647 research outputs found
Correction: Corrigendum: Lipid-II Independent Antimicrobial Mechanism of Nisin Depends On Its Crowding And Degree Of Oligomerization
No full textScientific Reports 6: Article number: 37908; published online: 29 November 2016; updated: 10 February 2017. The original version of this Article contained an error in the spelling of the author Pankaj Ror which was incorrectly given as Pankaj Kumar. This has now been corrected in the PDF and HTML versions of the Article.</jats:p
Update of CSIC author affiliations in ROR (Research Organization Registry)
No full textLa Red.-- Transparencia y visibilidad: soluciones y reflexiones en el día a día de nuestra labor.[ES] Research Organization Registry (ROR) es un registro global de identificadores persistentes abiertos para organizaciones de investigación. En 2023, el CSIC se asoció con ROR, actualizando exhaustivamente sus centros en el registro para mejorar la normalización de las filiaciones de sus autores.[EN] Research Organization Registry (ROR) is a global registry of open persistent identifiers for research organizations. In 2023, CSIC partnered with ROR, comprehensively updating its centers in the registry to improve the standardization of its authors' affiliations.Peer reviewe
Correspondances pour organisations de recherche incluant identifiants ROR/Research organization matching including ROR identifiers
No full textDonnées permettant d'uniformiser les différentes formes des noms des organisations de recherche, et d'associer un identifiant ROR. Un total de 133 058 formes réfèrent à 100 155 noms uniformisés, dont 98 238 sont associés à un identifiant ROR. Les données ont été collectées notamment lors d'analyses d'affiliations sur la plateforme d'Érudit et pour cette raison les organisations présentes se trouvent notamment au Canada, puis en France et aux États-Unis.
Dataset created to standardize the various names of research organizations, and to associate a ROR identifier. A total of 133,058 names refer to 100,155 standardized names, of which 98,238 are identifiable by a ROR identifier. The data were collected while analyzing author affiliations on the Érudit platform, and for this reason the organizations present are typically from Canada, as well as France and the United States.</i
Biochanin A enhances ROR gamma activity through STAT3-mediated recruitment of NCOA1
No full textInterleukin (IL)-17-producing T cells play important roles in autoimmunity, chronic inflammation and host protection against extracellular bacteria and fungi. The retinoic acid receptor-related orphan receptors (ROR) alpha and beta are key regulators of the IL-17-producing phenotype. We previously showed that the isoflavone biochanin A enhanced ROR-mediated transcriptional activity. Here, we investigated the possible mechanisms underlying this ROR activation. Biochanin A-treated murine thymoma EL4 and primary splenocytes demonstrated enhanced induction of IL-17. Biochanin A also induced tyrosine-phosphorylation of signal transducer and activator of transcription 3 (STAT3) in these cells. Stable knockdown of either ROR gamma or STAT3 in EL4 cells canceled biochanin A-induced upregulation of IL-17 expression. Importantly, biochanin A enhanced complex formation between ROR gamma and STAT3 or nuclear-receptor coactivator 1 (NCOA1). Furthermore, the biochanin A-induced ROR gamma-NCOA1 complex was disrupted by a dominant negative mutant of STAT3 or by the STAT3 specific inhibitor Stattic. These results suggest that biochanin A activates ROR gamma-dependent IL-17 transcription through the enhancement of STAT3 phosphorylation and STAT3-mediated recruitment of NCOA1 to ROR gamma. (C) 2017 Elsevier Inc. All rights reserved
Use of Research Organizations Registry (ROR) identifiers in author academic profiles: the case of Google Scholar Profiles [dataset]
No full textDocument in .xlsx format. Contains 2 sheets. The first, entitled "profiles", has 10 columns (Orcid no.; id; Name; Domain; Citations; Description; Keywords; Field; Gender and Type) and 1032 rows (number of authors' profiles). The second sheet contains the discarded profiles.
To protect personal data, Name column data values (Profiles Sheet: C Column; Discarded Sheet: B Column) have been replaced by a correlation number and Citations column data values (Profiles Sheet: E Column; Discarded Sheet: D Column) have been replaced by X value.
The purpose of this work is to determine the use of Research Organizations Registry (ROR) IDs in author academic profiles, specifically in Google Scholar Profiles (GSP). To do this, all the Google Scholar profiles including the term ROR in any of the public descriptive fields were collected and analyzed. The results evidence a low use of ROR IDs (1,033 profiles), mainly from a few institutions
Effectiveness and Contribution Of Street Lighting Tax (STL) to Regional Original Revenue (ROR) of Medan City
No full textOne of the factors that affect the amount of Regional Original Revenue in Medan City is local taxes. Local taxes are one of the main sources of revenue whose proceeds are used to finance local expenditures in the implementation of development and government. One of the local taxes in Medan City is the Street Lighting Tax (STL). Street Lighting Tax (STL) is one of the local taxes that contribute to Medan City's Local Revenue. Therefore, the author then wants to discuss it in this final project with the title "Effectiveness and Contribution of Street Lighting Tax (STL) to Regional Original Revenue (ROR) of Medan City".
