324,992 research outputs found
Fulvio Papi lettore di poesia
No full textMy paper analyzes Fulvio Papi’s essays on poetry. First of all, I consider his reflecting and theoretical essays concerning the forms of philosophical questioning of poetry as a writing practice. I then examine his 2009 essay on Antonia Pozzi’s poetic production. Papi shows how the poet’s vital experience is transfigured in the compositional and enunciative rules of the text
Statistically based multiwavelet denoising
No full textAbstractIn this work, we consider a statistically based multiwavelet thresholding method which acts on the empirical wavelet coefficients in groups, rather than individually, in order to obtain an edge-preserving image denoising technique. Our strategy allows us to exploit the dependencies between neighboring coefficients to make a simultaneous thresholding decision, so that estimation accuracy is increased.By interpreting the multiwavelet analysis in a statistical context, we propose a new weighted multiwavelet matrix thresholding rule, based on the statistical modeling of empirical coefficients. This allows the thresholding decision to be adapted to the local structure of the underlying image, hence producing edge-preserving denoising. Extensive numerical results are presented showing the performance of our denoising procedure
‘A Local Habitation and a Name’: The Dublin Mechanics’ Institute and the Evolution of Dublin’s Public Sphere, 1824–1904
No full textThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Research for this article has been partially funded by the University of Oviedo through the Emerging Research Project PAPI-17-PEMERG-18 and a Campus de Excelencia staff mobility grant (2018)
La scienza di Roma
No full textDa sempre Roma è un crocevia della scienza, personaggi del calibro di Galileo Galilei, Niccolò Copernico, Angelo Secchi, Enrico Fermi, Giovanni Battista Grassi, Stanislao Cannizzaro, Guglielmo Marconi, Vito Volterra, per citarne solo alcuni, nel tempo hanno dato vita ad una miriade di vicende storico-scientifiche note e meno note fatte di umanità, di curiosità e di passione per la ricerca. Aerospazio, agronomia, antropologia, astronomia, biologia, chimica, fisica, matematica, medicina, scienze della Terra: non esistono discipline che non abbiano trovato nella città di Roma la sede per il loro sviluppo e spesso il loro momento fondativo basti pensare all’astrofisica o alla fisica nucleare.
Obiettivo e punto di forza dell’esposizione è quello di raccontare la storia delle idee scientifiche e il loro impatto nella società attraverso i grandi scienziati che a Roma hanno lavorato e le grandi scoperte che qui sono state fatte; il tutto attraverso una commistione di linguaggi in cui si fondano il rigore scientifico e la suggestione estetica, la spiegazione e l’emozione. Una narrazione testuale sintetica e suggestiva accompagna il visitatore nelle nove sezioni della mostra, alternandosi alla contemplazione di reperti scientifici originali emozionanti e spesso inediti come, ad esempio, gli acquarelli delle fasi lunari disegnate da Galileo Galilei, il cranio originale dell’uomo di Neanderthal di Saccopastore, gli strumenti originali dei “ragazzi di via Panisperna”, le tavole sciateriche di Athanasius Kircher. Pensare la Roma del nuovo millennio significa rappresentare l’immagine e l’identità di una storia unica. Una storia nella quale la scienza è fondamentale anche per affrontare le sfide drammatiche del mondo contemporaneo.
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Rome has always been a crossroads of science; figures of the calibre of Galileo Galilei, Copernicus, Angelo Secchi, Enrico Fermi, Giovanni Battista Grassi, Stanislao Cannizzaro, Guglielmo Marconi and Vito Volterra, to name but a few, have breathed life over the centuries into a myriad well-known or lesser-known historical and scientific events imbued with humanity, curiosity and a passion for research. Aerospace, agronomy, anthropology, astronomy, biology, chemistry, physics, mathematics, medicine and earth sciences: there is not a single discipline that has not found in the city of Rome the perfect stage for its development and indeed on many occasions even its founding moment - one has but to think of astrophysics and nuclear physics.
The exhibition sets out to illustrate the history of scientific ideas and their impact on society through the great scientists who have worked in Rome and the major discoveries that have been made here, the whole through a combination of different languages merging scientific stringency and aesthetic appeal, explanation and emotion. A pithy and intriguing textual narrative accompanies the visitor through the nine sections of the exhibition, alternating with the contemplation of exciting original scientific exhibits often never shown in public before, for example the watercolours depicting the phases of the moon painted by Galileo Galilei, the original skull of Neanderthal Man from Saccopastore, the original implements used by the “boys from Via Panisperna” or Athanasius Kircher's Sciateric Tables.
The exhibition layout is enriched with video exhibits and iconographical apparatus in a fascinating and gripping setting designed to integrate players of different kinds (students, citizens, tourists, students,) also through an approach based on science for the people, by the people. Devising the Rome of the new millennium means representing the image and identify of a unique history. A history in which science also plays a crucial role in addressing the dramatic challenges of the contemporary world
Is Pulmonary Artery Pulsatility Index (PAPi) a Predictor of Outcome after Pulmonary Endarterectomy?
