- 0.139(stat) +- 0.064(syst) with a 1.9 sigma significance

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Expanding “Communities and Collections” in the K-State Research Exchange (K-REx) to benefit the K-State Community and Beyond

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    Kansas State University has used its institutional repository, the K-State Research Exchange (K-REx), to store and share its first year experience program, K-State First, and notably its common reading program, K-State First Book. We have done so with the aim that the accessibility and preservation of these documents ensures program stability, promotes engagement with first year programming, and provides the ability to foster growth,educational opportunities, and community building outside of K-State. Moving away from research concentrated repositories and taking a more holistic approach to scholarship, especially when realizing the pedagogical significance of collaborative campus programming, institutions can showcase, discover, preserve, and grow programs that shape campus communities and engagement. This session will provide an overview of K-REx and spotlight the digital archive of the university’s first year experience program and common reading program, K-State First Book. We will discuss the benefits and challenges to expanding the purview of your repositories. We talkthrough the types of materials we decide to host in our repository and why we share what we do. We will also provide recommendations on new ways to evaluate what belongs in institutional repositories and how this diversity can benefit your program, your institution, the community, and others

    Ready Player One Program Event Poster

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    K-State Book NetworkA poster advertising an author talk by Ernest Cline at Kansas State University on October 10, 2013. Ernest Cline's book "Ready Player One" was selected as the 2013-2014 common book

    Depolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution

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    Non-steroidal anti-inflammatory drugs (NSAIDs) contribute to gastrointestinal ulcer formation by inhibiting epithelial cell migration and mucosal restitution; however, the drug-affected signaling pathways are poorly defined. We investigated whether NSAID inhibition of intestinal epithelial migration is associated with depletion of intracellular polyamines, depolarization of membrane potential (Em) and altered surface expression of K+ channels. Epithelial cell migration in response to the wounding of confluent IEC-6 and IEC-Cdx2 monolayers was reduced by indomethacin (100μM), phenylbutazone (100μM) and NS-398 (100μM) but not by SC-560 (1μM). NSAID-inhibition of intestinal cell migration was not associated with depletion of intracellular polyamines. Treatment of IEC-6 and IEC-Cdx2 cells with indomethacin, phenylbutazone and NS-398 induced significant depolarization of Em, whereas treatment with SC-560 had no effect on Em. The Em of IEC-Cdx2 cells was: −38.5±1.8mV under control conditions; −35.9±1.6mV after treatment with SC-560; −18.8±1.2mV after treatment with indomethacin; and −23.7±1.4mV after treatment with NS-398. Whereas SC-560 had no significant effects on the total cellular expression of Kv1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of Kv1.4, but also the cell surface expression of both Kv1.4 and Kv1.6 channel subunits in IEC-Cdx2. Both Kv1.4 and Kv1.6 channel proteins were immunoprecipitated by Kv1.4 antibody from IEC-Cdx2 lysates, indicating that these subunits co-assemble to form heteromeric Kv channels. These results suggest that NSAID inhibition of epithelial cell migration is independent of polyamine-depletion, and is associated with depolarization of Em and decreased surface expression of heteromeric Kv1 channels.ID: S0006295207001931; M3: Article; Accession Number: S0006295207001931; Author: L.C. Freeman (b); Author: D.F. Narvaez (a); Author: A. McCoy (a); Author: F.B. von Stein (c); Author: S. Young (b); Author: K. Silver (a); Author: S. Ganta (b); Author: D. Koch (b); Author: R. Hunter (b); Author: R.F. Gilmour (c); Author: J.D. Lillich (a, ⁎); Affiliation: Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, United States; Keyword: Non-steroidal anti-inflammatory drugs; Keyword: Intestinal epithelial cells; Keyword: Membrane potential; Keyword: Potassium channels; Number of Pages: 12; Language: English;Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=edselp&AN=S0006295207001931&site=eds-live&scope=sit
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