1,216 research outputs found
Evaporative efficiency of the boiler of locomotive Schenectady no. 2; using crude petroleum as fuel
No full textTypescriptThesis (B.S.)--Purdue University, 1902Mechanical EngineeringB.S
Pleiotropic actions of mIR-21 highlight the critical role of deregulated stromal microRNA's during colorectal cancer progression
No full textThe oncogene microRNA-21 (miRNA; miR-21) is overexpressed in most solid organ tumours; however, a recent examination of stage II colorectal cancer (CRC) specimens suggests this may be a stromal phenomenon and not only a feature of cancer cells. In vitro and in vivo studies show that miR-21 has potent pro-metastatic effects in various malignant carcinoma cell lines. The tumour microenvironment has also been identified as a key actor during the metastatic cascade; however to date the significance of deregulated miR-21 expression within the cancer-associated stroma has not been examined. In the present study, a quantitative RT-PCR-based analysis of laser microdissected tissue confirmed that miR-21 expression is associated with a four-fold mean increase in CRC stroma compared with normal tissue. In situ hybridisation using locked nucleic acid probes localised miR-21 expression predominantly to fibroblasts within tumour-associated stroma. To study the molecular and biological impact of deregulated stromal miR-21 in CRC, stable ectopic expression was induced in immortalised fibroblasts. This resulted in upregulated ?-smooth muscle actin expression implying miR-21 overexpression is driving the fibroblast-to-myofibroblast transdifferentiation. Conditioned medium from miR-21-overexpressing fibroblasts protected CRC cells from oxaliplatin-induced apoptosis and increased their proliferative capacity. 3D organotypic co-cultures containing fibroblasts and CRC cells revealed that ectopic stromal miR-21 expression was associated with increased epithelial invasiveness. Reversion-inducing cysteine-rich protein with kazal motifs, an inhibitor of matrix-remodelling enzyme MMP2, was significantly downregulated by ectopic miR-21 in established and primary colorectal fibroblasts with a reciprocal rise in MMP2 activity. Inhibition of MMP2 abrogated the invasion-promoting effects of ectopic miR-21. This data, which characterises a novel pro-metastatic mechanism mediated by miR-21 in the CRC stroma, highlights the importance of miRNA deregulation within the tumour microenvironment and identifies a potential application for stromal miRNAs as biomarkers in cancer
Conference papers of Barc Scientists and engineers : a citation based study
No full textThis paper highlights the importance of conference papers in the scientific communication process. Carried out a citation analysis of 474 (8.52%) conference papers of BARC Scientists and Engineers published during 1999-2007 as per Scopus database. The highest number of papers (117) were published in 2004 and these papers have received the highest (183) number of citations. The average number of papers published per year was 52.66 and the average number of citations per paper was 1.81. Identified highly cited authors and highly cited conference papers. Concludes that conference literature has to be integrated with the databases so as to avoid the missing link in the knowledge development process
BONDEFRIHED OG ANDRE VERDENSBILLEDER IDEHISTORISKE STUDIER AF B.S. INGEMANNS DANMARKSHISTORIE 1824-1836
No full textABSTRACTPeasants’ Freedom and other Ideas of History:Studies in the Historical Literature of B.S. Ingemann 1824-1836Using a New Historicist approach this article examines four worldviews imbedded in a reading of B.S. Ingemanns historical literature which was published between 1824-1836 in the genre of two poems and four historical novels. The worldview of the author-subject (1), a worldview related to the relationship between the monarchy and the people, largely conceived within the so called ‘myth of an original peasants freedom’, a founding myth within Danish historiography (2), a worldview related to the defense of the Danish version of monarchism, in particular the thoughts put forward by the Danish lawyer Jacob Mandix (3), and finally a worldview related to notions of the ideal ‘Rechtsstat’, where Ingemanns literature is read within the context of the discipline “Law and Literature” (4). The article displays personal experiences with monarchism which becomes the primary object of investigation in the context of empirical analysis of prose fiction
Kandel, Phoebe M., B.S. A.M.
