1,721,033 research outputs found
Telemonitoraggio e telecontrollo di impianti per la gestione del servizio integrato idrico della GORI
No full textMetodologie di analisi e di progettazione di alcuni sottosistemi di un impianto di distribuzione di acqua potabile e di depurazione delle acque reflue. Realizzazione di un sistema prototipale di telemonitoraggio della torbidezza e della resistività e di telecontrollo di una pompa e/o di una elettrovalvola
Immunobiology of essential mixed cryoglobulinemia
Full text linkIntroduction
Mixed cryoglobulinemia (MC) is characterized by the production of monoclonal (type II MC) or polyclonal (type III MC) rheumatoid factors (RF), which form with endogenous IgG cold-precipitable immune complexes that cause small-vessel vasculitis and multi-organ damage. Hepatits C virus is the causative agent in 90% of MC patients, usually characterized by the expansion of an anergic B cell subpopulation called CD21low B cells. Only a minority of the patients has idiopathic or essential MC (EMC) and the B cell population has been scarcely investigated so far.
Objective: to characterize the phenotypical and functional proprieties of B cells in EMC and compare them with those of HCV-related MC and from healthy donors.
Method
The B cell phenotype and function was studied in 13 patients with EMC and compared to 24 patients with HCV-MC. The proliferative response of B cells was investigated through the CFSE assay, the intracellular pERK content was measured by the BD Phos-Flow system and apoptosis was measured through annexin/7AAD staining. All the analyses were performed by flow-cytometry.
Results
EMC patient showed significant lower absolute numbers of circulating B cells compared to HCV-MC (mean ± SD: 185/mm3 ± 236 vs 529/mm3 ± 795). Interestingly percentages and absolute numbers of CD21low B cells were significantly higher in EMC compare to HD but lower than HCV-MC patients. Similarly to CD21low B cells found in HCV MC, CD21low B cells in EMC proliferated poorly in response to TLR9 stimulation, displayed dysregulated pERK signaling and were apoptosis prone.
Conclusion
Similar features of virus-specific exhaustion and anergy induced by continual antigenic stimulation observed in B cells expanded in HCV-MC are found in B cells EMC. Our findings open the question of a possible role of a still yet unknown antigen responsible for the development of EMC
A. Berselli, A. Bertondini, L. Dal Pane, S. Nardi, A. Pagani, G. Porisini, Nullo Baldini nella storia della cooperazione.
No full textDavico Rosalba. A. Berselli, A. Bertondini, L. Dal Pane, S. Nardi, A. Pagani, G. Porisini, Nullo Baldini nella storia della cooperazione.. In: Annales. Economies, sociétés, civilisations. 22ᵉ année, N. 6, 1967. pp. 1364-1367
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Soft microrobotics
No full textIn the last few decades, the highly multisciplinary field of microrobotics has seen important developments. Among the most significant landmarks in the field is the introduction of soft materials in the microfabrication of untethered devices. Novel functionalities and actuation strategies have been implemented thanks to the use of soft and smart materials. In this context, it is useful to take stock of the current situation of soft microrobotics to provide a complete overview of the field. The present chapter describes materials, fabrication techniques, actuation strategies and applications of microrobots fabricated of soft materials. Finally, we also focus on some peculiar types of materials such as biological structures and hard-soft hybrids
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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