23 research outputs found
The SRF/NKX 2.5 Regulatory Node
No full textSerum Response Factor, SRF, is a regulatory protein that helps with the process of gene transcription. SRF binds to DNA sequences called Serum Response Elements (SRE). A model of SRF and NKX 2.5 was constructed to understand the feasibility and scope of my proposed project. The x-ray crystal structures of the proteins used for SRF and NKX 2.5 were 1HBX and 3RKQ, respectively. SRF was bound on the opposite side of the DNA relative to NKX 2.5 based on our sequence alignment. This configuration makes the preliminary model plausible. The two proteins was loaded into the program Pymol: “fetch 1hbx” and “fetch 3rkq” chain W from 1HBX will be aligned with chain C from 3RKQ and their residues will be from -4 to -3 and 2 to 8, respectively. Then aligned based on the selected residues for each chain, so the subsequent command will be: “align 1hbx_resid_-4-3, 3rkq_resid_2-8.” The model showed NKX 2.5 and SRF were trans to each other meaning SRF was on the opposite side of DNA from NKX 2.5. It was seen that two strands from NKX 2.5 and SRF went down the same groove leading to a steric clash or potentially leading to conformational change. Transcription regulation by direct and mutated TF could spawn a new class of therapeutic agents. The action of SRF can be nudged toward proliferation or conversely nudged toward differentiation. Both effects could have a significant impact on wound healing and heart repair.Biology and Biochemistry, Department ofHonors Colleg
Spräktabu og tabuomräder i norsk
No full textThe aim of the article is to present the various aspects of language taboo in Norwegian. The author tries to account for the term "language taboo" and draw some kind of distinction between the primiive "taboo of fear", the evolving "taboo of delicacy" and "taboo of proriety" in modem Norwegian. The latter has a social background and ranges from statements with a slightly vulgar tinge to extremely offenive acts of verbal abuse regarded as Face Threatening Acts. Social taboos generally include the deity, sex, excretion and strangers. In the conclusions the author underlines that taboo in Norwegian remains a little explored area and suggests a possible approach to a comprehensive analysis of the phenomenon. Further research in this field seems to be a necessity and should comprise both the anthropological, semantic and functional aspects of taboo, both within the culture and the language
Spräktabu og tabuomräder i norsk
No full textThe aim of the article is to present the various aspects of language taboo in Norwegian. The author tries to account for the term "language taboo" and draw some kind of distinction between the primiive "taboo of fear", the evolving "taboo of delicacy" and "taboo of proriety" in modem Norwegian. The latter has a social background and ranges from statements with a slightly vulgar tinge to extremely offenive acts of verbal abuse regarded as Face Threatening Acts. Social taboos generally include the deity, sex, excretion and strangers. In the conclusions the author underlines that taboo in Norwegian remains a little explored area and suggests a possible approach to a comprehensive analysis of the phenomenon. Further research in this field seems to be a necessity and should comprise both the anthropological, semantic and functional aspects of taboo, both within the culture and the language
Nawyki komunikacyjne cyfrowych odbiorczyń zamieszkujących mniejsze miejscowości. Przyczynek do badań historyczno-medioznawczych
No full textCelem artykułu jest prezentacja wyników badań przeprowadzonych w 2019 i 2020 r., które miały odpowiedzieć na pytanie, w jaki sposób, z jaką intensywnością i w jakich okolicznościach następuje percepcja treści medialnych przez użytkowniczki mediów cyfrowych zamieszkujące mniejsze miejscowości. Z przeprowadzonej analizy wynika, że założone hipotezy dotyczące rosnącej roli mediów społecznościowych oraz źródeł internetowych się potwierdziły. Co istotne, w opinii respondentów również media tradycyjne, tj. radio i telewizja, stanowią cenne źródło informacji i rozrywki dla kobiet, których możliwości partycypacji w kulturze są ograniczone ze względu na miejsce zamieszkania. Z przeanalizowanych danych wynika również, że tradycyjną telewizję linearną, niekiedy nazywaną programową, zastępuje telewizja strumieniowa, choć – jak zaznaczają respondentki – wciąż najwygodniejszym urządzeniem odbiorczym pozostaje telewizor. Podobne do wyników ogólnopolskich są również wyniki słuchalności radia. Niewielki odsetek czytelniczek prasy codziennej i czasopism jest obserwowany w badaniach czytelnictwa na poziomie ogólnopolskim, w szczególności w badanej grupie wiekowej. Interesującym zjawiskiem jest wykazane w trakcie badań przywiązanie respondentek do czytelnictwa prasy podczas wyjazdów lub urlopów. Zaprezentowane dane mają charakter badań wstępnych.The aim of the article is to present the results of research conducted in 2019 and 2020 to answer the question of how, with what intensity and under what circumstances the perception of media content by digital natives living in smaller towns occurs. The analysis shows that the assumed hypotheses regarding the growing role of social media and internet sources have been confirmed. Importantly, in the opinion of the respondents, also the traditional media, i.e. radio and television, are a valuable source of information and entertainment for women whose opportunities to participate in culture are limited by their chosen place of residence. The analyzed data also shows that traditional linear television, sometimes referred to as programmed television, is being replaced by streaming services, although, as the respondents point out, the most convenient receiving device is still a television set. The results of radio listenership are also similar to the national results. A small percentage of readers of the daily press and magazines is also a nationwide trend, especially in the studied demographic, although attachment to reading the press during trips or holidays is an interesting phenomenon that is currently the object of in-depth description in the extended research conducted by the author. The presented data are preliminary studies necessary to expand and discuss future methods and goals
Monitoring And Evaluation Of Adverse Drug Reaction In Emergency Medicine Department: A Prospective Observational Study
No full textBackground: Any deviation from the intended beneficial effect of a medication results in a drug related problem. Adverse drug reactions (ADRs) are negative consequences of drug therapy. It is the fourth to sixth leading cause of mortality in the United States of America.
