1,726,585 research outputs found
Prachi Deshpande
No full textPrachi Deshpande is Associate Professor of History at the Centre for Studies in Social Sciences, Calcutta (CSSSC). She has an MA from Jawaharlal Nehru University, New Delhi, and a PhD from Tufts University, Medford. Her research interests are in the social and cultural history of historiography, language, and regional identities, especially over the transition from the early modern into the colonial eras in the Indian subcontinent. She is the author of Creative Pasts: Historical Memory and Id..
The Association of Opioid Prescribing Continuity and the Risk of Opioid Use Disorder among Older Adults
No full textPoster Presenter: Prachi Prajapati
Research Team: Prachi Prajapati, Shadi Bazzazzadehgan, Yi Yang, Kaustuv Bhattacharya, Shishir Maharjan, John P. Bentley, Sujith Ramachandran
Abstract: Study objectives: To evaluate the association between opioid prescribing continuity and risk of Opioid Use Disorder (OUD) among older Medicare beneficiaries on Long Term Opioid Therapy (LTOT)
The Legends of a lost civilization – The Prachi Valley
No full textSoutheast India that covers a vast extensive area between the two mighty rivers- the Ganga and Godavari, is hemmed with thick clad of jungle, mountainous ranges, and at the east by the sea, forms an ideal ground which makes an unique history of its own. Thisregion, which was known as Utkal or Odra, now betterknown as Odisha. Right from its past, the people of Odisha have played significant role in the cultural and political ferments of the whole country as the Hindu period was longest in this reason and the dynasties that ruled the area were all long lived and sufficiently strong to maintain the integrity of this geographical unit. Odisha, thus possessing a rich culture, once cradled a civilization which was varied in character, glorified the entire land. This civilization famous as the Prachi Valley Civilization that flourished on the bank of river Prachi was considered as the holiest river of Odisha. This civilization has everything that makes the history of Odisha most outstanding and glorious. Though the origin of Prachi is still wrapped in mystery, legends, as embodied in different Puranas take the sanctity of this civilization to mythical times. This paper aims highlighting the legendary stories of the valley that played an important role in making the history of Odisha. Recorded events and traditional accounts also are excellent elements of history. However, bizarre and incredulous they might look, they certainly contain some germs of truth, and the distilled wisdom of ages cannot be ignored for which we have incorporated them at several places, sometimes without examining their authenticity
Privatization and Education for All: Unravelling the mobilizing frames
No full textPrachi Srivastava argues that the seeming paradox of privatization within the context of Education for All is a result of the limited number of policy options that were legitimized by key policy actors of the movement, due to its internally contentious alliance. She identifies four ‘mobilizing frames’ that are strategically used to coalesce action around privatization: scarce resources, efficiency, competition-choice-quality, and social equity.
Pharmacokinetics of Inhaled Clofazimine in Mice
No full textTuberculosis (TB) is primarily an infectious disease of lungs caused by Mycobacterium tuberculosis. Despite current therapeutic approaches, it continues to be a serious disease killing more than 1 million people annually. In developed countries, TB treatments conventionally last six-month and involve multiple anti-tubercular agents. Inappropriate treatment implementation, patient non-compliance and extensive treatment regimen has led to increasing prevalence of multidrug resistant (MDR) and extremely drug resistant (XRD) Mycobacterial strains. Therefore, there is an urgent need for alternative TB treatments including the development of new anti-mycobacterial drugs or repurposing of existing antibiotics. Clofazimine (CFZ) is one example of a repurposed antibiotic that is currently approved for the treatment of leprosy. Recently, it gained interest for the treatment of TB as a second line agent in the treatment of MDR and XDR-TB by the World Health Organization (WHO). However, oral CFZ therapy induces serious adverse effects including the discoloration of skin, and conjunctiva, and localized inflammation in GI causing abdominal pain, and splenic infarction. A study published in 2013 established inhaled CFZ as a potential treatment for pulmonary TB. As a result, recent reports describe inhaled CFZ formulation development.
The purpose of this study is to evaluate in vivo pharmacokinetics (PK) of inhaled CFZ in healthy male Swiss Webster mice. Mice were divided in 2 major groups that received a single inhaled CFZ dose while the other received multiple inhaled CFZ doses twice weekly for 4 weeks followed by a washout period (no doses) for 4 weeks. Mice in both the groups received either a low or high dose inhaled CFZ. Animals were euthanized at set time points and blood and tissues were collected for quantification of CFZ in biological matrices using a LC-MS method. Pharmacokinetic evaluation of CFZ in plasma and tissues after single and multiple inhaled doses was performed using Non-Compartmental Analysis by Phoenix WinNonlin.
Following a single inhaled CFZ dose, substantial drug retention in plasma and tissues occurs for 72 hr with no discernable elimination phase and minimum systemic absorption. After multiple doses, substantial CFZ accumulation occurs in tissues during active dosing and can persist for 4 weeks even after inhaled CFZ doses were stopped. Substantial lung concentrations were found to be of several orders of magnitude higher than plasma concentration indicating low systemic CFZ exposure following inhalation. Inhaled CFZ administration suggests dose independent PK parameters with very long CFZ elimination processes.ProQuest Traditional Publishing Optio
Book review: Data feminism by Catherine D’Ignazio and Lauren F. Klein
No full textIn Data Feminism, Catherine D’Ignazio and Lauren F. Klein use an intersectional feminist lens to examine unequal power structures in the realm of data, and highlight attempts made to rectify them. Showing how the data we collect is representative of our unequal society, this book is a call to action that will particularly benefit feminists seeking to learn how activism can contribute to creating a more equitable form of data science, writes Prachi Shukla
Actors and Networks in the Megacity
Full text linkThis study is a concise introduction to Bruno Latour's Actor-Network Theory and its application in a literary analysis of urban narratives of the 21st century. We encounter well-known psycho-geographers such as Iain Sinclair and Sam Miller, and renowned authors, Patrick Neate and Suketu Mehta. Prachi More analyses these authors' accounts of vastly different cities such as London, Delhi, Mumbai, Johannesburg, New York and Tokyo. Are these urban narratives a contemporary solution to documenting an ever-evasive urban reality? If so, how do they embody "matters of concern" as Latour would have put it, laying bare modern-day "actors" and "networks" rather than reporting mere "matters of fact"? These questions are drawn into an inter-disciplinary discussion that addresses concerns and questions of epistemology, the sociology of knowledge as well as urban and documentary studies.</jats:p
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