324 research outputs found
Matilde Serao in Sweden. A Voice of "The New Italy"
No full textThis chapter examines the contemporary reception of Matilde Serao's works in Swedish newspapers from 1885 to the first years of the twentieth century. This analysis provides a historical background for understanding why Serao's masterpiece Il paese di cuccagna (1891) was translated in Swedish as early as 1892. In fact, Serao was already known to the Swedish public through the activity of C.D. af Wirsén, an important conservative critic who reviewed her original work and contributed to establishing Serao's reputation as a major contemporary author. Furthermore, examination of recently digitalized Swedish newspapers shows that Serao's short stories were published on at least twenty occasions from 1888 to 1897. These anonymous translations can be attributed with a high degree of probability to the pen of Ellen Lundberg-Nyblom, the translator of Il paese di cuccagna. Swedish reviewers greeted Serao as a master of vivid description and an insightful painter of human passions. At the same time, the fact that Serao, being a woman, was professionally active as a journalist and a newspaper editor attracted attention of Swedish media, transforming the Neapolitan author into a public figure known to a broader audience.Ce chapitre traite de la réception des œuvres de Matilde Serao dans les journaux suédois, de 1885 aux premières années du xxe siècle. Avant la traduction de son chef-d’œuvre Il paese di Cuccagna (1891) dès 1892, Serao était déjà connue en Suède grâce au critique C.D. af Wirsén, qui l’a présentée comme une autrice contemporaine de premier plan. Les traductions anonymes des nouvelles de Serao, publiées entre 1888 et 1897 et attribuées ici à Ellen Lundberg-Nyblom, ont joué un rôle tout aussi important.</p
Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset epithelial ovarian cancer
No full textEarly-onset or hereditary ovarian cancer is mostly associated with BRCA1 or BRCA2 mutations. Mismatch repair genes sequence alteration frequently cause colorectal cancer, and, in less extent, other tumors, such as ovarian cancer. Subjects with personal and/or family history suggestive for hereditary cancer should be addressed to cancer genetic counseling. The multistep Cancer Genetic Counseling model, adopted at our unit, is aimed to identification, definition and management of hereditary cancer syndrome, by a multidisciplinary approach. A woman with a very early onset epithelial ovarian cancer underwent to cancer genetic counseling and genetic testing. Two germ-line mutations have been identified in exon 11 of MSH2 gene: c.1706A>T (p.Glu569Val) and c.1711G>T (p.Glu571*). Both DNA alterations were novel mutations not yet described in literature. The first is a missense mutation that is to be considered an unclassified variant; the second is nonsense mutation that created a premature stop codon resulting in a truncated not functioning protein. In conclusion, the present report finds out two unpublished sequence alterations in exon 11 of the MSH2 gene, one on which can be considered causative of Lynch phenotype, and stresses the importance of the onco-genetic counselling in order to offer the most appropriate management of the cancer risk for the patients and her family members
Malignant melanoma Clustering with some familial/hereditary tumors
No full textGermline mutations of the CDKN2 and CDK4 genes that are involved in the cell cycle regulation, have been associated with malignant melanoma (MM). However, these mutations have been detected only in some cases of familial MM, particularly in Sweden and in Italy, which suggests that other genes are involved in the pathogenesis of hereditary MM. Few data are available about the clustering between MM and familial or hereditary tumours (e.g. breast cancer, ovarian cancer, colon cancer, pancreatic cancer). In this respect, the Breast Cancer Linkage Consortium reported that carriers of germline mutations in the BRCA2 predisposing gene have a significantly increased risk for MM (RR = 2.58; 95% CI = 1.28-5.17). The aim of the present study was to determine the family history of 342 consecutive cases of MM observed from 1994 to date. Specifically, we looked for: MM associated with other malignant neoplasias; familial clustering of MM; and a family history of cancer. Malignant melanoma was associated with other tumours in 20/342 patients (5.84%); a history of MM was associated to a positive family history of cancer in 31/342 cases (9.06%); and familial clustering of MM was detected in 22/342 (6.4%) of the consecutive series of patients analysed. The pedigree of patient who have a family history of MM or other cancers is being constructed
Management of patients with BRCA1/2-associated breast cancer
No full textBRCA1/2-related breast cancers (BC) can be considered a separate entity compared to sporadic ones. Current
knowledge suggests that the overall management is different. Herein, the different topics of management
of BRCA1/2-associated BC are considered including cancer genetic counseling, surveillance, chemoprevention,
prophylactic surgery, oncological treatment and psychosocial aspects. Cancer genetic counseling is a specific
