1,197 research outputs found
No association of the mitochondrial DNA A12308G polymorphism with increased risk of stroke in patients with the A3243G mutation
No full textFanniry, Patrick (Death, 1870-06-11)
No full textAddress: 38 AccomondPg 45/1870/114/M W S/Cinti/no doctor/Schaefer/HebrewOriginal record filed in drawer labeled 'EWRY-FARRICK'
Mitochondrial protein quality control by the proteasome involves ubiquitination and the protease Omi.
No full textpeer reviewedWe report here that blocking the activity of the 26 S proteasome results in drastic changes in the morphology of the mitochondria and accumulation of intermembrane space (IMS) proteins. Using endonuclease G (endoG) as a model IMS protein, we found that accumulation of wild-type but to a greater extent mutant endoG leads to changes in the morphology of the mitochondria similar to those observed following proteasomal inhibition. Further, we show that wild-type but to a greater extent mutant endoG is a substrate for ubiquitination, suggesting the presence of a protein quality control. Conversely, we also report that wild-type but not mutant endoG is a substrate for the mitochondrial protease Omi but only upon inhibition of the proteasome. These findings suggest that although elimination of mutant IMS proteins is strictly dependent on ubiquitination, elimination of excess or spontaneously misfolded wild-type IMS proteins is monitored by ubiquitination and as a second checkpoint by Omi cleavage when the proteasome function is deficient. One implication of our finding is that in the context of attenuated proteasomal function, accumulation of IMS proteins would contribute to the collapse of the mitochondrial network such as that observed in neurodegenerative diseases. Another implication is that such collapse could be accelerated either by mutations in IMS proteins or by mutations in Omi itself
Changes in self-reported and parent-reported health-related quality of life in overweight children and adolescents participating in an outpatient training: findings from a 12-month follow-up study
No full textFinne E, Reinehr T, Schaefer A, Winkel K, Kolip P. Changes in self-reported and parent-reported health-related quality of life in overweight children and adolescents participating in an outpatient training: findings from a 12-month follow-up study. Health and Quality of Life Outcomes. 2013;11(1): 1.Background
Health-related quality of life (HRQoL) was found to improve in participants of weight management interventions. However, information on moderately overweight youth as well as on maintaining HRQoL improvements following treatment is sparse. We studied the HRQoL of 74 overweight, but not obese participants (32.4% male, mean age = 11.61 ± 1.70 SD) of a comprehensive and effective six-month outpatient training at four time-points up to 12 months after end of treatment.
Methods
HRQoL was measured by self-report and proxy-report versions of the generic German KINDL-R, including six sub domains, and an obesity-specific additional module. Changes in original and z-standardized scores were analyzed by (2×4) doubly multivariate analysis of variance. This was done separately for self- and proxy-reported HRQoL, taking into account further socio-demographic background variables and social desirability. Additionally, correlations between changes in HRQoL scores and changes in zBMI were examined.
Results
There were significant multivariate time effects for self-reported and proxy-reported HRQoL and a significant time-gender interaction in self-reports revealed (p < .05). Improvements in weight-specific HRQoL were evident during treatment (partial η2 = 0.14-0.19). Generic HRQoL further increased after end of treatment. The largest effects were found on the dimension self-esteem (partial η2 = 0.08-0.09 for proxy- and self-reported z-scores, respectively). Correlations with changes in weight were gender-specific, and weight reduction was only associated with HRQoL improvements in girls.
Conclusions
Positive effects of outpatient training on generic and weight-specific HRQoL of moderately overweight (not obese) children and adolescents could be demonstrated. Improvements in HRQoL were not consistently bound to weight reduction. While changes in weight-specific HRQoL were more immediate, generic HRQoL further increased after treatment ended. An extended follow-up may therefore be needed to scrutinize HRQoL improvements due to weight management
