325 research outputs found
Mitogenomes from Two Uncommon Haplogroups Mark Late Glacial/Postglacial Expansions from the Near East and Neolithic Dispersals within Europe
No full textThe current human mitochondrial (mtDNA) phylogeny does not equally represent all human populations but is biased in favour of representatives originally from north and central Europe. This especially affects the phylogeny of some uncommon West Eurasian haplogroups, including I and W, whose southern European and Near Eastern components are very poorly represented, suggesting that extensive hidden phylogenetic substructure remains to be uncovered. This study expanded and re-analysed the available datasets of I and W complete mtDNA genomes, reaching a comprehensive 419 mitogenomes, and searched for precise correlations between the ages and geographical distributions of their numerous newly identified subclades with events of human dispersal which contributed to the genetic formation of modern Europeans. Our results showed that haplogroups I (within N1a1b) and W originated in the Near East during the Last Glacial Maximum or pre-warming period (the period of gradual warming between the end of the LGM, ~19 ky ago, and the beginning of the first main warming phase, ~15 ky ago) and, like the much more common haplogroups J and T, may have been involved in Late Glacial expansions starting from the Near East. Thus our data contribute to a better definition of the Late and postglacial re-peopling of Europe, providing further evidence for the scenario that major population expansions started after the Last Glacial Maximum but before Neolithic times, but also evidencing traces of diffusion events in several I and W subclades dating to the European Neolithic and restricted to Europe
A DH-Leavened Musicological Toolbox
No full textGraduate-level training in music research methodologies tends to ignore digital humanities work and overlook the use of digital tools created in support of new forms of reading. Training instead focuses on source material in the student’s area of interest. This material includes secondary and primary (archival) resources, as well as information resources, such as: monuments of music and critical editions; indexes; bibliographies and thematic catalogs; dictionaries and encyclopedias; digital libraries of scores or editions; and databases of period-specific newspapers or journals. Graduate students taking research methods courses already have a toolbox built from their experiences as musicians and students of music, including the ability to read and interpret music notation, to understand theoretical and analytical concepts in music, as well as a command of music history, including the canon of musical works.
Digital humanities has become a major area of academic endeavor at the “interface of technological development, epistemological change and methodological concerns." An important characteristic of digital humanities research has been its interdisciplinarity. We argue that graduate training in musicology needs to include coverage of methodologies applied by digital humanists in support of new forms of reading, not only to broaden the canon of research topics in musicology, but also to build common ground with researchers of other disciplines. We propose that librarians are well positioned to provide this expertise and training
Le differenti gioventù del '68, in: Uguaglianze/differenze. Riflessioni per Anna Rossi-Doria
No full textIn questo articolo l’A. riassume i punti essenziali della sua ipotesi interpretativa a proposito della “generazione del 68”.
Convinta della necessità di decostruire questa categoria, Francesca Socrate si propone di analizzare il profilo sociale e culturale delle studentesse e degli studenti universitari che fecero parte del movimento focalizzando l’attenzione in primo luogo sulla loro età, per arrivare alla definizione di almeno due “generazioni sociali” che, per quanto separate da una ridotta distanza anagrafica, portano i segni di due culture tra loro distanti: la prima è quella dei nati durante gli anni della guerra; la seconda, quella dei nati tra il ‘46 e il ’51. Alla prima coorte generazionale appartengono la maggior parte dei leader del movimento studentesco, alla seconda ragazzi e ragazze più giovani che sono presenti nel movimento, spesso con un’alta intensità di partecipazione, ma in una posizione gregaria. L’A. mette in rilievo come questo rapporto sia nella sostanza solo apparente, dal momento che nell’intreccio fra le due componenti generazionali saranno i più giovani a imporre la loro cultura generazionale, non tanto nelle sue teorizzazioni ma nelle pratiche, mentre le parole, le parole chiave e le parole d’ordine, saranno trovate dalla prima generazione, quella dei nati durante gli anni della guerra.The Diverse Youth Groups of '68
In this paper, the author summarises the main points of her interpretative hypothesis regarding the "'68 generation".
A conviction of the need to deconstruct this category prompted Francesca Socrates to attempt an analysis of the social and cultural profiles of the male and female university students who were part of the movement, focusing principally upon their age in order to define at least two "social generations" which, though separated by only a few years, bear the marks of two widely divergent cultures: the first is that of those born during the Second World War, and the second that of those born between 1946 and 1951. The first generational group contained most of the leaders of the student movement, while the second contained younger people whose role in the movement, though often highly active, was principally that of adherents. The author highlights how this apparent relationship is essentially superficial, since in the interweaving of the two components it was the younger generation who would impose their generational culture, less in theoretical than in practical terms, while the words, the catchphrases and slogans would derive from the first generation, those born during the war years.
