130,447 research outputs found
Kawasaki disease in Sicily: clinical description and markers of disease severity
No full textBackground: Kawasaki disease (KD) is an acute systemic vasculitis of small and middle size arteries; 15-25 % of untreated patients and 5 % of patients treated with intravenous immunoglobulin (IVIG) develop coronary artery lesions (CAL). Many studies tried to find the most effective treatment in the management of resistant KD and to select the risk factors for CAL. Our data are assessed on children from west Sicily, characterized by a genetic heterogeneity. Methods: We studied the clinical data of 70 KD Sicilian children (36 males: 51 %; 34 females: 49 %), analysed retrospectively, including: demographic and laboratory parameters; echocardiographic findings at diagnosis, at 2, 6 and 8 weeks, and at 1 year after the onset of the illness. Results: Forty-seven had Typical KD, three Atypical KD and twenty Incomplete KD. Age at the disease onset ranged from 0.1 to 8.9 years. IVIG were administered 5 ± 2 days after the fever started. Defervescence occurred 39 ± 26 hours after the first IVIG infusion. Fifty-six patients (80 %) received 1 dose of IVIG (responders); 14 patients (20 %) had a resistant KD, with persistent fever after the first IVIG dose (non responders). Ten (14 %) non responders responded to the second dose, 4 (5 %) responded to three doses; one needed treatment with high doses of steroids and Infliximab. Cardiac involvement was documented in twenty-two cases (eighteen with transient dilatation/ectasia, fifteen with aneurysms). Pericardial effusion, documented in eleven, was associated with coronaritis and aneurysms, and was present earlier than coronary involvement in seven. Hypoalbuminemia, D-dimer pre-IVIG, gamma-GT pre-IVIG showed a statistically significant direct correlation with IVIG doses, highlighting the role of these parameters as predictor markers of refractory disease. The persistence of elevated CRP, AST, ALT levels, a persistent hyponatremia and hypoalbuminemia after IVIG therapy, also had a statistical significant correlation with IVIG doses. Non responders showed higher levels of D-dimer and gamma-GT pre-IVIG, persistent high levels of D-dimer, CRP, AST, ALT, hypoalbuminemia and hyponatremia after IVIG. Conclusions: This is the first study on KD in Sicily. We suggest some laboratory parameters as predictive criteria for resistant KD. Patients who show early pericarditis need careful surveillance for coronary lesions
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Alterata espressione dei geni coinvolti nel processo di sumoilazione nel carcinoma papillare della tiroide.
No full textLa modificazione post-traslazionale di proteine da parte delle proteine SUMO (small ubiquitin-related modifiers) consiste nella loro coniugazione covalente e reversibile a specifici residui di lisina di proteine bersaglio, con conseguente alterazione della localizzazione subcellulare e dell’attività di queste ultime. La SUMOilazione è implicata in svariati processi biologici tra cui la proliferazione cellulare, l’apoptosi, la riparazione del DNA e la sopravvivenza cellulare. Studi recenti hanno mostrato che la deregolazione del sistema SUMO contribuisce alla trasformazione tumorale modificando l’attività di molteplici oncoproteine e oncosoppressori. Ad oggi, si conosce molto poco riguardo al ruolo della SUMOilazione nel carcinoma papillare della tiroide (PTC). Pertanto, la presente ricerca è stata volta a caratterizzare l’espressione a livello di mRNA di un pannello di geni coinvolti nel processo di SUMOilazione in questo tumore. In particolare, è stata analizzata l’espressione dei geni: a) codificanti per gli enzimi SENP, cistein-proteasi in grado di rimuovere le proteine SUMO dalle proteine bersaglio; b) codificanti per SAE1 e UBA2 che formano un eterodimero attivante le proteine SUMO; c) codificante l’enzima coniugante Ubc9; d) codificanti le E3 ligasi PIAS1-4, RanBP2, NSMCE2, CBX4 e ZMIZ1-2. A tal fine, 20 campioni di tessuto normale e tumorale prelevati da pazienti affetti da PTC sono stati sottoposti a RT-PCR quantitativa, e l’analisi dei dati è stata eseguita con il software Lightcycler Relative Quantification. I risultati ottenuti hanno evidenziato una diminuzione significativa dei livelli di mRNA dei geni SAE1, ZMIZ1, PIAS1, PIAS2 e SENP8. Benché la rilevanza di tali alterazioni nel contesto degli eventi di SUMOilazione debba essere ancora determinata, le nostre osservazioni evidenziano una deregolazione del processo di SUMOilazione nei PTC, che merita ulteriori approfondimenti al fine di accertarne l’eventuale ruolo patogenetico
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Scholarly Communication and Publishing Lunch and Learn Talk #11: The ULS Open Access Author Fee Fund
No full textAt the May 2014 talk, you will learn about the ULS Open Access Author Fee Fund--what it is, why we do it, how it works, and how the program is going so far
The R&D Tax Incentives
No full textThis article sets out some background information and reflections of the author on the R&D tax incentive schemes included in the Common Corporate Tax Base (CCTB) Proposal. In particular the author analyzes the stimulus to private R&D through ad hoc tax incentives included in the CCTB Proposal and dives into the actual provisions included in the Proposal highlighting the most relevant issues connected with their design and interpretation. Moreover, the author explores the interaction between the CCTB Proposal and the granting by Member States of domestic R&D tax incentives
Kinematics and geologic control of the deep-seated landslide affecting the historic center of Buonalbergo, southern Italy
No full textDeep-seated landslides are important agents of relief shaping and can have substantial impact on human settlements. Many examples are present in the Campania region of southern Italy, where the association of complex lithostratigraphic and structural geologic conditions might have effect on landslide initiation and evolution. On this basis and considering the effect that the deep-seated landslide have had in the last years on the urban settlement, the Buonalbergo landslide was analyzed in terms of decadal kinematics and geological control and insights in prospective evolution were provided. The analysis of data derived by geological and landslide field mapping, settlement damage analysis, Persistent Differential Interferometry SAR data analysis, and Finite Elements stability analysis revealed i) the approximately constant rate movement of the landslide in the last three decades with a consistent enlargement of its area, ii) the presence of a large overturned anticline, characterized by a complex lithostratigraphic arrangement and multiple discontinuity sets, iii) the presence of faults responsible for morphological depression development, iv) a rotational mechanism characterizing the upper sector of the landslide and the ongoing translational sliding of blocks located at its toe and v) the effect of potential pore pressure scenarios on prospective kinematics (i.e. single to multiple stages creep) with the observed constant rate movement potentially related to a pore pressure at the landslide base ranging between 300 and 400 kPa. Result interpretation suggests i) the role of the structural and lithostratigraphic setting of the slope as predisposing factor for landslide development, ii) the potential of fold-related fabric in controlling landslide geometry and fragmentation, iii) the possible occurrence of multiple landslide events affecting the slope affected by the deep-seated landslide and iv) the potential of hydrologic conditions in modulating landslide velocity and evolution toward slope failure. The relevance of results is related to the representativeness of the Buonalbergo landslide as common process in the Apennine context in terms of potential long-term morphologic evolution of the slope and the existence of many landslides that develop in similar geological conditions driving sediment production and inducing persistent topographic changes in mountainsides
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