604 research outputs found
Islamic Education Movie: Character Learning Through Nussa-Rara Movie
No full textThis article examines the Islamic cartoon film Nussa and Rara. The author used Nussa and Rara as a window to see the emergence of Islamic cartoon films. Its strengths are in conveying educational values to children and as a learning medium to build character education for children aged 12 years and under. To explain this phenomenon, the author employed the content analysis method and combined it with relevant data; those were strengthened by many research results and literature studies. Through this method, the author showed that Nussa and Rara movie shares Islamic value in each segment, such as the value of honesty, asking for prayers on time, respecting neighbors, and so on. The author tried to see how every figure, especially Umma as Nussa and Rara’s mother, explains and exemplifies how to be a good Muslim. Through this article, it could be concluded that films are not always judged to have a negative impact on the audience. Even films can contribute as a medium for education and dissemination of Islamic da'wah. Besides, through films, it can also contribute to building good character for children under 12 years of age. Some learning methods that can be used are the many steps or methods that can be planted in children, such as the habituation and storytelling methods. These methods can be used to apply the values of faith, moral values, and worship values. Thus, this article greatly contributes to enriching academic discourse related to character learning for children under 12 years of age. This article concluded that the Nussa and Rara cartoon film really strives to spread Islamic da'wah and build children's character from an early age with daily customs and begin to familiarize children to apply the values of Islamic teachings perfectly
Mataram Islam and Religiosity in Novel Trilogi Rara Mendut By YB. Mangunwijaya
No full textTrilogy novel, Rara Mendut is one of the historical evident in fictional-historical novel which reveals reality in fictional expression. Rara Mendut tells the main character, woman with strong and struggle oriented in gaining her goals. The struggle and principle of life dominated the story through its episodes compiling by the author, Y.B. Mangunwijaya. This research aims to dig up the principle of life, condition, and belief of people in Mataram Islam through the presentation of main character, Rara Mendut, Genduk Duku, and Lusi Lindri. Sociological approach and theory of sociology are used as theoretical framework to result the goal of the research. The result shows that in people of Mataram Islam had belief and perfoemed islam rules as the religion spred by Wali in Java island. The attitude and characters of Rara Mendut shows the values of Islamic teaching in the background of Matara Islam in novel Rara Mendut
Mataram Islam and Religiosity in Novel Trilogi Rara Mendut By YB. Mangunwijaya
No full textTrilogy novel, Rara Mendut is one of the historical evident in fictional-historical novel which reveals reality in fictional expression. Rara Mendut tells the main character, woman with strong and struggle oriented in gaining her goals. The struggle and principle of life dominated the story through its episodes compiling by the author, Y.B. Mangunwijaya. This research aims to dig up the principle of life, condition, and belief of people in Mataram Islam through the presentation of main character, Rara Mendut, Genduk Duku, and Lusi Lindri. Sociological approach and theory of sociology are used as theoretical framework to result the goal of the research. The result shows that in people of Mataram Islam had belief and perfoemed islam rules as the religion spred by Wali in Java island. The attitude and characters of Rara Mendut shows the values of Islamic teaching in the background of Matara Islam in novel Rara Mendut.
 
PML-RARA mutations confer varying arsenic trioxide resistance
No full textAcute promyelocytic leukemia (APL) caused by the malignant proliferation of bone marrow-derived cells, which is driven by the chromosomal translocation, leading to the fusion of the promyelocytic leukemia gene (PML) and the retinoic acid receptor-a gene (RARA) (de The et al., 1990; Goto et al., 2011). The oncogenic protein PML-RARA has been found specifically in more than 95% APL patients and is crucial for both the pathogenesis and therapeutics of APL(de The et al., 1990; Zhou et al., 2007; Wang and Chen, 2008). Arsenic trioxide (AS203), an ancient traditional Chinese medicine, has recently been adopted as the first-line treatment for APL patients by the National Comprehensive Cancer Network (Wang and Chen, 2008; Zhu and Huang, 2014), which greatly improved the 5-year overall survival of APL patients (Li et al., 2002; Zhou et al., 2007; Wang and Chen, 2008; Lo-Coco et al., 2013). Mounting biological studies revealed that AS203 cures APL by initiating PML-RARA degradation through specific binding to the PML moiety (Lallemand-Breitenbach et al., 2001; Zhang et al., 2010). Mechanistically, AS203 binds directly to the dicysteine residues C212/213 located in the B2 domain of PML, which induces PML oligomerization, NB formation, SUMOylation, and ultimate degradation of PML (Lallemand-Breitenbach et al., 2008; Jeanne et al., 2010; Zhang et al., 2010).National Natural Science Foundation of China [31470754, 31670786]; National High Technology and Development Program of China [2016YFC1302400]; Doctoral Fund of Ministry of Education of China [20130001130003]SCI(E)中国科学引文数据库(CSCD)LETTER4296-301
The \u3cem\u3eChica Rara\u3c/em\u3e as Observer in Concha Alós’s \u3cem\u3eLos Cien Pájaros\u3c/em\u3e
No full textThe article focuses on how the protagonist of the book Los cien pájaros, by Concha Alós can be understood through the concept of chica rara or strange girl given by author Carmen Martín Gaite. Topics discussed include the use of the term chica rara by Martín Gaite in the novel Nada, by Carmen Laforet, the issues involving prostitution and sexuality in the Los cienpájaros, and the portrayal of independent woman in the book
