66 research outputs found
STRATEGI CAMPAIGN KOMUNIKASI KPAID KAB. TASIKMALAYA TENTANG PERLINDUNGAN ANAK MELALUI FILM “ARUL HADIAH TERBAIK”
No full textBased on the real-time report of the Ministry of Women's Empowerment and Child Protection in the period from January 1 to the end of May 2024, there were more than 8,900 cases of violence in Indonesia. West Java occupies the top position in Indonesia in terms of the level of violence against children. The film "Arul Hadiah Terbaik" is the first film in Indonesia made by KPAID Tasikmalaya Regency in collaboration with the Police with the theme of education about the Child Protection Law. The purpose of this study is to know, analyze and describe how the KPAID Communication Campaign Strategy of Tasikmalaya Regency on Child Protection through the Film "Arul Hadiah Terbaik". In this study, the author uses a type of qualitative research. Data collection techniques are carried out by interviews, observations, documentation and literature studies. Theoretical triangulation was carried out to test the validity of the data used. This study discusses the process of delivering messages or information with campaign communication which is carried out through three processes, namely, awareness, attitudes and opinions, and behavior. This study uses a SWOT analysis method consisting of strengths, weaknesses, opportunities, and threats. The results of this study based on the delivery process with campaign communication show that this film plays an important role in raising awareness, forming attitudes and encouraging positive behaviors related to child protection. And based on the SWOT analysis of this study, it shows that the filming of Arul Hadiah Best is based on a true story, played by the original cast and directed by a local artist. The production and promotion process also faces challenges such as limited budgets and production fittings. However, with these limitations, this film maximizes the value contained in the storyline
Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells
No full textAbstract Background Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) and agonistic antibodies to death receptor 4 and 5 are promising candidates for cancer therapy due to their ability to induce apoptosis selectively in a variety of human cancer cells, while demonstrating little cytotoxicity in normal cells. Although TRAIL and agonistic antibodies to DR4 and DR5 are considered safe and promising candidates in cancer therapy, many malignant cells are resistant to DR-mediated, TRAIL-induced apoptosis. In the current work, we screened a small library of fifty-five FDA and foreign-approved anti-neoplastic drugs in order to identify candidates that sensitized resistant prostate and pancreatic cancer cells to TRAIL-induced apoptosis. Methods FDA-approved drugs were screened for their ability to sensitize TRAIL resistant prostate cancer cells to TRAIL using an MTT assay for cell viability. Analysis of variance was used to identify drugs that exhibited synergy with TRAIL. Drugs demonstrating the highest synergy were selected as leads and tested in different prostate and pancreatic cancer cell lines, and one immortalized human pancreatic epithelial cell line. Sequential and simultaneous dosing modalities were investigated and the annexin V/propidium iodide assay, in concert with fluorescence microscopy, was employed to visualize cells undergoing apoptosis. Results Fourteen drugs were identified as having synergy with TRAIL, including those whose TRAIL sensitization activities were previously unknown in either prostate or pancreatic cancer cells or both. Five leads were tested in additional cancer cell lines of which, doxorubicin, mitoxantrone, and mithramycin demonstrated synergy in all lines. In particular, mitoxantrone and mithramycin demonstrated significant synergy with TRAIL and led to reduction of cancer cell viability at concentrations lower than 1 μM. At these low concentrations, mitoxantrone demonstrated selectivity toward malignant cells over normal pancreatic epithelial cells. Conclusions The identification of a number of FDA-approved drugs as TRAIL sensitizers can expand chemotherapeutic options for combination treatments in prostate and pancreatic cancer diseases.</p
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No full textTendons are extracellular matrix (ECM)-rich structures that mediate muscle attachments with the skeleton, but surprisingly little is known about molecular mechanisms of attachment. Individual myofibers and tenocytes in Drosophila interact through integrin (Itg) ligands such as Thrombospondin (Tsp), while vertebrate muscles attach to complex ECM fibrils embedded with tenocytes. We show for the first time that a vertebrate thrombospondin, Tsp4b, is essential for muscle attachment and ECM assembly at myotendinous junctions (MTJs). Tsp4b depletion in zebrafish causes muscle detachment upon contraction due to defects in laminin localization and reduced Itg signaling at MTJs. Mutation of its oligomerization domain renders Tsp4b unable to rescue these defects, demonstrating that pentamerization is required for ECM assembly. Furthermore, injected human TSP4 localizes to zebrafish MTJs and rescues muscle detachment and ECM assembly in Tsp4b-deficient embryos. Thus Tsp4 functions as an ECM scaffold at MTJs, with potential therapeutic uses in tendon strengthening and repair
