10 research outputs found
Um artista em trânsito: o local e o global nas histórias em quadrinhos de Sérgio Bonson (1974-2005)
Get PDFThis paper proposal is to analyze comic books from a transnational perspective. Therefore, we chose as object of study the work of the Sérgio Bonson (1949-2005), an artist who worked in Florianópolis, SC, from 1974 to 2005. Draughtsman and watercolor artist, Bonson was author of numerous cartoons and comic books for newspapers and art exhibitions, he also developed contacts and transits at the national and international levels. The discussion turns on its focus to two sets of comic books: one, local, with characters from the city and the daily life in Florianópolis; and another global one, in which the artist presents himself as a character on a trip to France, entitled Impressions de France. Drawing on the analysis of these two series, we focus our attention on the artist’s transit between countries in America and Europe, and then perceive the transnational reverberations in his production, in order to identifying, on the one hand, articulations between local dimension and a widest element, the graphic humor, which refers to other times and places; on the other hand, in case of narratives with a transnational scale, highlight how the place is present through cultural translation and the experiences of present timeEste artigo propõe a análise de histórias em quadrinhos a partir de uma perspectiva transnacional. Para tanto, elegemos como objeto de estudo a obra do artista Sérgio Bonson (1949-2005), que atuou em Florianópolis, SC, no período de 1974 a 2005. Desenhista e aquarelista, autor de inúmeras charges e histórias em quadrinhos para jornais e exposições de arte, Bonson desenvolveu contatos e trânsitos no âmbito nacional e internacional. O foco da discussão se volta para dois conjuntos de HQs: um, local, com personagens da cidade e do cotidiano de Florianópolis; outro, global, no qual o próprio artista se apresenta como personagem de uma viagem à França, intitulado Impressions de France. A partir da análise dessas duas séries, repousamos nosso olhar sobre o trânsito do artista entre países da América e da Europa para, em seguida, percebermos as reverberações transnacionais na sua produção, com vistas a identificar, por um lado, articulações entre a dimensão local e um elemento mais amplo, o humor gráfico, que remete a outros tempos e lugares; e, por outro lado, no caso das narrativas com escala de abrangência transnacional, destacar como o local se faz presente por meio da tradução cultural e das experiências próprias ao tempo presente
Assessing the feasibility and stability of uracil base flipping in RNA-small molecule complexes using molecular dynamics simulations
Get PDFSmall molecules can be used to target RNAs that mediate disease. A fundamental understanding of binding interactions between RNA and small molecules and the structure of their complexes will further inform the design of new targeting agents. Two small molecule ligands were investigated for their ability to recognize the expanded CUG repeat sequence in RNA, the causative agent of myotonic dystrophy type 1. We report the use of molecular dynamics simulations to explore small molecule–RNA complexes and the finding of a stabilized base flipped conformation at UU mismatches. The results of this computational study support experimental observations and suggest that base flipping is feasible for CUG-repeat RNA.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
175 A Fas-4–1BB immunomodulatory fusion protein converts a pro-death to a pro-survival signal, enhancing T cell function and efficacy of adoptive cell therapy in murine models of AML and pancreatic cancer
No full textIowa History and Culture : A Bibliography of Materials Published Between 1952 and 1986, 1989
No full textThis bibliography was compiled by two reference librarians, Patricia Dawson and David Hudson with the goal of making it easier of tracking down material on Iowa history and culture. This supplements the Iowa History Reference Guide published in 1952 by William Petersen
Enhancing Aboriginal and Torres Strait Islander research trial leadership and participation: insights from the initial stages of the Australian Fans in Training Project in the Northern Territory of Australia
No full textInsufficiency of compound immune checkpoint blockade to overcome engineered T cell exhaustion in pancreatic cancer
