59 research outputs found
Erratum: a synonymous variant in GCK gene as a cause of gestational diabetes mellitus (diabetes mellitus. 2019;22(2). Doi: 10.14341/dm9938)
No full textAn erratum on «A synonymous variant in GCK gene as a cause of gestational diabetes mellitus» by Natalya A. Zubkova, Petr M. Rubtsov, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasiliev, Vasily M. Petrov, Anatoly N. Tiulpakov (2019). Diabetes mellitus. 22(2). doi: 10.14341/DM9938An error was made in the list of authors: Fatima F. Burumkulova was not indicated as author of this article. The correct list of authors: Natalya A. Zubkova, Petr M. Rubtsov, Fatima F. Burumkulova, Liudmila I. Ibragimova, Nina A. Makretskaya, Evgeny V. Vasiliev, Vasily M. Petrov, Anatoly N. Tiulpakov.The editorial board apologize for this error and state that this does not change the scientific conclusions of the article in any way.The original article has been updated
Genre Originality of Creativity Nikolay Rubtsov: the Problem of the Interaction of Folklore and Literary Traditions
No full textВ статье рассмотрена жанровая специфика творчества Николая Рубцова: выявлены и определены основные подходы к проблеме жанра как одной из фундаментальных категорий, участвующих в формировании художественного метода поэта. Предпринят идейно-образный, стилистический и фонический анализ рубцовских песен («Зимняя песня», «Прощальная песня», «Осенняя песня»), частушек и элегий («Дорожная элегия», «Элегия (Отложу свою скудную пищу…»), стихотворений-баллад («Старая дорога», «Видения на холме») и поэма-сказка «Разбойник Ляля». Среди жанровых признаков обнаруживаются как фольклорные, так и литературные элементы, что позволяет говорить о синтетической природе жанровых форм поэзии Николая Рубцова.The article discusses the issue of genre and the specifics of the creative work of Nikolai Rubtsov. The genre is seen by the author as one of the fundamental categories involved in the for-mation of the poet's artistic method. Rubtsov's songs («Winter song», «Farewell song», «Autumn song») and ditties, elegies («Road Elegy», «Elegy (I will Put aside my meager food...»), poems-ballads («Old road», «Visions on the hill») and the poem-fairy tale «Robber Lyalya» are subjected to ideological-figurative, stylistic and phonic analysis. Among the genre features are found both folk and literary elements, resulting in the conclusion about the synthetic nature of genre forms of poetry of Nikolai Rubtsov
ACTIVE INTERMEDIATES IN THE CHAIN OXIDATION OF DICHLOROSILANE
No full text D. Sameith, J.P. Monch, H.J. Tiller et al. Chem.Phys.Lett, 128, 483, (1986) V.V. Azatyan, A.S. Lukashev, S.S. Nagorny et al. Kinel Catal., 34, 404, (1993) V.P. Karpov, N.M. Rubtsov O.T. Ryzhkov et al. Chem.Phys.Reports, 17, 73, (1998)Author Institution: Russia, Institute for Structural Macrokinetics RAS, Moscow regionDichlorosilylenes have been detected in the branching chain reaction of the oxidation of dichlorosilane with for the first time. The emission spectra of rarified flame were recorded under static and flow conditions over the pressure range Torr and over the following intervals : in the range 220-280 nm in the range ; the continious emission caused by the blackbody radiation from the solid particles over 400nm. The intensive absorption in the range of 210-260 nm has been also observed under static conditions. The simultaneous recording of the mentioned intermediates as well as conductivity (revealed ) during the single ignition has been performed. The peaks of the signals are staggered in time. The first peak in time is (coincident with SiO), the second is the absorption peak, the third is the visible emission coincident with conductivity peak. 10\% additives (to fuel) of have a decreasing effect only on the absorption, visible emission and conductivity. It means that the absorbing intermediates contain Si-O bonds since has influence mainly on aerosol
The modes of gaseous combustion
No full textThis book provides an analysis of contemporary problems in combustion science, namely flame propagation, detonation and heterophaseous combustion based on the works of the author. The current problems in the area of gas combustion, as well as the methods allowing to calculate and estimate limiting conditions of ignition, and flame propagation on the basis of experimental results are considered. The book focuses on the virtually inaccessible works of Russian authors and will be useful for experienced students and qualified scientists in the area of experimental studies of combustion processes
INFLUENCE OF CHEMICALLY ACTIVE ADDITIVES ON EMISSION SPECTRA OF THE FLAMES OF HYDROGEN AND DEUTERIUM OXIDATION IN NEAR IR REGION
No full textAuthor Institution: Institute for Structural Macrokinetics and Material Science of Russian Academy of Sciences, 142432, Russian Federation, Noginski region, ChernogolovkaBand system in the region 852 880 nm and bands 670 and 846 nm over pressures 0.1 1 atm in the flames of mixtures of hydrogen with oxygen and air has been detected. The system is assigned to overtone transitions of HO (3) correspondingly arising from the reaction of HOHOHOO33.5 kcal/mole. The bands 670 and 846 nm are assigned to overtone transitions of HO radical (4) and (3) correspondingly arising from the reaction of HO(M)HO(M) 44 kcal/mole. By this means the extent of energy of these elementary processes is located in vibrational degrees of freedom of products. It has been detected that HO radicals occur originally in overtone-excited states in combustion both of hydrogen and deuterium in the presence of small additives of propylene as an inhibitor
