16 research outputs found
University of Nebraska College of Medicine Class of 1973
No full text1973 - Patrick J. Abbott, R. Stephen S. Amato, Douglas Alton Anderson, Arthur Steven Annin, Donald Leo Arkfeld, James Olen Armitage, Ronald L. Asher, Craig David Bartruff, Walter Eugene Baumann, Kent Jerome Beachler, Timothy J. Biga, Gary Herbert Bliss, William Carl Boelter, II, Norval Leon Books, Samuel Eugene Boon, Peter William Brill, James Donovan Brooke, Gary Eugene Canton, Frederick Dwight Catlett, Ward Alan Chambers, Donald Kenneth Chin, Mark Allen Christensen, Loran Tracy Clement, David Robert Colan, Winifred Jo Pringle Cromer, Daniel R. Cronk, Daniel Henry Dietrich, Stephen Baker Erickson, Joseph Graham Ewing, Gerald Saul Ferenstein, John James Ferguson, Harry Feurberg, Sidney William Frank, Philip Anthony Gasseling, Louis James Gogela, Charles DeLand Gregorius, Stephen Richard Grenier, Lawrence W. Hake, Neil Jeffrey Halbridge, Don LeRoy Halouska, Robert Duane Hanlon, James T. Hartford, Robert Herman Heise, II, David Patrick Heiser, Robert Charles Hendler, Barbara Maria Boczar Heywood, Richard Alan Hirschmann, Howard J. Hoody, Jr., Richard Allen Hranac, Gary Engelbert Hrnicek, Robert Harris Hurlbutt, IV, Brian Thomas Hurley, David C. Imes, Thomas Maynard Jensen, John Harry Jirka, Alan Kennedy Johnson, Richard Edwin Jones, Louis Eric Kleager, Ronald Walter Klutman, Barry Louis Kriesfeld, David Clark Krohn, Tyrone Langager, Jeffrey Wells Lewis, Edwin John Loeffel, Jr., Gerald Walter Luckey, William David Lux, William Wallace Lyons, III, Gregory Lynn Magnuson, William Robert Marsh, James Gelsin Marx, Michael Leroy McCoy, Jerry Eugene McCrcry, Patricia M. McGannon, Robert Harry Mcintyre, Jr., Charles Edwin McKinzie, David Lawrence Meyer, Mark H. Meyer, Dale Evan Michels, Edwin Jens Mikkelsen, Vernon Walter Miller, Donald Joseph Morris, Cary John Myers, Raymond Oliver Naumann, Gerald Edward Nearhood, Stephen Francis Noll, Russell Arthur Novak, Thomas Edward Novotny, William Joseph Origer, Richard Keith Osterholm, William Rodney Palmer, Douglas Gene Peter, Ronald Frederick Pfeiffer, Alois Frederick Proett, Gregory Lee Quick, Joseph Michael Rapoport, Peggy Fagan Rapoport, Andrew G. Rasmussen, Steven Marion Reppert, E. Charles Robacker, Dennis Lee Ross, William Robert Schlichtemeier, Curtis Paul Schworm, Peter Eugene Seda, Bruce Gordon Sheffield, Steven Engebret Shefte, Dell Allen Shepherd, Dean Allen Shuey, Larry Darrell Skinner, Stewart E. Sloan, Jeffery Michael Snow, Thomas Duane Spoonhour, James M. Steier, David Harvey Stoltzman, Cory Thomas Strobel, Craig Bennett Stucky, John David Swanson, Stephen Gene Swanson, Dean Robert Thomson, John William Timmerman, Douglas Earl Vickstrom, John Norman Walburn, Joseph Hulley Washburn, Jr., Francis Edward Watson, Susan Beachly Williams, Thomas L. Williams, Larry Flick Withers, III, David Alan Wolin, Christopher Jay Wrenn
September 28th, 1973 - Glen Erman Christensen
December 22nd, 1973 - James Saxton Bird, Steven Bruce Plettner, Bruce Everett Taylorhttps://digitalcommons.unmc.edu/comclass/1053/thumbnail.jp
The potential of novel phenol-derivative compounds for feeding deterrent control of several stored-product coleopteran pests
No full textThe development of new tactics for the management of stored-product insects is important as more conventional methods may becoming less effective due to pesticide resistance and the increasing interest in developing chemical control options with fewer of the negative side effects (e.g., environmental and health impacts). I screened several libraries of phenol-derived compounds with varying substitutions and substituents for their potential as feeding deterrents and insecticides using flour disk no-choice feeding bioassays against a total of five species of stored-product coleopteran: Tribolium castaneum, T. confusum, Sitophilus oryzae, S. zeamais, and Rhyzopertha dominica. By using structurally similar compounds, I was able to determine some structure-activity relationships, in particular meta- and para-substituted rings with mid-sized substituents showed the highest feeding deterrent activity. I was also able to show that while there where some similarities in both feeding behavior and mortality between the closely related species, there were also differences which highlights the