Keywords: generations; 19698; youth culture
Anna Vertua Gentile
No full textThe headword explains the biography and the contribution of the author Anna Vertua Gentile to the children's literatur
Codice Vittorio Emanuele 411 : Bonaventura da Bagnoregio, Legenda maior Sancti Francisci
No full textScheda storico-critica e descrittiva di un raro esempio di Legenda Maior riccamente illustrata. L’autore sottolinea come il manoscritto è stato impostato come un libro devozionale per una destinataria e aristocraticaEntry with art-historical presentation and description of a rare example of richly illuminated Legenda Maior. The author underlines how the book was produced for a lay and aristocratic female patro
Interdisciplinarity among the logics of displaying. Staging as an interaction between historical and design approaches
No full textDrawing on experience as an art historian actively engaged with exhibition designers, both in the realms of research and metaprojective reflection, as well as in teaching, the author aims in this paper to explore potential logics of shared understanding and delimitation between synergistic viewpoints. Examining sources as instruments of interdisciplinary connection, she focus on historical cases within the context of biennial exhibitions, in line with her areas of
expertise and research focus, spanning from the late nineteenth century to the 1970s
Correction to: An ethico-legal framework for social data science (International Journal of Data Science and Analytics, (2021), 11, 4, (377-390), 10.1007/s41060-020-00211-7)
No full textThe article ‘‘An ethico-legal framework for social data science’’, written by Nikolaus Forgó, Stefanie Hänold, Jeroen van den Hoven, Tina Krügel, Iryna Lishchuk, René Mahieu, Anna Monreale, Dino Pedreschi, Francesca Pratesi, David van Putten originally published electronically on the publisher’s internet portal (currently SpringerLink) on April 10, 2021 without open access. The copyright of the article changed t
Chelation motifs affecting metal-dependent viral enzymes: N′-acylhydrazone ligands as dual target inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H domain
No full textHuman immunodeficiency virus type 1 (HIV-1) infection, still represent a serious global health emergency. The chronic toxicity derived from the current anti-retroviral therapy limits the prolonged use of several antiretroviral agents, continuously requiring the discovery of new antiviral agents with innovative strategies of action. In particular, the development of single molecules targeting two proteins (dual inhibitors) is one of the current main goals in drug discovery. In this contest, metal-chelating molecules have been extensively explored as potential inhibitors of viral metal-dependent enzymes, resulting in some important classes of antiviral agents. Inhibition of HIV Integrase (IN) is, in this sense, paradigmatic. HIV-1 IN and Reverse Transcriptase-associated Ribonuclease H (RNase H) active sites show structural homologies, with the presence of two Mg(II) cofactors, hence it seems possible to inhibit both enzymes by means of chelating ligands with analogous structural features. Here we present a series of N′-acylhydrazone ligands with groups able to chelate the Mg(II) hard Lewis acid ions in the active sites of both the enzymes, resulting in dual inhibitors with micromolar and even nanomolar activities. The most interesting identified N′-acylhydrazone analog, compound 18, shows dual RNase H-IN inhibition and it is also able to inhibit viral replication in cell-based antiviral assays in the low micromolar range. Computational modeling studies were also conducted to explore the binding attitudes of some model ligands within the active site of both the enzymes
Le voci dei matti. Il ritrovamento dell'archivio sonoro di Anna Maria Bruzzone
No full textThe paper presents the discovering of an oral archive. Anna Maria Bruzzone’s book Ci chiamavano matti. Voci da un ospedale psichiatrico (Einaudi, Torino 1979) contains the testimonies of thirty-seven patients of the Arezzo psychiatric hospital collected in 1977. The book testimonies the patients’ miserable lives inside and outside the hospital and sheds light on the atrocity of their everyday condition by letting them speak for themselves. The author wrote it after a two-month stay in Arezzo, when she spent almost every day in the hospital, attending the general meetings and participating to the lives of the inpatients, in a continuous dialogue of which only a part is collected in the published interviews. The oral recordings on which the book is based were believed to be lost forever. After long and strenuous search I have been able to locate the original tapes. Such discovery is of great magnitude, because the digitisation and cataloguing of this archive would produce the first digital oral archive related to an Italian psychiatric hospital – which was located in the same buildings of my Department (Department of Educational Sciences, Human Sciences and Intercultural Communication of the University of Siena – Arezzo) where also the Historical Archive of the Arezzo psychiatric hospital is hosted
Le fabbriche di Figini e Pollini: da Olivetti alla Manifattura Ceramica Pozzi
No full textOne of the most emblematic moment in the Figini and Pollini’s career as architects
is the meeting with Adriano Olivetti, director of the homonymous factory in Ivrea
and author of what can be considered the main stage in the evolution of the relationship between architecture and the industrial sector. A connection characterized by him with a more humanistic attitude, aimed at protecting the natural environment and improving the well-being of workers and of the whole society as well.
The first originates from Milan, the second born in Rovereto, they fulfill and complement each other. An indivisible couple starting from the youth projects culminated
in the ‘Electric house’ designed for the Triennale in Monza in 1930 as an authentic manifesto of a new architecture.
During the V Triennale the three met for the first time, sharing from the beginning the need to go back to a rational and tradition path after the delirium of the war, which is just ended. Both the part support the spiritual value of creation, looking with hope at what is already happening in the ‘new world’, the United States.
Thus, while Olivetti develops a program to renovate and valorize the industry from a political and social point of view, Figini and Pollini give shape to his ideas, transforming a workplace into the ideal community project for contemporary civilization.
An ideal civilization that a few years later they will try to settle in the south of the country too, taking part in the Sparanise conversion project – a small village close to Caserta – from an agricultural area into an industrial site thanks to the establishment of the Manifattura Ceramica Pozzi. A project that, even if failed in its attempt to last, allows the two of them to see the vision of an ‘anti-city’, previously matured along their research, achieved. Made real here, through a factory conceived as an ideal harmonic dimension, marked by the search for a constant dialogue with nature, such as extension of the architecture itself
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