944 research outputs found
The association of gallstone disease with risk of colorectal cancer (CRC).
No full textSystematic Review
The association of gallstone disease with risk of colorectal cancer (CRC).
Searches
Three electronic databases: PubMed, Web of Science and Scopus will be searched from inception, without any restriction to language.
References from retrieved articles will be screened in order to find further relevant studies. For the same reason, we will evaluate in topic systematic reviews and meta-analyses identified during study search.
Types of study to be included
Observational studies
Condition or domain being studied
Gallstone disease(GD) is one of the most common ailments of the gastrointestinal tract. Numerous studies have been conducted to ascertain if cholecystectomy is associated with a higher risk of CRC with inconclusive results. To date there hasn’t been a systematic review on the association of symptomatic gallstones or screen-detected gallstones with CRC.
Participants/population
We will include studies conducted in adults (aged ≥18 years). Studies conducted exclusively on a group with a baseline chronic disease (e.g. CVD, type 2 diabetes, chronic kidney disease) or pregnant women will be excluded.
Exposure(s)
Screen-detected gallstones, symptomatic gallstones or cholecystectomy.
Comparator(s)/control
People who do not present with gallstones. Should there be prospective cohort studies without a comparator group we will perform further subgroup analyses.
Main outcome(s)
Colorectal cancer diagnosis.
* Measures of effect
Relative risks, Odds ratio/ Hazard ratio
Additional outcome(s)
None
Data extraction (selection and coding)
Observational studies will be included in this meta-analysis if they: 1) were observational in design; 2) reported the exposure of interest as screen-detected gallstones, symptomatic gallstones, gallstone disease or cholecystectomy ; 3) reported the outcome of interest as diagnosis of colorectal cancer; 4) provided odds ratios (OR) and/or relative risks (RR) and the corresponding confidence intervals (CI) or sufficient data to calculate them.
Two authors (G.P. and H.S.) independently will extract data on study characteristics. We will extract the following information from each study: study name, number of exposed, country name or geographical region, the last name of first author, publication year, study period or follow-up time, baseline age, ORs, RRs and 95% CIs for the association between each exposure category and CRC, and covariates.
Risk of bias (quality) assessment
Begg’s and Egger’s test will be used for publication bias.
The Newcastle-Ottawa quality assessment scale will be used for assessing the quality of the studies.
Strategy for data synthesis
All study estimates (OR/RR) will be interpreted as relative risk and used as effect size in analyses. They will be calculated using the DerSimonian and Laird random effects models. A two-tailed P value of <0.05 will be considered statistically significant.
Analysis of subgroups or subsets
A subgroup analysis by type of exposure, sex, adjustment for covariates, geographical region (US/ Europe/ Asia) and if necessary of studies without comparator groups will be conducted.
Contact details for further information
Georgios Polychronidis
Harvard T.H. Chan School of Public Health
Department of Epidemiology
[email protected]
Organisational affiliation of the review
Harvard T.H. Chan School of Public Health
Review team members and their organisational affiliations
Dr Georgios Polychronidis. Heidelberg University Clinic, Study Center of the German Surgical Society & Harvard T.H. Chan School of Public Health
Haziq Siddiqi. Harvard Medical School
Dr. Stefania Papatheodorou.Harvard T.H. Chan School of Public Health
Professor Albert Hofman. Harvard T.H. Chan School of Public Health
Assistant Professor Dr. Mingyang Song. Harvard T.H. Chan School of Public Health & Massachusetts General Hospital
Type and method of review
Epidemiologic, Meta-analysis, Systematic review
Anticipated or actual start date
01 July 2020
Anticipated completion date
30 January 2021
Funding sources/sponsors
Deutsche Forschungsgemeinschaft (DFG) Projektnummer 426308975
Conflicts of interest
None
Language
English
Country
USA
Stage of review
Review Ongoing
Subject index terms
Gallstones; Cholecystectomy; Colorectal cance
Factors affecting trust and communication in global virtual teams
No full textAuthor Georgios GousiasMasterarbeit Universität Linz 2022Arbeit auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
Factors affecting trust and communication in global virtual teams
No full textAuthor Georgios GousiasMasterarbeit Universität Linz 2022Arbeit auf den öffentlichen PCs in den Bibliotheken der JKU+Medizin abrufba
The association of gallstone disease with risk of colorectal cancer (CRC).
