21 research outputs found
Try It Out: Research Center
No full textFashion is technological, since the first clothing worn by early humans, the garments have been developed radically to become efficient and comfortable (quick dry, highly warm, extremely light) to match weatherability.Up until the last decade, fiber technology and materials science was limited to specialists. Since then, textile and clothing brands decided to invest in research and development. The lower costs of cutting-edge technology made it possible for independent designers as well as medium and larger companies to create concepts using innovative products. Additionally, there is a new consumer profile opting for environmentally responsible products that reflect their digital lifestyle.The Try It Out contribution - sited in the Andermatt, a village in the Swiss Alps - proposes a facility for the development of prototyping and testing of the textileperformance. Material research becomes increasingly paramount, as material innovation is one of the main drivers for the fashion industry to tackle environmental challenges. Improving the lifespan of fabrics (duration), creating better-performing garments (higher value), and revolutionizing production processes (production), will change how fashion is consumed (consumption).This contribution is part of Fashion House, a collective project on the spatial implications of a decentralized and more tightly regulated fashion industry across Europe that reimagines the function and design for a fashion house.https://thesisinprogress-theberlage.nl/Fashion-House-Introword This contribution is part of Fashion House, a collective project on the spatial implications of a decentralized and more tightly regulated fashion industry across Europe that reimagines the function and design for a fashion house. Try It Out is a research center for prototyping and testing of products that perform under extreme conditions. It combines cutting-edge equipment with the rapid growth of influencers reviewing products. It is sited in Andermatt, Swiss Alps, Switzerland.Collective Project: Fashion HouseIndividual Contribution: Try Ir Out Research CenterThe Berlage Post-MSc in Architecture and Urban Desig
Variação do conteúdo de água armazenada de um planossolo cultivado com soja sob plantio direto e preparo convencional.
No full textArmazenamento de água em planossolo cultivado com soja sob plantio direto e preparo convencional.
No full textThe Expression of Sphingosine-1 Phosphate Receptor-1 in Chronic Lymphocytic Leukemia Cells Is Impaired by Tumor Microenvironmental Signals and Enhanced by Piceatannol and R406
No full textChronic lymphocytic leukemia (CLL) is characterized by the progressive accumulation of clonal B lymphocytes. Proliferation occurs in lymphoid tissues upon interaction of leukemic cells with a supportive microenvironment. Therefore, the mobilization of tissue-resident CLL cells into the circulation is a useful therapeutic strategy to minimize the reservoir of tumor cells within survival niches. Because the exit of normal lymphocytes from lymphoid tissues depends on the presence of sphingosine-1 phosphate (S1P) and the regulated expression of S1P receptor-1 (S1PR1), we investigated whether the expression and function of S1PR1 can be modulated by key microenvironment signals. We found that activation of CLLcells with CXCL12, fibroblast CD40L(+), BCR cross-linking, or autologous nurse-like cells reduces their S1PR1 expression and the migratory response toward S1P. Moreover, we found that S1PR1 expression was reduced in the proliferative/activated subset of leukemic cells compared with the quiescent subset from the same patient. Similarly, bone marrow-resident CLL cells expressing high levels of the activation marker CD38 showed a lower expression of S1PR1 compared with CD38(low) counterparts. Finally, given that treatment with BCR-associated kinase inhibitors induces a transient redistribution of leukemic cells from lymphoid tissues to circulation, we studied the effect of the Syk inhibitors piceatannol and R406 on S1PR1 expression and function. We found that they enhance S1PR1 expression in CLL cells and their migratory response toward S1P. Based on our results, we suggest that the regulated expression of S1PR1 might modulate the egress of the leukemic clone from lymphoid tissues.Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Remes Lenicov, Federico. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Nannini, Paula Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Alicandú, María M. de los Ríos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Podaza, Enrique Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Ceballos, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Fernandez Grecco, Horacio. Sanatorio Municipal Dr. Julio Méndez; ArgentinaFil: Cabrejo, María. Sanatorio Municipal Dr. Julio Méndez; ArgentinaFil: Bezares, Raimundo F.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Dr. Teodoro Álvarez"; ArgentinaFil: Morande, Pablo Elías. Instituto Pasteur de Montevideo; Uruguay. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Oppezzo, Pablo. Instituto Pasteur de Montevideo; UruguayFil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentin
Discutindo a proposta contemporânea de uma teoria das virtudes intelectuais colmo teoria do conhecimento
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Hmanas, Programa de Pós-Graduação em Filosofia, Florianópolis, 2013.Abstract: This research seeks to expand the discussion of central problems of traditional epistemology, as knowledge and justification. In contemporary epistemology the nature of knowledge has been subject to different interpretations by two approaches: internalists and externalists. In this context, an approach based on the concepts of intellectual virtues was introduced as a possible solution to the impasse between internalism and externalism in epistemology. This work has of object to study the discussion of how the intellectual virtues appear as a successful proposal to the problem of knowledge. To do so far will need an understanding of the analogies between discourse ethics and epistemology. The composition of this work was distributed in the introduction, first, second and third chapters and remarks. We reserve the first chapter to detail the differences between approaches of virtue and the other competing conceptions. In this respect, epistemology turns his attention to the proposed Linda Zagzebski, contemporary epistemologist, justifying the viability of his conception by considering the intellectual virtue as the main normative component of justified belief and knowledge. The second chapter presents the design proposed of Zagzebski's pure virtue, inspired by the Aristotelian model of acquisition of virtues, the nature of virtue and eudaimonia. Also in the second chapter, it is approached on the thesis of this author about the author of this thesis definition of knowledge as cognitive contact with the reality of what sorts of "acts of intellectual virtue The third chapter is to discuss about the motivation of Zagzebski in replacing the term true belief for cognitive contact with reality, presenting her criticism of internalist and externalist approaches, mainly to reliabilism, as well as the critical imposed by internalism and externalism to addressing the epistemic virtues, especially the design of Zagzebski. As remarks, the observations are presented, on the possibilities and limits of the thesis of Linda Zagzebski
A organização do trabalho de treinadores de futebol: estratégias de ação e produtividade de equipes profissionais
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.Hoje, o futebol é considerado o esporte mais popular da terra, atraindo cada vez mais, grandes investimentos financeiros. Este estudo tem por objetivo trazer sua contribuição através do questionamento e análise das estratégias de ação de treinadores do Brasil, atuantes no futebol profissional, para através da visão organizacional de suas funções, auxiliar na formação de novos profissionais e, conseqüentemente, melhorar sua produtividade. Este trabalho propõe algo além da análise de scalts próprios. Busca-se o estudo dos aspectos físicos, técnicos, táticos, psicológicos e das equipes adversárias, cujas informações poderão contribuir na construção de novas estratégias que facilitarão atingir aos objetivos propostos no trabalho dos treinadores.Com este intuito, realizou-se um levantamento de dado descritivo junto aos treinadores que atuam nos clubes participantes do Campeonato Brasileiro de 2001, 1ª divisão, onde pretende-se trazer informações que possam contribuir nos aspectos produtivos destes profissionais
Cyclin D1 is a NF-κB corepressor
No full textAbstractNF-κB regulates the expression of Cyclin D1 (CD1), while RAC3 is an NF-κB coactivator that enhances its transcriptional activity. In this work, we investigated the regulatory role of CD1 on NF-κB activity. We found that CD1 inhibits NF-κB transcriptional activity through a corepressor function that can be reverted by over-expressing RAC3. In both, tumoral and non-tumoral cells, the expression pattern of RAC3 and CD1 is regulated by the cell cycle, showing a gap between the maximal expression levels of each protein. The individual increase, by transfection, of either CD1 or RAC3 enhances cell proliferation. However the simultaneous and constitutive over-expression of both proteins has an inhibitory effect. Our results suggest that the relative amounts of CD1 and RAC3, and the timing of expression of these oncogenes could tilt the balance of tumor cell proliferation in response to external signals