No full textBackground: Pulmonary endarterectomy (PEA) is the gold standard therapy for chronic thromboembolic pulmonary hypertension (CTEPH). Traditionally, pulmonary vascular resistance (PVR) represents the main prognostic factor after surgery. The pulmonary artery pulsatility index (PAPi) has been proposed for the assessment of RV in advanced heart failure, but it has never been applied in CTEPH patients. The aim of the present study is to describe PAPi in patients who underwent PEA, before and after surgery, and to define its predictive impact on postoperative outcomes. Methods: We retrospectively reviewed 188 consecutive adult patients who underwent PEA, between December 2003 and December 2021. PAPi was calculated for 186 patients and reported. Patients were partitioned in two groups using median preoperative PAPi as cutoff value: Group 1 with PAPi ≤ 8.6 (n = 94) and Group 2 with PAPi > 8.6 (n = 92). The propensity-score-matched analysis identified 67 pairs: Early outcomes were compared between two groups. Results: Mean preoperative PAPi was 10.3 ± 7.2. Considering matched populations, no differences emerged in terms of postoperative hemodynamics; Group 1 demonstrated higher 90-day mortality significance (10.4% vs. 3.0%, p = 0.082); the need for mechanical circulatory support (MCS) was similar, but successful weaning was unlikely (25% vs. 85.7%, p = 0.032). Conclusions: Mean PAPi in the CTEPH population is higher than in other diseases. Low PAPi (≤8.6) seems to be associated with lower postoperative survival and successful weaning from MCS
Optimal Asset-Liability Management with Constraints: A Dynamic Programming Approach.
No full textThis paper is devoted to the analysis of a discrete-time dynamic programming algorithm for the numerical solution of an optimal asset-liability management model with transaction costs and in presence of constraints. By exploiting the financial properties of the model, we propose an approximation method based on the classical dynamic programming algorithm, which reduces significantly the computational and storage requirements of the algorithm and avoids any artificial boundary condition. The regularity of the value function is used to estimate the global error introduced by the numerical procedure and to prove a convergence result
PhD
No full textdissertationThe expression of Pap pili alternates between ON (pili+) and OFF (pili-) states, a process called phase variation. Pap phase variation is controlled by Leucine responsive regulatory protein (Lrp), PapI, and Deoxyadenosine methylase (Dam). Methylation patterns of two GATC sites in the pap regulatory region are established by competition between Dam methylation and Lrp binding. In the phase OFF state, Lrp binds cooperatively to promoter proximal binding sites (1,2,3) and protects GATC-II from methylation whereas GATC-I is methylated. In the phase ON state Lrp binds to distal binding sites (4,5) protecting GATC-I from methylation whereas GATC-II is methylated. Lrp binding to GATC-I required PapI, suggesting that PapI is required for switching to the phase ON state. PapI bound specifically to Lrp-pap DNA complexes, but not Lrp-ilvIH, Lrp in solution or pap DNA. PapI reduced the affinity of Lrp for sites (1,2,3) and increased the affinity for sites (4,5) resulting in translocation of Lrp from the pap GATC-II region to the pap GATC-I region. These observations suggested that Lrp and PapI may directly interact in switching to phase ON. To identify PapI-Lrp binding sites, mutagenesis of papI and lrp was performed. Mutagenesis of papI yielded mutations that resulted in unstable proteins. A novel two color genetic screen was performed to identify pap-specific mutations in lrp. papBA-phoA (blue indicator) and ilvIH-lacZYA (red indicator) fusions generated purple colonies in the presence of wild type lrp. Red colonies were chosen because they contained lrp mutations that could activate ilvIH but not papBA transcription. One mutant, designated Lrp[E133G failed to translocate to GATC-I but was competent for pap and ilvIH DNA binding and PapI-pap DNA binding. Another pap-specific mutation, LrpY115C] may be defective in PapI binding. Furthermore, radiolabeled PapI bound to an Lrp peptide spanning amino acids 105-118. Together, these data indicate that Lrp contains a PapI binding site and a region required for translocation to GATC-I. A model for PapI mediated translocation of Lrp in the phase OFF to phase ON switch is presented
Un lungo percorso con Guido
No full textThe essay looks back at the most important steps of the relationship between the author and his friend Guido Davide Neri: it is remembered the different way they used to approach the philosophy of history, in particular Marxism, although they were both students of the same professor, Banfi. Their attitude towards the historical background of those years was different too because Neri moved towards socialism, made a theoretical-philosophical consideration, while Papi was more pragmatic and focused on practical policy. The author runs through the philosophical season of 70’s shared and experienced with his friend, when the theoretical background of the University of Milan was focused on the Husserl’s lifeworld, inaugurated in Italy by Enzo Paci
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