401 research outputs found
Effects of once-daily Tadalafil on erectile function in men with erectile dysfunction and signs and symptoms of benign prostatic hyperplasia
No full textCopyright © 2009 European Association of Urology. Published by Elsevier B.V.Hartmut Porst, Kevin T. McVary, Francesco Montorsi, Peter Sutherland, Albert Elion-Mboussa, Anne M. Wolka and Lars Viktru
Fritz Schumacher & Heinrich Tessenow: Architecture, an Art or a Craft?
No full textThis booklet contains the inaugural lectures of Fritz Schumacher and Heinrich Tessenow given on the occasion of their appointment respectively as professors at the Technical University in Dresden and The Art Academy in Dresden.The lectures provide novel insights into their understanding of architecture and into their proposals for reform of architectural education. they are proceeded by an introductory essay of the guest editor architectural historian Hartmut Frank.History, Form & Aesthetic
Preliminary Validation of a German Version of the Sexual Complaints Screener for Women in a Female Population Sample
No full textBackground: To date, neither the original English nor any of the translated versions of the Sexual Complaints Screener for Women (SCS-W) have been tested for their psychometric properties. Aim: To evaluate the validity and utility of the German version of the SCS-W by assessing content, convergent, and discriminant validity. Methods: A population sample of 309 women (mean age = 26.9 years) completed the online survey and had matching data available on the SCS-W and the Female Sexual Function Index (FSFI). Spearman bivariate correlations between the SCS-W and FSFI domain scores and exploratory factor analysis with principal component analysis were conducted. Outcomes: Convergent validity was excellent for the domain of orgasm, good for satisfaction, dyspareunia, and the total questionnaire score, and acceptable for desire, lubrication, arousal, and vaginismus. Discriminant validity was present for all domains apart from arousal, lubrication, and vaginismus. Varimax rotation suggested an 8-factor model was the most robust. Clinical Implications: This brief screener seems suitable to provide a brief overview of female patients' sexual problems in a clinical setting. Strengths and Limitations: This is the 1st study to assess the psychometric properties of the German version of the SCS-W. However, available information on the psychometric properties of the German SCS-W was limited because the validity of the screener could not be counterchecked against a clinical diagnosis of female sexual dysfunction. Conclusion: Our results provide preliminary evidence of good validity of the German version of the SCS-W. Overall, the SCS-W can offer support for clinicians who are less familiar with sexual medicine and who might not routinely discuss sexual issues with their patients.Burri A, Porst H. Preliminary Validation of a German Version of the Sexual Complaints Screener for Women in a Female Population Sample. Sex Med 2018;6:123–130. Key Words: Female Sexual Dysfunction, Assessment, Sexual Complaints Screener for Women (SCS-W), Validation, Psychometric Properties, Screene
Sociedades modernas, sociedades de obsolescência: a sociologia temporal de Hartmut Rosa / Modern societies, obsolescence societies: Hartmut Rosa's temporal sociology
No full textResenha de: ROSA, Hartmut. Aceleração: a transformação das estruturas temporais na modernidade. São Paulo: Editora Unesp, 2019. Centrado na revisitação da modernidade a partir de uma perspectiva temporal, Hartmut Rosa sustenta o conceito de aceleração social como aspecto fundante do projeto moderno. Explorando diferentes variáveis causais para o conceito da aceleração social, a resenha examina as transformações das instituições morais, valorativas e políticas ocorridas ao longo do desenvolvimento histórico da modernidade como episódios induzidos pela obsolescência. Sendo esta um produto de campos de ação crescentemente cambiantes e acelerados, o autor mobiliza esse conceito para fundamentar inédita proposta de diferenciação entre a modernidade e a modernidade tardia como momentos históricos calcados em diferentes níveis de compressão espaço-temporal, estabilidade institucional e temporalização de projetos individuais e coletivos de futuro.***AbstractCentered on revisiting modernity from a temporal perspective, Hartmut Rosa supports the concept of social acceleration as a fundamental aspect of the modern project. Exploring different causal variables for the concept of social acceleration, the review examines the transformations of moral, valuative and political institutions that occurred during the historical development of modernity as episodes induced by obsolescence. As this is a product of increasingly changing and accelerated fields of action, the author mobilizes this concept to substantiate an unprecedented proposal for differentiation between modernity and late modernity as historical moments based on different levels of space-time compression, institutional stability and temporalization of individual and collective future projects
