60 research outputs found
RESEARCHING CELEBRITY IN THE MEDIEVAL TIME: A CASE STUDY OF CELEBRITY NGUYEN TRAI
No full textBài viết nghiên cứu những đặc điểm nổi bật của danh nhân Việt Nam thời trung đại: tài năng về nhiều mặt, có nhiều đóng góp đối với dân tộc ở nhiều lĩnh vực khác nhau, “người xưa của ta nay”. Từ đó đề xuất quan điểm và phương pháp nghiên cứu trường hợp (Case study) danh nhân Nguyễn Trãi. Về quan điểm nghiên cứu Nguyễn Trãi: Thiên tài hội tụ nhiều tài năng, Đóng góp to lớn với dân tộc, mang tầm vóc quốc tế. Về phương pháp nghiên cứu Nguyễn Trãi: Đặt tác giả và tác phẩm trong một hệ quy chiếu, Nghiên cứu đến tận cùng những vấn đề đặt ra từ tác phẩm, Đặt tác giả, tác phẩm trong bối cảnh thời đại và trong bối cảnh tương lai. Nghiên cứu trường hợp Nguyễn Trãi để phát huy vai trò “người xưa của ta nay” từ danh nhân thời trung đại nói chung, Nguyễn Trãi nói riêng.The article studies the outstanding characteristics of famous Vietnamese figures in the medieval period: multi-talented individuals who made significant contributions to the nation in many fields, embodying the concept of "our historical figures in today\u27s context" From there, the paper proposes the viewpoint and method of a case study of the historical figure Nguyen Trai. Regarding Nguyen Trai\u27s research perspective: a genius who converges many talents, a figure who made great contributions to the nation, and a historical figure of international stature. Regarding Nguyen Trai\u27s research methodology, I will place the author and works in a broader frame of reference, conduct a esearch of the problems raised by his works, and place the author and his workw in the context of his current time and future. Studying the case of Nguyen Trai promotes the role of "our historical figures in today\u27s context" drawing from medieval famous people in general and Nguyen Trai in particular
Size-independent versus size-dependent policies in scheduling heavy-tailed distributions
No full textThesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2008.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (p. 47-48).We study the problem of scheduling jobs on a two-machine distributed server, where the job size distribution is heavy-tailed. We focus on two distributions, for which we prove that the performance of the optimal size-independent policy is asymptotically worse than that of a simple size-dependent policy. First, we consider a simple distribution where incoming jobs can only be of two possible sizes. The motivation is that with two largely different sizes, the simple distribution captures the important aspects of a heavy tail. Second, we extend to a bounded Pareto distribution, which has an actual heavy tail. For both cases, we analyze the performance with regards to slowdown (waiting time divided by job size) for several size-independent and size-dependent policies. We see that the size-dependent policies perform better, and then go on to prove that even the best size-independent policy cannot achieve the same performance. We conclude that as we increase the variance of our job size distribution, the gap between size-independent and size-dependent policies grows.by John Nham.M.Eng
Disparate requirements for the Walker A and B ATPase motifs ofhuman RAD51D in homologous recombination
No full textIn vertebrates, homologous recombinational repair (HRR) requires RAD51 and five RAD51 paralogs (XRCC2, XRCC3, RAD51B, RAD51C, and RAD51D) that all contain conserved Walker A and B ATPase motifs. In human RAD51D we examined the requirement for these motifs in interactions with XRCC2 and RAD51C, and for survival of cells in response to DNA interstrand crosslinks. Ectopic expression of wild type human RAD51D or mutants having a non-functional A or B motif was used to test for complementation of a rad51d knockout hamster CHO cell line. Although A-motif mutants complement very efficiently, B-motif mutants do not. Consistent with these results, experiments using the yeast two- and three-hybrid systems show that the interactions between RAD51D and its XRCC2 and RAD51C partners also require a functional RAD51D B motif, but not motif A. Similarly, hamster Xrcc2 is unable to bind to the non-complementing human RAD51D B-motif mutants in co-immunoprecipitation assays. We conclude that a functional Walker B motif, but not A motif, is necessary for RAD51D's interactions with other paralogs and for efficient HRR. We present a model in which ATPase sites are formed in a bipartite manner between RAD51D and other RAD51 paralogs
Utilizing Bibliometrics to Understand the Role of Machine Learning in the Current Orthopedic Arthroplasty Literature
No full textBackground: Machine learning technology has been demonstrated to be a very useful tool in current orthopedic research. Furthermore, machine learning has shown to be quite impactful in the field of arthroplasty solving many clinical and scientific problems, leading to greater utilization in retrospective studies. This current study aims to identify machine learning arthroplasty research and predict future hotspots. We hypothesize that the production of current scientific literature on machine learning will be produced by US-based national institutions and will have exponentially grown in the past 5 years.
Methods: Machine learning arthroplasty publications between 1996 and 2023 were identified using the Web of Science Core Collection of Clarivate Analytics. Then bibliometric indicators were obtained and imported for further analysis with VOSviewer and Bibliometreix to identify previous and ongoing trends within this field.
Results: The bibliometric sourcing identified a total of 235 documents that were associated with machine learning applications to arthroplasty. 34 countries published articles on the topic and the United States demonstrated to be the largest contributor. The year 2022 had the highest number of publications produced in a year, totaling 66 articles. A total of 405 institutions across the world had published articles, the most relevant institutions with the highest production were Harvard University and Harvard Medical School with 41 and 34 articles produced respectively. Kwon YM was the most productive author while Haeberle HS and Ramkumar PN are the most impactful based on h-index. Co-occurrence visualization and thematic map identified niche and major themes within the literature.