No full textBackground Achieving robust responses with adoptive cell therapy for the treatment of the highly lethal pancreatic ductal adenocarcinoma (PDA) has been elusive. We previously showed that T cells engineered to express a mesothelin-specific T cell receptor (TCRMsln) accumulate in autochthonous PDA, mediate therapeutic antitumor activity, but fail to eradicate tumors in part due to acquisition of a dysfunctional exhausted T cell state.Methods Here, we investigated the role of immune checkpoints in mediating TCR engineered T cell dysfunction in a genetically engineered PDA mouse model. The fate of engineered T cells that were either deficient in PD-1, or transferred concurrent with antibodies blocking PD-L1 and/or additional immune checkpoints, were tracked to evaluate persistence, functionality, and antitumor activity at day 8 and day 28 post infusion. We performed RNAseq on engineered T cells isolated from tumors and compared differentially expressed genes to prototypical endogenous exhausted T cells.Results PD-L1 pathway blockade and/or simultaneous blockade of multiple coinhibitory receptors during adoptive cell therapy was insufficient to prevent engineered T cell dysfunction in autochthonous PDA yet resulted in subclinical activity in the lung, without enhancing anti-tumor immunity. Gene expression analysis revealed that ex vivo TCR engineered T cells markedly differed from in vivo primed endogenous effector T cells which can respond to immune checkpoint inhibitors. Early after transfer, intratumoral TCR engineered T cells acquired a similar molecular program to prototypical exhausted T cells that arise during chronic viral infection, but the molecular programs later diverged. Intratumoral engineered T cells exhibited decreased effector and cell cycle genes and were refractory to TCR signaling.Conclusions Abrogation of PD-1 signaling is not sufficient to overcome TCR engineered T cell dysfunction in PDA. Our study suggests that contributions by both the differentiation pathways induced during the ex vivo T cell engineering process and intratumoral suppressive mechanisms render engineered T cells dysfunctional and resistant to rescue by blockade of immune checkpoints
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy
No full textAddressing uncomfortable issues: the role of White health professionals in Aboriginal health
Get PDFThis research investigated the role of White health professionals in addressing Aboriginal health in South Australia. Set within the discipline of nutrition and dietetics and the area of obesity prevention, it explored the practice of White health professionals from the point of view of Aboriginal and White workers.
This research, currently in the form of an unpublished Doctor of Philosophy thesis, arose from practice dilemmas the author experienced as a dietitian working in rural and remote South Australia.
The setting for this research was the eat well be active Community Programs, a community-based, childhood obesity prevention program in South Australia. In order to conduct ethical research, the author worked closely with Aboriginal community members and workers, through building and maintaining relationships and activities of reciprocity.
This research is positioned in a social constructionist epistemology and uses a critical theoretical approach. Critical social research and reflexivity are the methodological approaches. The kept a reflexive journal and conducted 41 semi-structured interviews with White health professionals and Aboriginal health workers and one focus group with White health professionals; all of which formed the data for this research.
This research identified that there are a number of elements to the practice of White health professionals that make it ideal when they are working with Aboriginal communities. However, such ideal practice does not always occur and this research sought to identify why. The organisation, profession and individual were identified as systems within the wider system of Aboriginal health.
Within these systems, the author identified structures (rules and resources) that either constrain or enable the practice of White health professionals with Aboriginal people. While many White health professionals focussed on external factors that constrained their practice, this thesis identifies the role of individuals in creating and maintaining barriers and enablers, thus highlighting their agency. It was also identified that White health professionals progress through a number of stages in their work in Aboriginal health, from not knowing how, to being scared, to finding it too hard and ultimately being able to practice regardless of barriers.
In summary, this research identified that moving forward in Aboriginal health requires White health professionals to look at themselves, which generally requires them to address uncomfortable issues
Supplementary Figures 1-4 from Differential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma
No full textSupplementary Figures 1-4</p
0001
No full textTHE DAILY PALO ALTO TIMES.
*rurai-*kam*?*dc4h'i^9i*ic*ma>u*mam •*•*
Be Healthy
i£ Tbe *ure*t *nd nafoit way to a
■j* pre*erv-*> or reg*la your health g
X Is to be careful what you eat 9
£ Wbea you buy erocerle* be £
j! sure aad set tbe beat Quality, g
5 reasonable prlcos anil prompt -J
<£ service. We lead la tbe gro-
5 eery line.
i. _— . t
| La Piere & Son |
£ 521 Ramona St
«aiW.-*m.-«n-**^.-*v>.*w
The cat's ou. of (lie Oas*. Every
one ha* cAiif-ha on to tlie fact that
we do Iii--.li-. 1.1-- plumbing work.