Hypogonadal Men Nonresponders to the PDE5 Inhibitor Tadalafil Benefit from Normalization of Testosterone Levels with a 1% Hydroalcoholic Testosterone Gel in the Treatment of Erectile Dysfunction (TADTEST Study)
No full textIntroduction. Addition of testosterone (T) may improve the action of phosphodiesterase type 5 inhibitors (PDE5-Is) in patients with erectile dysfunction not responding to PDE5-Is with low or low-normal T levels. Aims. To confirm this add-on effect of T in men optimally treated with PDE5-Is and to specify the baseline T levels at which such an effect becomes significant. Methods. A multicenter, multinational, double-blind, placebo-controlled study of 173 men, 45-80 years, nonresponders to treatment with different PDE5-Is, with baseline total T levels < 4 ng/mL or bioavailable T < 1 ng/mL. Men were first treated with tadalafil 10 mg once a day (OAD) for 4 weeks; if not successful, they were randomized in a double-blind, placebo-controlled design to receive placebo or a 1% hydroalcoholic T gel (50 mg/5 g gel), to be increased to 10 mg T if results were clinically unsatisfactory. Main Outcomes Measures. Mean change from baseline in the Erectile Function Domain Score of the International Index of Erectile Function and rate of successful intercourses (Sexual Encounter Profile 3 question). Results. Erectile function progressively improved over a period of at least 12 weeks in both the placebo and T treatment groups. In the overall population with a mean baseline T level of 3.37 +/- 1.48 ng/mL, no additional effect of T administration to men optimally treated with PDE5-Is was encountered. The differences between the T and placebo groups were significant for both criteria only in the men with baseline T < 3 ng/mL. Conclusions. The maximal beneficial effects of OAD dosing with 10 mg tadalafil may occur only after as many as 12 weeks. Furthermore, addition of T to this PDE5-I regimen is beneficial, but only in hypogonadal men with baseline T levels < 3 ng/mL. Buvat J, Montorsi F, Maggi M, Porst H, Kaipia A, Colson MH, Cuzin B, Moncada I, Martin-Morales A, Yassin A, Meuleman E, Eardley I, Dean JD, and Shabsigh R. Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST study). J Sex Med 2011;8:284-293
A critical analysis of the role of testosterone in erectile function: From pathophysiology to treatment - A systematic review
Get PDFContext: Androgen modulation of erectile function (EF) is widely accepted. However, the use of testosterone replacement therapy (TRT) in men with erectile dysfunction (ED) has generated an unprecedented debate. Objective: To summarize the relevant data on the incidence, diagnosis, and management of ED coexisting with hypogonadism and to develop a pathophysiology-based treatment algorithm. Evidence acquisition: We reviewed the relevant medical literature, with a particular emphasis on original molecular studies, prospective observational data, and randomized controlled trials performed in the past 20 yr. Evidence synthesis: Testosterone modulates nearly every component involved in EF, from pelvic ganglions to smooth muscle and the endothelial cells of the corpora cavernosa. It also regulates the timing of the erectile process as a function of sexual desire, coordinating penile erection with sex. Epidemiologic studies confirm the significant overlap of hypogonadism and ED; however, most guidelines do not consider the differential diagnosis of hypogonadism or the relevance of subclinical disease. Various clinical tools can help the physician to assess and restore androgen levels in men with ED. Special attention is given to fertility-sparing treatments, due to the increasing number of older men desiring fatherhood. The simultaneous use of phosphodiesterase type 5 inhibitors (PDE5-Is) and TRT has recently been questioned. Originally proposed as a salvage therapy for nonresponders to PDE5-Is, this approach has been inappropriately transformed into a combination therapy. Clinical data are consistent when reinterpreted in the proper framework, whereas molecular evidence remains controversial. Conclusions: A body of molecular and clinical evidence supports the use of TRT in hypogonadal patients with ED, although the benefit-risk ratio is uncertain in advanced age. Critical appraisal of this evidence enabled the development of a pathophysiology-oriented algorithm designed to avoid inappropriate treatments and support whether to start with TRT, PDE5-I only, or both. Apparently divergent findings are reconciled when TRT is correctly indicated. An improved diagnosis and individualized management is desirable in light of the many available options. © 2013 European Association of Urology
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