Aims: To find out the proportion of medical emergency admissions that are secondary to Adverse Drug Reactions(ADRs).
Settings and Designs: An observational, prospective study conducted at the Emergency Medicine Department, at Tertiary Care Teaching Hospital for 12 months, daily from 9 am to 5pm.
Materials and Methods: Patients aged ≥ 18, who have given a written informed consent were included and patients not able to give willing consent and women presented with pregnancy were excluded in the study. The data was recorded in the case record form, The causality assessment was performed using WHO causality assessment scale. To determine the ADR severity, Modified Hartwig and Siegel scale was used.
Statistical Analysis: The statistical evaluation was done with the help of Statistical Package for Social Science (SPSS) version 21.0 manufactured by IBM (demo version) and Microsoft Excel 2016. p< 0.05 was considered as statistically significant.
Results: Elderly patients were having higher incidence of ADRs. Among all drug groups, the highest incidence were antimicrobials and drugs acting on blood. Majority patients either recovered or were in a recovering phase. Most of the ADRs were not preventable.
Conclusions: Reporting of ADRs in a systematic way allows appropriate analysis and intervention which will improve the patient’s safety. Many ADRs could be preventable by avoiding certain drug/drug combinations, hospitalization, dose dependent side effects, appropriate individual dosing and applying the Antimicrobial Stewardship Programme.
Keywords: Adverse Drug Reactions(ADRs), Antimicrobials, Emergency Medicine Departmen
AUDIOSPHERE IN REVITALIZATION
No full textThe article attempts to draw attention to the potential of audio-data, addressing the issue from the point of view of diagnosis made for use in social revitalization process. The author points to the role of sound in the perception and valorization of urban space by its users. It is also pointed out what cognitive possibilities, important from the sociological point of view and resulting from the studies on audio-sphere, exist there. The article outlines the prospect of enriching diagnoses and revitalization projects with information, so far not accounted for but essential in everyday functioning of city residents. Also, the article contains proposals and methodological recommendations directed at persons wishing to incorporate sound aspects into the research accompanying revitalization processes. The author indicates also the basic cognitive and practical advantages that increase the quality of revitalization projects, the realization of which will be possible through integration of phonic studies into the range of diagnosis undertaken with the use of participation.Tekst stanowi próbę zwrócenia uwagi na potencjał drzemiący w danych dźwiękowych, z punktu widzenia diagnoz prowadzonych na użytek procesu rewitalizacji społecznej. Autor wskazuje na rolę dźwięku w postrzeganiu i waloryzowaniu przestrzeni miasta przez jego użytkowników.Wskazuje także możliwości poznawcze, ważne z punktu widzenia socjologii, płynące z badań nad audiosferą. Tekst nakreśla perspektywę wzbogacenia diagnoz i projektów rewitalizacyjnych o nieuwzględniane dotychczas, a istotne dla codziennego funkcjonowania mieszkańców miast informacje. Artykuł zawiera także propozycje i zalecenia metodologiczne skierowane do osób chcących włączyć aspekt dźwiękowy do badań towarzyszących procesom rewitalizacji. Autor wskazuje także podstawowe korzyści poznawcze i praktyczne podnoszące jakość projektów rewitalizacyjnych, których uzyskanie będzie możliwe dzięki włączeniu badań fonicznych w repertuar diagnoz podejmowanych z zastosowaniem partycypacji
Autorstwo 4.0. Czy algorytm może być twórcą?
