1,795 research outputs found
RIC-HSCT for MF/SS
No full textAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
Ruolo della PCR nel rilevamento di differenti genotipi virulenti di Actinobacillus actinomycetemcomitans nel cavo orale, mediante sistema integrato colturale/molecolare, risultati preliminari
No full textPCR real time con sonde FRET per il rilevamento e la quantificazione dei genotipi 652 a JP2 di Actinobacillus actinomycetemcomitans nel cavo orale
No full textActinobacillus actinomycetemcomita ns (Aa) è un coccobacillo gram negativo associato a malattie infettive di tipo odontostomatologico, ma anche a patologie di natura non orale (endocarditi, polmoniti). Sotto il profilo odontostomatologico, la parodontite aggressiva causata da Aa si presenta con una notevole perdita di attacco gengivale e di supporto osseo alveolare che può portare alla precoce
perdita dell’elemento dentario.Tra i diversi fattori di virulenza descritti , Aa è in grado di produrre una leucotossina, (Ltx) che puo’ presentare diversi livelli di espressione a seconda dell’ organizzazione del promotore dell’operone ltx . Nel genotipo JP2 (altamente leucotossico) è presente una delezione pari a 530 bp, mentre nel genotipo 652 (mediamente leucotossico) è assente (Hritz et a l . 1996)
Effects of different ecological conditions and extraction techniques on the quality of volatile oils from flaxleaf fleabane (Erigeron bonariensis L.)
No full textThe objective of this study was mainly to compare the chemical composition of essential oils from the whole parts of Erigeron bonariensis obtained by traditional hydrodistillation technique and by supercritical fluid extraction recognized as an alternative efficient method. A comparison of the effects of different ecological conditions on the chemical composition of essential oil samples collected in different localities, Monastir (Tunisia) and Cagliari (Sardinia, Italy), has been also performed. Thus, interestingly gas chromatography/mass spectrometry (GC/MS) analysis showed that the volatile fraction prepared by supercritical fluid extraction from Tunisian E. bonariensis was richer in terpenes components (90.6%) compared with the essential oil obtained by traditional hydrodistillation (86.2%). Chemical analysis revealed that although roughly the same compounds were extracted using both supercritical fluid extraction (SFE) and hydrodistillation (HD) but with different percentages. Furthermore, the essential oil of Tunisian E. bonariensis obtained by traditional hydrodistillation has high content of caryophyllene oxide (18.7%), spathulenol (18.6%) and α-curcumene (10.2%) whereas Sardinian essential oil was richer in Cis-lanchnophyllum ester (14.2%) and (E)-β-farnesene (12.0%)
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