6,648 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
No full textThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Mammographic breast density patterns and role of supplemental screening by ultrasound
No full textObjective: To study“breast density patterns on
mammography” in local population, to analyse the need for
supplemental screening by high resolution ultrasound of both
breasts, to compare obtained density patterns with other
populations and finally to contribute my data to the authorised
baseline data.
Materials and Methods : Female patients above age 30 years
who are referred to department of Radiology, Prathima
Institute of Medical Sciences, for mammography on
senographe DMR model of GE MAMMOGRAPHY machine of
0.5mm Pb equivalent thickness,40 to 100 mA range, grid ratio
of 30:1.These patients were evaluated for density patterns
according to BIRADS lexicon , fifth edition and were subjected
to high resolution ultrasound breast on Phillips Affinity 70
ultrasound machine . Patients belonging to the local population
and are chosen between the study period of June 2016 to
January 2017 and of sample size 50 .
Results : A total number of 50 patients who were subjected to
mammography and high reso-lution ultrasonography of both
breasts, 44% of our study group had dense breasts( among
which 14%had heterogeneously dense breasts and 8% had
extremely dense breasts),56%had non dense breasts( among
which 24%had fatty breast and 16% had scattered
fibroglandular breasts) according to BIRADS Lexicon of fifth
edition.Among these dense breasts( of total 44%) 54.54% of
them were negative for any kind of lesion on mammography
but ultrasound showed positive findings in them.
Conclusion : The results of our study group suggest that in
woman with dense breast pattern on mammography , more
than half of them are negative for any kind of lesion may it be
be-nign or malignant on mammogram, where ultrasound
displayed positive findings.Hence supplemental screening with
ultrasound is also an option adjunct to mammography
RLCH: Reliable Link lifetime based Cluster Head election in MANET
No full textClustering has been widely considered in wireless ad hoc networks as a useful mechanism for solving the scalability problems, improving the stability, increasing the network’s energy efficiency, etc. The idea behind clustering is to group a flat network into a number of clusters. Cluster heads serve as backbones to establish communication routes between sources and destinations in a mobile ad hoc network (MANET). However, election of a Cluster Head (CH) within a local cluster structure is very important in setting up relatively stable cluster structure. This thesis proposes an efficient method to choose cluster heads in wireless ad hoc networks for improving the network stability and energy efficiency. Considering basic requirements in wireless ad hoc network, we propose a novel reliable link lifetime based cluster head election (RLCH) method to determine which nodes are more qualified to serve as cluster heads.
RLCH takes many factors affecting cluster head election into consideration and, unlike the previous approaches proposed in the literature, employs no weight combination when considering the impact of several factors on choosing a CH. In addition, a link lifetime calculation model and a maximum cluster updating interval model are proposed. An adaptive cluster update interval selection process is developed based on an energy threshold approach for prolonging the network lifetime. Four metrics including average number of clusters, cluster update rate, member exchange rate, and energy consumption distribution are evaluated in our simulations. By comparing with other well-known cluster head election algorithms, our simulations indicate that RLCH can achieve better stability, energy saving and longer network lifetime in most cases
Les diminutifs basques avec ch
No full textSe presentan formaciones similares a los diminutivos vascos con "ch" en España y América latina. Se dan ejemplosThe author introduces similar formations to the Basque diminutive "ch" in Spain and Latin America. Examples are provide
Incidence and risk factors for Retinopathy of pre maturity
No full textIntroduction: Retinopathy of prematurity (ROP) or retrolental fibroplasia as it was originally named,has had a most curious life span as a twentieth century disease.These out breaks of the disease occurred approximately 25 years apart in the mid 1950s and late 1970s. Retinopathy of prematurity is becoming a major cause of potentially preventable blindness among children in middle income countries that have introduced neonatal intensive care units for preterm and low birth weight babies.
Aims and Objective :So the present study helps to determine the incidence of retinopathy of prematurity in neonates and to determine its association with certain risk factors. Materials and Methods :It is a clinical study of all neonates with a gestational age less than 36 weeks and /or a birth weight of less than 2000gms at Prathima Institute of Medical Sciences,Karimnagar for a period 2years. Neonates were evaluated through detailed clinical history, detailed anterior segment examination and indirect ophthalmoscopy after full dilatation of pupils.