importance of not extrapolating behavior even to closely related species. There was also evidence that, in general, the primary pests (S. oryzae, S. zeamais, and R. dominica) showed more sensitivity to the test compounds compared to the secondary pests (T. castaneum and T. confusum), which may be explained by looking at these species as specialist and generalist feeders. Finally, during the course of the experiments, an alternative method of measuring feeding in the flour disk bioassays was developed (surface area) and compared to the established method (weight). The methods are comparable and surface area analyses may be a less expensive, alternative way of measuring feeding in some scenarios. Ultimately I was able to identify several compounds that show potential to be feeding deterrents for some stored-product coleopteran pests without significant mortality.stored-product insectspesticide resistancephenol-derived compoundsinsecticides using flour diskstored-product coleopteranTribolium castaneum, T. confusu
Evidence for a high-spin β-decaying isomer in
No full textNuclei in the A similar to 180 region have been populated and investigated in a series of multinucleon transfer and deep-inelastic reactions involving an 11.4 MeV per nucleon Xe-136 beam produced by the GSI UNILAC accelerator, impinging on a selection of tantalum and tungsten targets. The reaction products were released from a thermal ion source and subsequently mass selected using the GSI on-line mass separator. The unexpectedly high yield of gamma rays associated with the decay of the well established K-pi=37/2(-),t(1/2)=51.4 min isomer in Hf-177(72) and anomalous half-life characteristics associated with this decay lead to these data being interpreted as the beta(-) decay of a high-K isomer in the mother nucleus, Lu-177. By comparing the experimental findings with the predictions obtained from multi-quasiparticle blocked-BCS-Nilsson calculations, the proposed decay is suggested to be from a K-pi=39/2(-) five-quasiparticle state in Lu-177(71). A half-life of 7 +/- 2 min is determined for this beta-decay path which is estimated to have an excitation energy of approximate to3.9 MeV above the Lu-177 ground state.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000220491300030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, NuclearSCI(E)0ARTICLE2null6
Intrinsic state lifetimes in (103)Pd and (106,107)Cd
No full textThe mean-lifetimes, tau, of various medium-spin excited states in (103)Pd and (106,107)Cd have been deduced using the Recoil Distance Doppler Shift technique and the Differential Decay Curve Method. In (106)Cd, the mean-lifetimes of the I(pi)=12(+) state at E(x)=5418 keV and the I(pi)=11(-) state at E(x)=4324 keV have been deduced as 11.4(17)ps and 8.2(7)ps, respectively. The associated beta(2) deformation within the axially-symmetric deformed rotor model for these states are 0.14(1) and 0.14(1), respectively. The beta(2) deformation of 0.14(1) for the I(pi)=12(+) state in (106)Cd compares with a predicted beta(2) value from total Routhian surface (TRS) calculations of 0.17. In addition, the mean-lifetimes of the yrast I(pi) = 15(-)/2 states in (103)Pd (at E(x)=1262 keV) and (107)Cd (at E(x)=1360 keV) have been deduced to be 31.2(44)ps and 31.4(17)ps, respectively, corresponding to beta(2) values of 0.16(1) and 0.12(1) assuming axial symmetry. Agreement with TRS calculations are good for (103)Pd but deviate for that predicted for (107)Cd.Physics, NuclearSCI(E)3ARTICLE6null7
Spruce giga‐genomes: structurally similar yet distinctive with differentially expanding gene families and rapidly evolving genes
No full textSpruces (Picea spp.) are coniferous trees widespread in boreal and mountainous forests of the northern hemisphere, with large economic significance and enormous contributions to global carbon sequestration. Spruces harbor very large genomes with high repetitiveness, hampering their comparative analysis. Here, we present and compare the genomes of four different North American spruces: the genome assemblies for Engelmann spruce (Picea engelmannii) and Sitka spruce (Picea sitchensis) together with improved and more contiguous genome assemblies for white spruce (Picea glauca) and for a naturally occurring introgress of these three species known as interior spruce (P. engelmannii × glauca × sitchensis). The genomes were structurally similar, and a large part of scaffolds could be anchored to a genetic map. The composition of the interior spruce genome indicated asymmetric contributions from the three ancestral genomes. Phylogenetic analysis of the nuclear and organelle genomes revealed a topology indicative of ancient reticulation. Different patterns of expansion of gene families among genomes were observed and related with presumed diversifying ecological adaptations. We identified rapidly evolving genes that harbored high rates of non-synonymous polymorphisms relative to synonymous ones, indicative of positive selection and its hitchhiking effects. These gene sets were mostly distinct between the genomes of ecologically contrasted species, and signatures of convergent balancing selection were detected. Stress and stimulus response was identified as the most frequent function assigned to expanding gene families and rapidly evolving genes. These two aspects of genomic evolution were complementary in their contribution to divergent evolution of presumed adaptive nature. These more contiguous spruce giga-genome sequences should strengthen our understanding of conifer genome structure and evolution, as their comparison offers clues into the genetic basis of adaptation and ecology of conifers at the genomic level. They will also provide tools to better monitor natural genetic diversity and improve the management of conifer forests. The genomes of four closely related North American spruces indicate that their high similarity at the morphological level is paralleled by the high conservation of their physical genome structure. Yet, the evidence of divergent evolution is apparent in their rapidly evolving genomes, supported by differential expansion of key gene families and large sets of genes under positive selection, largely in relation to stimulus and environmental stress response
Integrated genomic characterization of endometrial carcinoma
No full textWe performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ~25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.National Institutes of Health (U.S.) (Grant 5U24CA143799-04)National Institutes of Health (U.S.) (Grant 5U24CA143835-04)National Institutes of Health (U.S.) (Grant 5U24CA143840-04)National Institutes of Health (U.S.) (Grant 5U24CA143843-04)National Institutes of Health (U.S.) (Grant 5U24CA143845-04)National Institutes of Health (U.S.) (Grant 5U24CA143848-04)National Institutes of Health (U.S.) (Grant 5U24CA143858-04)National Institutes of Health (U.S.) (Grant 5U24CA143866-04)National Institutes of Health (U.S.) (Grant 5U24CA143867-04)National Institutes of Health (U.S.) (Grant 5U24CA143882-04)National Institutes of Health (U.S.) (Grant 5U24CA143883-04)National Institutes of Health (U.S.) (Grant 5U24CA144025-04)National Institutes of Health (U.S.) (Grant U54HG003067-11)National Institutes of Health (U.S.) (Grant U54HG003079-10)National Institutes of Health (U.S.) (Grant U54HG003273-10
Divergent clonal selection dominates medulloblastoma at recurrence
No full textThe development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5%). Whole-genome sequencing of 33 pairs of human diagnostic and post-therapy medulloblastomas demonstrated substantial genetic divergence of the dominant clone after therapy (<12% diagnostic events were retained at recurrence). In both mice and humans, the dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present at diagnosis. Targeted therapy is unlikely to be effective in the absence of the target, therefore our results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy
Fabrication and application of embedded spiral electrodes
No full text碩士本研究係以低溫非平面製程(non-planar process)方式，製作內嵌式螺旋微電極於SU-8流道內壁。
第一部分係製作螺旋微電極；首先以電子束蒸鍍機(E-beam evaporator)於毛細玻璃管上蒸鍍鈦、金導電種子層(seeding layer)，並搭配旋轉曝光(rolling exposure)的技術與後續的黃光微影製程，成型黃金螺旋微電極，再以電鍍鎳層的方式增厚電極，將厚度為5μm的鎳質螺旋微電極製作於毛細玻璃管外表面上。
第二部分係以具有鎳質螺旋微電極的毛細玻璃管作為犧牲層(sacrificial layer)，搭配SU-8光阻為結構層，最後以氫氟酸(HF)溶除毛細玻璃管，即可將此鎳質螺旋微電極轉嫁於SU-8材質的流道內壁。
完成的晶片通以直流電壓25V，可成功驅動無水酒精，體積流率達4.5 μl/min；預期此晶片可應用於離子牽引式幫浦(ion drag pump)。This paper proposes a low-temperature and non-planar process to fabricate spiral electrodes on the inner surface of a SU-8 circular microchannel. The fabrication process can be divided into two parts.
