32 research outputs found
Varuna litterata (Fabricius) Lectin (VLL) Purification and Characterization
No full textpathogens, identification and tying of carbohydrates were some of the biological processes
which happens. The adaptive and innate immune response, adaptive and innate immune response has an
important part which is the binding features of universal ancient molecules called Sialic acid-binding
lectins (SABLs). In this research, a novel sialic-binding lectin was isolated from the swimming crab Varuna
litterata (Fabricius). The obstruction of growth and the abolishment of bacteria and fungi can be promoted
by the accuracy of several carbohydrates present in the Lectins. The presence of reagents in biochemical
research and the investigation of diagnosis were employed in the research of sialic acids for the treatment
of pathogenic diseases and tumors which has attained a lot of interest in sialic acid-specific lectins. The
molecular mass of the lectin was identified as 70 kDa on SDS-PAGE. In the current analysis, research was
going on to isolate, identify and categorize the lectins from the haemolymph of agglutinin. To hinder
agglutination, the potentiality of several glycoproteins and sugars (mono and oligosaccharides) was tested
by making use of a hemagglutination inhibition (HAI) assay. After 1-hour, total inhibition of agglutination
has been provided by the reciprocal of the lowest dilution of inhibitors which was shown by
hemagglutination inhibition titer. The cross-adsorption assays have proceeded to identify whether there is
the presence of single or multiple agglutinins in the hemolymph. Along with the desialylated rat
erythrocytes, the agglutinin's preference for sialic acid is demonstrated by a decrease in hemagglutination
activity. Moreover, a sepharose 4B column was connected with bovine submaxillary mucin which was
triggered by CNBr to purify the lectin. Hemolymph agglutinin showed greater affinity towards the
protease-treated rat erythrocytes and lesser affinity towards neuraminidase-treated rat erythrocytes than
the native rat erythrocytes. As the O-acetyl sialic acid, a high preference was given for the inhibition of
purified lectin by bovine submaxillary mucin and the non-inhibitory action of de-O-acetylated bovine
submaxillary mucin. The results confirm the presence of an O-acetyl sialic acid-specific lectin in the
hemolymph of the crab Varuna litterata respectively. The production of anti-tumor and antiviral drugs
based on O-acetyl sialic acid-specific lectin in the hemolymph lectin of Varuna litterata may also have a
significant utility in therapeutic industry
Interventions to Mitigate the Effects of Interruptions During High-risk Medication Administration
No full textResearch suggests that interruptions are ubiquitous in healthcare settings and have a negative impact on patient safety. However, there is a lack of solutions to reduce harm arising from interruptions. Therefore, this research aimed to design and test the effectiveness of interventions to mitigate the effects of interruptions during medication administration. A three-phased study was conducted. First, direct observation was conducted to quantify the state of interruptions in an ambulatory unit where nurses routinely administered high-risk medications. Secondly, a user-centred approach was used to design interventions targeting errors arising from these interruptions. Finally, the effectiveness of these interventions was evaluated through a high-fidelity simulation experiment. Results showed that medication administration error rates decreased significantly on 4 of 7 measures with the use of interventions, compared to the control condition. Results of this work will help guide the implementation of interventions in nursing environments to reduce medication errors caused by interruptions.MAS
The Changing Rotational Light-curve Amplitude of Varuna and Evidence for a Close-in Satellite
No full textOriginal content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.From CCD observations carried out with different telescopes, we present short-term photometric measurements of the large trans-Neptunian object Varuna in 10 epochs, spanning around 19 years. We observe that the amplitude of the rotational light curve has changed considerably during this period of time from 0.41 to 0.55 mag. In order to explain this variation, we constructed a model in which Varuna has a simple triaxial shape, assuming that the main effect comes from the change of the aspect angle as seen from Earth, due to Varuna's orbital motion in the 19 year time span. The best fits to the data correspond to a family of solutions with axial ratios b/a between 0.56 and 0.60. This constrains the pole orientation in two different ranges of solutions presented here as maps. Apart from the remarkable variation of the amplitude, we have detected changes in the overall shape of the rotational light curve over shorter timescales. After the analysis of the periodogram of the residuals to a 6.343572 hr double-peaked rotational light-curve fit, we find a clear additional periodicity. We propose that these changes in the rotational light-curve shape are due to a large and close-in satellite whose rotation induces the additional periodicity. The peak-to-valley amplitude of this oscillation is in the order of 0.04 mag. We estimate that the satellite orbits Varuna with a period of 11.9819 hr (or 23.9638 hr), assuming that the satellite is tidally locked, at a distance of ∼1300 km (or ∼2000 km) from Varuna, outside the Roche limit.