Oct tn the pi mi'" by joining the
larg-. army favorin-j us with pltunb*
bu* contract*. We want to jcet In
i.-urh with you. Write u« for aa -■—
timato on your plumbing nocd*.
Christeiisen-Darling
Company
Plumbiii--, Tinning. Hardware, Paints
aMlOlla.
**S*J L'nlverity Ave. Itioae Mala AS
Kttc*ii^**i*i*>'±.+>'±*;±a;i^aii;;a;Ka>
Gents! {
j Your Laundry f
J Will come bsck on Ume look- £
§ las; neat, with no saw athrau £
< if seat to the Stanford Lann- g
J The latest Improved ma- *
calnery and skilled workmen f*
J svoabl* us to guarant** you -J-
C sailsfactlon. **
c Telephone Red SI. »
! Stanford Laundry I
* Cur. Ramona Street '
and Forest kit. ■?■
PrtLO ALTO
«w.
.<•***•**'*-**l.*a*r-»X(^
Stanford
Home Bakery
JOHN NICOL, Proprietor
All kinds of Bakery Goods.
Cakes and Pastries for entertainments, parties and weddings a specialty. Only the
best materials used.
-115 University Ave. Palo Aito
Wl! E S LOVER
dlAI.I.Is KUOHS RUES ii'Lii
■BOTB INTO THK BODY
OP BDWARD FAHltEL.
A Triii-■•-!■■ ataaetad in Rmo In Which
Four Innocent Itysta micro Aro
Murr or I ■■■■■•> injured.
R*oo, Nr-v., Nov. 9.—True to his
threat that he would kill tha de*
ipolk-r ot hi* home unless he left
Reno, taking with him the woman
that be bad alienated from her lawful husband, Charles Kucas, a former resident of Oakland, Cal., aad
once manager of the Umpire Theatre of that city, Monday night shot
and Instantly killed Edward (Silvers) Farrel and wound**d four other
men, Clifford Bonson, E, U. Light,
O. L. White and Herbert McCul-
lougb. Tbe shooting began In tbe
Palace gambling houso and was
completed on Center street, Just
outside tbe club house, where the
sid-.-walk, for a few moments, wa*
Uttered wltb the dead and Injured,
six men being picked up with blood
streaming from tbelr wound*.
Ktichii wa* arrested by Oficur Lester Cndle nnd taken to th? police
station.
Thc nfT&tr Is the direct result or
Fsrrel Invading Kticb'a home and
debauching his wife, a young woman,
easily fascinated by the gny company, wine and midnight -nippers
that go with a fast life.
Repeatedly Farrel was ndvin«d by
friends to leave the city as Kuchs
bad sworn to kill him.
The Itrsota were crowded when
Knchs walked Into the Palace saloon and gambling house, looking
for Farrel. The latter was stand-
lag behind the crap table at the
Center titreet entrance. Ills back to
the wall.
"Do you know what 1 am going to
do?" shouted Kucns.
The answer came from both men
as two revolvers flashed Into the air,
and Kuch. Urine first, sent four bullets entirely through Farrel'* body
from his Colt's automatic, piercing
the breast, side and abdomen. Farrel staggered against the wall but
recovered in it second and replied
with a series of shots that broke
Kuch's right arm nliove the elbow,
shot away a finger of his right hand
and sont a bullet through bis hat,
producing a slight abrasion oa top
of bis head.
Five of Kuchs' bullets penetrated
the wall of the gambling bouse-and
two of them struck persons In the
street.
Clifford Benson, * nephew of Governor John Sparks, received a slight
wound that drew blood fn.in bis lips
as a ballet sung past him.
E. H. Light was slightly wounded
In the right leg by s stray shot.
O. L. White was struck In the
groin by a bullet which was deflected by his pocket kalfe.
DBPBW WILL ItKSt'MK SEAT.
New York Nenntor Will Soon go to
Waohlugioit.
New York. Nov. 9.—Senator Depew. who ha* been spending the
summer and fall at the Bishop villa,
Ardscy-ln-the-Hudson, will move
to his own house of November IS,
and leave for Washington December
1st to bo la his scut when tbo Senate convene*.
