1,720,953 research outputs found
The importance of Brain Derived Neurotrophic Factor in the treatment of Major Depressive Disorder : evidence from animal models and pharmacology
No full textIl Disturbo Depressivo Maggiore è una patologia complessa ed altamente invalidante che
influisce negativamente sulla qualità della vita di chi ne soffre e grava sui sistemi sanitari che
prendono in cura questi pazienti. Sebbene questa patologia sia caratterizzata da chiari e
distinti segni e sintomi, la sua eziologia non è del tutto chiara. Dal versante biologico, nel
corso del tempo, sono state postulate molte teorie che comunque non danno una visione
chiara ed unificata dell9eziologia di questo disturbo che ad oggi è ritenuta di natura
multifattoriale. Un ruolo importante in ciò sembra essere rappresentato dall9azione (e dalla
disfunzione) del BDNF. Questa molecola proteica svolge un ruolo importante nella
sopravvivenza, nella crescita, nella proliferazione delle cellule, così come risulta implicata nei
processi di strutturazione del sistema nervoso e in varie forme di neuroplasticità. In questo
lavoro si è cercato di portare delle evidenze su come il BDNF, oltre che ad essere coinvolto
nella genesi del Disturbo Depressivo Maggiore, sia di fondamentale importanza nel
trattamento della patologia stessa. Attraverso la raccolta di dati in letteratura, sia provenienti
dal modello animale sia in studi sugli agenti farmacologici comunemente utilizzati, sono state
riportate evidenze che sottolineano come gli effetti antidepressivi, comportamentali e
cellulari, siano mediati dall9azione del BDNF; e come tale azione potrebbe essere, in futuro,
un target per lo sviluppo di nuovi farmaci, molecole o trattamenti non farmacologici, atti a
contrastare questa patologia.Major Depressive Disorder is a complex and highly disabling disease that negatively affects the
quality of life of those who suffer from it and burdens the health systems that treat these patients.
Although this condition is characterized by clear and distinct signs and symptoms, its etiology is not
fully understood. On the biological side, over time, many theories have been postulated which,
however, do not give a clear and unified view of the etiology of this disorder, which to date is
considered multifactorial in nature. An important role in this seems to be represented by the action
(and disfunction) of the BDNF. This protein molecule plays an important role in cell survival,
growth, proliferation, as well as being involved in the structuring processes of the nervous system
and in various forms of neuroplasticity. In this work we tried to bring evidence on how BDNF, in
addition to being involved in the genesis of Major Depressive Disorder, is of fundamental
importance in the treatment of the pathology itself. Through the collection of data in literature, both
from the animal model and from studies on commonly used pharmacological agents, evidence has
been reported that underlines how the antidepressant, behavioral and cellular effects are mediated
by the action of BDNF; and how this action could be, in the future, a target for the development of
new drugs, molecules or non-pharmacological treatments, aimed at combating this pathology
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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