No full textPhoebe Kandel was born in Greentown, Ohio in 1882. Ms Kandel received her diploma from Canton Actual Business College and was a graduate of the Lakeside Hospital Training School for Nurses (now the Frances Bolton School of Nursing, Case Western Reserve University) in 1908. Ms Kandel received her both her B.S. (1923) and A.M. (1934) from The Teachers College, Columbia University. Ms Kandel was an Instructor at the Jewish Hospital School of Nursing, Cincinnati, Ohio from 1916-1918; Superintendent of City Hospital, Springfield, Ohio 1918 and Instructor of Nursing at the University of Cincinnati (1919-1924) and Director and Associate Professor of Nursing (1924-1926). Ms Kandel was State Director of Nursing Education for Nebraska from 1928-1930. Ms Kandel was Professor and Director of Nursing Education at Colorado State College, Greeley from 1930-1941. Ms Kandel came to the University as Professor of and Director of Nursing Education (1941-1943). Ms Kandel was later associated with the University of Georgia (1944-1949) and with the Mississippi State Board of Nurses Examiners and Registration (1949). Ms. Kandel was the author of the books, From Mud to Crystal (1923) and Hospital Economics for Nurses (1930). Phoebe Kandel died in 1982
J.Barnes, J.Fowles, and B.S. Johnson: case studies in the postmodern, the author, & text-editing
No full textThis thesis explores how practices of text-editing can shed new light on the utility of the terms ‘modernism’ and ‘postmodernism’ as ways of categorising mid- to late-twentieth-century fiction. The research does not aim to interrogate editorial theory or critical theory per se; but to bring these areas of the discipline into productive dialogue to further our understanding of what is meant by ‘radical’ or ‘subversive’ fiction, and the extent to which it resists interpretation. The thesis focuses on three works by three different authors: The Unfortunates by B.S. Johnson, The Magus by John Fowles, and Flaubert’s Parrot by Julian Barnes. These three novels have complex relationships with postmodernism, a label which, this thesis argues, is losing precision through overuse. I contest the categorisation of these three works as postmodern, arguing that there is value to be found in recognising their differences as well as their similarities. I call for the reinscription of the figure of the author into the text as a way of opening up new avenues of interpretation for the reader. I explore how an understanding of authorial persona, authorial intention, and the author’s creative processes can be a source of elucidation, particularly when a work has become historically distanced from a modern-day readership. The practices of text-editing are employed to demonstrate how a work like The Magus is not as radical as the postmodern label suggests it to be; how The Unfortunates is more subversive than indicated by the accusations of gimmickry and pejorative connotations of experimentalism that have hovered around the work since its publication; and how Flaubert’s Parrot, although decisively postmodernist, has subtle nuances of meaning that may be overlooked if the concept of the author is disregarded. As part of this discussion, I explore the ethics and implications of each author’s use of source material via appropriation, translation, and revision; and I show how an awareness of such processes gives us new insight into an author’s intentions. The argument is supported by archival research undertaken at the Harry Ransom Center and the British Library into authorial manuscripts and autograph notes. The thesis concludes by making a case for critical editions of these novels, along with other late twentieth-century novels that are becoming increasingly historical, with the view to reinvigorating interest in them
J.Barnes, J.Fowles, and B.S. Johnson: case studies in the postmodern, the author, & text-editing
No full textThis thesis explores how practices of text-editing can shed new light on the utility of the terms ‘modernism’ and ‘postmodernism’ as ways of categorising mid- to late-twentieth-century fiction. The research does not aim to interrogate editorial theory or critical theory per se; but to bring these areas of the discipline into productive dialogue to further our understanding of what is meant by ‘radical’ or ‘subversive’ fiction, and the extent to which it resists interpretation. The thesis focuses on three works by three different authors: The Unfortunates by B.S. Johnson, The Magus by John Fowles, and Flaubert’s Parrot by Julian Barnes. These three novels have complex relationships with postmodernism, a label which, this thesis argues, is losing precision through overuse. I contest the categorisation of these three works as postmodern, arguing that there is value to be found in recognising their differences as well as their similarities. I call for the reinscription of the figure of the author into the text as a way of opening up new avenues of interpretation for the reader. I explore how an understanding of authorial persona, authorial intention, and the author’s creative processes can be a source of elucidation, particularly when a work has become historically distanced from a modern-day readership. The practices of text-editing are employed to demonstrate how a work like The Magus is not as radical as the postmodern label suggests it to be; how The Unfortunates is more subversive than indicated by the accusations of gimmickry and pejorative connotations of experimentalism that have hovered around the work since its publication; and how Flaubert’s Parrot, although decisively postmodernist, has subtle nuances of meaning that may be overlooked if the concept of the author is disregarded. As part of this discussion, I explore the ethics and implications of each author’s use of source material via appropriation, translation, and revision; and I show how an awareness of such processes gives us new insight into an author’s intentions. The argument is supported by archival research undertaken at the Harry Ransom Center and the British Library into authorial manuscripts and autograph notes. The thesis concludes by making a case for critical editions of these novels, along with other late twentieth-century novels that are becoming increasingly historical, with the view to reinvigorating interest in them
Multiple sets of solutions for harmonic elimination PWM bipolar waveforms: Analysis and experimental verification
No full textMultiple sets of solutions for the selective harmonic elimination pulse-width modulation method for inverter control exist. These sets present an independent solution to the same problem but further investigation reveals that certain sets may offer an improved overall harmonic performance. In this paper, a minimization method is discussed as a way to obtain these multiple sets of switching angles. A simple distortion harmonic factor that takes into account the first two most significant harmonics present in the generated waveform is considered in order to evaluate the performance of each set. The bipolar waveform is thoroughly analyzed and two cases are considered; single-phase patterns which eliminate all odd harmonics and three-phase counterparts which eliminate only the nontriplen odd harmonics from the line-to-neutral pattern but such harmonics are naturally eliminated from the line-to-line waveform. Experimental results support the theoretical considerations reported in the paper
Birefringence of hexagonal single crystals of helium-4 at various pressures
No full textApplied Science
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