728 research outputs found
Beyond physical mobility: Other ways to internationalise the academic profession
No full textThe chapter focuses on the growing importance that some academic activities apart from the physical mobility of students and scholars have in the internationalisation of both higher education and the academic profession. After a brief sketch of some literature on internationalisation beyond physical mobility, building on data collected through an international survey, the chapter analyses the extent to which academics are involved in international teaching, research and dissemination activities looking at differences across disciplines and countries, briefly discusses academics’ involvement in international knowledge transfer and in internationalisation “at home”, and their contribution to the integration of various international activities. Finally, some conclusions and implications for further investigations are provided
The Geographic Turn in Social Media: Opportunities for Spatial Planning and Geodesign
No full textThis paper introduces the concept of Social Media Geographic Information
(SMGI) as an emergent pluralist source of information which – it is
argued- may find valuable application in spatial planning and Geodesign. On
the base of empirical research, the author proposes a tentative framework for
SMGI Analytics in spatial planning. Among other methods, Spatial-Temporal
Textual Analysis (STTx) is proposed as a tool to investigate people perceptions
and interest in space and time. Possible implications and benefits of SMGI analytics
for the planning practice emerge from the overall discussion
Studio delle funzioni fisiologiche e delle implicazioni patologiche di HSPB3, il membro più deviante della famiglia delle HSPB.
No full textHSPB3 è una proteina da shock termico espressa prevalentemente nelle cellule muscolari. A differenza di altri membri della famiglia delle HSPB, HSPB3 non è indotto da shock termico e non conferisce termotolleranza. Nei mioblasti umani, HSPB3 è indotta durante il differenziamento sotto il controllo del fattore regolatore miogenico MyoD. Tuttavia, non è noto se HSPB3 partecipi al differenziamento miogenico, quesito oggetto di questa tesi. L'uscita dal ciclo cellulare e l’inizio del differenziamento sono regolati a livello trascrizionale e richiedono un rimodellamento della cromatina. Questo processo è modulato dalla sottoregolazione del recettore della Lamina B (LBR) e dal suo distacco dalla cromatina e dall'involucro nucleare (NE). Studi di immunofluorescenza mostrano un arricchimento di HSPB3 al NE. Questa osservazione ha suggerito l'ipotesi che HSPB3 possa agire a livello nucleare facilitando il rimodellamento della cromatina durante il differenziamento. L'analisi dell'espressione e lo studio della localizzazione subcellulare di LBR nei mioblasti dimostrano che esiste una connessione tra HSPB3 e LBR. In particolare, i livelli di mRNA di HSPB3 sono inversamente correlati a quelli di LBR. Inoltre, HSPB3 interagisce direttamente con LBR e promuove la sua rilocalizzazione nel nucleoplasma. Sebbene non possiamo escludere la possibilità che, oltre a LBR, HSPB3 possa interagire con altre proteine associate al NE, i nostri dati dimostrano che HSPB3 agisce sul rimodellamento di NE e cromatina, promuovendo l'espressione di geni specifici per il differenziamento. In accordo, l'analisi trascrittomica rivela la capacità di HSPB3 di modulare l'espressione dei geni coinvolti nell'organizzazione della matrice extracellulare e nello sviluppo del muscolo scheletrico. Dei 4 mutanti di HSPB3 associati a malattie neuromuscolari, l’analisi trascrittomica dimostra l’incapacità di R116P e R7S di modulare l’espressione genica come la forma wildtype, suggerendo che le mutazioni diminuirebbero la capacità di differenziamento e il potenziale rigenerativo dei muscoli.
L'espressione di HSPB3 è stata rilevata anche in popolazioni neuronali, ma finora non è stato identificato alcun ruolo fisiologico. Una delle funzioni delli HSPB è rappresentata dall'attività di chaperone e dalla prevenzione dell'aggregazione irreversibile di svariati substrati. Studi in vitro volti a caratterizzare l'attività chaperone di HSPB3 hanno dimostrato che essa inibisce l'aggregazione dell'α-sinucleina. In particolare, l'interazione tra l'α-sinucleina e le superfici lipidiche innesca la sua conversione da uno stato solubile a uno stato aggregato, processo che contribuisce allo sviluppo della malattia di Parkinson. Siccome è noto che diverse HSPB interagiscono con i lipidi e nel primo capitolo di questo lavoro è stato dimostrato che HSPB3 influenza l'inserimento di LBR nel NE, ci siamo chiesti se HSPB3 possa interferire con il legame proteine-lipidi. Nel secondo capitolo, abbiamo cercato di indagare se HSPB3 e altre HSPB meglio caratterizzate (HSPB5, HSPB6, HSPB7 e HSPB8) influenzano l'aggregazione dell'α-sinucleina e l'interazione con i lipidi. Utilizzando un metodo sviluppato nel laboratorio del Prof. M. Vendruscolo, abbbiamo dimostrato che tutti le HSPB studiate riducono l'aggregazione dell'α-sinucleina indotta dai lipidi, il prolungamento delle fibrille e la nucleazione secondaria. Più specificamente, le HSPB legano l'α-sinucleina nelle sue forme monomerica, oligomerica, fibrillare, nonché le membrane lipidiche.
