1,721,009 research outputs found
SGLT2 Inhibitor: an Emerging Pillar in Heart Failure Therapeutics?
No full textHeart failure (HF) is a worldwide pandemic that affects at least 26 million people and is becoming more prevalent. Heart failure health expenditures are substantial and will considerably increase with population aging. Newer medications for treating type 2 diabetes include sodium-glucose cotransporter-2 inhibitors (SGLT2). Recent clinical studies and research have shown the efficacy of this class in treating heart failure by lowering the risk of cardiovascular events, hospitalization, and mortality. In addition, there is undeniable evidence that SGLT2 inhibitors have a beneficial effect on metabolic function, even though the mechanisms responsible for these drugs' practical consequences have not been completely elucidated. In this narrative review, we discuss the effects of SGLT2 inhibitors on the provision of cardiac energy by ketone bodies, pathological remodeling of the ventricle, arterial stiffness, and inflammation in patients with HF
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Progettazione e realizzazione di un prototipo di simulatore di specifiche di sistemi peer to peer
No full textCome in tutti i sistemi, da quelli più semplici a quelli più complessi, durante la progettazione e lo sviluppo delle singole componenti, si rende necessario l’analisi dei comportamenti dei singoli elementi, ovvero controllare che le operazioni svolte dai singoli peer nell’interagire con l’ambiente esterno siano corrette e (soprattutto) siano eseguite nell’ordine corretto. Avendo a che fare con gruppi eterogenei composti da molti peer aventi magari caratteristiche, servizi e comportamenti molto differenti, si è reso necessario dotarsi di uno strumento, di un tool in grado di analizzare il comportamento di ogni singola unità in modo da poter essere confrontato con gli altri in un determinato contesto per cercare di capirne il funzionamento ed eventualmente i problemi.
Per capire il comportamento di singola unità P2P, l’applicazione dovrebbe poter simulare tutti i possibili workflow, sia in assenza che in presenza di fault: solo in questo modo si potrebbe analizzare in maniera soddisfacente il comportamento complessivo dell’entità (peer oppure servizio). Come è possibile intuire, la mole di dati computati dal programma potrebbe essere non indifferente quindi è naturale pensare ad un prototipo in grado di poter salvare questi dati in un formato standard (come, per esempio, xml) in modo da poterli riutilizzare (analizzare) in un secondo momento, anche con strumenti software differenti dal tool in questione (cioè con altri programmi con funzionalità totalmente differenti).
Inoltre, per poter usare lo strumento in maniera semplice, dovrebbe essere dotato di una interfaccia grafica snella, in grado di offrire naturalmente un accesso a tutte le funzionalità e in grado di visualizzare, istante per istante, lo stato corrente dell’applicazione in maniera chiara, istantanea.
In questa ottica è stato sviluppato un simulatore di workflows per il linguaggio di modellazione SMoL: con questa applicazione è possibile simulare tutte le possibili tracce (e quindi i comportamenti) descritte da un file SMoL affinché sia possibile, ancora prima di passare alla parte implementativa vera e propria (risparmiando così una discreta quantità di tempo), accertare la validità di un servizio o meno in presenza di fault, di comportamenti anomali o semplicemente durante una esecuzione normale ed eventualmente correggere queste anomalie
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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