119 research outputs found
The role of affective temperaments and chronotype in pharmacotherapy response in patients with obsessive-compulsive disorder
No full textBACKGROUND: Comorbid mood disorders affect the prognosis of obsessive-compulsive disorder (OCD) negatively. Affective temperaments are assumed to be subsyndromal symptoms and precursors of mood disorders, but its effects on OCD outcome still remain unclear. There is a body of evidence, which supports the association between circadian rhythm disturbances and mood disorders in the literature. In contrast, there is limited data concerning the effects of chronobiological differences among the patients with OCD and OCD comorbid mood disorders. The main objective of this present study was to examine the clinical effects of affective temperaments and chronotype differences in patients with OCD. METHODS: The study participants were 76 patients with OCD, who have been under treatment at least for 12 weeks, and 55 healthy controls. The participants were administered the Yale-Brown Obsessive Compulsive Scale, Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire, Morningness and Eveningness Questionnaire, Hamilton Depression Rating Scale, and Hamilton Anxiety Scale. RESULTS: OCD patients scored higher in depressive, cyclothymic, irritable, and anxious temperament scores compared to the healthy controls. There were significant differences between patients with remission and not remission in depressive, cyclothymic, irritable, and anxious temperaments. Eveningness chronotype was more frequent in OCD patients; however, the difference was not statistically significant. CONCLUSIONS: Understanding the effects of affective temperaments and chronotype differences on the outcome of patients with OCD might provide valuable insights in developing new treatment approaches especially in treatment-resistant OCD cases
Pseudo Picard Operators On Generalized Metric Spaces
No full textAltun, Ishak/0000-0002-7967-0554; Samet, Bessem/0000-0002-6769-3417In this paper, we present a new class of pseudo Picard operators in the setting of generalized metric spaces introduced recently in [M. JLELI AND B. SAMET: A generalized metric space and related fixed point theorems, Fixed Point Theory Appl., (2015) 2015:61]. An example is provided to illustrate the main result.Deanship of Scientific Research at King Saud UniversityDeanship of Scientific Research at King Saud University [RGP-237]The second author extends his appreciation to the Deanship of Scientific Research at King Saud University for funding this work through research group No RGP-237
Synthesis, structure and bioactivity of a mononuclear octahedral [Prolinate2-Na(MeOH)4]−H+ complex
No full textThe synthesis of a mononuclear octahedral [Prolinate2-Na(MeOH)4]−H+ complex is achieved from a [3 + 2] cycloadduct with excess of NaOMe in methanol. The slow crystallization provides the hexacoordinated complex stabilized by four molecules of solvent. The antibacterial, antifungal and anti-tuberculosis activity of this compound is also evaluated.This work is a part of Samet Belveren's ongoing PhD thesis granted by Mersin University (Project no. BAP-SBE TEB(SB) 2017-2-TP3-2564). We gratefully acknowledge financial support from Mersin University and the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), University of Alicante and Mersin University (Project. MEU-2017-COL-01007-M150D)
Meir-Keeler Type Contractions on Js-Metric Spaces and Related Fixed Point Theorems
No full textKARAPINAR, ERDAL/0000-0002-6798-3254We introduce two classes of Meir-Keeler type contractions in the framework of JS-metric spaces introduced by Jleli and Samet (2015). For each class, a fixed point result is derived. Some interesting consequences which follow from our obtained results are discussed.King Saud University (Saudi Arabia)The second author extends his appreciation to Distinguished Scientist Fellowship Program (DSFP) at King Saud University (Saudi Arabia)
Espor : Türkiye’de alternatif hayran araştırması
No full textCataloged from PDF version of article.Includes bibliographical references (leaves 76-80).A fan can be anyone who has both potential media consumer and producer. Fandom
as we call, is a community of fans interested in a specific media context such as
actor, author or TV series. This study is about the developing fandom around
eSports (electronic sports) in Turkey, analyzing game fans interaction with League of