No full textSystematic Revie
The association of gallstone disease with risk of colorectal cancer (CRC).
No full textSystematic Revie
Der griechische Gelehrte Georgios Zachariadis und sein Beitrag zum slawischen Schrifttum im 19. Jahrhundert
No full textAmong the Greek scholars who lived during the 19th century in the north-eastern Balkans, and also in Central Europe, and by their work contributed to the spiritual development of the Balkan Slavs, pride of place must be given to Georgios Zachariadis. Unfortunately, however, no detailed monograph on Zachariadis exists. On this account the problems that arise concerning the life and activities of this Greek scholar are still many and varied. In his study the author tries to fill one part of this lacuna. At the beginning of the work the following are examined, on the basis of new historical evidence: the date and place of Georgios Zachariadis’ birth, his studies and tenure as teacher in the Greek school at Zemun, the Serbian school at Šabac, and the Greek school in Vienna. The author continues his study by analyzing the various works of Zachariadis, which are written on Old Church^Slavonic, and the translations this Greek scholar made from Greek into Old Church Slavonic. Finally, the extent of Georgios Zachariadis’ contribution to Slavonic letters is made clear
The political program of Hellenism in Turkey
No full textTitle: Tό πoλιτικόν πρόγραμμα τοῦ Έλληνισμοῦ έν Tουρκία (The political program of Hellenism in Turkey) Originally published: as a leaflet in Istanbul, 1912 Language: GreekThe excerpts used are from the original which can be found at the ‘Ion Dragoumis archive’ in the Gennadion Library in Athens, pp. 7–9, 11–13, 24–25. About the author Georgios Boussios [1876, Grevena (Ottoman Macedonia) – 1929, Athens]: activist, politician and journalist. He was born into a well-off family of merchants. He c..
Correction: Do chemistry and rheology follow the same laboratory ageing trends in bitumen?
No full text Correction to: Materials and Structures (2022) 55:146 https://doi.org/10.1617/s11527-022-01986-w The article “Do chemistry and rheology follow the same laboratory ageing trends in bitumen?”, written by Georgios Pipintakos, Caitlin Lommaert, Aikaterini Varveri and Wim Van den bergh, was originally published in volume 55, issue 5, ID 146 without open access. With the society's decision to grant Open Choice the copyright of the article changed in February 2023 to © The Author(s) 2022 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0. Open access funding enabled and organized by RILEM.Pavement Engineerin
The evaluation of the effect of PAMAM dendrimers in the solubility of lmiquimod
No full textCharles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Supervisor: Dr. Georgios Paraskevopoulos, Ph.D. Consultant: Eleni Panoutsopoulou Author: Mgr. Thu Thao Truongová Title of the thesis: The evaluation of the effect of PAMAM dendrimers in the solubility of Imiquimod Dendrimers are highly branched polymeric compounds with defined properties. They are used as a nanoparticle delivery system, however concurrently they have significant potential in enhancing the solubility of poorly water soluble drugs. Dendrimers work as drug carriers either by encapsulating the drug in their branched internal structure or they create interactions with the drug in the outer layer via terminal functional groups. The aim of this work was to evaluate the effect of polyamidoamine (PAMAM) dendrimers on the solubility of the hydrophobic drug imiquimod. Solutions of zero, first, second and third generation dendrimers were prepared at six different concentrations. During the experiment, the pH of the solutions was measured before and after addition of excess amount of imiquimod. Subsequently, analysis was performed by high-performance liquid chromatography. The measured results show that the first generation of PAMAM dendrimers is able to increase the solubility of imiquimod in...C2-Internal Abstrakt Univerzita Karlova, Farmaceutická fakulta v Hradci Králové Katedra Farmaceutické technologie Školitel: Dr. Georgios Paraskevopoulos, Ph.D. Konzultant: Eleni Panoutsopoulou