200 research outputs found
LGBTI variations in crime reporting: how sexual identity influences decisions to call the cops
No full textResearch shows that people vary in their willingness to report crime to police depending on the type of crime experienced, their gender, age, and their race or ethnicity. Whether or not lesbian, gay, bisexual, transgender, and intersex (LGBTI) and heterosexual people vary in their willingness to report crime to the police is not well understood in the extant literature. In this article, I examine variations in LGBTI respondents' attitudes, subjective norms, and perceived behavioral control on their intentions to report crimes to the police. Drawing on a survey of LGBTI individuals sampled from a Gay Pride community event and online LGBTI community forums (N = 329), I use quantitative statistical methods to examine whether LGBTI people's beliefs in police homophobia are also directly associated with the behavioral intention to report crime. Overall, the results indicate that LGBTI and heterosexual people differ significantly in their intention to report crime to the police, and that a belief in police homophobia strongly influences LGBTI people's intention to underreport crime to the police
Keeping objects live
No full textIt is often assumed that museum exhibits are inert but, in contrast to artifacts in most mainstream institutions, those at the Museum of Witchcraft, The Valiant Soldier community museum, and the Dartmoor Prison Museum are felt to be fully functioning and, to some extent, potent or dangerous. In order to consider why this is the case, this essay investigates how museums are considered to “kill off” their exhibits and why this process does not occur in these small, independent organizations. Notably, the three venues have few or no paid members of staff and limited opportunities for gaining state funding. Operating largely independently of the public sector, they have no need to adopt official priorities and in consequence their modes of practice differ from those encountered in major institutions. They also have close links to their immediate location and communities. Focusing on these museums therefore raises the possibility that the “death” of objects is not a necessary condition but that their demise depends upon the specific character and circumstances of display
Straw Hat Players programs, 1992 (1992)
No full textMicheal Brannan, Jeffrey D. Boyd, Amber Carlsgaard, Karl L. G. Crose, Jennifer R. Daly, Dayna Del Val, Todd Denning, Edia A. Durdin, Dan W. Erickson, Elizabeth A. Evert, Nicole Fenstad, Patricia Fike, David M. Filmore, jr., Michael Garver, Michael J. Hance, Bryndis Hovde, Jarrod D. Iversen, Chadwyn Knutson, Jay Kopita, Betsy Kruse, Randy E. Long, Michael Messano, Lisa Moes, Dan Moore, Betsi Morrison, R. Anne Nelson, Timothy N. Nelson, Paul Neumann, Jeffrey Nibbe, Susan Nickel, Susan M. Pederson, Mary M. Pelletier, John Peters, J. Caleb Peterson, Libby Pitts, John Proctor III, Leah Roy, Jeremy A. Simonson, Joey Siti, Nancy Spiegel, Toby Sprague, Kay Sterner, Doreen S. Thorson, Dean Tschider, Aasne Vigesaa, C. Patrick Ward, Matthew P. Weil, Jennifer Weir, Michael Wildehttps://red.mnstate.edu/shp_programs/1027/thumbnail.jp
Beginning teachers’ mathematical knowledge: What is needed?
No full textOver the past decade there has been growing interest in describing and measuring the kinds of mathematical knowledge needed by teachers. Such efforts are in parallel with the development of national standards for teachers, indicating levels of expectation across the years of teachers’ careers. This presentation provides an opportunity for teacher educators and teachers to consider the nature of mathematical knowledge needed by beginning teachers at all levels of schooling. Discussion will be informed by data from an ALTC funded national project that aims to improve the quality of pre-service teachers’ outcomes in mathematics and by the AAMT Standards framework
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies
No full textMutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of major RPGR isoforms (RPGR 1-19 and RPGR ORF15), we have generated isoform-specific antibodies and examined their expression and localization in the retina. Using sucrose-gradient centrifugation, immunofluorescence and co-immunoprecipitation methods, we show that RPGR isoforms localize to distinct sub-cellular compartments in mammalian photoreceptors and associate with a number of cilia-centrosomal proteins. The RCC1-like domain of RPGR, which is present in all major RPGR isoforms, is sufficient to target it to the cilia and centrosomes in cultured cells. Our findings indicate that multiple isotypes of RPGR may perform overlapping yet somewhat distinct transport-related functions in photoreceptors
Autologous Cell Seeding in Tracheal Tissue Engineering
No full textPurpose of Review: There is no consensus on the best technology to be employed for tracheal replacement. One particularly promising approach is based upon tissue engineering and involves applying autologous cells to transplantable scaffolds. Here, we present the reported pre-clinical and clinical data exploring the various options for achieving such seeding. Recent Findings: Various cell combinations, delivery strategies, and outcome measures are described. Mesenchymal stem cells (MSCs) are the most widely employed cell type in tracheal bioengineering. Airway epithelial cell luminal seeding is also widely employed, alone or in combination with other cell types. Combinations have thus far shown the greatest promise. Chondrocytes may improve mechanical outcomes in pre-clinical models, but have not been clinically tested. Rapid or pre-vascularization of scaffolds is an important consideration. Overall, there are few published objective measures of post-seeding cell viability, survival, or overall efficacy. Summary: There is no clear consensus on the optimal cell-scaffold combination and mechanisms for seeding. Systematic in vivo work is required to assess differences between tracheal grafts seeded with combinations of clinically deliverable cell types using objective outcome measures, including those for functionality and host immune response
Hundreds of variants clustered in genomic loci and biological pathways affect human height
No full textMost common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways
Molecular systematic perspectives on biome origins and dynamics
No full textPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/88115/1/j.1469-8137.2011.03991.x.pd
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
No full textApproaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups
Lake Lillian (Toby Benches Society) - Andreen, Wilmer, & Neave Creek Watershed Features
No full textGeospatial Technologies & Natural Resource ManagementColumbia Basin Watershed Networ
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