This study aims to determine the Effectiveness and Contribution of Street Lighting Tax (STL) to Regional Original Revenue (ROR) of Medan City with the object of this final project research is "Medan City Street Lighting Tax 2018 - 2022".
This research uses a simple quantitative approach that is descriptive in nature used to explain and obtain measurable numerical data, and provide a more objective picture of the effectiveness and contribution of street lighting tax to local revenue.
Through research that has been conducted by the author, the effectiveness of Street Lighting Tax on Medan City's Regional Original Revenue (ROR) tends to decrease from 2018 - 2022 with criteria ranging from very effective to less effective and the contribution of Street Lighting Tax to Medan City Regional Original Revenue (ROR) in 2018 - 2022 is also included in the criteria less with an average contribution of 19.4%.84 PagesKertas Karya Diplom
Uso de identifcadores del Registro de Organizaciones de Investigación (ROR) en perfles académicos de autor: el caso de Google Scholar Profles
No full text[EN] Research organizations¿ persistent identifiers allow for
reducing affiliation ambiguities, enable accurate institutional
analyses and favor the design of modern online scholarly
databases suited for research discovery and research
evaluation. However, few studies have attempted to
quantify their degree of use. The purpose of this work is
precisely to determine the use of Research Organizations
Registry (ROR) IDs in author academic profiles, specifically
in Google Scholar Profiles (GSP). To do this, all the Google
Scholar profiles including the term ROR in any of the public
descriptive fields were collected and analyzed. The results
evidence a low use of ROR IDs (1,033 profiles), mainly from
a few institutions (e.g. Pontificia Universidad Javeriana
in Colombia, and Escuela Superior Politécnica del Litoral
in Ecuador hold 55.7% of all profiles), from low citationbased impact authors (45.1% of profiles attain less than
100 citations each), belonging mainly to Social Sciences
(26.3%), Engineering fields (25.3%), and Natural Sciences
(22.2%). Although Google Scholar does not facilitate
the inclusion of identifiers, it seems that the world¿s
leading research institutions are not recommending their
researchers include these identifiers in their profiles yet.[ES] Los identificadores persistentes de las organizaciones de
investigación permiten reducir las ambigüedades de afiliaciones, realizar análisis institucionales precisos y favorecen
el diseño de modernas bases de datos online académicas adecuadas para el descubrimiento y la evaluación la
investigación. Sin embargo, pocos estudios han intentado
cuantificar su grado de utilización. El propósito de este trabajo es precisamente determinar el uso de los ID del Registro
de Organizaciones de Investigación (ROR) en los perfiles
académicos de los autores, específicamente en los perfiles
de Google Scholar (GSP). Para ello, se recopilaron y analizaron todos los perfiles de Google Scholar que incluían el
término ROR en alguno de los campos descriptivos públicos.
Los resultados evidencian un bajo uso de identificadores ROR
(1.033 perfiles), principalmente de pocas instituciones (por
ejemplo, la Pontificia Universidad Javeriana en Colombia y
la Escuela Superior Politécnica del Litoral en Ecuador tienen
el 55,7% de todos los perfiles), de autores de bajo impacto
basado en citas (el 45,1% de los perfiles alcanzan menos
de 100 citas cada uno), pertenecientes principalmente a los
campos de Ciencias Sociales (26,3%), Ingenierías (25,3%)
y Ciencias Naturales (22,2%). Aunque Google Scholar no
facilita la incorporación de identificadores, parece que las
principales instituciones de investigación del mundo aún no
recomiendan a su personal investigador la inclusión de estos
identificadores en sus perfilesThis project has been supported by the project UNIVERSEO (Ref. GV/2021/141), funded by the regional government (Generalitat) of Valencia (Spain).Orduña Malea, E.; Bautista-Puig, N. (2022). Use of Research Organizations Registry (ROR) identifiers in author academic profiles: the case of Google Scholar Profiles. Hipertext.net. (25):113-122. https://doi.org/10.31009/hipertext.net.2022.i25.11S1131222
Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors alpha and gamma
No full textThe retinoic acid receptor-related orphan receptors a and gamma (ROR alpha and ROR gamma), are key regulators of helper T (Th)17 cell differentiation, which is involved in the innate immune system and autoimmune disorders. In this study, we investigated the effects of isoflavones on ROR alpha/gamma, activity and the gene expression of interleukin (IL)-17, which mediates the function of Th17 cells. In doxycycline-inducible CHO stable cell lines, we found that four isoflavones, biochanin A (BA), genistein, formononetin, and daidzein, enhanced ROR alpha- or ROR gamma-mediated transcriptional activity in a dose-dependent manner. In an activation assay of the Il17a promoter using Jurkat cells, these compounds enhanced the ROR alpha- or ROR gamma-mediated activation of the Il17a promoter at concentrations of 1 x 10(-6) M to 1 x 10(-5) M. In mammalian two-hybrid assays, the four isoflavones enhanced the interaction between the RORa- or ROR gamma-ligand binding domain and the co-activator