modality for the management of at-risk subjects that foresees a multidisciplinary approach and patientsfocused
interventions. An integrated multidisciplinary approach in cancer genetic counseling (CGC) is required
to support women with high inherited risk of developing hereditary cancers in the complex decisions related
to cancer risk management choice. Surveillance for at-risk body sites should be integrated to the conventional
oncological follow-up of BC patients and offered to the healthy family members. Chemoprevention and
prophylactic surgery are viable options of cancer risk management. Particularly, prophylactic surgery can be
considered an effective strategy for BRCA1/2 mutation carriers, because of a significant reduction of BC and
ovarian cancer risk. Promising findings concern specific oncological treatment, including also target therapies
in this setting. It is necessary that during CGC process the subject at-risk takes an active role, facilitated by a
personalized approach and a focus on the patient’s emotional state. A patient-centered approach by a biopsychosocial
perspective is needed for the taking charge of at-risk women
Matilde Espinosa o la Metáfora de la Poesía
No full textThe work written by the Colombian poet Matilde Espinosa de Pérez de serves to be
known and recognized by the literary review, so according to this, the article below is a study
about two of her last works: The dark land and The town gets into dark. This paper analyses the
poetic conception of the female author, the a esthetic connection of her work with her passing
within everyday life as a mother, woman and female writer and, the standing she considers
among pain, life and death as elements that constitutes her poetic ar
Pretreatment Serum Concentration of Vitamin D and Breast Cancer Characteristics: A Prospective Observational Mediterranean Study
No full textBACKGROUND:
Recent studies of the correlation between breast cancer (BC) and vitamin D yielded contrasting results. Although preclinical and clinical evidence has implicated vitamin D in BC prevention and outcome, little is known about the link between vitamin D and specific BC histologically defined subtypes. In the attempt to clarify this association we correlated vitamin D levels with BC characteristics.
PATIENTS AND METHODS:
We enrolled 220 pre- and postmenopausal women with early BC in this prospective observational trial. Data on the patients' clinical and specific BC pathological characteristics were collected and related to vitamin D levels, stratified in deficient ( 30 ng/mL). BC subtypes were defined according to the 14th St Gallen Breast Cancer Conference.
RESULTS:
Deficient vitamin D levels were correlated with Grade 3 (P = .015) and node-positive (P = .043) BC, and with a higher body mass index (P = .017). Insufficient vitamin D levels were associated with estrogen receptor expression in the primary tumor (P = .033). Vitamin D levels were unrelated to the histological molecular subtypes of BC.
CONCLUSION:
Deficient vitamin D levels were correlated with more aggressive disease, namely, node-positive high grade BC, and with obesity. Should our findings be confirmed in larger prospective studies, nutritional programs designed to reduce body weight, and vitamin D supplementation might be considered a BC prevention strategy
Long-term survival and BRCA status in male breast cancer: A retrospective single-center analysis
No full textYoroppa, tokuni Itaria ni okeru Encho no juyo ni tsuite
No full textThe essay analyzes the reception of San'yutei Encho, in Europe and in Italy, starting from the fundamental role of Lafcadio Hearn to the most recent translation in Italian, "The Peony Lantern", of the author of the essay. After the stages of presentation of Encho in Europe, the author of the essay points out that in the case of Italy, the contemporary Italian ghosts literature prepared a fertile ground to receive Encho in Italy
Mori Ogai. Il romanticismo e l'effimero. La trilogia tedesca
No full text"Il romanticismo e l’effimero" raccoglie e commenta, con un approccio originale, i primi tre racconti dello scrittore Mori ?gai, conosciuti nell’insieme come “trilogia tedesca”, mettendo in evidenza come l’autore abbia unito il tema romantico europeo con l’estetica dell’effimero giapponese. "Romanticism and the ephemeral" gathers and comments, with an original approach, the first three stories of the author Mori ?gai, known as "German trilogy", highlighting how the author has joined the European romantic theme with the Japanese aesthetics of ephemerality
Kaidan kurabe. Napori to Edo, Tokyo no hikaku no kokoromi
No full textIn this paper the author analyse the differences between the some aspetcs of japanese ghost novel and italian ghost novel, in particular the Napoli's modern repartory. In every country ghost stories show different aspects and characteristics. The religion and several aspects of a culture influence the relationship between every day life and the realm of the dead. In this paper the author analyse the differences between the some aspetcs of japanese ghost novel and italian ghost novel, in particular the Napoli's modern literature repartory
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