First, the Ti/Au electric seeding layer was deposited on the cylindrical surface of a glass capillary with 350μm diameter by an E-beam evaporator. After doing a rolling exposure process by adjusting the rotation speed of the glass capillary according to the proper UV dosage and using suitable etchants respectively, the author formed the continuous gold spiral electrodes around the glass capillary. Moreover, by electroplating nickel layers of 5μm thick to improve the strength of electrodes, the nickel spiral electrodes can be achieved on the outer surface of the glass capillary successfully.
Second, SU-8 photoresist was coated all over the above workpiece as a structure for the circular microchannel, then the glass capillary was removed by HF acid. Therefore, the nickel spiral electrodes were transferred to the inner surface of the SU-8 circular microchannel.
The complete chip experimentally drives the ethyl alcohol to have the volumetric flow rate of 4.5 μl/min by applying a DC voltage of 25V, and can be applied as an ion drag micropump.中文摘要 …………………….……………………………………… Ⅰ
英文摘要 ……………………………………………………………. Ⅱ
目錄 ……………………………………………………………. Ⅲ
圖目錄 …………………………………………………………..... Ⅴ
表目錄 ………………………………………………………….....
Ⅷ
第一章 緒論…………………………………...……………..…… 1
1-1研究動機……………………………….…………..… 1
1-2文獻回顧……………………………….…………..… 4
1-3研究目的……………………………….…………..… 11
1-4論文架構……………………………….…………..… 12
第二章 實驗設備………………………………………………..... 14
2-1單面對準曝光機加裝步進馬達模組………………... 14
2-2電鍍設備……………………………….………..…… 18
第三章 內嵌螺旋微電極之圓形微流道製程設計………………. 22
3-1螺旋微電極製程設計……………………………...… 22
3-2內嵌螺旋微電極之圓形微流道製程設計…………... 23
3-3螺旋微電極光罩設計……………………………...… 25
3-4外接導線設計………………………………………... 28
3-5外接管路設計……………………………………...… 31
第四章 製程詳細步驟與結果討論………………………………. 32
4-1螺旋微電極製程……………………………………... 32
4-2內嵌螺旋微電極之圓形微流道製程………………... 42
第五章 量測與分析………………………………………………. 48
5-1實驗量測設備…………………………………...…… 48
5-2實驗設計……………………………….…………..… 49
5-3量測結果與分析…………………………………...… 50
第六章 結論與未來建議…………………………………………. 56
6-1結論…………………………………………………... 56
6-2未來方向與建議……………………………………... 56
6-3未來的工程應用……………………………………... 63
參考文獻 ……………………………………………………………. 65
附錄 A 參與第三屆亞太傳感器暨微奈米技術學術研討會(Asia-Pacific Conference of Transducers and Micro-Nano Technology－APCOT 2006)論文全文－
A CIRCULAR MICROCHANNEL INTEGRATED WITH EMBEDDED SPIRAL ELECTRODES…………..
69
圖目錄
圖1-1 具有可動組件之薄膜式幫浦............................................... 2
圖1-2 不具可動組件之離子牽引式幫浦………………………... 3
圖1-3 以聚焦離子束輔助化學氣相沈積系統製作出微螺旋結構…………………………………………………………...