Autor: Mgr. Thu Thao Truongová Název rigorózní práce: Hodnocení účinku PAMAM dendrimerů na rozpustnost imiquimodu Dendrimery jsou velmi rozvětvené polymerické sloučeniny s definovanými vlastnostmi. Používají se jako nanočásticový distribuční systém, zároveň však mají významný potenciál v oblasti zvyšování rozpustnosti ve vodě špatně rozpustných léčiv. Dendrimery fungují jako nosiče léčiva buď na principu enkapsulace molekuly léčiva ve své rozvětvené vnitřní struktuře nebo vytvářejí interakce s léčivem ve vnější vrstvě skrze terminální funkční skupiny. Cílem této práce bylo zhodnotit účinek polyamidoaminových (PAMAM) dendrimerů na rozpustnost hydrofobního léčiva imiquimod. Postupně byly připraveny roztoky dendrimerů nulté, první, druhé a třetí generace v šesti různých koncentracích. Během experimentu se měřilo pH roztoků před a po přidání nadbytečného množství imiquimodu. Následně byla provedena analýza vysokoúčinnou kapalinovou chromatografií. Z naměřených výsledků použitých generací PAMAM dendrimerů vyplývá, že první generace těchto dendrimerů dokázala nejvíce zvýšit rozpustnost imiquimodu ve vodném prostředí. Do...Department of Pharmaceutical TechnologyKatedra farmaceutické technologieFaculty of Pharmacy in Hradec KrálovéFarmaceutická fakulta v Hradci Králov
Effect of PAMAM dendrimers on the solubility and the skin permeation of flufenamic acid
No full textUniverzita Karlova, Farmaceutická fakulta v Hradci Králové Katedra Farmaceutické technologie Školitel: Dr. Georgios Paraskevopoulos, Ph.D. Autor: Lenka Novotná Název diplomové práce: Vliv PAMAM dendrimerů na rozpustnost a kožní permeaci kyseliny flufenamové Kyselinu flufenamovou (FFA) patří do skupiny nesteroidních antiflogistik. Léčiva ze skupiny nesteroidních antiflogistik jsou nejhojněji užívané léky na celém světě. Škála použití je velmi rozsáhlá. Účinek léčiv je protizánětlivý, proti bolesti a teplotě. Problém jejich použití, zejména perorálně, tkví ve velkém množství nežádoucích účinků. Pro snížení výskytu nežádoucích účinků lze FFA podávat v lokální formě. Přestup látek přes kožní bariéru je obtížný. Látky musí splňovat určitá kritéria, aby molekuly byly schopné penetrovat přes hydrofilní a zároveň hydrofóbní část lamelární lipidové multivrstvy obsažené v části epidermis. Pro zlepšení rozpustnosti FFA ve vodě bylo využito výhodných vlastností poly(amidoaminových) (PAMAM) dendrimerů. PAMAM dendrimery jsou sférické makromolekuly s velmi dobře organizovanou strukturou. Fungují i jako akceleranty kožní permeace neboli kožní enhancery. Skupina těchto pomocných látek přechodně snižuje propustnost kožní bariéry a usnadňuje transdermální podání léčiv. Mezi další výhodné vlastnosti patří výborná...Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Supervisor: Dr. Georgios Paraskevopoulos, Ph.D. Author: Lenka Novotná Title of the thesis: Flufenamic acid (FFA) belongs to the group of non-steroidal anti-inflammatory drugs. Medicines from the group of non-steroidal anti-inflammatory drugs are the most widely used drugs worldwide. The range of uses is very extensive. The effect of the drugs is anti- inflammatory, they also serve against pain and fever. The problem with their use, especially orally, lies in the large number of side effects. To reduce the incidence of adverse effects, FFA can be administered topically. The transfer of substances through the skin barrier is demanding. The substances must meet certain criteria so that the molecules are able to penetrate through the hydrophilic and at the same time hydrophobic part of the lamellar lipid multilayer contained in the epidermis. To improve the solubility of FFA in water, we used the advantageous properties of poly(amidoamine) (PAMAM) dendrimers. PAMAM dendrimers are spherical macromolecules with a very well-organized structure. They work well as skin permeation accelerators or skin enhancers. A group of these excipients temporarily reduces the skin barrier and facilitates the transdermal...Department of Pharmaceutical TechnologyKatedra farmaceutické technologieFarmaceutická fakulta v Hradci KrálovéFaculty of Pharmacy in Hradec Králov
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