Incident Of Defamation On The Internet In United State, United Kingdom And Malaysia
No full textIn this research paper the author will analyse and discuss the challenges and issues related to Defamation on the Internet. The focus will be on Internet Defamation in the United States, the United Kingdom and Malaysia
THE EFFECT OF SOCIAL MEDIA ON CUSTOMER RELATIONSHIP MANAGEMENT; A CASE OF AIRLINE INDUSTRY CUSTOMERS
No full textThe current study is about the effect of social media on customer relationship management program in the context of the airline passengers. For this purpose, the study uses a model of social media characteristics which consist of five aspects namely connectedness, community, conversation, openness, and participation. The outcome variable in this study is the customer relationship management program (loyalty program). The adapted methodology is quantitative approach, cross sectional survey design. The data collection is based on participants from Pakistan (n=159). The key findings of the study are that social media characteristics including participation (?=.203, P<0.05); openness (?=.423, P<0.05); conversation (?=.277, P<0.05); and community (?=.523, P<0.05) exert a positive and significant influence, while, connectedness (?=-.098, P>0.05) exert a negative and insignificance influence on customer relationship management program. Based on the findings, it can be concluded that social media characteristics are important in fostering a favorable customer relationship management program.
Keywords: Customers, Social Media, Openness, Community, Online, Customer Relationship Management, Airlines
A Framework to assess Data Quality in university web portals
No full textData quality is often described as “data that is fit for use by data consumers”. The development of the internet and the various web technologies has increased the expectations of good data quality level among the data consumers. Web portals are meant to attract a wide variety of users and serve as an important means to access data in this information era. There is a need to assess the quality of these data, and so a framework to assess the data quality is wanted. This thesis proposes a framework to assess data quality in university web portals. The proposed framework captures essential DQ dimensions in four categories namely Intrinsic, Representational, Contextual, and Accessibility. In order to develop this framework, DQ dimensions were derived from literature. Next to that special attention was given to data consumers (users of university web portals), this led to the expansion and modification of the dimensions to emphasize the growing importance of the user’s perspective. The set of DQ dimensions has been tested with users using two pre-validations before the final validation of the framework. The proposed framework containing 35 dimensions is validated with user groups of two different universities: TU-Delft, The Netherlands and Pondicherry University, India. The validation showed that all DQ dimensions in the framework were valuable and important from the data consumer’s view of perspective. As an evaluation approach, this framework has been compared with an existing portal data quality model and found this new framework has important DQ dimensions in the context of a UWP. As a consequence, the proposed framework emphasizes the user’s perspective on data quality.Computer Science /Information Architecture TrackElectrical Engineering, Mathematics and Computer Scienc
Internal Sulphate Attack in Slag Blended Systems: A Susceptibility Study
No full textWith rapid industrialisation, the infrastructure sector has seen exponential growth in prefabricated concrete elements due to their speedy construction and efficient usage of material. Precast concrete elements have thus observed some deterioration due to increased internal temperature as a result of rapid curing, and also through deliberate heat curing techniques. This has led to researchers in the past to study the effect of such curing conditions on the durability aspect of the binders, especially their impact on Delayed Ettringite Formation. Precast elements such as railway sleepers, exposed to in the humid environment were thus prone to internal sulphate attack and needs to be investigated. Use of Ground Granulated Blast Furnace Slag (GGBFS) as a substitution for binder content in conventional portland cement in the Netherlands has been prevalent since the early 1900s primarily because of its abundant resource from iron industry. The benefits of slag have been then exploited as it was one of the supplementary cementitious systems which along with being a sustainable solution, provides good resistance to environmental degradation such as chloride penetration resistance. However, their advantages surrounding extreme curing conditions have to be studied, unless used at optimised quantities. The research