Rates for 1, 2-migration in alkylchlorocarbenes
No full textPT: J; CR: FRENKING G, 1984, TETRAHEDRON, V40, P2123 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 JACKSON JE, 1988, J AM CHEM SOC, V110, P5595 JONES M, 1980, REACTIVE INTERMEDIAT, V2 JONES WM, 1980, REARRANGEMENTS GROUN, V1 KIRMSE W, 1971, CARBENE CHEM KYBA EP, 1977, J AM CHEM SOC, V99, P8330 LIU MTH, 1987, CHEM DIAZIRINES, CH5 MOSS RA, 1970, J AM CHEM SOC, V92, P6951 MOSS RA, 1978, J AM CHEM SOC, V100, P6788 MOSS RA, 1978, J CHEM SOC CHEM COMM, P775 SCHAEFER HF, 1979, ACCOUNTS CHEM RES, V12, P288 TOMIOKA H, 1984, J AM CHEM SOC, V106, P454; NR: 13; TC: 60; J9: J AMER CHEM SOC; PG: 2; GA: AG637Source type: Electronic(1
Study of 1, 2-chlorine migration in (Alpha,alpha-dichlorobenzyl) chlorocarbene generated by laser flash photolysis of 3-chloro-3-(Alpha,alpha-dichlorobenzyl) diazirine
No full textPT: J; CR: BONNEAU R, 1989, J AM CHEM SOC, V111, P5973 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 JONES M, 1973, CARBENES, V1 JONES M, 1975, CARBENES, V2 JONES WM, 1980, REARRANGEMENTS GROUN, V1 KIRMSE W, 1971, CARBENE CHEM LAVILLA JA, 1989, J AM CHEM SOC, V111, P6877 LIU MTH, IN PRESS J PHOTOCHEM LIU MTH, IN PRESS J PHYS ORG LIU MTH, 1987, CHEM DIAZIRINES LIU MTH, 1989, J AM CHEM SOC, V111, P6873 LIU MTH, 1990, J AM CHEM SOC, V112, P3915 LIU MTH, 1990, J CHEM SOC CHEM COMM, P1650 MORGAN S, 1991, J AM CHEM SOC, V113, P2782 MOSS RA, 1990, J AM CHEM SOC, V112, P5642 REGITZ M, 1989, METHODEN ORGANISCH E, V19 SCHAEFER HF, 1979, ACCOUNTS CHEM RES, V12, P288; NR: 17; TC: 4; J9: J ORG CHEM; PG: 3; GA: HN858Source type: Electronic(1
Electronic effect on 1,2-hydrogen shift in chlorocarbenes
No full textPT: J; CR: BRADLEY GF, 1967, THESIS U SOUTHAMPTON ELIEL EL, 1966, CONFORMATIONAL ANAL GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 JONES WM, 1980, REARRANGEMENTS GROUN, V1 KIRMSE W, 1978, CHEM BER, V100, P1972 KIRMSE, 1971, CARBENE CHEM MOSS RA, 1970, J AM CHEM SOC, V92, P6951 MOSS RA, 1978, J CHEM SOC CHEM COMM, P775 SCHAEFER HF, 1979, ACCOUNTS CHEM RES, V12, P288 SU DTT, 1978, J AM CHEM SOC, V100, P1972; NR: 10; TC: 6; J9: TETRAHEDRON LETT; PG: 2; GA: RU129Source type: Electronic(1
Measurement of the absolute rate of 1,2-hydrogen migration in benzylchlorocarbene
No full textPT: J; CR: ALTMANN JA, 1974, J AM CHEM SOC, V96, P4196 ALTMANN JA, 1975, J AM CHEM SOC, V97, P5217 BODOR N, 1972, J AM CHEM SOC, V94, P9103 GOULD IR, 1985, TETRAHEDRON, V41, P1587 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 GRILLER D, 1982, J AM CHEM SOC, V104, P5549 JACKSON JE, 1988, J AM CHEM SOC, V110, P5595 JONES M, 1980, REACTIVE INTERMEDIAT, V2 JONES WM, 1987, REARRANGEMENTS GROUN, V1, CH8 KIRMSE W, 1971, CARBENE CHEM KYBA EP, 1977, J AM CHEM SOC, V99, P8330 LEOPOLD DG, 1984, J CHEM PHYS, V81, P1048 LIU MTH, 1985, J CHEM SOC CHEM COMM, P982 LIU MTH, 1986, J PHYS CHEM-US, V90, P75 MCKELLAR ARW, 1983, J CHEM PHYS, V79, P5265 MOSS RA, 1980, ACCOUNTS CHEM RES, V13, P58 MURRAY KK, 1988, J CHEM PHYS, V89, P5442 NOBES RH, 1980, CHEM PHYS LETT, V74, P269 RAGHAVACHARI K, 1982, CHEM PHYS LETT, V85, P145 SCHAEFER HF, 1979, ACCOUNTS CHEM RES, V12, P288 SOUNDARARAJAN N, 1988, J AM CHEM SOC, V110, P7143 STEVENS IDR, 1988, TETRAHEDRON LETT, V30, P481 SU DTT, 1978, J AM CHEM SOC, V100, P1872 TOMIOKA H, 1984, J AM CHEM SOC, V106, P454 TOMIOKA H, 1984, J CHEM SOC CHEM COMM, P476 WARNER PM, 1984, TETRAHEDRON LETT, V25, P4211; NR: 26; TC: 56; J9: J AMER CHEM SOC; PG: 2; GA: AM216Source type: Electronic(1
Reactive intermediates in the photolysis and thermolysis of 3-chloro-3-benzyldiazirine
No full textPT: J; CR: BRADLEY GF, 1977, J CHEM SOC P2, P1214 DOLBY LJ, 1966, J ORG CHEM, V31, P110 ENGEL PS, 1980, CHEM REV, V80, P99 GRILLER D, 1983, J ORG CHEM, V48, P1359 HEGARTY AF, 1978, CHEM DIAZONIUM DIA 2, P511 JENNINGS BM, 1976, J AM CHEM SOC, V98, P6416 LIU MTH, 1974, J CHEM SOC P2, P937 LIU MTH, 1981, J CHEM SOC P2, P53 LIU MTH, 1982, CHEM SOC REV, V11, P127 MO YK, 1976, CARBONIUM IONS, V5, P2135 NAIDAN VM, 1972, ZH ORG KHIM, V8, P2172 SCHAEFER HF, 1979, ACC CHEM RES, V12, P88 SCHMITZ E, 1979, ADV HETEROCYCL CHEM, V24, P63 SMITH NP, 1979, J CHEM SOC P2, P213 SMITH RAG, 1975, J CHEM SOC P2, P686 TOMIOKA H, UNPUB TURRO NJ, 1980, J AM CHEM SOC, V102, P7576; NR: 17; TC: 12; J9: TETRAHEDRON; PG: 6; GA: SG656Source type: Electronic(1
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