Results :Of the 100 neonates screened, 53 were males (53 %) and 47 were females (47%). Among the neonates who developed ROP, 23 were males (51.11%) and 22 were females (48.88%). Incidence of ROP among male and female babies is nearly equal and no statistically significant correlation could be found.Of the 45 neonates who were found to have ROP, 13 neonates were in stage 1 (28.88%), 16 in stage 2 (35.55%), 13 in stage 3 (28.88%), 2 in stage 4 (4.44%) and 1 in APROP stage of the disease. 12 infants had plus 42.05%.
Conclusion : The incidence of ROP in the present study was 42.05% for any stage of which 62.22% were in stage 1 or 2 of the disease. The incidence of ROP showed a significant statistical correalation with prematurity, low birth weight, RDS, supplemental oxygen, blood transfusion, and injection betamethasone to mother. Injection betamethasone to the mother has a significant protective effect on the development of ROP
COUPLING OF THE C-H STRETCH TO LARGE-AMPLITUDE TORSION AND INVERSION MOTIONS: COMPARISON OF CHCH, CHOH AND CHNH
No full textAuthor Institution: Department of Polymer Science and Department of Chemistry, The University of Akron; Department of Chemistry, The University of Akron, OH 44325In each of the title molecules, torsional and inversion tunneling occurs between six equivalent minima. Coupling of these degrees of freedom to the CH stretch occurs via variation of the C-H stretching force constants as a function of the torsional () and inversion () angles. Maps of the couplings have been computed at the MP2/6-311++G(3df,2p) level. Both the single bond CH stretch force constants and the bilinear couplings between CH bonds are presented as a function of and . Although the torsional barriers differ by more than a factor of 20, the torsion-inversion-vibration coupling patterns are very similar for CHNH and CHCH. On the other hand, the torsion-inversion-vibration coupling in the charged species CHOH is much weaker
Reply to the Ch. Lagrange’s note
No full textThe author answers to a Ch. Lagrange’s note who refutes his theory on the diurnal nutation.L’auteur répond à une note de Ch. Lagrange qui réfute sa théorie sur la nutation diurne
NATURE OF TORSION-INVERSION COUPLING IN CHNH, CHOH AND CHCH
No full textAuthor Institution: Department of Chemistry, The University of Akron, OH; 44325-3601Two-dimensional torsion-inversion surfaces for methylamine, protonated methanol and ethyl radical were calculated and fit to a function containing a polynomial in the inversion angle() and trigonometric functions of the torsional angle(). Calculations were done at the B3LYP, MP2, and CCSD(T) levels with the 6-311++G(d,p) and 6-311++G(3df, 2p) basis sets and partial optimization. CHNH, CHOH and CHCH have G symmetry with 6-equivalent minima which are located by the various calculations at inversion angles 6.5 to 11; 42 to 45.5 and 52.5 to 55 degrees respectively on either side of planar. The three molecules have very different barriers to inversion ranging from no barrier for CHCH to 838 cm for CHOH to 1837 cm for CHNH. The dominant torsion-inversion coupling term in all cases has the form
Note about Mr. Ch. Lagrange’s recent communication
No full textThe author establishes a note about Mr. Ch. Lagrange’s communication on the Eulerian nutation period.L’auteur établit une note au sujet d’une communication de Ch. Lagrande sur la période de la nutation eulérienne
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Using δ¹³C-CH₄ and δD-CH₄ to constrain Arctic methane emissions
No full text© Author(s) 2016.We present a global methane modelling study assessing the sensitivity of Arctic atmospheric CH₄ mole fractions, δ¹³C-CH₄ and δD-CH₄ to uncertainties in Arctic methane sources. Model simulations include methane tracers tagged by source and isotopic composition and are compared with atmospheric data at four northern high-latitude measurement sites. We find the model's ability to capture the magnitude and phase of observed seasonal cycles of CH₄ mixing ratios, δ¹³C-CH₄ and δD-CH₄ at northern high latitudes is much improved using a later spring kick-off and autumn decline in northern high-latitude wetland emissions than predicted by most process models. Results from our model simulations indicate that recent predictions of large methane emissions from thawing submarine permafrost in the East Siberian Arctic Shelf region could only be reconciled with global-scale atmospheric observations by making large adjustments to high-latitude anthropogenic or wetland emission inventories
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