6 research outputs found
Inspection of Electronics Components for Cryogenic Temperature Operation
No full textElectronics operating at cryogenic temperatures play a critical role in future science experiments and space exploration programs. The Deep Underground Neutrino Experiment (DUNE) uses a cold electronics system for data taking. Specifically, it utilizes custom-designed Application Specific Integrated Circuits (ASICs). The main challenge is that these circuits will be immersed in liquid Argon and that they need to function for 20+ years without any access. Ensuring quality is critical, and issues may arise due to thermal stress, packaging, and manufacturing-related defects: if undetected, these could lead to long-term reliability and performance problems. This paper reports an investigation into non-destructive evaluation techniques to assess their potential use in a comprehensive quality control process during prototyping, testing, and commissioning of the DUNE cold electronics system. Scanning acoustic microscopy (SAM) was used to investigate permanent structural changes in the ASICs associated with thermal cycling between room and cryogenic temperatures. Data are assessed using a correlation analysis, which can detect even minimal changes happening inside the ASICs.This is a manuscript of an article published as Poonthottathil, Navaneeth, Frank Krennrich, Amanda Weinstein, Jonathan Eisch, Leonard J. Bond, Dan Barnard, Zhan Zhang, and Lucas W. Koester. "Inspection of Electronics Components for Cryogenic Temperature Operations." Journal of Nondestructive Evaluation, Diagnostics and Prognostics of Engineering Systems 4, no. 2 (2021): 024501. DOI: 10.1115/1.4049300. Posted with permission.</p
Observational Evidence to Logistic Dark Energy Driving the Accelerating Universe
No full textWe present logistic dark energy model (LDEM), where the dark energy density follows a logistic function for the scale factor. The equation of state parameter of dark energy () transitioned from in the distant past to its current value of , closely resembling the CDM model in the early epoch and showing significant deviation in the late phase. The evolution of the deceleration parameter in the LDEM signifies its success in explaining the late-time cosmic acceleration. Model selection based on the Bayesian Information Criterion (BIC), incorporating observations from Type Ia Supernovae (SNe Ia), Observational Hubble data (OHD), and Baryon Acoustic Oscillation (BAO) strongly favors the LDEM over the conventional CDM model, where BIC is estimated to be . Incorporating the shift parameter derived from the Cosmic Microwave Background (CMB) data shows competing evidence of the LDEM over the standard CDM. Remarkably, the Hubble constant () value computed using any of the datasets tends to align closely with the predictions from the Cosmic Microwave Background (CMB), suggesting a need to reconsider the local measurement
Emergence of Cosmic Space and Horizon Thermodynamics from Kaniadakis Entropy
No full textUtilizing Kaniadakis entropy associated with the apparent horizon of the
Friedmann-Robertson-Walker (FRW) Universe and applying the emergence of cosmic
space paradigm, we deduce the modified Friedmann equation for a non-flat
(n+1)-dimensional universe. Employing the first law of thermodynamics, we
arrive at the same modified Friedmann equation, showing the connection between
emergence of cosmic space and first law of thermodynamics. We also establish
the condition to satisfy the Generalized second law of thermodynamics within
the Kaniadakis framework. Our study illuminates the intricate connection
between the law of emergence and horizon thermodynamics, offering a deeper
insight through the lens of Kaniadakis entropy
Selection between aztreonam and cephalosporins for treatment of infections with pseudomonads needs more caution
No full textBhoj R Singh Division of Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar, IndiaIn the recently published study1 to evaluate the use of aztreonam as an active empiric therapy against subsequent culture of Pseudomonas aeruginosa, empiric therapy failure using aztreonam is reported more common than on using β-lactam antibiotics in patients suffering P. aeruginosa infection. Though the study is interesting and revealing important findings regarding antibiotic use for treatment of P. aeruginosa infection, it should be accepted with caution as suggested by the authors1 repeatedly due to limited number of cases. In our observations on P. aeruginosa (95) and other pseudomonads (40) isolates from veterinary clinical cases we found that instead of generalizing the lesser efficacy of aztreonam in-depth studies are required. Although insignificant, aztreonam inhibited more numbers of extended spectrum β-lactamase (ESBL) producing (57) P. aeruginosa strains (56.1%) than most of the β-lactams including cefotaxime, ceftriaxone and piperacillin (53.3%). However, on non-ESBL producing (37) strains aztreonam inhibited 42.1% isolates, much less than cefepime (68%), ceftriaxone (50%) and piperacillin + tazobactam (61.1%). Therefore, it is suggested to use the two classes of antibiotics (aztreonam and β-lactams) judiciously based on antibiotic stewardship principle1 instead of following some general rule for infections with pseudomonads. Authors’ reply Michael Hogan,1 Mary Barna Bridgeman,1 Gee Hee Min,1 Deepali Dixit,1 Patrick J Bridgeman,1 Navaneeth Narayanan1,21Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA; 2Division of Infectious Diseases, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA We appreciate the author of this letter reading our article with such great interest. We believe, however, in this response that here is limited application to the context and overall content of our clinical study of human patients. First, the data cited n this response are from veterinary clinical cases. Though general principles of understanding of antibiotic sensitivity testing and resistance mechanisms apply regardless of species, there are major differences that impede reasonable comparisons between the assertions in this letter and findings of our original study. View the original paper by Hogan and colleague
Deep Underground Neutrino Experiment (DUNE) Near Detector Conceptual Design Report
No full textThe Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. The experiment consists of a near detector, sited close to the source of the beam, and a far detector, sited along the beam at a large distance. This document, the DUNE Near Detector Conceptual Design Report (CDR), describes the design of the DUNE near detector and the science program that drives the design and technology choices. The goals and requirements underlying the design, along with projected performance are given. It serves as a starting point for a more detailed design that will be described in future documents.This report describes the conceptual design of the DUNE near detecto
Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume II DUNE Physics
No full textThe preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume II of this TDR, DUNE Physics, describes the array of identified scientific opportunities and key goals. Crucially, we also report our best current understanding of the capability of DUNE to realize these goals, along with the detailed arguments and investigations on which this understanding is based. This TDR volume documents the scientific basis underlying the conception and design of the LBNF/DUNE experimental configurations. As a result, the description of DUNE's experimental capabilities constitutes the bulk of the document. Key linkages between requirements for successful execution of the physics program and primary specifications of the experimental configurations are drawn and summarized. This document also serves a wider purpose as a statement on the scientific potential of DUNE as a central component within a global program of frontier theoretical and experimental particle physics research. Thus, the presentation also aims to serve as a resource for the particle physics community at large