In sintesi, i nostri risultati aprono la strada ad una migliore comprensione dell'implicazione di HSPB3 nella fisiopatologia del sistema neuromuscolare.HSPB3 is a small heat shock protein found predominantly in muscle cells. In contrast to other HSPBs, it is not upregulated upon heat-shock and it does not confer thermotolerance. In human myoblasts, HSPB3 is induced upon differentiation under the control of the myogenic regulatory factor MyoD. Yet whether HSPB3 plays a role in myogenic differentiation is unknown. The focus of this thesis was to assess whether HSPB3 participates in myogenic differentiation. Cell cycle exit and commitment to differentiation are regulated at the transcriptional level and require extensive chromatin remodeling. This process is modulated by the downregulation of Lamin B Receptor (LBR) and its detachment from chromatin and the nuclear envelope (NE). Immunofluorescence studies show that HSPB3 is enriched at the NE. This observation prompted the hypothesis that HSPB3 could act at the nuclear level facilitating the chromatin remodeling during muscle differentiation. Expression analysis and study of the subcellular localization of LBR in human myoblasts demonstrated that an interplay exists between HSPB3 and LBR. In particular, HSPB3 levels inversely correlate with LBR. Moreover, we demonstrate that HSPB3 directly interacts with LBR and promotes its relocalization into the nucleoplasm. Although we cannot exclude the possibility that, besides LBR, HSPB3 might also interact with other NE-associated proteins, our data clearly show that HSPB3 influences NE and chromatin remodeling, ultimately promoting the expression of pro-differentiating genes. In agreement, transcriptomic analysis links HSPB3 to changes in the expression of genes involved in extracellular matrix organization and skeletal muscle development. From the 4 identified mutations linked to neuromuscular pathologies, transcriptomic analysis evidences a loss of myogenic-specific gene activation by R116P and R7S, and an unexpected induction of the UPR (Unfolded Protein Response) due to R116P. These results open the possibility that mutations may decrease the differentiation capacity and regenerative potential of muscles.
HSPB3 expression has also been detected in neuronal populations, but no physiological role has been identified so far. The best characterized function of HSPBs are the chaperone activity and prevention of irreversible aggregation. In vitro studies aimed at characterizing the chaperone activity of HSPB3 have demonstrated its ability to inhibit α-synuclein aggregation. In particular, the interaction between α-synuclein and lipid surfaces has been shown to trigger its conversion from a soluble state into the aggregated stated, associated to the development of Parkinson’s disease. Of note, several HSPBs have been shown to interact with lipids but this function has not yet been linked to their anti-aggregation functions. The work presented in the first chapter indicates that HSPB3 affects LBR insertion into the NE opening the possibility that HSPB3 might interfere with protein-lipid binding. In the second chapter of this thesis, we sought to investigate whether HSPB3, and other better characterized HSPBs (HSPB5, HSPB6, HSPB7 and HSPB8) affect α-synuclein interaction with lipids and aggregation. Using a three-pronged approach developed in the laboratory of Prof. M. Vendruscolo, we find that all HSPBs studied have an impact on α-synuclein lipid-induced aggregation, elongation, and secondary nucleation. More specifically, HSPBs could bind α-synuclein in its monomeric, oligomeric and fibrillar forms, as well as to the lipid membranes themselves.
