79 research outputs found
Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies
No full textAlthough survival rates for lymphoproliferative disorders are steadily increasing both in the US and in Europe, there is need for optimizing front-line therapies and developing more effective salvage strategies. Recent advances in molecular genetics have highlighted the biological diversity of lymphoproliferative disorders. In particular, integrative approaches including whole genome sequencing, whole exome sequencing, and transcriptome or RNA sequencing have been instrumental to the identification of molecular targets for treatment. Herein, we will discuss how genomic, epigenomic and proteomic approaches in lymphoproliferative disorders have supported the discovery of molecular lesions and their therapeutic targeting in the clinic
On the Productive Use of Hegemony (Laclau, Hall, Chatterjee)
No full textThe concept of Hegemony is central to Gramsci's thought, but it has been also the main vector of his fortune around the world. This article maps some uses of this Gramscian concept from the point of view of its political productivity insted of its philological fidelity to the author. The concept of hegemony, in these examples, shows its ability to produce political innovation
Ferrovia: compositional path
No full textFerrovia: percurso composicional é a monografia deste trabalho de conclusão do curso de Música – Composição da UNESP realizada pelo compositor Rafael Filippini, que apresenta a criação da peça musical Ferrovia, uma obra de música erudita contemporânea para seis instrumentos (2 violinos, 2 violas, 1 violoncelo e 1 contrabaixo) inspirada em sons de trem, como peça principal do trabalho, em conjunto com um portfólio de obras realizadas pelo presente autor durante o período da graduação. Esta monografia reflete as principais ideias, materiais musicais, visão estética e reflexões sobre o processo de realização de Ferrovia e apresenta os pontos principais das demais obras contidas no portfólio.Ferrovia: percurso composicional is the monograph of this final work of the Music – Composition course at UNESP carried out by composer Rafael Filippini, which presents Ferrovia, a piece of contemporary classical music for six instruments (2 violins, 2 violas, 1 cello and 1 double bass) inspired by train sounds, as the main piece of the work, and also a portfolio of musical pieces created by the author during the undergraduate period. This monograph reflects on the main ideas, musical materials, aesthetic vision and creative process of Ferrovia and presents the main particulars of the other works contained in the portfolio
Introduzione. Shock e rinascite nel Medioevo
No full textOn the basis of the findings presented in the book, the author identifies a number of trend lines regarding the representation of traumatic events and the ways in which they interact with institutional processes of system restructuring
Gastrointestinal stromal tumors treatment in the Imatinib era. The role of fair indication
No full textMinerva Chirurgica 2012 Aprile;67(2):165-73 lingua: Inglese Tumori stromali gastrointestinali nell’era dell’Imatinib. Il ruolo della corretta indicazione Vendettuoli M., Pironi D., Pontone S., Panarese A., La Gioia G., Arcieri S., Romani A. M., Palazzini G., Filippini A. ✉ Department of Surgical Sciences, La Sapienza University, Rome, Italy PDF Obiettivo. I tumori stromali gastrointestinali (gastrointestinal stromal tumors, GIST) rappresentano la più comune causa di tumori mesenchimali dell’apparato digerente. La chirurgia rimane il trattamento di prima scelta. Nel nostro studio abbiamo analizzato i tassi di sopravvivenza e recidiva in due gruppi di pazienti trattati chirurgicamente prima e dopo l’avvento dell’Imatinib. Metodi. Sono stati analizzati due gruppi di pazienti sottoposti a chirurgia per GIST selezionati tra il gennaio del 1997 e il dicembre 2002 (gruppo Pre-IM) e tra il gennaio 2003 e il dicembre 2008 (gruppo Post-IM). Caratteristiche anagrafiche e anamnestiche, manifestazioni cliniche, sede e stadiazione dei tumori sono state registrate e confrontate. Risultati. Nel gruppo Pre-IM il tasso di sopravvivenza media e stato di 24,6 mesi (15-51). I pazienti appartenenti al gruppo Post-IM sono attualmente sotto stretto controllo oncologico (follow-up medio 50,7 mesi; range 26-74) manifestando una ottima risposta alla terapia farmacologica. Conclusioni. La diagnosi precoce e la chirurgia radicale rimangono ad oggi le armi più efficaci nel trattamento dei GIST. Gli ottimi risultati ottenuti con l’utilizzo dell’Imatinib suggeriscono un più ampio utilizzo nel trattamento farmacologico. La nostra esperienza suggerisce un’elevata correlazione tra lo stato mutazionale della proteina KIT e la prognosi clinica. Questo aspetto merita ulteriori approfondimenti in futuri studi randomizzatiMinerva Chir. 2012 Apr;67(2):165-73. Gastrointestinal stromal tumors treatment in the Imatinib era. The role of fair indication. Vendettuoli M1, Pironi D, Pontone S, Panarese A, La Gioia G, Arcieri S, Romani