2,946 research outputs found
Supporting disabled children and their families in Scotland: A review of policy and research
No full textThe Joseph Rowntree Foundation has been supporting research about disabled children and their families for a number of years. An earlier Foundations covering the messages from these projects has already been published (1). This Foundations places the messages from that work into the Scottish context. It gives an overview of current policies affecting disabled children and their families in Scotland and draws on research carried out north of the border
The new enfant du siècle: Joseph de Maistre as a writer
No full textThe essays contained within this volume were first presented at Reappraisals/Reconsidérations, the Fifth International Colloquium on Joseph de Maistre, held at Jesus College, Cambridge on 4 and 5 December 2008.Series editor-in-chief: Guy Rowlands, University of St AndrewsJoseph de Maistre's reputation as a writer is legendary. His style, unique and alive, moulded the French language anew. It sabotaged his attempts at anonymous publication and earned him, through the centuries, the praises of enemies and admirers. Yet the relationship between Maistre's thought and writing remains ill-known. This collection is the first to examine how Maistre's ideas – including his denunciation of the written word – intersected with his writing practices and personas. The essays disclose an author formed by duty and affectionate relationships, by the conventions of public combat, by an intense sense of history, and by the imperatives of Revolution.Introduction: assessing Maistre's style and rhetoric / Richard A. Lebrun -- Joseph de Maistre as pamphleteer / Richard A. Lebrun -- Joseph de Maistre, letter writer / Pierre Glaudes ; translated by Kevin Michael Erwin and Richard A. Lebrun -- Joseph de Maistre: the paradox of the writer / Benjamin Thurston -- Epilogue: the forced inhabitant of history / Carolina ArmenterosPublisher PD
Open Space Inventory: Millstone Township, Monmouth County, New Jersey
No full textThis inventory details the assessment of government owned open space in Millstone Township. The open space inventory serves as a basis for the assessment and development of open space with the Township. The objective of the report is an inventory of the various types of open space and township owned land within Millstone Township that are under state, county, and local ownership
The Beat of the Economic Heart: Joseph Schumpeter and Arthur Spiethoff on Business Cycles
No full textThe paper discusses the relationship between Arthur Spiethoff and Joseph A. Schumpeter, the men and their works. Had it not been for Spiethoff Schumpeter would in all probability have forever been lost to scientific work. It was Spiethoff who brought the Austrian back to academia and research after a sequence of serious mishaps in politics and banking. Spiethoff's contribution to an analysis of business cycles is then summarized and important similarities and some differences between it and Schumpeter's are pointed out. The view of Spiethoff and Schumpeter that cycles are endogenous and cannot possibly be eliminated without at the same time eliminating the dynamism of the capitalist economy is then couterposed with views of some of their contemporaries and particularly modern mainstream macroeconomics that this is not so.Schumpeter; Spiethoff; business cycles; innovations; creative destruction
Letter from Gordon Hirabayashi to Joseph R. Goodman, June 9, 1942
No full textLetter from Gordon Hirabayashi to Joseph R. Goodman, sent from King County jail in Seattle. Hirabayashi describes events leading up to his arrest after turning himself in to the F.B.I., his experiences in jail, and positive regard for his fellow inmates. He mentions Goodman's upcoming visit to his family in an incarceration camp.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
Detecting Polygenic Adaptation in Admixture Graphs
No full textAbstract
Polygenic adaptation occurs when natural selection changes the average value of a complex trait in a population, via small shifts in allele frequencies at many loci. Here, Racimo, Berg, and Pickrell present a method...
