1,720,973 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Roll compaction integrated work stream
No full textThis thesis focuses on the study of powder and granule characterization in order to improve the
formulations and properties of solid oral dosage forms as final products. The main goal is to
investigate the effect of excipients on formulation, granule properties and morphology and on the
active pharmaceutical ingredient (API) release rate of final products. Release rate and controlled
release behaviour of drugs are considered as the main quality attributes of products in this project. A
natural biopolymer, Alcell lignin is used as an excipient to modify formulations and granule
properties in order to improve the final quality of products. In addition, the effect of lignin on drug
release and controlled release behaviour is studied.
Firstly, powder and granule properties are investigated using dry granulation by the roll compaction
process considering various formulations and process parameters. Then, tablet properties are studied
using dry granulation via the roll compaction process, considering lignin as excipient and
acetylsalicylic acid as API. The influence of lignin on the drug release rate is assessed using gastric
fluid (pH 1.2).
Subsequently, artificial neural network (ANN) is applied for the prediction of drug release. ANN is
developed considering the following parameters: roll pressure, screw speed and lignin content. The
model was developed and validated through comparison with obtaind experimental data.
Compatibility was observed, thereby confirming the model as a predictive model tool for release rate
determination.
Finally, the controlled release behaviour of drugs are investigated considering modified lignin as an
excipient using varying formulations. Here, paracetamol is considered as an API in all formulations.
The results show the positive influence of adding modified lignin as an excipient, as it increases the
drug release rate. Moreover, controlled release behaviour of drugs is investigated at different pH,
gastric (pH 1.2) and intestine fluid (pH 7.2) and results show pH-sensitive behaviour when modified
lignin is utilised in the formulation lignin
Tenoxicam (Mobiflex) Solubility in Carbon Dioxide under Supercritical Conditions
No full textWe reported the solubility values for an active pharmaceutical ingredient (API) at different operational conditions. Tenoxicam was considered as the API model in this work, and the values of API solubility were determined between 308-338 K and 120-400 bar under supercritical conditions in CO2 as a dense solvent. The solubility measurements were performed via gravimetric technique in a designed pressure-volume-temperature (PVT) cell. The experimental data showed that the solubility of tenoxicam changes between 0.0000151 and 0.000786 mole fraction versus system pressure/temperature. The lowest tenoxicam solubility was obtained at the pressure of 120 bar and the highest temperature of 338 K. On the other hand, the highest solubility was obtained at the maximum pressure (400 bar) and temperature. As such, it turned out that the pressure had a direct influence on the API solubility such that the highest solubility was obtained at the maximum pressure. On the other hand, at low pressures, the temperature showed a negative effect on solubility. Furthermore, a theoretical study was carried out to correlate five different semiempirical correlations to the tenoxicam data, and among the employed models, the Méndez-Santiago-Teja (MST) model indicated the best performance with an AARD of 11.9%. The employed models indicated a linear trend, which can be exploited for extrapolation of the measured tenoxicam data
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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