LXXLL peptide in a dose-dependent manner. In addition, these isoflavones potently enhanced Il17a mRNA expression in mouse T lymphoma EL4 cells treated with phorbol myristate acetate and ionomycin, but showed slight enhancement of Il17a gene expression in ROR alpha/gamma-knockdown EL4 cells. Immunoprecipitation and immunoblotting assays also revealed that BA enhanced the interaction between ROR-gamma t and SRC-1, which is a co-activator for nuclear receptors. Taken together, these results suggest that the isoflavones have the ability to enhance IL-17 gene expression by stabilizing the interactions between ROR alpha/gamma, and co-activators. This also provides the first evidence that dietary chemicals can enhance IL-17 gene expression in immune cells. (C) 2015 Elsevier Ireland Ltd. All rights reserved
Ror Wolfs radikaler Realismus im Kontext experimenteller Prosa der 1950er-1980er Jahre
No full textWeltabgewandter Sprachspieler oder »radikaler Realist«? Fremd- und
Selbstzuschreibung gehen in Bezug auf den Autor Ror Wolf weit auseinander. Dies
gründet auf einer nur scheinbaren Paradoxie: In Wolfs vielgestaltigem Werk
vollzieht sich der Zugriff auf Wirklichkeit gerade im Modus der Sabotage,
Unterbrechung, Irritation oder Verzerrung – kurz: im Modus der Störung.
Ausgehend von der langen Prosa fragt Barbara Bausch nach möglichen Formen
literarischer Referenzialität. Dabei konturiert sie Wolfs experimentelle und
zugleich engagierte Poetik des ästhetisch produktiven Störens als Kreuzungspunkt
verschiedenster Suchbewegungen des Prosaschreibens in den 1950er bis 1980er
Jahren.In reviews, the prose of Ror Wolf has often been described as a play on words because of its experimental procedures, while the author calls himself, albeit tongue-in-cheek, a ‚radical realist‘. Between these poles, the present study tries to sound out Wolf’s poetics. The analyses focus a prose writing that leaves traditional narrative procedures far behind and pursues a wide range of disruptive strategies. With this poetics, that I contour as a ‚poetics of disruption‘, the specific ‚realism‘ of Wolf’s prose comes into view. According to the guiding thesis, his long prose works model their access to reality precisely through practices of disruption, which include e.g. the disruption of the fluid progress of the prose, the referential function of language or the idea of the text as a ‚whole‘. Far from a realistic technique, Wolf’s approach to reality ranges from forms of disclosing the reality of the literary text itself, to reflecting on the possibilities of (realistic) representation and the relation of the modern subject to reality, to critical references to social reality. On the one hand, Wolf’s poetics articulate a desire for the disclosure of a linguistically non-representable real; at the same time, this desire is marked as a utopian aspiration that―if at all―can only find realization in the process of reading. By means of comparative references to prose works and poetological reflections of contemporary authors, it becomes clear that Ror Wolf, who throughout his life occupied a marginal position in the literary field, finds himself at the intersection of the most diverse literary movements of his time. Wolf’s poetics of disruption, which is experimental and politically engaged at the same time, is to be read in particular in the context of the 1960s, the period in which it emerged: It feeds on literary tendencies of the 1950s and early 1960s, breathes the provocative spirit of ‚1968‘, and anticipates developments that will only come to full bloom in the further course of literary history
Towards adjoint-based mesh refinement for Large Eddy Simulation using reduced-order primal solutions: Preliminary 1D Burgers study
No full textAdaptive Mesh Refinement (AMR) is potentially an effective way to automatically generate computational meshes for high-fidelity simulations such as Large Eddy Simulation (LES). When combined with adjoint methods, which are able to localize error contributions, AMR can generate meshes that are optimal for computing a physical quantity of interest (e.g. lift or drag). In order to apply adjoint-based AMR techniques to LES, primal flow solutions are needed to solve the adjoint problem backward in time. However, the resources required to store primal flow solutions can be huge, even prohibitive, in practical problems because of the typically very fine meshes and long averaging times for computing the statistical quantities of interest. Here, a Reduced-Order Representation (ROR) based upon proper orthogonal decomposition is introduced to address this issue. We develop an Enhanced Online Algorithm (EOA) based on incremental singular value decomposition to build this ROR online, which makes adjoint-based AMR feasible for practical applications. An adjoint-based error estimation procedure is first introduced, and verified using a manufactured solution. Then a ROR-driven AMR strategy is studied using a 1D unsteady Burgers problem with a multi-frequency forcing term. This is also used to evaluate the EOA for ROR-driven AMR. Numerical results demonstrate that the enhanced online algorithm generates RORs that are sufficiently accurate for AMR, avoiding the storage of almost all of the primal solution data.Aerodynamic
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