Upper limit on the flux of photons with energies above 1019 eV using the Telescope Array surface detector
No full textWe search for ultra-high energy photons by analyzing geometrical properties of shower fronts of events registered by the Telescope Array surface detector. By making use of an event-by-event statistical method, we derive upper limits on the absolute flux of primary photons with energies above 1019, 1019.5, and 1020 eV based on the first three years of data taken. © 2013 American Physical Society.0SCOPUS: ar.jinfo:eu-repo/semantics/publishe
High heterogeneity in genomic differentiation between phenotypically divergent songbirds: A test of mitonuclear co-introgression
No full textAbstractComparisons of genomic variation among closely related species often show more differentiation in mitochondrial DNA (mtDNA) and sex chromosomes than in autosomes, a pattern expected due to the differing effective population sizes and evolutionary dynamics of these genomic components. Yet, introgression can cause species pairs to deviate dramatically from general differentiation trends. The yellowhammer (Emberiza citrinella) and pine bunting (E. leucocephalos) are hybridizing avian sister species that differ greatly in appearance and moderately in nuclear DNA, but that show no mtDNA differentiation. This discordance is best explained by adaptive mtDNA introgression—a process that can select for co-introgression at nuclear genes with mitochondrial functions (mitonuclear genes). To better understand these discordant differentiation patterns and characterize nuclear differentiation in this system, we investigated genome-wide differentiation between allopatric yellowhammers and pine buntings and compared it to what was seen previously in mtDNA. We found significant nuclear differentiation that was highly heterogeneous across the genome, with a particularly wide differentiation peak on the sex chromosome Z. We further investigated mitonuclear gene co-introgression between yellowhammers and pine buntings and found support for this process in the direction of pine buntings into yellowhammers. Genomic signals indicative of co-introgression were common in mitonuclear genes coding for subunits of the mitoribosome and electron transport chain complexes. Such introgression of mitochondrial DNA and mitonuclear genes provides a possible explanation for the patterns of high genomic heterogeneity in genomic differentiation seen among some species groups.MethodsFull methods can be found in the linked 2023 Heredity paper with additional details provided in the attached scripts and text files. Briefly, DNA was extracted from blood and tissue samples taken from avian individuals and then sequenced using a Genotyping-By-Sequencing approach. DNA reads were processed using the scripts provided in the "GBS_Reads_processing_to_VCF.txt" file and then analyzed using the scripts provided in both the "Heredity_Pub_PopulationGenetic_Analysis_Code.R" and "Heredity_Pub_Mitonuclear_Analysis_Code.R" files. The former of these two R files contains general genetic analyses while the latter contains mitonuclear analyses.Usage notesGBS_Reads_processing_to_VCF.txt
This text file contains the scripts used to convert raw Illumina GBS sequence reads into a genome-wide variant site file (in "012NA" format) and into chromosome-specific "all sites" files which include both variant and invariant sites (in "012NA" format). The resulting files were input into R and investigated with genetic and mitonuclear analyses. These scripts were adapted from those applied in Irwin et al. (2018; citation below). The scripts employed by Irwin et al. (2018) are available on Dryad at: https://doi.org/10.5061/dryad.4j2662g
GBS_Plate#_Barcods.txt
These four text files contain the nucleotide barcodes associated with DNA samples that were sequenced on four GBS plates. This information is necessary when running the GBS read processing scripts contained within "GBS_Reads_processing_to_VCF.txt".
Genome_wide_variant_site_files.zip
This zip file contains the files produced (.indv, .pos, .012NA) when using the scripts available in "GBS_Reads_processing_to_VCF.txt" to create a genome-wide variant site dataset (in "012NA" format). The produced files were loaded into R and analyzed using the scripts contained in "Heredity_Pub_Mitonuclear_Analysis_Code.R" and "Heredity_Pub_PopulationGenetic_Analysis_Code.R".
Chromosome_Info_site_files.zip
This zip file contains the files produced (.indv, .pos, .012NA) when using the scripts available in "GBS_Reads_processing_to_VCF.txt" to create chromosome-specific "all sites" datasets that contain both variant and invariant sites (in "012NA" format). There is a trio of files associated with each of the chromosomes analyzed in this research. The "all sites" files were loaded into R and analyzed using the scripts contained in "Heredity_Pub_Mitonuclear_Analysis_Code.R" and "Heredity_Pub_PopulationGenetic_Analysis_Code.R".
