149 research outputs found
Molecular targets of omega-3 fatty acids for cancer therapy
No full textNowadays, dietary guidelines acknowledge the therapeutic role of omega-3 polyunsaturated fatty acids, as the most important class of fatty acids, against different human diseases. During the last two decades, the average level of consumption of omega-3 polyunsaturated fatty acids has increased from 0.1 to 0.2 g per day. Omega-3 polyunsaturated fatty acids are a group of long-chain polyunsaturated fatty acids which are identified in different foods such as fatty fish, shellfish, and vegetable oils. A growing body of epidemiological and experimental evidence supports the anticancer effects of omega-3 polyunsaturated fatty acids, which led to the identification of their molecular targets in several cancer models. The present review focuses on the basic evidence supporting the potential applications of omega-3 polyunsaturated fatty acids in cancer therapy
DIODE LASER SPECTRA OF AND OTHER MOLECULES AT 12-14 m
No full text P. P. Das, V. Malathy Devi and K. Narahari Rao, J. Mol. Spectrosc. (in press). J. M. Flaud, C. Camy-Peyret, V. Malathy Devi P. P. Das. K. Narahari Rao, J. Mol. Spectrosc. (in press).Author Institution:Perpendicular bands of several symmetric and near symmetric top molecules like , etc., have been studied using a tunable diode laser spectrometer in the region. The limited tunability of the diode laser is compensated by its high resolution and sensitivity so that from the analysis of the Q branches alone precise band centers and rotational constants could be determined. It is known from microwave studies that has a large nuclear quadrupole coupling constant. The nuclear spin (I) of of iodine combines with J and splits the rotational levels into 2I + 1 = 6 components for J. Selection rules show that for J line of the band is split into several components which should be resolved under Doppler-limited resolution. Such splittings were seen in the spectrum of The effect of diode laser line width on the observed spectrum will also be discussed. In the case of the presence of a single D atom removes the degeneracy of in and splits it into and , Although the asymmetry is extremely small (x = -0.9983), spectacular asymmetry effects were observed in the band for and 3. A sixth order Watson reduced Hamiltonian was used to explain these effects. In , the electron spin couples with the rotational angular momentum J of the molecule and splits it into two components Such, splittings have been observed in the band spectrum of from which accurate spin-rotation interaction constants have been $determined.^{2}
Molecular targets of curcumin for cancer therapy: an updated review
No full textIn recent years, natural edible products have been found to be important therapeutic agents for the treatment of chronic human diseases including cancer, cardiovascular disease, and neurodegeneration. Curcumin is a well-known diarylheptanoid constituent of turmeric which possesses anticancer effects under both pre-clinical and clinical conditions. Moreover, it is well known that the anticancer effects of curcumin are primarily due to the activation of apoptotic pathways in the cancer cells as well as inhibition of tumor microenvironments like inflammation, angiogenesis, and tumor metastasis. In particular, extensive studies have demonstrated that curcumin targets numerous therapeutically important cancer signaling pathways such as p53, Ras, PI3K, AKT, Wnt-β catenin, mTOR and so on. Clinical studies also suggested that either curcumin alone or as combination with other drugs possess promising anticancer effect in cancer patients without causing any adverse effects. In this article, we critically review the available scientific evidence on the molecular targets of curcumin for the treatment of different types of cancer. In addition, we also discuss its chemistry, sources, bioavailability, and future research directions
Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway
No full textCardiovascular diseases comprise of non-communicable disorders that involve the heart and/or blood vessels and have become the leading cause of death worldwide with increased prevalence by age. mTOR is a serine/threonine-specific protein kinase which plays a central role in many physiological processes including cardiovascular diseases, and also integrates various proliferative signals, nutrient and energy abundance and stressful situations. mTOR also acts as central regulator during chronic stress, mitochondrial dysfunction and deregulated autophagy which are associated with senescence. Under oxidative stress, mTOR has been reported to exert protective effects regulating apoptosis and autophagy processes and favoring tissue repair. On the other hand, inhibition of mTOR has been suggested to have beneficial effects against atherosclerosis, cardiac hypertrophy and heart failure, and also in extending the lifespan. In this aspect, the use of drugs or natural compounds, which can target mTOR is an interesting approach in order to reduce the number of deaths caused by cardiovascular disease. In the present review, we intend to shed light on the possible effects and molecular mechanism of natural agents like polyphenols via regulating mTOR
THE V3 SPECTRAL REGION OF : ASSIGNMENTS AND MOLECULAR CONSTANTS
No full textAuthor Institution: Physics Department, College of William and Mary; Laboratoire d'Infrarouge, Universit\'e de Paris-Sud; Department of Physics, Ohio State UniversityPositions of a few thousand spectral lines on the Fourier transform and diode laser spectrea by Malathy Devi have been measured. Numerous transitions involving and have been identified and assignments made for over 20 bands. Molecular constants have been derived for the identified bends and comparisons of these constants with the previously reported values for nine bands will be made. Comparison to theoretically predicted values will be made for all of the bands. 1V. Malathy Devi, G. Guelachvili, D.C. Benner and K. Narahari Rao, this session
THE HIGH RESOLUTION SPECTRUM AND ROTATIONAL ANALYSIS OF THE BAND OF CARBONYL FLUORIDE