focused on the potential of blast furnace slag systems to undergo internal sulphate attack due to high internal temperatures. The simulation of high internal temperature was done through heat curing inside an oven following which continuous storage under lime solution was carried out in order to saturate the system. Slag systems at low and high substitution levels (20% & 50%) were used along with a combination of coarser and finer surface areas, to investigate their subsequent influence was chosen for the study. Also, since infrastructure industry adopts CEM II & CEM III-A cement type, where the former was low slag concentration with moderate fineness and the latter with higher substitution level of slag in combination with high overall fineness, their potentials for DEF have also been studied. For all the mixes, the influence of high curing temperature and exposure to moisture was studied through microstructural changes, pore size variations and mineralogical composition effect along with fineness on paste specimens. All studies were compared to reference systems of CEM I, which was observed to be the most detrimental due to DEF. Test results indicate that at lower substitution levels of slag secondary ettringite forms in significant quantities in neat systems along with traces of carbo-aluminate phases in the case of slag systems. Also, higher substitution levels does not appear to completely suppress the formation of ettringite after exposure. Its formation in both the cases showed more or less no influence of fineness of slag added, except in the case of pore size distribution. The significant presence of carbo-aluminates was observed in the case of all slag systems that could prove to be beneficial as they do not translate to deteriorative expansion.Civil Engineering | Structural Engineerin
INVESTIGATION OF WORK-LIFE BALANCE PRACTICES AS MODERATOR BETWEEN THE RELATIONSHIP OF WORK-FAMILY CONFLICT AND SATISFACTION AMONG FACULTY STAFF OF OMAN
No full textIn the current competitive academic environment, work-family conflict among faculty members is very common. The higher educational institutes adopt various policies and practices to enable staff to overcome such work-family conflict. One common strategy is work-life balance practices (WLB). In the present study, the effects of work-family conflict and its employee outcomes are investigated with moderating role of WLB. By design, the study is cross-sectional and survey-based. The sampling method is used to collect data from selected HEI staff in Oman (n=138). The analysis is based on two stages including Confirmatory Factor Analysis for establishing reliability and validity of the measures involved; and path analysis for hypotheses testing. The key findings are that work-family conflict exert a negative and significant influence on satisfaction towards family life (Beta=-.214, P<.05); and satisfaction towards work-life (Beta=-.237, P<.05). Furthermore, WLB positively influences satisfaction towards family life (Beta=.323, P<.05); and satisfaction towards work-life (Beta=.275, P<.05). Additionally, moderation analysis shows that WLB significantly moderate the work-family conflict and satisfaction relationship. Based on these findings, we conclude that WLB is important for faculty staff and must be offered.
Keywords: Work-Life Balance, Family, Work, Conflict, Faculty, Higher Education, Oman
Corrigendum: How do smart device apps for diabetes self-management correspond with theoretical indicators of empowerment? an analysis of app features: (International Journal of Technology Assessment in Health Care (2019) 35 (150-159) DOI: 10.1017/S0266462319000163)
No full textIn the article by Brew-Sam and Chib the incorrect author information was provided for reference #84 in the original published article. The correct reference is as follows: Debussche X, Besançon S, Balcou-Debussche M, Ferdynus C, Delisle H, Huiart L, Sidibe AT (2018) Structured peer-led diabetes self-management and support in a low-income country: The st2ep randomised controlled trial in Mali. PLoS ONE 13, e0191262. doi: 10.1371/journal.pone.0191262 The authors apologize for the error
Spirit of the land : politics, memory, and the sacred in South African land claims
No full textBibliography: leaves 224-242.This thesis examines the role of sacred space in people's attachment to land, analysing the ways in which people create sacred space through labour, ritual, myth, and memory. Three case studies explore the human interpretation of the sacred through the history and politics of land acquisition and dispossession. While providing historical background and legal analysis of forced removals, evictions, and relocations, the thesis calls attention to the role of religion in South African land claims. Although the people in these case studies believe that returning to their original land will materially improve their lives, their main concern is to reconnect with their alienated sacred space. This study explores the changing nature of the sacred and its formulative role in shaping and informing peopIe's identities and memories
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