In summary, our findings pave the way for a better understanding of HSPB3 implication in the physiology and pathology of the neuromuscular system
A Preliminary Result of Implementing a Deep Learning-Based Earthquake Early Warning System in Italy
No full textIn this paper we present the preliminary results of a study using a deep-learning tool named LSTM (Long Short-Term Memory) network, to classify seismic events as near-source and far-source, with the final purpose of developing efficient earthquake early warning systems. We use a similar approach as in [15], applied to a database, named Instance, containing information about 54,008 earthquakes that occurred in Italy. Although these are preliminary results, the method shows a good ability to detect far-source events with an accuracy of about 67 %. For near-source events, the method shows an improvable result with an accuracy of 57 %. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG
Dichotomius (Dichotomius) telamon
No full textDichotomius (Dichotomius) telamon (Harold, 1869) (Figs. 3 A–B) Pinotus pelamon Harold, 1869a: 128 (original description). Type locality: Brésil [= Brazil]. Type series. The holotype (female) is deposited at the MNHN (examined, see Figs. 3 A–B). Remarks: According to Luederwaldt (1929) this species has a length of 30 mm. It is distributed in Brazil (Gillet 1911: 62; Vaz-de-Mello 2000: 193); and Guianas (Gillet 1911: 62; Vulcano & Pereira 1967: 585; Hielkema & Hielkema 2019: 53 as Dichotomius pelamon). The epithet “ pelamon ” was an involuntary and typographical error that the author himself corrected in the same year (see Harold 1869 b: 60).Published as part of Chamorro, William, Lopera-Toro, Alejandro & Rossini, Michele, 2021, A new species and distribution records of Dichotomius Hope, 1838 (Coleoptera Scarabaeidae: Scarabaeinae) in Colombia, pp. 193-206 in Zootaxa 4942 (2) on page 195, DOI: 10.11646/zootaxa.4942.2.3, http://zenodo.org/record/460044
Correction to: Ultra-late response (> 24 weeks) to anti-CGRP monoclonal antibodies in migraine: a multicenter, prospective, observational study (Journal of Neurology, (2024), 271, 5, (2434-2443), 10.1007/s00415-023-12103-4)
No full textIn the original version of this article, degree “ERT” of author Bonassi Stefano was incorrectly written as author in author group. Author group which previously read: Piero Barbanti1,2 · Cinzia Aurilia1 · Gabriella Egeo1 · Stefania Proietti3 · Florindo D’Onofrio4 · Paola Torelli5 · Marco Aguggia6 · Davide Bertuzzo6 · Cinzia Finocchi7 · Michele Trimboli8 · Sabina Cevoli9 · Giulia Fiorentini1 · Bianca Orlando1 · Maurizio Zucco10 · Laura Di Clemente10 · Ilaria Cetta11 · Bruno Colombo11 · Monica Laura Bandettini di Poggio12 · Valentina Favoni9 · Licia Grazzi13 · Antonio Salerno14 · Antonio Carnevale15 · Micaela Robotti16 · Fabio Frediani16 · Claudia Altamura17 · Massimo Filippi11 · Fabrizio Vernieri17 · Stefano Bonassi2,4 · ERT; for the Italian Migraine Registry study group. Should have read: Piero Barbanti1,2 · Cinzia Aurilia1 · Gabriella Egeo1 · Stefania Proietti3 · Florindo D’Onofrio4 · Paola Torelli5 · Marco Aguggia6 · Davide Bertuzzo6 · Cinzia Finocchi7 · Michele Trimboli8 · Sabina Cevoli9 · Giulia Fiorentini1 · Bianca Orlando1 · Maurizio Zucco10 · Laura Di Clemente10 · Ilaria Cetta11 · Bruno Colombo11 · Monica Laura Bandettini di Poggio12 · Valentina Favoni9 · Licia Grazzi13 · Antonio Salerno14 · Antonio Carnevale15 · Micaela Robotti16 · Fabio Frediani16 · Claudia Altamura17 · Massimo Filippi11 · Fabrizio Vernieri17 · Stefano Bonassi2,3 · for the Italian Migraine Registry study group. And affiliation details for author Stefano Bonassi were incorrectly given as 2San Raffaele University, Rome, Italy 4Headache Center Neurology Unit, San Giuseppe Moscati Hospital, Avellino, Italy 2San Raffaele University, Rome, Italy 4Headache Center Neurology Unit, San Giuseppe Moscati Hospital, Avellino, Italy but should have been: 2San Raffaele University, Rome, Italy 3Clinical and Molecular Epidemiology, IRCCS San Raffaele (not 2 and 4) 2San Raffaele University, Rome, Italy 3Clinical and Molecular Epidemiology, IRCCS San Raffaele (not 2 and 4
Boana bandeirantes
No full textBoana bandeirantes (Caramaschi & Cruz) The advertisement call of Boana bandeirantes has been described previously as a compound call with two note types “A” and “B” (Pinheiro et al. 2012), but the type calls were not investigated according to the social context. We observed short calls formed from one to three equal notes, that we consider here as the advertisement calls (Table 2; Figure 4A; SM I). This call is considered a pulse repetition sound (Köhler et al. 2017). We consider the type “B” as a territorial call, emitted less frequently (approximately 35% of the registered calls), observed when males’ density was higher (personal observation). This call is longer and composed of several equal notes emitted quickly (Figure 4B).Published as part of Manzano, Maria Carolina Rodella, Takeno, Michele Fernandes & Sawaya, Ricardo J., 2022, Advertisement calls of 18 anuran species in the megadiverse Atlantic Forest in southeastern Brazil: review and update, pp. 453-472 in Zootaxa 5178 (5) on page 459, DOI: 10.11646/zootaxa.5178.5.3, http://zenodo.org/record/703392
Production of the meiobentic harpacticoid copepod Canuella perplexa
No full textSecondary production of C. perplexa was estimated in a brackish water lagoon of the Po River Delta (Italy). Three generation peaks and a nonproductive overwintering population were observed. Estimates of the annual production of copepodites and adults using 3 methods are similar: 6.76, 6.09 and 6.78 g dry wt m-2. Egg production was 0.02 g dry wt m-2; nauplii production was 0.38 g dry wt m-2. These values show a relatively constant P/B ratio per generation (3-4). -from Author
Food and eating in fiction since 1950 with particular reference to the writing of Angela Carter, Doris Lessing, Michele Roberts and Alice Thomas Ellis.