© 2019. The American Astronomical Society..E.F.V. acknowledges UCF 2017 Preeminent Postdoctoral Program (P3). Part of the research leading to these results has received funding from the European Unions Horizon 2020 Research and Innovation Programme, under Grant Agreement No. 687378 (SBNAF). We would like to acknowledge financial support by the Spanish grant AYA-2017-84637-R and the financial support from the State Agency for Research of the Spanish MCIU through the >Center of Excellence Severo Ochoa> award for the Instituto de Astrofisica de Andalucia (SEV-2017-0709). This work is partially based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Fundacion Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias. We thank the director of the Telescopio Nazionale Galileo for allocation of Director's Discretionary Time. We acknowledge Raul Carballo-Rubio for providing useful comments that helped improve this manuscript and Pedro Gutierrez for helpful discussions
Designing Health Care IT for Interruption-Filled Environments: Redesigning Interface Elements of a Chemotherapy Medication System
No full textBroad Ligament Lipoleiomyoma Masses: Two curious cases masquerading as ovarian carcinomas
No full textLipoleiomyomas are an extremely rare form of uterine leiomyoma; moreover, the occurrence of this type of tumour on the broad ligament is even rarer. We report two cases of broad ligament lipoleiomyomas in 15- and 38-year-old female patients who presented to the Lok Nayak Jai Prakash Hospital in New Delhi, India, between 2016 and 2017. In both cases, the preoperative diagnosis was of a solid ovarian malignancy. Most broad ligament tumours are mistaken for ovarian masses as they are difficult to diagnose radiologically
Larvae of the Indian mackerel, Rastrelliger kanagurta (Cuvier) from the west coast of India
No full textLarvae of the Indian mackerel, Rastrelliger kanagurta (Cuvier) have been
identified by the author from the plankton of the south west coast of India and
the Laccadive Sea collected during the cruises of R. V. VARUNA. Prolarval
and postiarval sta-ges from the size 1.73 mm to 8.6 mm (T.L.) are described
from the graded series present in the collections to highlight the salient features
during the larval development. This account also represents the first descriptions
with illustrations of the mackerel larvae from the west coast of India
Not Available
No full textNot AvailableLarvae of the Indian mackerel, Rastrelliger kanagurta (Cuvier) have been
identified by the author from the plankton of the south west coast of India and
the Laccadive Sea collected during the cruises of R. V. VARUNA. Prolarval
and postiarval sta-ges from the size 1.73 mm to 8.6 mm (T.L.) are described
from the graded series present in the collections to highlight the salient features
during the larval development. This account also represents the first descriptions
with illustrations of the mackerel larvae from the west coast of India.Not Availabl
Introduction of Reusable Learning Objects in a First-year Materials Science and Engineering Course
No full textSvetlo a temnota – synkretizmus praslovanských reliktov a stredovekého kresťanského konceptu v slovanskom folklóre
No full textRelation between lightness and darkness in Early Slavic model of the world was depicted in the most contrast and thoughtful way within mythology bound up with the first function of religious sovereignty in connection with its ancient Indo-European duality. To analyse Slavic texts characteristic by pagan-Christian syncretism the author uses Dumézil\u27s concept of two opposing and complementary faces of the highest power: on the one hand, legal and priestly, kind, benevolent, shining, close to the world and people (“as Mitra”) and, on the other hand, magic, violent, threatening, dark, invisible, and distant (“as Varuna”). The author formulates a hypothesis about a personified source of Early Slavic “light” lying out of military function and closely connected (by important and joined conceptual metaphors) to wisdom, peace, agreements and law rather, than to fighting and violence
Svetlo a temnota – synkretizmus praslovanských reliktov a stredovekého kresťanského konceptu v slovanskom folklóre
No full textRelation between lightness and darkness in Early Slavic model of the world was depicted in the most contrast and thoughtful way within mythology bound up with the first function of religious sovereignty in connection with its ancient Indo-European duality. To analyse Slavic texts characteristic by pagan-Christian syncretism the author uses Dumézil\u27s concept of two opposing and complementary faces of the highest power: on the one hand, legal and priestly, kind, benevolent, shining, close to the world and people (“as Mitra”) and, on the other hand, magic, violent, threatening, dark, invisible, and distant (“as Varuna”). The author formulates a hypothesis about a personified source of Early Slavic “light” lying out of military function and closely connected (by important and joined conceptual metaphors) to wisdom, peace, agreements and law rather, than to fighting and violence