Conclusions: Machine learning in arthroplasty research continues to show an increasing trend since 2021 with contributions from authors and institutions globally. United States institutions and authors are the leading contributors to machine learning applications in arthroplasty research. This study identifies previous, current, and developing trends within this field for future hotspot development
From a children's classic book to toy-book: overview of peter rabbit’s rewritings in Portugal
No full textPretende-se, neste texto, proceder ao levantamento e à categorização das principais publicações disponíveis no mercado editorial português inspiradas no universo da personagem Pedrito Coelho, criada por Beatrix Potter no início do século XX. Para além da tradução das obras originais, os últimos anos têm sido pródigos na oferta de diferentes tipos de livros, com muitos elementos manipuláveis, identificados com o livro-brinquedo ou livro-objeto. Trata-se de publicações cuja leitura e exploração inclui um conjunto de competências diversas, muitas vezes associadas à literacia emergente, aproximando as crianças, sobretudo as mais pequenas, do livro e da leitura, transformados, respetivamente, em brinquedo e em jogo.Se pretende, en este texto, estudiar y categorizar las principales publicaciones disponibles en el mercado editorial portugués inspiradas en el universo del personaje Pedrito Conejo, creado por Beatrix Potter a principios del siglo XX. Además de la traducción de las obras originales, los últimos años han sido pródigos en la oferta de diferentes tipos de libros, con muchos elementos manipulables, identificados con el libro-juguete o libro-objeto. Se trata de publicaciones cuya lectura y exploración incluye un conjunto de competencias diversas, muchas veces asociadas a la alfabetización emergente, acercando a los niños, sobre todo a los más pequeños, al libro y a la lectura, transformados, respectivamente, en juguete y en juego.The aim of this article is to identify and categorize the main publications available in the Portuguese publishing market inspired by the universe of Peter Rabbit, created by Beatrix Potter in the early 20th century. In addition to the translation of the original works, the last years have been fertile in the publication of different types of books, with many movable elements, identified with toy books or object books. These publications demand specific kind of reading and exploration which includes different competences, often associated with emerging literacy, bringing children, especially the smaller ones, closer to books and reading, transformed into toys and play, respectively.publishe
Phát hiện mới về thư tịch hán văn sứ trình Việt Nam: Khảo biện tác giả khuyết danh triều Tây Sơn của sử trình thi tập
No full textQuyển 8 của bộ Việt Nam Hán văn Yên hành văn hiến tập thành (Việt Nam sớ tàng biên đã in lại văn bản Sứ trình thi tập mang ký hiệu A.l123 lưu trữ tại Viện Nghiên cứu Hán Nôm (VNCHN), đồng thời nhận định tác giả của sách này chắc chắn không phải người được ghi trên sách là Phan Thanh Giản (1796-1867), mà là một sứ thân khuyết danh triều Tây Sơn từng sang Trung Hoa, nhưng chưa có căn cứ để xác định là ai. Giới học thuật nghiên cứu về vấn đề tác giả của thi tập chữ Hán này, có người cho rằng là người đồng hành với sứ thần triều Tây Sơn Nguyễn Đề (1761-1805), có người chủ trương đây không phải là sáng tác của một người trong một thời diểm. Tác giả bài viết thông qua việc thu thập tư liệu và khảo sát điền dã, đã phát hiện được kết quả nghiên cứu mới nhất, xác định đó là tập thơ chữ Hán của một sứ thân triều Tây Sơn, Nguyền Thế Trực còn gọi là Nguyền Viết Trực (1745-1807), vào năm Cảnh Thịnh nguyên niên (1793) đã cùng Chánh sứ Ngô Thời Nhậm (1746-1803), Át Phó sứ Nguyền Văn Thái đi sứ Trung Hoa cáo tang và cầu phong.The 8th volume of the Vietnamese Chinese Yarning Literature Collection (Collected in Vietnam) had included a copy of the work Shi Cheng Shi Ji which archived by the Institute of Sino-Nom Studies with the archive number of A.l 123, and suggests that Phan Thanh Gian (1796-1867), who has his name written on the book, is actually not the author of this book, but an unknown envoy of the Tay Son dynasty who had also attended the trip to China. The academia has several discussion about the author of this work, one suggestion is it belongs to Nguyen De (1761 -1805) who had accompanied the Tay Son envoys; another suggestion is that the work was not created by one person at a time. By the results of fieldwork and searching evidence, we have discovered the envoy who is the real author of the Chinese written poems collection - Shi Cheng Shi Ji. This envoy is Nguyen The True, also known as Nguyen Viet Truc (1745-1807). In the first year of Jing Sheng era (1793), he had accompanied the chief ambassador Ngo Thoi Nham (1746-1803) and the deputy ambassador Nguyen Van Thai on the mission to China to report the funeral of the late king - Quang Trung - and seek the acknowledgment and crowning for the new king from the emperor of Qing
Influence of homologous recombinational repair on cell survival and chromosomal aberration induction during the cell cycle in γ-irradiated CHO cells
No full text
Disparate contributions of the Fanconi anemia
No full textpathway and homologous recombination in preventing spontaneous mutagenesi
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