83 research outputs found
Effect of supplementation with high-selenium yeast on plasma lipids: a randomized, controlled trial
No full textA randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin
No full textToenail zinc as a biomarker: relationship with sources of environmental exposure and with genetic variability in MCC-Spain study
No full textThe study was supported by the “Acción Transversal del Cáncer”, approved on the Spanish Ministry Council on the 11 October 2007, by the Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), by the Instituto de Salud Carlos III grants, co-funded by FEDER funds -a way to build Europe- PI08/1770, PI09/0773, PI12/00715, PI09/1903,PI09/2078; PI09/1662; PI11/01403; PI12/00150; PI12/00488; PI15/00914; PI17CIII_00034; by the Fundación Marqués de Valdecilla grant API 10/09, by the Consejería de Salud of the Junta de
Andalucía grant 2009-S0143, by the Conselleria de Sanitat of the Generalitat Valenciana grant AP061/10, by the Regional Government of the Basque Country, by the Fundación Caja de Ahorros de Asturias, by the
University of Oviedo and by the Spanish Ministry of Economy and Competitiveness Juan de la Cierva de Incorporación grant IJCI-2014-20900.Gutiérrez-González E., Fernández-Navarro P., Pastor-Barriuso R., García-Pérez J., Castaño-Vinyals G., Martín-Sánchez V., Amiano P., Gómez-Acebo I., Guevara M., Fernández-Tardón G., Salcedo-Bellido I., Moreno V., Pinto-Carbó M., Alguacil J., Marcos-Gragera R., Gómez-Gómez J.H., Gómez-Ariza J.L., García-Barrera T., Varea-Jiménez E., Núñez O., Espinosa A., Molina de la Torre A.J., Aizpurua-Atxega A., Alonso-Molero J., Ederra-Sanz M., Belmonte T., Aragonés N., Kogevinas M., Pollán M., Pérez-Gómez B
Serum selenium and peripheral arterial disease: Results from the National Health and Nutrition Examination Survey (NHANES) 2003-2004
No full textSocial engagement within the facility increased life expectancy in nursing home residents: a follow-up study [Dataset]
No full textStudy data, STATA do-file, and R script to study the potential causal effect of social engagement on long-term, all-cause mortality in care home residentshttps://repisalud.isciii.es/handle/20.500.12105/11382 [Artículo] https://repisalud.isciii.es/handle/20.500.12105/9378 [Preprint]Social engagement (SE) has been consistently shown to improve survival among community- dwelling older people, but the evidence in nursing home residents is inconclusive and prone to short-term reverse causation and confounding by major health determinants. A representative cohort of 382 nursing home residents in Madrid without severe physical and cognitive impairments at baseline was followed up for 10-year all-cause mortality. Standardized"Pastor-Barriuso_et_al_2020_BMC_Geriatrics_Social_engagement_and_mortality_Data.csv"; "Pastor-Barriuso_et_al_2020_BMC_Geriatrics_Social_engagement_and_mortality_Stata_dofile.txt"; "Pastor-Barriuso_et_al_2020_BMC_Geriatrics_Social_engagement_and_mortality_R_script.txt"; "Pastor-Barriuso_et_al_2020_BMC_Geriatrics_Social_engagement_and_mortality_README.txt"S
Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials
No full textBackground: Laboratory and observational studies suggest that antioxidant and B vitamin supplementation may prevent atherosclerosis. Although trials have not shown a benefit of these supplements on clinical cardiovascular events, it is unknown whether they affect the progression of atherosclerosis as measured by imaging techniques.
Objective: The objective was to perform a meta-analysis of randomized controlled trials of the effect of vitamin-mineral supplementation on atherosclerosis progression.
Design: We searched the MEDLINE, EMBASE, and CENTRAL databases for relevant studies. No language restrictions were applied. We separately analyzed trials using antioxidants (vitamins E and C,
f-carotene, or selenium) and trials using B vitamins (folate, vitamin B-6, or vitamin B-12). The progression of atherosclerosis was evaluated by B-mode ultrasound, intravascular ultrasound, or angiography. Effect sizes were calculated for the difference in slope of atherosclerosis progression between participants assigned to supplements and those assigned to the control group.