No full text C. P. Rinsland et al., preceding abstract. J. H. Carpenter, J. Mol. Spectrosc., 50, 182-201 (1974). Address of Thakur and Rao: Physics Department, The Ohio State University, 174 West 18th Avenue, Columbus, Ohio, 43210. Address of Friedl: Jet Propulsion Laboratory, Mail Stop 183-601, 4800 Oak Grove Drive, Pasadena, California, 91109. Address of Rinsland: NASA Langley Research Center, Mail Stop 401A, Hampton, Virginia, 23665-5225. Address of Malathy Devi: Physics Department, college of William and Mary, Williamsburg, Virginia, 23185.Author Institution:The asymmetric top molecule has gained additional interest as the presence of the and bands of it have been observed recently in resolution spectra of the . To provide spectroscopic parameters needed for the analysis of absorption in such atmospheric spectra, resolution laboratory spectra of the band have been recorded at room temperature and a full rotatinal analysis has been performed. The laboratory data were obtained with a Bomen Fourier transform spectrometer at the Jet Propulsion Laboratory. Lines in the band of OCS were used for calibration. Although the strong Q branch at is only partially resolved in the laboratory data, most of the K structure of various J subgroups in the P and R branches is fully resolved. With the help of ground-state rotational constants obtained from the microwave data of , around 1300 transition up to have been assigned and fitted to a standard deviation of . By incorporating quartic and sextic centrifugal distortion coefficients of Watson's reduced Hamiltonian into the analysis, upper state rotational constants A, B, and C have been determined to an accuracy better than . The results will be discussed along with the asymmetry splitting of the low K transitions for each J. This work was supported under USAF Agreement RES D5-674 with the Air Force Geophysics Laboratory
Analisis Yuridis Putusan Sengketa Merek antara Starbucks Corporation dan PT Sumatra Tobacco Trading Company(Studi Putusan Makamah Agung Nomor 836 K/PDT.SUS-HKI/2022)
No full textA trademark, which is a form of intellectual property, is essentially a sign used
to distinguish the origin of goods and services from one company from those of
another. The brand dispute case that arose in Cassation Decision Number 836
K/PDT.SUS-HKI/2022 pitted the Sumatra Tobacco Trading Company against the US
coffee franchise Starbucks. Several issues were raised as a result of this decision,
including how to protect registered trademarks, how to settle trademark disputes, and
what the judge's legal considerations were in the trademark dispute between
Starbucks Corporation and PT Sumatra Tobacco Trading Company over Strbuck as
a well-known brand based on decision No. 836 K/Pdt. Sus-Hki/2022.
A case study approach to decisions is the research methodology employed in
this work, which is juridical-normative. The author employed primary, decisionbased,
and secondary research data. The author's method for gathering data included
looking through some data or supporting sources through literature research, and the
study's data analysis was qualitative.
Well-known brands can be protected in two different ways: through preventive
legal measures like trademark registration and reflective legal measures like filing a
lawsuit. According to the Supreme Court's ruling in case number 836 K/Pdt.Sus-
HKI/2022, it was established that PT.STTC had performed the Mark matching even
though many class types were registered. Arbitration or other alternative dispute
resolution procedures can be used to address trademark issues. Legislation Number
20 of 2016 governing Trademarks and Geographical Indications, which requests the
deletion of the "Starbucks" Mark for Class 34 owned by PT Sumatra Tobacco
Trading Company (STTC), is the foundation for the judge's consideration in Decision
Number 836 K/Pdt.Sus-HKI/2022.141 HalamanTesis Magiste
Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: An<i>in vitro</i>study
No full textABSOLUTE INTENSITIES OF LINES IN THE 9-11 REGION
No full textM. A. Smith, C. P. Rinsland, V. Malathy Devi and D. Chris Benner, 51st International Symposium on Molecular Spectroscopy, Paper MH14 (1996). H. M. Pickett, D.B. Peterson, and J.S. Margolis, J. Geophys. Res 97,20,787-20793 (1992). D. Chris Benner, C.P. Rinsland, V. Malathy Devi, M.A.H. Smith and D. Atkins, JQSRT 53, 705-721(1995). L. S. Rothman, R.R. Gamache, R. H. Tipping, C.P. Rinsland, M.A.H. Smith, D.C. Benner, V. Malathy Devi, J.M. Flaud, C. Camy-Peyrer, A. Perrin, A. Goldman, S.T. Massiee, L.R. Brown, and R.A. Toth, JQSRT 48,469-507(1992); L.S. Rothman et. al., in preparation.(1997). M.R. DeBacker and D. Courtois, 50th International Symposium on Molecular Spectroscopy, Paper RA06 (1995). M.R. DeBacker, B. Parvitte, V. Zeninari, and D. Courtois, JQRST 54, 1009-1018(1995).Author Institution: Atmospheric Sciences Division, NASA Langley Research Center; Department of Physics, The College of William and MaryWe have extended our previous analysis of high-resolution absorption spectra of to determine absolute intensities of nearly 200 lines in the 9-11 region. The spectra were recorded at room temperature using the Fourier transform spectrometer at the McMath-Pierce facility of the National Solar Observatory at Kitt Peak, covering the region at resolution. The ozone samples were contained in a glass cell having crossed IR-transmitting and UV-transmitting paths approximately 10 cm in each direction. A 254 nm UV-absorption monitor of the same design as Pickett was used to measure the ozone partial pressures, which were kept at approximately 0.3 to 0.5 Torr to prevent the appearance of saturated lines. Only spectra for which the ozone partial pressure varied by during the recording time were selected for analysis. Using our multispectrum nonlinear least-squares we have fit four spectra simultaneously to determine intensities for numerous lines in both the P and R branches of the fundamental band and several lines in the band. On average, our measured intensities are only 1% larger than the values on the current HITRAN . Our measurement set includes 44 lines in common with other recent experimental Comparison of these various measurements shows excellent agreement for a few lines and adequate agreement (considering all possible sources of uncertainty and systematic errors) for the others
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