Heredity_Pub_PopulationGenetic_Analysis_Code.R
This R file contains the R scripts used to both conduct the genetic analyses and produce the figures found in the associated paper. Author comments accompany major lines of code to explain their purpose. The input files for these analyses can be found within "Genome-wide_variant_site_files.zip" and "Chromosome_Info_site_files.zip". To run these analyses, the "Genomics_R_functions_TajD.Ellen.Fixes.R" file must also be loaded in R. This file contains necessary functions that are applied in the analysis scripts. Also, two additional CSV files ("All_Plates_Fst_Allo_Sym.csv" and "Allopatric_Map_Info.csv") are needed to run certain parts of the analysis.
Heredity_Pub_Mitonuclear_Analysis_Code.R
This R file contains the R scripts used to conduct the mitonuclear analyses described in the associated paper. Author comments accompany major lines of code to explain their purpose. The input files for these analyses can be found within "Genome-wide_variant_site_files.zip" and "Chromosome_Info_site_files.zip". To run these analyses, the "Genomics_R_functions_TajD.Ellen.Fixes.R" file must also be loaded into R. This file contains necessary functions that are applied in the analysis scripts. Also, one additional CSV file ("All_Plates_Fst_Allo_Sym.csv") is needed to run certain parts of the analysis.
Genomics_R_functions_TajD.Ellen.Fixes.R
This R file contains the R functions that were used to conduct the genetic and mitonuclear analyses contained within the "Heredity_Pub_PopulationGenetic_Analysis_Code.R" and "Heredity_Pub_Mitonuclear_Analysis_Code.R" files. This file was adapted from the functions file employed by Irwin et al. (2018) but contains some modifications and additional functions that can be used to calculate Tajima's D for the populations being analyzed. The scripts employed by Irwin et al. (2018) are available on Dryad at: https://doi.org/10.5061/dryad.4j2662g
All_Plates_Fst_Allo_Sym.csv
This CSV file contains the descriptive metadata for the samples analyzed in this study. This file contains information on the sex, phenotype, species, distribution and location of collection for each sample. This file was used to sort samples into discrete groups that were then compared in the genetic and mitonuclear analyses contained within the "Heredity_Pub_PopulationGenetic_Analysis_Code.R" and "Heredity_Pub_Mitonuclear_Analysis_Code.R" files.
Allopatric_Map_Info.csv
This CSV file contains the information necessary to create the map included in Figure 1 of the associated paper using scripts contained within the "Heredity_Pub_PopulationGenetic_Analysis_Code.R" file. This CSV file describes the number and the identities of individuals collected at specific sampling locations as well as the latitude and longitude of each sampling location. Some sampling locations were combined on the map because they were too close together to be shown accurately. Information on how sampling locations were combined can be found in the associated paper.
References:
Irwin, D. E., Milá, B., Toews, D. P. L., Brelsford, A., Kenyon, H. L., Porter, A. N., Grossen, C., Delmore, K. E., Alcaide, M., & Irwin, J. H. (2018). A comparison of genomic islands of differentiation across three young avian species pairs. Molecular Ecology, 27(23), 4839-4855. https://doi.org/10.1111/mec.14858</p
Subtype of Neuroblastoma Cells with High KIT Expression Are Dependent on KIT and Its Knockdown Induces Compensatory Activation of Pro-Survival Signaling
No full textNeuroblastoma (NB) is a pediatric cancer with high clinical and molecular heterogeneity, and patients with high-risk tumors have limited treatment options. Receptor tyrosine kinase KIT has been identified as a potential marker of high-risk NB and a promising target for NB treatment. We investigated 19,145 tumor RNA expression and molecular pathway activation profiles for 20 cancer types and detected relatively high levels of KIT expression in NB. Increased KIT expression was associated with activation of cell survival pathways, downregulated apoptosis induction, and cell cycle checkpoint control pathways. KIT knockdown with shRNA encoded by lentiviral vectors in SH-SY5Y cells led to reduced cell proliferation and apoptosis induction up to 50%. Our data suggest that apoptosis induction was caused by mitotic catastrophe, and there was a 2-fold decrease in percentage of G2-M cell cycle phase after KIT knockdown. We found that KIT knockdown in NB cells leads to strong upregulation of other pro-survival growth factor signaling cascades such as EPO, NGF, IL-6, and IGF-1 pathways. NGF, IGF-1 and EPO were able to increase cell proliferation in KIT-depleted cells in an ERK1/2-dependent manner. Overall, we show that KIT is a promising therapeutic target in NB, although such therapy efficiency could be impeded by growth factor signaling activation
Erratum to: Quantum spin fluctuations and evolution of electronic structure in cuprates (npj Quantum Materials, (2018), 3, 1, (54), 10.1038/s41535-018-0128-x)
No full textDuring the typesetting process of the original version of this Article the nomenclature for the nodal and anti-nodal points was incorrectly given. This has now been corrected in the HTML and PDF versions of the Article. © 2018, The Author(s)
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