Legends which has become a product of popular culture. To investigate eSports
fandom, this study relies on interviews with professional and amateur players and
virtual ethnographic methods. Findings of the interviews and ethnographic data aim
to ground the similarities between League of Legends players reproducing and code
switching techniques in the light of Anglo American studies on series and movie
fandom.by Samet Taygun Özbıçakçı
Yeraltısuyu akımı problemlerinin diferansiyel kareleme yöntemiyle sayısal analizi
No full textWithin the scope of this study, in addition to traditional solution methods such as finite differences, finite elements and boundary elements in the numerical solution of groundwater flow problems, it is aimed to introduce the new and developing Differential Quadrature Method (DQM) and to apply it to groundwater flow problems. In the study, one and two-dimensional groundwater flow problems were examined, and the numerical calculation of spatial derivatives using the DQM method was investigated by using various nodal point distributions according to the preferred polynomial approach. In time-dependent one and two-dimensional groundwater flow problems, it is aimed to convert the time-dependent partial differential equation to an ordinary differential equation system with the Method of Lines (MOL) for the calculation of temporal derivatives. The resulting ordinary differential equation systems were solved numerically using different time schemes. The method was first applied to the modeling of a one-dimensional confined aquifer. Since there was no analytical solution here, the accuracy of the model results was investigated with reference solutions. In the second problem, the modeling of two-dimensional steady-state groundwater flow with known analytical solutions was performed. Finally, the current method was applied to one- and two-dimensional unsteady-state pollutant transport problems with known analytical solutions. The numerical results obtained were compared with analytical and literature solutions. When the performance of the method is examined as a result of the comparisons, it is revealed that it produces efficient and high-accuracy solutions with minimum computational effort.Bu çalışma kapsamında, yeraltısuyu akımı problemlerinin sayısal çözümünde sonlu farklar, sonlu elemanlar ve sınır elemanlar gibi geleneksel çözüm yöntemlerinin yanı sıra yeni ve gelişmekte olan Diferansiyel Kareleme Yöntemi (DQM)'in tanıtılması ve yeraltısuyu akımı problemlerine uygulanması amaçlanmıştır. Yapılan çalışmada bir ve iki boyutlu yeraltısuyu akımı problemleri incelenmiş olup, tercih edilen polinom yaklaşımına göre çeşitli düğüm nokta dağılımlarının kullanılması ile uzaysal türevlerin DQM yönteminden faydalanarak sayısal olarak hesaplanması araştırılmıştır. Zamana bağlı bir ve iki boyutlu yeraltısuyu akımı problemlerinde ise zamansal türevlerin hesaplanması için zamana bağlı olan kısmi diferansiyel denklem Çizgiler Yöntemi (MOL) ile adi diferansiyel denklem sistemine dönüştürülmesi amaçlanmaktadır. Oluşan adi diferansiyel denklem sistemleri farklı zaman şemaları kullanılarak sayısal olarak çözülmüştür. Yöntem ilk önce bir boyutlu basınçlı akiferin modellenmesine uygulanmıştır. Burada analitik çözüm mevcut olmadığından referans çözümler ile modelin sonuçlarının doğruluğu araştırılmıştır. İkinci problemde ise analitik çözümü bilinen iki boyutlu kararlı durumdaki yeraltısuyu akışının modellenmesi gerçekleştirilmiştir. Son olarak mevcut yöntem analitik çözümü bilinen bir ve iki boyutlu kararsız durumdaki kirletici taşınım problemlerine uygulanmıştır. Elde edilen sayısal sonuçlar analitik ve literatür çözümleri ile karşılaştırılmıştır. Karşılaştırmalar sonucunda yöntemin performansı incelendiğinde minimum hesaplama çabası ile verimli ve yüksek doğrulukta çözümler ürettiği ortaya çıkmaktadır
Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties
No full textPlatinum complexes, derived from two families of bidentate funcionalized aroylaminocarbo-N-thyoyl prolinates, are prepared using mild conditions from prolinates, which are available via 1,3-dipolar cycloadditions. The resulting four coordinated neutral square-planar platinum(II) complexes are very stable and are fully characterized. Their structures are determined by spectroscopic and analytical methods and one of them by single crystal X-ray diffraction analysis. In this pattern, the platinum exhibits distorted square planar geometry, with cis-bond angles ranging from 89.42(2) and 94.37(6)° and trans-bond angles of 176.19(6) and 177.08(6)°, respectively. Anti(myco)bacterial and antifungal studies of all these new compounds are carried out under standardized protocols.This work is a part of Samet Belveren's ongoing PhD thesis granted by Mersin University (Project no. BAP-SBE TEB(SB) 2017-2-TP3-2564). We gratefully acknowledge financial support from Mersin University and the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), University of Alicante and Mersin University (Project. MEU-2017-COL-01007-M150D)