Results: In trials not involving percutaneous transluminal coronary angioplasty, the pooled effect size was \u960.06 (95% CI: \u960.20, 0.09; 7 trials) for antioxidants and \u960.93 (95% CI: \u962.11, 0.26; 4 trials) for B vitamins. In trials involving percutaneous transluminal coronary angioplasty, the pooled relative risk of restenosis was 0.82 (95% CI: 0.54, 1.26; 3 trials) for antioxidants and 0.84 (95% CI: 0.34, 2.07; 2 trials) for B vitamins.
Conclusion: Our meta-analysis showed no evidence of a protective effect of antioxidant or B vitamin supplements on the progression of atherosclerosis, thus providing a mechanistic explanation for their lack of effect on clinical cardiovascular events
Escritura y poder en las casas nobiliarias: Materiales de trabajo comentados (Taller)
No full textCon autorización de la editorial para este capítulo.Proyecto I+D (MINECO, ref. HAR2012-34756), «Scripta manent: textos, memoria y poder en linajes bajomedievales sobre los conceptos de nobleza y linaje»
A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin
No full textBackground: Evidence that selenium affects the risk of type-2 diabetes is conflicting, with observational studies and a few randomized trials showing both lower and higher risk linked to the level of selenium intake and status. We investigated the effect of selenium supplementation on the risk of type-2 diabetes in a population of relatively low selenium status as part of the UK PRECISE (PREvention of Cancer by Intervention with SElenium) pilot study. Plasma adiponectin concentration, a recognised independent predictor of type-2 diabetes risk and known to be correlated with circulating selenoprotein P, was the biomarker chosen. Methods: In a randomized, double-blind, placebo-controlled trial, five hundred and one elderly volunteers were randomly assigned to a six-month intervention with 100, 200 or 300 μg selenium/d as high-selenium or placebo yeast. Adiponectin concentration was measured by ELISA at baseline and after six months of treatment in 473 participants with one or both plasma samples available. Results: Mean (SD) plasma selenium concentration was 88.5 ng/g (19.1) at baseline and increased significantly in the selenium-treatment groups. In baseline cross-sectional analyses, the fully adjusted geometric mean of plasma adiponectin was 14% lower (95% CI, 0-27%) in the highest than in the lowest quartile of plasma selenium (P for linear trend = 0.04). In analyses across randomized groups, however, selenium supplementation had no effect on adiponectin levels after six months of treatment (P = 0.96). Conclusions: These findings are reassuring as they did not show a diabetogenic effect of a six-month supplementation with selenium in this sample of elderly individuals of relatively low selenium status
Reconciling the Evidence on Serum Homocysteine and Ischaemic Heart Disease: A Meta-Analysis
No full textThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
ICF-Based Disability Survey in a Rural Population of Adults and Older Adults Living in Cinco Villas, Northeastern Spain: Design, Methods and Population Characteristics
No full textBackground: This article describes the methods of a door-to-door screening survey exploring the distribution of disability and its major determinants in northeastern Spain. This study will set the basis for the development of disability-related services for the rural elderly in northeastern Spain. Methods: The probabilistic sample was composed of 1,354 de facto residents from a population of 12,784 Social Security card holders (age: 6 50 years). Cognitive and disability screenings were conducted (period: June 2008-June 2009). Screening instruments were the MMSE and the World Health Organization Disability Assessment Schedule. Participants screened positive for disability underwent an assessment protocol focusing on primary care diagnoses, disability, lifestyle, and social and health service usage. Participants screened positive for cognitive functioning went through in-depth neurological evaluation. Results: The study sample is described. Usable data were available for 1,216 participants. A total of 625 individuals (51.4%) scored within the positive range in the disability screening, while 135 (11.1%) scored within the positive range of the cognitive screening. The proportion of positively screened individuals was higher for women and increased with age. Conclusions: Screening surveys represent a feasible design for examining the distribution of disability and its determinants among the elderly. Data quality may benefit from methodological developments tailored to rural populations with a low education level. Copyright (C) 2010 S. Karger AG, Base
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