No full textPhDEating is a fundamental activity. What people eat, how and with whom, what
they feel about food, what they do or do not want to eat and why - even who
they eat - are of crucial significance in any reading of human behaviour.
In this thesis, I consider the diverse and complex uses of food and eating
in fiction since 1950, especially that written by women. I argue both that food
and eating carry much of the meaning of a novel or story and that the acts of
cooking, feeding and eating depicted are inseparable from issues of power and
control: individually, interpersonally, culturally, politically.
My discussion centres on the writing of Angela Carter, Doris Lessing,
Michele Roberts and Alice Thomas Ellis. Drawing on psychoanalytic theory,
sociology, anthropology, Foucault, Bakhtin and others, the thesis aims to
construct an interdisciplinary perspective which both resists reductive
interpretations and emphasises the centrality, complexity and diversity of food
and eating in literature in our culture.
I begin with an examination of the ambiguities of maternal feeding and
nurturing, moving on to explore the links between appetite, eating and sexuality.
I explore cannibalism and vampirism as manifestations of oppression, but also as
indicating insatiable emptiness and transgressive appetite. The body itself is
crucial, and my argument considers the paradox of not eating as
control/enslavement, also tracing self-starvation as a positive route towards
wholeness and connection. The last part of my argument focuses on social
eating, examining conventions, rituals and food itself in connection with power
relations, and finally considers how we might truly speak of food and eating in
the context of society as a whole
Author Correction: Diagnostic and therapeutic workup of male infertility: results from a Delphi consensus panel (International Journal of Impotence Research, (2021), 10.1038/s41443-021-00511-x)
No full textThe following acknowledgments have been added: Authors want to acknowledge all collaborators who completed the questionnaire during the first and second round of voting: Paolo Turchi, Gianmartin Cito, Ilaria Natali, Alessandro Natali, Antonio Corvasce, Lucilla Divenuto, Stefano Impedovo, Michele Tedeschi, Francesco Paolo Turri, Antonio Vavallo, Antonio Vitarelli, Francesco Sebastiani, Davide Arcaniolo, Francesco Bottone, Francesco Chiancone, Lorenzo Cirigliano, Michelangelo Sorrentino, Giuseppina Peluso, Ottavio Sicuro, Pietro Paolo Cozza, Manuela Andreozzi, Marco Bitelli, Giorgio Franco, Vincenzo Gentile, Giuseppe La Pera, Andrea Ortensi, Pietro Salacone, Federica Sanna, Giovanni Tuffo, Paola Asero, Danilo Di Trapani, Vincenzo Favilla, Ignazio Gattuccio, Emilio Italiano, Bruno Giammusso, Filippo Montalto, Paolo Panella, Salvatore Privitera, Pietro Russo, Giuseppe Sidoti, Andrea Fabiani, Giorgio Gentile, Alessandro Franceschelli, Carlo Maretti, Edoardo Pescatori, Pasquale Scarano, Massimo Polito, Luigi Quaresima, Andrea Salonia, Gaetano Donatelli, Antonio Avolio, Daniele Tiscione, Andrea Galantini, Matteo Titta, Giorgio Piubello, Luca Boeri, Massimo Iafrate, Filippo Migliorni, Giovanni Liguori, Gioacchino De Giorgi, Emanuele Baldassarre, Giorgio Del Noce, Michele Manica, Carla Pasquale, Maurizio Ruggieri, Paolo Capogrosso, Fabrizio Ildefonso Scroppo, Elisabetta Micelli, Michele Rizzo
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