AM, Palazzini G, Filippini A. Author information Abstract AIM: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Surgery remains the elective treatment. We retrospectively compared two group of patients, who underwent surgery for GIST before and after Imatinib advent in order to analyze the recurrence and survival rate. METHODS: Two patient groups who underwent surgery for GIST, from January 1997 to December 2002 (Pre-Imatinib group) and from January 2003 to December 2008 (Post-Imatinib group) were compared. Patients were evaluated on the base of gender, age, clinical manifestations, primary location and metastasis positivity, tumor size, mitotic index, immunoreactivity for CD117 and the outcome, including date of death. RESULTS: In the Pre-IM group only one patient died for prostate cancer, 12 months after operation, the other died because of GIST with a 24.6 months of median survival rate (range 15-51). In the remaining 12 patients the median follow up period was 55 months (range 6-152 months). In the Post-IM group the mean follow up was 50.7 months (range 26-74) and they are still being assessed for oncological as well as surgical treatment. CONCLUSION: Early diagnosis and radical resection remain the standard of cure for GISTs. To date, the use of Imatinib lead to its utilization as adjuvant and neo-adjuvant therapy in adults. Our experience suggests that there is a correlation between the mutational status of KIT and clinical outcome. These aspects should be explored for targeted therapy that can effectively combine biological therapy to surgery. PMID: 22487918 [PubMed - indexed for MEDLIN
ORAL CONTRIBUTION - “Correlations between dip coating-fabricated cellulose acetate membranes characteristics and their permeability to glucose and glucose oxidase” - PRESENTING AUTHOR
No full textEditorial: Dietary acrylamide in human health
No full textCopyright © 2024 Laguzzi, Filippini and Virgolino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Acrylamide, a food processing contaminant, has raised concerns due to potential health risks to humans. It is known to be formed mainly in starch-rich foods, cooked or processed at high temperatures (above 120°C) in the absence of moisture, via the Maillard reaction when a reduced carbohydrate (glucose and fructose) combines with the amino acid asparagine. Moreover, evidence suggests that acrylamide may also form from the degradation of proteins and fats.
Acrylamide is present in a large variety of commonly consumed products such as coffee, potato-derived products, and cereal-derived products, including breakfast cereals, bread, and biscuits. Except for boiling, acrylamide may form with the most common cooking methods e.g., grilling, baking, roasting, and frying. Additionally, several chemical and physical factors, namely pH, can affect acrylamide formation during food cooking or processing. By improving our understanding of how to modify these factors, it is possible to significantly reduce acrylamide formation in cooked and processed foods, thereby mitigating potential health risks associated with acrylamide.info:eu-repo/semantics/publishedVersio
ORAL CONTRIBUTION - “Biopolytronics for the computer-assisted fabrication of bioelectronic devices” - PRESENTING AUTHOR
No full textThe Yin and Yang of non-neuronal α7-nicotinic receptors in inflammation and autoimmunity
No full textThe alkaloid nicotine, a major addictive component of tobacco, exerts anti-inflammatory and immune-modulating activities on multiple cell types, such as T cells, B cells, dendritic cells, mononuclear phagocytes and polymorphonuclear leukocytes, in lung, spleen, liver, kidney and gastrointestinal tract. In addition, nicotine may blunt pro-inflammatory cytokine release, with prominent effects on T helper type 1 (Th1) and Th17 cytokines. The nonneuronal alpha 7-nicotinic cholinergic receptors are a primary target for nicotine through the JAK2 and STAT3/NF-kappa B pathways, ultimately mediating the inhibition of pro-inflammatory gene transcription. The present paper reviews the growing evidence in favor of detrimental as well as beneficial effects of nicotine and other alpha 7-nicotininc receptor agonists in pre-clinical models of organ-specific and systemic inflammatory and autoimmune diseases. These data may portend favorable implications for the targeted treatment of chronic and debilitating human disorders, such as diabetes, arthritis, asthma and inflammatory bowel disease, with alpha 7-selective ligands
Introduction
No full textThrough a reading of all the articles collected in the monographic section of «Scienza & Politica», this introduction shows how "cooperation" is a multifaceted concept, crisscrossed by contradictions and ambivalences. The author provides a brief historical and political analysis of the concept of cooperation, stressing its importance in contemporary debates and pointing out both the most productive and problematic aspects of the recent development of a political theory of cooperation
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