Senator Depew spends most of his
time playing golf, taking long automobile rides and attending dinner
parties. He has greatly Improved In
health.
% Blacksmithing |
j —m—
% Horseshoeing |
I
Bring your work lo the old- J
eaUbllaht-d firm. Oar workmen 9
2 aro experienced, our equipment
t complete, and our work la first- Z
I *•"«• I
I
j Vandervoort & Co. f
| a..
■x-*>»**>^**at^-*v!*..w^.i* nf*nf*nf*nM
9T AM FORD ALTOMOIULB
OARAGE.
511 Alma Street
Automobile snd Motor Cycle It*
palling. Grinding, Polishing. Mod-*!
work. Bras* and Iron Casting*. Nick
el Plating. electrical Repairing, Ma
chin* screw* and supplies.
da 112.
Old papers for under carpets. 10
cents a hundred. Times office. •*
W.ir-iihi. Henriy fur l'i. i.v-n.
Newport News. Va,, Nov. 9.—Tbe
battleship Louisiana and her convoy,
the cruiser* Washington and Tennessee, sailed yesterday for Pino Dluff,
In upper Chesapeake Bay. where
President Roosevelt and party will
board Iho battleship from the Dolphin.
Tbe pilots aboard the w«rshlp ox-
peel to pass out of the Capes, bound
for Panama, some time this afternoon. Tbe Louisiana has been
equipped with a 30-non-stnkable and
Bon-capsitable llfebont, which is sop-
piled with provisions and wuter for
six days and I* manned by twelve
picked men of tbe navy to he used
tn case of mishap.
Railway** Indicted.
Minneap"!!-. Minn. Nov. ft.—In-
dletment* havo been returned by the
■jJocial Federal Grand Jury which
convened in Minneapolis victoher
22 to Investigate alleged freight re-
hates. In the case of the railroads
the indictment* contained 141
counts. .The minimum penalty for
conviction In each case 1* f 1,000 aad
the maxlmam |2,000.
w
OMAN'S CLUB
COLUMN**
i *ry**«i-r****--*a-^^ K****m*-*^ik*m9>9
The I!-.-n afternoon at the Woman's Club proved a decided success
in that the members generally ro-'
sponded so ably to tbe demands of
tho occasion, while realizing the Impossibility of doing themselves and
the subject Justice in the time assigned. Henrlk Ibsen, dramatist. I
poet, radical. Is said by some to be
the great-rut author of his period, a]
poet of rxtraordlnary gift, a radical
who protested that he advocated
nothing, but merely reported life as!
iaw li and allowed It to teach it*
own morai; he was tblnkor, lighter
and propho'. Opposed to tradition* ■■
and conditio-.--, he consistently pro-:
seated In life and writings his doc-|
trine of Individualism, and found
his greatest -latlsfaction, as ho him*'
self, said. In productivity. The program giveo was practically as out-;
lined ln n prcviuos Issus of The
Time* and need not be noted at
length.
bo club In Us discussion of busl-'
neas voted to return to Fraternity1
hall for regular meeting placo. That!
"homo" for so many years that
since the earthquake dispossessed
tlittn the members havo fett some-!
what like refugee*.
rs. G, R. Pnrklnson hns consent-:
ed to resume the i>ost of doorkeeper.!
aad members wishing to Invite
guests should remember cards may!
be obtained of the treasurer, Mrs.'
Weisshsar. *
Mrs. Thompson reported for the''
department of village improvement;,
the club approved or work already■
done and endorsed the resolution,
stating necessity for public parks,'
and asking that a proposition to acquire *uch be submitted to the voter-*,
of the town. Attention was called!
lo the dato set for the "out-door
houso cleaning" and the hope ex-j
pressed that co-operation on Saturday will result In great benefit.
Delegates to tlie District Federu-j
tlon to be held In Santa Clara. December 4th and f'th. nn follow-*:
Mrs. M. J. Greene, Mrs. C. A. Flro-.
baugh, with Mrs. Annette Allen and
Mrs. M. E. Welsshnar alternates. Tho
president or her appoints will als>>
be In attendance, Mrs. Alice L. Park
and Mrs. J. S. Lakln are memhors ct
the district executive board, and M. i.
