1,354,486 research outputs found
Cardiotoxicity of Tyrosine Kinase Inhibitors in Philadelphia-Positive Leukemia Patients
No full textIn the past twenty years, tyrosine kinase inhibitors (TKIs) have substantially changed the therapeutic landscape and the clinical outcome of several cancers, including Philadelphia-chromosome positive chronic myeloid leukemia and acute lymphoblastic leukemia, chronic eosinophilic syndromes, gastrointestinal stromal tumors, and others. Despite the obvious advantages offered in terms of efficacy and the overall safety profile, this new class of agents presents novel side effects, sometimes different from those induced by conventional chemotherapy. Among others, the potential cardiac toxicity, characterized by possible arrhythmias and the highest rates of cardiac ischemic disease and heart failure, were predominantly investigated. In this article, the authors review the most significant evidence in this regard, highlighting the overall benefit of TKI usage and the need for careful monitoring, especially in elderly patients
Giovanni Muzio e il progetto per il "Villaggio SAFFA" a Pontenuovo di Magenta (MI), 1954-1962
No full textBetween the 1950s and the 1960s the Società Italiana Fabbriche Fiammiferi e Affini (SAFFA) entrusted the Milanese architect Giovanni Muzio (1893-1982) with the design of some public buildings intended for the working community of the industrial settlement of Pontenuovo di Magenta, in the province of Milan. The initiative, materialized in a small company town, offered Muzio the opportunity to look at similar episodes in Northern Europe, making the village of Pontenuovo an emblematic case of reception of the design culture of Germany, Scandinavia, and the Baltic regions in the Italian context. Through the analysis of archival sources and unpublished documents, the contribution focuses on the genesis of the settlement and on Muzio’s architectures, highlighting the links with possible Nordic and Germanic models and drawing attention to the condition of decay and abandonment in which the settlement has been lying since 2005, when SAFFA ceased its activity
Development and test of large size GEM detectors
No full textWe discuss the main operating features of GEM detectors, optimized for use as trackers in a high radiation environment. The construction, tests and performances of large prototypes for the COMPASS experiment are also described, as well as the results of an exposure to very high intensity beams. (11 refs)
A direct, real-time, size-resolved analytical strategy to follow drug loading and release from biocompatible gold nanoparticles
No full textBackground: Analytical methods for the characterization of nanoparticle-based drug delivery systems often rely on the quantification of unbound drug to provide information on drug loading and delivery, but fail to account for system complexity, address the state of the releasing system, or simulate the physiological environment. There is a clear need for new analytical methods capable of following the entire process of drug loading, stability and release under physiological conditions, based on multi-parametric analytical platforms. Asymmetric flow field-flow fractionation (AF4) can be used to size sort and isolate nanoparticles for further analysis or characterization by online, uncorrelated techniques. Results: We propose AF4 coupled with online multiple detectors to investigate the model drug delivery system consisting of albumin (BSA)-coated gold nanoparticles (AuNPs) loaded with curcumin (CUR). A maximum loading efficiency of 88.9 % is achieved by optimizing various experimental parameters. The absorbance ratio of nanocarriers at 401 nm and 530 nm was successfully proposed as an index for evaluating drug loading (full load was 0.77 ± 0.01) and release from the carrier surface. At 37 °C, Au-BSA-CUR exhibits rapid drug release, achieving 34.8 % total release. This process is accompanied by swift degradation and efficient diffusion of the drug into the surrounding reservoir (∼30 %). The appearance of new absorbance peaks in fractograms (curcumin aggregation) at lower temperatures (20 or 30 °C) indicates the special properties of hydrophobic drugs, which are monitored by the AF4 platform for the first time. Significance: The tailored strategy employed in our investigation provided detailed, real-time, in situ analysis, making it a powerful tool for designing and optimizing drug delivery systems, providing insight into both loading and release mechanisms, assessing nanoparticle stability, and tolerating saline media. These results suggest that AF4-DAD-MALS is a more reliable and insightful technique for studying the stability, loading efficiency, and release dynamics of nanoparticle-based drug delivery systems
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Congenitally corrected transposition of the great arteries in an 83-year-old asymptomatic patient: Description and literature review
No full textWe describe the case of an 83-year-old asymptomatic man followed in our centre. Transoesophageal echocardiography disclosed congenitally corrected transposition of great arteries (CCTGA) with no associated anomalies and only mild aortic regurgitation. Cardiac MR confirmed the diagnosis and revealed preserved systemic ventricle systolic function with a normal perfusional pathway. This report is a demonstration that CCTGA without associated anomalies can reach older life in an asymptomatic condition. This is the oldest asymptomatic living patient with CCTGA ever described
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Con gli occhi di D’Annunzio e Berenson: I viaggi paralleli di Anne MacDonell e Carlo Placci nell’Italia di mezzo
No full textAll'inizio del Novecento l'Abruzzo fu la meta di due viaggi paralleli, ma del tutto diversi: uno fu compiuto da Anne MacDonell, scrittrice e traduttrice inglese di vaglia, l'altro coinvolse Carlo Placci, mondano intellettuale e giornalista di fama internazionale. Entrambi lasciarono memoria scritta di quelle esperienze: la prima con un dettagliato resoconto odeporico pubblicato come volume illustrato nel 1908, il secondo con un ben più breve racconto che apparve inizialmente su «Il Marzocco» l’8 luglio 1906 e fu poi incluso due anni dopo nella raccolta In Automobile (1908). Partendo dai punti in comune tra l’autrice e lo scrittore – cronologia e luoghi descritti, contesto e riferimenti culturali a loro disposizione – il contributo intende offrire una prima riflessione su come gli evidenti fattori di diversità tra MacDonell e Placci abbiano influenzato i rispettivi racconti
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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