1,720,999 research outputs found
Intrapancreatic Accessory Spleen Detected by 68Ga DOTANOC PET/CT and 99mTc-Colloid SPECT/CT Scintigraphy
No full textA 77-year-old man was referred to our center for a suspected neuroendocrine neoplasm in the pancreatic tail, incidentally detected at CT. Ga DOTANOC PET/CT showed intense tracer uptake in the pancreatic lesion. At MRI, the lesion was similar to the spleen on all sequences, suggesting the presence of intrapancreatic accessory spleen. A Tc-colloid SPECT/CT scan performed to differentiate spleen tissue from neuroendocrine tumor revealed a focal uptake in the pancreatic lesion, thus confirming the presence of ectopic spleen and avoiding unnecessary surgery
Comparison of metaiodobenzylguanidine scintigraphy with positron emission tomography in the diagnostic work-up of pheochromocytoma and paraganglioma: a systematic review.
No full textAIM: The aim of this paper was to systematically review published data about the
comparison of radiolabelled metaiodobenzylguanidine (MIBG) scintigraphy and
positron emission tomography (PET) with different radiopharmaceuticals in
patients with pheochromocytoma and paraganglioma (Pheo/PGL).
METHODS: A comprehensive literature search of studies published in PubMed/MEDLINE
and Embase databases through September 2012 and regarding MIBG scintigraphy and
PET imaging with different radiopharmaceuticals in patients with Pheo/PGL was
carried out.
RESULTS: Twenty-eight studies comprising 852 patients who underwent both MIBG
scintigraphy and PET or PET/CT with different radiopharmaceuticals were included
and discussed. Three studies evaluated carbon-11-hydroxyephedrine ([11C]HED) as
PET radiopharmaceutical, nine studies fluorine-18-dopamine ([18F]DA), eight
studies fluorine-18-dihydroxyphenylalanine ([18F]DOPA), twelve studies
fluorine-18-fluorodeoxyglucose ([18F]FDG) and five studies
gallium-68-somatostatin analogues.
CONCLUSIONS: Despite the heterogeneity of the studies included in the analysis,
it can be concluded that the diagnostic performance of PET with various agents is
clearly superior to that of MIBG scintigraphy in patients with Pheo/PGL, mainly
for familial, extra-adrenal and metastatic diseases; however, MIBG maintains a
unique role in selecting patients suitable for 131I-MBG therapy. Further larger
prospective studies comparing MIBG and different PET tracers in patients with
Pheo/PGL as well as a cost-effectiveness analysis of the two techniques are
needed
A rare case of synchronous bilateral pulmonary neuroendocrine tumor detected by 68Ga-DOTANOC PET/CT
Full text linkA 64-year-old man was referred to our center for metabolic characterization of 2 bilateral pulmonary lesions, incidentally detected at computed tomography (CT). 18F-FDG PET/CT scan showed a weak radiopharmaceutical uptake in both pulmonary lesions. A subsequent 68Ga-DOTANOC PET/CT showed intense radiopharmaceutical uptake in both pulmonary lesions. Subsequently, the patient underwent histopathological examinations of both lesions, which showed a synchronous well-differentiated pulmonary neuroendocrine carcinoma (typical carcinoid tumor). This case reports a rare occurrence of synchronous pulmonary carcinoid, highlighting the role of different PET tracers for metabolic characterization of pulmonary nodule
The accessory spleen is an important pitfall of 68Ga-DOTANOC PET/CT in the workup for pancreatic neuroendocrine neoplasm
No full textObjective: The aim of the study was to assess the value and potential pitfalls of 68Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) in patients with suspected pancreatic neuroendocrine neoplasms (pNEN). Methods: Consecutive patients referred for 68Ga-DOTANOC PET/CT for suspected pNENbetweenMay 1, 2011, andOctober 31, 2014, were retrospectively assessed. Scan data were compared with cytological/ histological final diagnosis. Pancreatic neuroendocrine neoplasm detection rate was determined on per-patient and per-lesion basis. Maximum standardized uptake values of lesions were determined. Results: Fifty-eight patients with 65 lesions were enrolled. Twelve patients had nonconfirmed diagnosis; of these, 7 were positive and 5 negative at PET/CT. Of 46 patients with confirmed diagnosis, 36 had pNEN; of these, 33 were positive, 1 negative, and 2 nonevaluable at PET/CT. Ten patients had non-NE lesions, of which 8 were positive, 1 negative, and 1 nonevaluable at PET/CT. Of 48 patients with positive PET/CT, 8 proved to have non-NE lesions, of which 6 were intrapancreatic accessory spleen. No significant maximum standardized uptake values difference was found between pNEN and non-NE lesions. Conclusions: Intrapancreatic accessory spleen is an important pitfall in 68Ga-DOTANOC PET/CT for suspected pNEN. Cytological/histological confirmation is mandatory before any surgical procedure is undertaken
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The role of adrenal scintigraphy in the diagnosis of subclinical Cushing's syndrome and the prediction of post-surgical hypoadrenalism
No full textManagement of subclinical Cushing's syndrome (SCS) remains controversial; it is not possible to predict which patients would benefit from adrenalectomy. In the present study we aimed to evaluate the role of adrenocortical scintigraphy (ACS) in the management of patients with SCS
Surgical prophylaxis of pouchitis in ulcerative colitis.
No full textIleal pouch-anal anastomosis (IPAA) is now the procedure of choice for most patients requiring proctocolectomy for ulcerative colitis. The J-shaped pouch, usually 15-20 cm in length, is easiest to construct and has functional outcomes identical to those of the more complex designs. IPAA is a complex procedure, and complications occur frequently. Despite the significant improvements this surgical advance has made on the quality of life in these patients, inflammation of the surgically created ileal pouch or pouchitis remains a major late postoperative complication that can often overshadow the benefits of this otherwise curative operation. Several inflammatory and noninflammatory complications can occur after IPAA. Pouchitis is the most common, occurring in ≈50% of patients. Whereas acute pouchitis can be treated rapidly and successfully in the majority of patients, refractory and chronic pouchitis remain therapeutic challenges to patients and physicians. The problem is believed to be caused by stasis of feces in the pouch with overgrowth of aerobic and anaerobic organisms. The size of the pouch has a significant influence on the incidence of pouchitis: a smaller pouch usually empties better than a larger pouch and so may be less susceptible to pouchitis
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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