Geraldlnc E. Friable is chain mn of
the committee on revision of :*.. -i-v*.
for the district.
Mrs. Robert Potter Hill, state
president of the California Fvdera-f
tlon of Women's Clubs, Is now beginning the tour which will Include,
attendance at the annual convention*
of each of thc six districts of the.
nUte. The sorles begins with tho
Alameda district, convening at Stockton, nnd will conclude with that of
San Francisco, mee'.lng at Santa riant early ln December. Owing to the
largo membership or this district, (
which comprise* the clubs of four-'
teen counties nnd an enrollment of I
nearly **,000 women. It is difficult toj
condense business and reports sum-,
clently for a one-day program and al
hair day will be added this year, the)
convention opening Tues-ln*. after- j
noon, December 4th.
The following brief report of im-|
portant points in Dr. Jordan'i .-..!-
dress at the recent State oullrage
convention In San Francisco is (uken
from thc current issue of the yellow
Ribbon:
Tho essentlsl in Republicanism
Is not good government. Th'u n tUm-
pot can give. Government by the
people exists that the peoplo may he
trained. Its purpose Is li> enlarge
tho sympathies of men. to extend
their wisdom and to morge their
prejudices In patience and tolerance.
It looks forward to tbe time when
government by thc people nliull be
wl-te government; when all citizen*,
icn and women, shall luku part in
It. und none shall bo weak in venal
or corrupL
"Tho extension of the suffrage to
woman has tho *amo Justiflcat-on It
wlll not secure better government--
at least not for a generation or two
But if It help the intellectual growth
of the mothers of tho country, give
them clearer views of life, brouder
sympathies and higher wli-dom, then
Its purpose will be accomplished."
TO WED SOON
WIDOW OF LATE MILLIONAIRK
TO WED I-OIULAR NEW
YORK CLUBMAN.
Hon-uit Robln*on, Real Estate Operator, Said to Have Won
Widow'* Hand.
Newport, R. I., Nov. 9.—A rumor
has been current ln society circles
hers for some days past that an
announcement of tbe engagement of
Mr*. Thresa Oelrichs to Moncurs
Robinson, on* of the most popular
men member* of th* "Smart Set,"
who Is also well known as a successful real estate operator In New York
and Baltimore, will soon be mads.
Mrs. Oelrichs and Mr. Robinson
hav* been seen together a great d*al
since the return of the widow from
San Francisco, whero she went to
settle the dispute over tho oatat* of
h*r late husband.
Friend* ot both ths Interested
parties, however, declare there Is absolutely no haBls for the report that
aa engagement Is likely to be announced. Thoso persona say that
Mrs. Oelrichs Is quite satisfied to
continue enjoying tho freedom ol
widowhood: while thc former Baltimore clubman Is determined to adhere to his bachelor existence, although he finds tho fair widow *
charming companion.
SMOOT WILL STAY IN SENATE.
Republican Virion--- ln I'tnh and
Idaho llt*l|i Mormon*-.
Washington, Nov. 9.—That Senator Smoot wilt be left In his seat despite development* adverse lo him
during the latter week* of the past
session ts the opinion of Democrats
and many other observers who have
studlod th,- reports from Utah and
Idaho. Tn both States the Mormon
Church Is the Issue and In both thc
Republicans won; In both, too, the
victory Is frankly attributed to cooperation of the Salt Lake hierarchy.
It bas been alleged that tbe church
authorities Issued orders to opposs
the Democrats and support the Republican* and thst this solidarity ot
the Mormon vote defeated Dubois In
Idabo Is not much doubted.
Seek Ins the Life of RoosevrIL
New York, Nov. 9.—A Pansms
special says .lerinan Kehi. who In
1903 tried to gain admission to tht
White House with the oociarcd view
Of killing Mr. Roosevelt, nrrlvod ln
Panama yesterday from Chill and
was put under arrest. Phvsfclani
declared him Insane. He will bf
sent back to Chill.
