1,721,090 research outputs found
Foamy gland pancreatic ductal adenocarcinoma diagnosed on EUS-FNA: A histochemical, immunohistochemical, and molecular report
No full textThe foamy gland pattern (FGP) may impart to pancreatic ductal adenocarcinoma (PDA) a deceptively benign appearance. Thus, its diagnosis on FNA is challenging. A case of PDA with FGP, that was suspected on Diff Quik smears, diagnosed on cell-block preparation and confirmed by ancillary stains and molecular techniques, is here reported. The diagnostic interpretation of foamy atypical cells on direct smears may benefit from cell block preparation and from ancillary technique
Expression of NK-associated antigens in extramedullary lymph nodal blast crisis of chronic myeloid leukemia on fine-needle cytology
No full textA case is reported of a 62-yr-old male suffering from chronic
myelogenous leukemia (CML) who developed an extramedullary,
para-orthic lymph-nodal blast crisis without blood or bone marrow
involvement and expression of CD56/NK associated marker.
The diagnosis was performed on ultrasound-guided fine-needle
cytology by an immunocytochemical and flow cytometric analysis.
Conventional smears showed a monomorphous population of disperse,
undifferentiated cells without cytoplasm. Cells showed fragile
nuclei, vesicular chromatin, and evident nucleoli. Immunocytochemistry
performed on cytospin slides were negative for
cytokeratin, LCA, CD20, CD45Ro, and myeloperoxidase (MPO).
Flow cytometry analysis proved the myeloid origin of the tumor by
expression of CD13, CD34, and CD38 and showed aberrant
expression of CD56. Cytological diagnosis was confirmed by histological
examination. CD56 expression is generally an expression
of NK lymphoid proliferation and may be observed in acute
myelogenous leukemia but has rarely been reported in CML and
its related blast crisis. This unusual expression, its possible explanation,
the related technical problems, and clinicopathological
aspects are discussed
CYTOLOGICAL APPROACH TO THE DIAGNOSIS OF LYMPHOPROLIFERATIVE PROCESSES OF THE ORAL CAVITY
No full textPrimary non-Hodgkin lymphoma of the oral cavity (OCL), represent less than 3% of all the
NHL. pNHL may be clinically indistinguishable from other tumoral and non-tumoral lesions of the same
area and the microscopical diagnoses may be hampered by the morphological overlap with reactive
processes. An accurate pre-operative diagnosis should be mandatory because of the difficulties of a
surgical biopsy and of a complete excision of the corresponding lesions. Fine needle cytology (FNC) has
been successfully utilized in the preoperative diagnosis of oral cavity masses and NHL as well. The aim
of this study has been to review the cytopathological features of a series of OCL.
Materials and Methods:The series accounts for 10 cytological cases of OCL; one case of myeloma and
one of florid lymphoid reactive hyperplasia were added to the series too. Corresponding lesions were
from palatal soft tissue (2 cases); palatal bone (4 cases); floor of the mouth (1 case), vestibules (2 cases)
and gums (3 cases). In all the cases, a traditional FNC was performed, in 7 cases, a second FNC was
performed to prepare additional smears for immunocytochemistry (ICC) (2 cases), using antibodies CD3
and CD20 or suspended in PBS and used for flow cytometry (FC) in 5 cases. Cytological diagnoses were
rendered on the basis of cytological features only (5 cases), or combined to ICC (2 cases) and/or FC (5
cases). All the diagnoses were histologically controlled.
Results: Clinical presentation was generally represented by sub-mucosal masses which bulged in the
oral cavity. In all the cases cytological smears showed a monomorphous lymphoid cell population;
corresponding cells had nuclear atypia (enlargement, dispersed chromatin, membrane irregularity and
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International Academy of Cytology
85.18.242.249 - 6/20/2013 1:42:07 PM
large nucleoli) in 6 cases and more bland appearance in the 5 cases. One case showed a proliferation of
atypical plasma-cells including binucleated and immature cells. Cytological diagnoses were suspect
NHL in 7 cases including a case subsequently diagnosed as reactive hyperplasia. OCL was diagnosed in
4 cases and myeloma in 1 case. All the lesions were histologically diagnosed as NHL in 10 cases, myeloma
(1) and florid lymphoid reactive hyperplasia (1).
Conclusion: The cytological diagnosis of OCL is generally difficult, nonetheless a preoperative cytological
diagnosis should be advisable to differentiate the corresponding masses from other tumoral and nontumoral
processes, to avoid unnecessary extensive surgery and to sped up the therapeutic procedure
Pemphigus vulgaris of the esophagus: role of digestive endoscopy in diagnosis and therapeutic managemen
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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