No full textArticle discusses issues related to copyright law and its adaptation to modern technologies, particularly in the context of artificial intelligence (AI) and its role in the creative process. The author analyzes the historical development of copyright law, its impact on creativity and innovation, as well as on economic development. He particularly focuses on the challenges posed to copyright law by the development of AI, including issues of authorship and intellectual property. The article discusses specific AI legal cases, such as Thaler and the DABUS system, OpenAI and Microsoft v. Non-Fiction Authors, and Thomson Reuters v. ROSS Intelligence concerning authorship issues in a technology-determined modern world. The purpose of the article is, on the one hand, to open a debate on the question of authorship and its form and, on the other hand, the author emphasizes the complexity and dynamic nature of intellectual property protection in the digital age, pointing to the need for constant adaptation of legal and technological frameworks.Niniejszy artykuł omawia zagadnienia związane z prawem autorskim i jego adaptacją do nowoczesnych technologii, szczególnie w kontekście sztucznej inteligencji (AI) i jej roli w procesie twórczym. Autor analizuje historyczny rozwój prawa autorskiego, jego wpływ na kreatywność i innowacje, a także na rozwój gospodarczy. Szczególnie koncentruje się na wyzwaniach, jakie stawia przed prawem autorskim rozwój AI, w tym na kwestiach autorstwa i własności intelektualnej. W artykule omówione są konkretne przypadki prawne dotyczące AI, takie jak sprawa Thalera i systemu DABUS, OpenAI i Microsoft przeciwko autorom non-fiction, oraz Thomson Reuters przeciwko ROSS Intelligence dotyczące kwestii autorstwa w zdeterminowanym przez technologię współczesnym świecie. Celem artykułu jest z jednej strony rozpoczęcie debaty nad kwestią autorstwa i jego formy a z drugiej autor podkreśla złożoność i dynamiczny charakter ochrony własności intelektualnej w erze cyfrowej, wskazując na potrzebę ciągłego dostosowywania prawnych i technologicznych ram
Functional Models of Economic Propaganda in Different Political and Economic Systems – Socialism and Capitalism. Example of Selected Forms of Broadcast Advertising Messages in Poland in the Second Half of the Twentieth Century
No full textMarketing communication in modern times is similar to the propaganda model, i.e. persuasive communication in all possible fields of exploitation. The last three decades in Central and Eastern Europe constituted a time of transformation in many areas of social, political and economic life. Thanks to immanent changes depending on the economic situation and the clash of demand and supply, it was possible to create functional models in three selected time intervals distinguished by the author (socialism, transformational period and capitalism). The use of functional models gives the opportunity to indicate how many changes have taken place in such a short period of time both in terms of consumer mentality and in satisfying the needs of producers. The basis for the application of this type of operationalization of the idea is the statement that “the functional model consists in mapping the functioning of a given system. It should give an idea of the functions and processes taking place in a given system” (Sabryła, Trzciniecki 1986). The purpose of this article is also to start a discussion on contemporary models of product communication
Optimizing Bio-Based Polyurethane Coatings for Enhanced Mechanical Strength and Hydrophobicity through Glycerol and HMDS Modification
No full textThis study focuses on the development of durable, eco-friendly bio-based polyurethane (PU) coatings as sustainable alternatives to petroleum-based products. The research aims to reduce environmental impact while maintaining high performance in coating applications. Bio-based PU coatings were synthesized using soybean oil polyol (SOP), glycerol (GLY) as a crosslinker, and methylene diphenyl diisocyanate (MDI). The study was conducted in two phases: first, optimizing the glycerol content to enhance mechanical properties, and second, incorporating hexamethyldisilane (HMDS) to improve hydrophobicity and chemical resistance. In the first phase, PU coatings were prepared with varying weight percentages (wt.%) of glycerol (0, 5, 10, 15, and 20), and mechanical testing revealed that 10 wt.% GLY provided the best mechanical strength. In the second phase, the optimized formulation was further modified by adding HMDS in different wt.% (10, 20, 30, 40, and 50). The results indicated that 10 wt.% HMDS offered the best tensile strength, but higher concentrations of HMDS negatively affected crosslinking and homogeneity, leading to reduced mechanical performance. FT-IR analysis confirmed the formation of urethane bonds, while DSC and TGA analyses demonstrated the thermal stability of the coatings. Additionally, gel content and degree of swelling tests were conducted to evaluate the crosslinking density. The findings suggest that bio-based PU coatings with optimized glycerol and HMDS content can serve as effective, sustainable alternatives for industrial coating applications, offering a balance of mechanical strength, chemical resistance and environmental benefits
Design & Implementation of Arduino based Self Defense System
No full textLife’s protection wants of the moment nowadays. There are many cases of crimes. Safety of human being things let is whether or not at home, out of doors or it is their workplace. The literature surveyed suggests that a number of weapons are used for human beings' protection purposes. One current research indicates that there is a sneakers chip that is stuck to the footwear that receives activated when the person taps one leg behind the different 4 times. We focus on growing a prototype that is a clever glove that gets activated by using tapping on the switch. Once the system is activated it begins sending the GPS area to the ICE contacts and police manage rooms through GSM. It sends the modern-day vicinity of the victim. A piezoelectric buzzer siren will get activated after 1-2 minutes of the device gets switched on. A shock generator circuit is provided that generates an electric current. On the glove, there are two steel buttons that emit the electric shock when the two buttons come in contact with any surface or anybody. Until the gadget gets off it will keep on sending the location on the interval of 20 seconds and will keep on beeping continuously