There are * number of secret service men nuw on the Isthmus to loos
after the safety of the ProsIdsnL
For weeks thi- canal tone pollco and
detectives have kept close fab on an
arrivals at port* between Panama
and Colon.
Congregational Church—Morning
service at 11; Sunday School at
12:15; Junior Choir at 3:30; Young
People's Society of Christian Eni1--a
vor at 6:16: evening service at 7:30
The pastor wlll speak especially to
young men In tthi* evening
"Christian Cltltenshlp."
Ask your friends to Palo Alto for
tho November iCtb celebration. Olve
them ride*'along Waverly street and
University avenue and let them se->
tho prettiest town ln the state.
Water System to CoM 4101,000,000.
New York, Nov. 9.—The flrat step
to begin the actual construction of
the city's proposed new |161,000,-
000 water system was taken yesterday, when bids were anked for the
building of ihe first section of the
huge nqueduci. ten mil- ■ In length.
Four years an- allowed for tha completion of this section, and bids must
be received hy December 4. It Is
Mtltnatcd that tbe cost of tbe first
section will be about 6.00 per year. .
I
2 Things 2 Remember |
I
rrrrrr——i
I
The "Delmonte Blend of H. J." Is
of the highest-test coffees on tbe
msrket—rich flavor. *.
It Is for sale only at
COfflPTOIN'S TEA-COF'F'EE STORE
321-323 I'nUrrsity Avenue Phono Main 82.
GAS! GAS! GAS!
ry K-nges ry
VlClaJ Gralcs and Lots vlCtaJ
Oiens
Unadrj .Sio.es
Saldcriaj- Furnace*
Gas
leslurajil Ranges
Cand* Furnaces
Broilers
No Flues Necessary When You Use Gas
THE BEST FUEL IS
GAS! GAS! GAS!
547 MIQH ST.
PHONE MAIN 62
What
You
Can
Do
. 'yyyiAii
mm
This
Oil
Neater
With a Perfc*tion Oil Heater yon can heat a cold
Inil iiin**t mill i • *ick-roo*n mo-re comfortable, wai-a *
chilly hallway, heat water quickly, aad do many thing*
better than can be done with any other stove no matter
what fuel it born*. Tbe superior, t j of the
PERFECTION
Oil Heater
{Equipped wllli Smokelcs-i Device)
lie-, in tha f*a*t that It I***n**SInteriM heal without ■moka
oram-ll. Th*; oil fount ant: tin* wlelc ca-tler arc taadc ot braaa
Uiroa-rt-out, urtllch lotuira dturabllllj. lima Fit*t beat ata-nall
coat, lount ha« oil ia liralor an.1 handle. Heater la li**hl and
Krtatiir. At-jaolutcl**- aafc and aim pic—wick cannot be turned
> hl-*li or too low. Ofcrai-d aa *-aall** a* a ta —
eaaily cl-ane-l. Two flnl***-*-a~alckel and Japan
.,. All part.
._. E-reryh-aur
warraaled. If aot al j-oai* dealer-* write ncareat a-r-n-r*- for
at-acrlpUf-e circular.
The
ISayO Lamp
bet all-rc
aad la tbe beat ali-coaad
hoarse lamp *=*tl-. Glrea
a clear, -rtead-r ll*hl. I*
Ihe aafeat laap you caa
buy. nr-aia thrOQch'-Ut and alckel plated. Bqulppe.! wtlh
the lat-tt l-apr*o"*I bur-Kt. lIau4*o*n*--alm*-4e---^*tUf-wto-T.
t'-r-rt-y lamp warraaled. Write to nearest agency If you cannot
get It from your dealer,
** .'-TANDARD OIL COMPANY
Poa-rta-iaatcr* Appointed.
Wasbtngioa, Nov. 9.—Louis Die
lack ha* been appointed poetmastei
ct Corcoran. Kin's* county. Cal.; Wll-
llam McLean at Ethena, Rlrersidi
oounty, Cal
G. H. Allen Oil Co.
AGENTS FOS
Perftclion Oil Hester.
and R*vo Lamps
Proonetora*>. ALTO bnud high -pa-** oil, eapec tally a*»t Si &
lof tbeac beater*, and Urn pa.
520 Hlrh Street phone Main 1