KNJIGE IZ 16. STOLETJA: PRIMER ZBIRKE »RARA« V OSREDNJI KNJIŽNICI SREČKA VILHARJA V KOPRU
No full textAbstractIn the article, the author presents the characteristics of 16th century books. These books are part of a bigger collection of rare and valuable books named the »Rara« from the Srečko Vilhar Public Library in Koper. The origins and history of printing, from its beginnings till the 17th century, in Istria and Koper, are also described. The characteristics of the books originating from the 16th century and the comparison with the incunabula are also given. From the Rara collection, summarized descriptions of 38 titles (33 volumes) of books are presented.IzvlečekV prispevku avtorica predstavlja značilnosti knjig iz 16. stoletja, ki so del obsežnejše zbirke redkih in dragocenih knjig »Rara«, ki jo hranijo v Osrednji knjižnici Srečka Vilharja v Kopru. Opisani so tudi začetki tiskarstva v Istri in Kopru, zunanje značilnosti knjig iz 16. stoletja v primerjavi z inkunabulami in kratek opis 38 naslovov oziroma 33 enot knjig iz omenjene zbirke
Varying responses of PML-RARA with different genetic mutations to arsenic trioxide
No full textResistance to arsenic and/or all-trans retinoic acid (ATRA) is a challenging problem in the clinical management of acute promyelocytic leukemia (APL). Acquired genetic mutations in the PML moiety of the PML-RARA fusion gene are found in some patients with relapsed/refractory APL. Whether all of the identified point mutations play a role and have a similar function in the mechanisms of arsenic resistance remains unknown. Here we performed in vitro functional analyses and a retrospective analysis of APL patients to investigate the effect of PML-RARA mutations in mediating resistance to arsenic trioxide. Among the 5-point mutations in the PML part of PML-RARA identified in patients with relapsed APL, we found that A216V, S214L, and A216T mutations could attenuate the negative regulation of arsenic on PML-RARA, resulting in the retention of oncoproteins. In contrast, L217F and S220G mutations functioned weakly in this context. Furthermore, we demonstrated that either increasing the concentration of arsenic trioxide or combining it with ATRA could overcome the mutation-triggered arsenic resistance in vitro. In addition to presenting more evidence to reinforce the correlation of genetic mutations in PML-RARA with arsenic efficacy, we provide novel insight into the functional difference of acquired mutations of PML-RARA both in vitro and in the clinical setting. Our findings may help predict the prognosis and select more effective strategies during APL therapy.SCI(E)[email protected]
Le Rara de Léogâne : Entre fête traditionnelle liée au vodou et patrimoine ouvert au tourisme
No full textLe Rara de Léogâne, une pratique rituelle des collectivités haïtiennes, a fait l’objet de plusieurs réaménagements au fil des évolutions sociétales. Les événements composés de musiques, de danses et de processus ritualisés sont organisés en bande et dirigés par des chefs. Ce sont eux qui, les premiers, ont changé l’image de cette pratique hautement culturelle à l’occasion du premier festival de Rara, qui a eu lieu en 1992. L’étude de leurs communications avec les médias lors de ce premier événement centralisateur démontre une médiation culturelle auprès du public qui a été appuyée par l’ensemble des acteurs de la gouvernance sociale, la mairie, la députation et le ministère de la Culture. L’auteur, dans cet article, se questionne sur les processus qui ont fait du Rara un patrimoine identitaire territorial et met en lumière l’importance de la potentialité touristique de l’événement, qui s’impose en tant que ressource de développement dans une zone ravagée par des confrontations humaines et des catastrophes naturelles répétées.The Rara of Léogâne, a ritual practice in Haitian communities, has been the subject of several reworkings in the course of social evolution. The events made up of music, dance and ritual procedures are organized as a group and orchestrated by leaders. It is they who first changed the image of this unique cultural practice at the first Rara Festival in 1992. The study of their communications with the media at the time of this first consolidating event, shows a cultural mediation in connection with the public, which found support on the part of all the players in social governance, the mayor’s office, members of parliament and the Ministry of Culture. In his article, the author muses about the processes which have conveyed on Rara a territorial heritage of identity, and he brings to light the importance of the tourist potential latent in this event as a developmental resource in an area torn apart by repeated human confrontations and natural disasters
FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia
No full textFIP1-like 1 (FIP1L1) is associated with two leukemogenic fusion genes: FIP1L1-retinoic acid receptor alpha (RARA) and FIP1L1-platelet-derived growth factor receptor alpha (PDGFRA). Analyses of a series of deletion mutants revealed that the FIP1 motif in FIP1L1-RARA plays a pivotal role in its homodimerization and transcriptional repressor activity. However, in FIP1L1-PDGFRA, the C-terminal PDGFRA portion possesses the ability of forming a homodimer by itself, making FIP1L1 dispensable for constitutive activation of this kinase. Both the full-length and the C-terminal PDGFRA portion of FIP1L1-PDGFRA could transform the IL-3-dependent hematopoietic cell line, BAF-B03. Moreover, when either the full-length or the C-terminal PDGFRA portion of FIP1L1-PDGFRA was introduced in these cells, they grew in the absence of IL-3. The cells having the C-terminal PDGFRA portion of FIP1L1-PDGFRA, however, were partially IL-3 dependent, whereas the cells having the full-length FIP1L1-PDGFRA became completely IL-3 independent for their growth. Taken together, these results show that FIP1L1 differentially contributes to the pathogenesis of distinct types of leukemia
Rara
No full textPiece originally appeared on author\u27s blog, but no longer accessible to anyone.
https://www.shortlatinastories.com
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