Synthesis of highly functionalized 2-(pyrrolidin-1-yl)thiazole frameworks with interesting antibacterial and antimycobacterial activity
No full textA versatile, facile and concise approach to access to highly substituted functionalized 2-(pyrrolidin-1-yl)thiazole ring system is accomplished. The efficient protocol proceeds by the reaction of corresponding racemic or enantiomerically enriched pyrrolidines and readily available benzoylisothiocyanate in acetonitrile followed by sequential reaction of readily available alpha-bromo ketones in acetone. The selectivity and good yield in the desired product is another important advantage of this reaction protocol. In a few cases, the resulting N-benzoylthiourea intermediate cyclizes spontaneously before reacting with the benzophenone component. Finally, a wide study of the biological scope of this new bisheterocyclic molecules is reported.This work is a part of Samet Belveren's ongoing PhD thesis granted by Mersin University (Project no. BAP-SBE TEB(SB) 2017-2-TP3-2564). The authors thank Mersin University (Turkey) and the University of Alicante for support. We also thank the Scientific and Technological Research Council of Turkey (TÜBİTAK), the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P, and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), (Consolider Ingenio 2010, CSD2007-00006) for research financing
N-Benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety: Synthesis, characterization, crystal structure, in vitro ChEs inhibition, and antituberculosis, antibacterial, antifungal studies
No full textA series of novel N-benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety has been prepared and their various biological activities are evaluated. The ability of forming intermolecular hydrogen-bonds of these molecules was pursued in the search of the best antimicrobial activity. The synthesized compounds were tested to search whether they had an enzyme inhibitory potency against AChE and BChE, which are the main targets for Alzheimer's disease. The prepared compounds were also screened for antituberculosis activity against M. tuberculosis H37Rv strain and the antibacterial activity against E. coli, A. baumannii, S. aureus, B. subtilis, A. hydrophila, bacteria. In addition, their antifungal activities are also evaluated against C. tropicalis, C. albicans, C. glabrata strains.This work is a part of Samet POYRAZ's Ph.D. thesis granted by Mersin University (Project no: 2019-1-TP3-3463) and (Project no: 2020-1 AP4-3982). We also gratefully acknowledge support from Çukurova University (Project no: TSA-2021-13814), Alicante University and Mersin University
Equity as a vehicle for law reform: The case of unilateral mistake
No full textIn this paper I ask whether English Law should permit rescission for unilateral mistakes in the formation of contract, in circumstances where the defendant (D) knew or should have known about the claimant’s (C) mistake, and if so, should Equity be (re)employed to deploy the remedy. The paper introduces the Caveat Emptor Common Law rule on this issue, which rules out rescission, and the various considerations that count in its favour. I argue that neither considerations from efficiency, nor those based in ethics can justify the current rule, and that new, flexible and morally-sensitive resolution is called for. If we examine the way in which Equity intervenes to reform areas of law where the Common Law fails to provide a satisfactory solution to legal disputes, we will see that the Caveat Emptor rule displays exactly the kind of defects that Equity does a very good job at remedying. The law on the duty to disclose information at the precontractual stage emerges as an excellent example for Equity’s great potential as a vehicle for improving the law in a measured, nuanced and imaginative way.Peer reviewe
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