5
圖1-4 以自我組裝的方式製作出微螺旋結構…………………... 5
圖1-5 微螺旋結構陣列…………………………………………... 6
圖1-6 三維的球型加速度計……………………………………... 7
圖1-7 以分層堆疊的方式製作出三維微結構…………………... 7
圖1-8 以旋轉曝光的方式製作出圓管型鈦鎳合金……………... 7
圖1-9 以熔融接合的方式製作出具有圓形截面的微流道……... 9
圖1-10 以分層堆疊SU-8光阻製作出矩形微流道………………. 9
圖1-11 以SU-8光阻搭配光纖為犧牲層材料所製作的圓形微流道…………………………………………………………...
10
圖1-12 圓形微流道製程示意……………………………………... 10
圖1-13 論文架構…………………………………………………... 13
圖2-1 旋轉曝光示意……………………………………………... 14
圖2-2 曝光機加裝步進馬達模組設計構思……………………... 15
圖2-3 對準曝光機加裝步進馬達模組實體……………………... 17
圖2-4 電鍍設備實體……………………………………………... 19
圖2-5 電鍍試片示意……………………………………………... 21
圖3-1 螺旋微電極製程設計……………………………………... 23
圖3-2 內嵌螺旋微電極之圓形微流道製程設計………………... 24
圖3-3 光罩尺寸示意……………………………………………... 25
圖3-4 光罩圖形捲曲成圓管形狀………………………………... 26
圖3-5 具有斜線構型的光罩示意………………………………... 27
圖3-6 光罩圖形角度與毛細玻璃管外徑不配合產生的錯位現象…………………………………………………………...
27
圖3-7 兩相鄰的螺旋光阻連接情況良好…………………….….. 28
圖3-8 搭接導線不易接出………………………………………... 29
圖3-9 打線方向些微偏離欲想位置，造成螺旋微電極斷線……. 29
圖3-10 用人工方式，以銀膠黏接螺旋微電極和矽基板上的金屬線路………………………………………………………...
30
圖3-11 以探針刮斷電極示意……………………………………... 30
圖3-12 流體測試示意……………………………………………... 31
圖4-1 毛細玻璃管蝕刻測試……………………………………... 33
圖4-2 毛細玻璃管實體…………………………………………... 34
圖4-3 以光學顯微鏡拍攝拉製後的毛細玻璃管………………... 35
圖4-4 毛細玻璃管蒸鍍金屬前…………………………………... 36
圖4-5 毛細玻璃管蒸鍍金屬後…………………………………... 37
圖4-6 以膠帶將毛細玻璃管固定於夾治具上…………………... 38
圖4-7 微螺旋光阻………………………………………………... 38
圖4-8 黃金螺旋微電極實體……………………………………... 39
圖4-9 載玻片和毛細玻璃管並聯………………………………... 40
圖4-10 鎳質螺旋微電極成品……………………………………... 40
圖4-11 探針測試機台實體………………………………………... 41
圖4-12 探針接觸螺旋微電極……………………………………... 41
圖4-13 線路佈局…………………………………………...……… 42
圖4-14 毛細玻璃管固定於矽基板上，並以銀膠接出螺旋微電極 43
圖4-15 螺旋微電極黏接銀膠實體………………………………... 44
圖4-16 以SU-8光阻封裝毛細玻璃管，並顯影出蝕刻窗口和金屬接點……………………………………………………...
45
圖4-17 毛細玻璃管蝕刻過程…....................................................... 46
圖4-18 製作完成的晶片…………………………………………... 47
圖5-1 實驗量測架構……………………………………………... 48
圖5-2 實驗量測設備……………………………………………... 49
圖5-3 離子牽引式幫浦驅動無水酒精連續鏡頭………………... 50
圖5-4 氣泡於微圓管內流動……………………………….…….. 51
圖5-5 氣泡流動情形…………….…………………………..…… 52
圖5-6 氣泡流動情形..……………………………………………. 53
圖5-7 氣泡流動情形…………………...………………………… 54
圖6-1 具備旋轉機構的蒸鍍機台………………………………... 58
圖6-2 內嵌螺旋微電極之圓型微流道…………………………... 60
圖6-3 增強螺旋微電極內嵌效果製程示意……………………... 62
表目錄
表2-1 鎳電鍍液配方……………………………………………... 19
表4-1 毛細玻璃管規格…………………………………………... 33
表4-2 毛細玻璃管蝕刻結果比較………………………………... 33學號: 691340615, 學年度: 9