An open question in human evolution is the importance of polygenic adaptation: adaptive changes in the mean of a multifactorial trait due to shifts in allele frequencies across many loci. In recent years, several methods have been developed to detect polygenic adaptation using loci identified in genome-wide association studies (GWAS). Though powerful, these methods suffer from limited interpretability: they can detect which sets of populations have evidence for polygenic adaptation, but are unable to reveal where in the history of multiple populations these processes occurred. To address this, we created a method to detect polygenic adaptation in an admixture graph, which is a representation of the historical divergences and admixture events relating different populations through time. We developed a Markov chain Monte Carlo (MCMC) algorithm to infer branch-specific parameters reflecting the strength of selection in each branch of a graph. Additionally, we developed a set of summary statistics that are fast to compute and can indicate which branches are most likely to have experienced polygenic adaptation. We show via simulations that this method—which we call PolyGraph—has good power to detect polygenic adaptation, and applied it to human population genomic data from around the world. We also provide evidence that variants associated with several traits, including height, educational attainment, and self-reported unibrow, have been influenced by polygenic adaptation in different populations during human evolution.</jats:p
Ancient DNA reveals key stages in the formation of Central European mitochondrial genetic diversity
No full textThe processes that shaped modern European mitochondrial DNA (mtDNA) variation remain unclear. The initial peopling by Palaeolithic hunter-gatherers ~42,000 years ago and the immigration of Neolithic farmers into Europe ~8000 years ago appear to have played important roles but do not explain present-day mtDNA diversity. We generated mtDNA profiles of 364 individuals from prehistoric cultures in Central Europe to perform a chronological study, spanning the Early Neolithic to the Early Bronze Age (5500 to 1550 calibrated years before the common era). We used this transect through time to identify four marked shifts in genetic composition during the Neolithic period, revealing a key role for Late Neolithic cultures in shaping modern Central European genetic diversity.Guido Brandt, Wolfgang Haak, Christina J. Adler, Christina Roth, Anna Szécsényi-Nagy, Sarah Karimnia, Sabine Möller-Rieker, Harald Meller, Robert Ganslmeier, Susanne Friederich, Veit Dresely, Nicole Nicklisch, Joseph K. Pickrell, Frank Sirocko, David Reich, Alan Cooper, Kurt W. Alt, The Genographic Consortiu
False positive peaks in ChIP-seq and other sequencing-based functional assays caused by unannotated high copy number regions
No full textAbstract
Motivation: Sequencing-based assays such as ChIP-seq, DNase-seq and MNase-seq have become important tools for genome annotation. In these assays, short sequence reads enriched for loci of interest are mapped to a reference genome to determine their origin. Here, we consider whether false positive peak calls can be caused by particular type of error in the reference genome: multicopy sequences which have been incorrectly assembled and collapsed into a single copy.
Results: Using sequencing data from the 1000 Genomes Project, we systematically scanned the human genome for regions of high sequencing depth. These regions are highly enriched for erroneously inferred transcription factor binding sites, positions of nucleosomes and regions of open chromatin. We suggest a simple masking procedure to remove these regions and reduce false positive calls.
Availability: Files for masking out these regions are available at eqtl.uchicago.edu
Contact: [email protected]; [email protected]; [email protected]; [email protected]
Supplementary information: Supplementary data are available at Bioinformatics online.</jats:p
Memorandum from Central Headquarters, Division of Public Safety, to Inter-Faith Church Council, January 5, 1943
No full textMemo from Inspector S. Moriwaki and George K. Adachi, acting captain of the Division of Public Safety at Topaz incarceration camp, to Inter-Faith Church Council, regarding a statement on the relationship between military police and incarcerees at the camp. The memo lists three incidents of harassment of incarcerees by military police that occurred on December 28 and December 31, 1942. Mentions incidents reported in chs_ms840_0352 and chs_ms840_0353.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
Tagging of Biomedical Articles on CiteULike: A Comparison of User, Author and Professional Indexing
No full textThis paper examines the context of online indexing from the viewpoint of three different groups: users, authors, and professional indexers. User tags, author keywords and descriptors were collected from academic journal articles, which were both indexed in Pubmed and tagged on CiteULike, and analysed. Descriptive statistics, informetric measures, and thesaural term comparison shows that there are important differences in the use of keywords between the three groups in addition to similarities which can be used to enhance support for search and browse. While tags and author keywords were found that matched descriptors exactly, other terms which did not match but provided important expansion to the indexing lexicon were found. These additional terms could be used to enhance support for searching and browsing in article databases as well as to provide invaluable data for entry vocabulary and emergent terminology for regular updates to indexing systems. Additionally, the study suggests that tags support organisation by association to task, projects and subject while making important connections to traditional systems which classify into subject categories
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