1,721,018 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Management of iron overload in myelodysplastic syndromes: combined deferasirox and deferoxamine in a patient with liver disease
Full text linkRegarding "Hepatitis B surface antigen positivity is an independent unfavorable prognostic factor in diffuse large B-cell lymphoma in the rituximab era"
No full textReply to the letter to the editor "chronic disseminated candidiasis" by Kenneth Rolston
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Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A Novel Score to Predict Interferon-Alpha Therapy Responsiveness in Patients with Essential Thrombocythemia
No full textInterferon alpha (IFN-α) is an attractive agent for the treatment of Essential Thrombocythemia (ET) due to its ability to induce clonal complete remission, sometimes lasting beyond treatment discontinuation, and to its recognized non-leukemogenicity.
However, despite decades of clinical experience with IFN-α in patients with MPNs, optimal dose schedules, treatment duration and the ultimate molecular basis of the heterogeneous response still remain undefined.
Hence, the early identification of IFN-sensitive patients may help limit IFN-α exposure to those who really benefit from treatment.
Aim.
Here we report the results of a trial involving 61 ET patients treated with IFN-α, aimed to identify the baseline molecular and clinical parameters able to predict response to treatment.
Methods.
IFN treatment schedule implied an initial induction phase with 3MU/five times a week; in patients who reached a platelet count 600x109/L or platelet reduction was <50% the baseline level, the patient was considered resistant to the IFN therapy (Bad-R).
Careful medical history, main laboratory data and spleen volume, assessed by ultrasonography scan were recorded in all patients at presentation and during follow-up. Complete hematological response (CHR) is defined as the normalization of both platelet and WBC counts (<400x109/L and <10x109/L, respectively) and the absence of disease-related symptoms.
mRNA levels of JAK1, JAK2, STAT1, STAT3, SOCS1, SOCS3 and TYK2 were assayed in pre-treatment bone marrow specimens by Real-Time PCR using the SYBR Green method.
Results.
After a median follow-up of 41.2 months, 72% of patients achieved CHR and were considered Good-Rs for subsequent analysis, whereas the remaining 17 were considered Bad-Rs. Among the Good-Rs, 24 (54%) are still on therapy with standard IFN-α doses (i.e. 3 MU 3 or 2 times a week), whereas 10 (23%) are maintained in CHR by the administration of very low doses of IFN-α-2b (3 MU every 7 or 15 days), and 3 (7%) have maintained CHR after therapy discontinuation (up to a median time of 31 months).
The initial univariate analysis indicated that the mRNA levels of JAK1, STAT3, SOCS3 were significantly lower in Good-R than in Bad-R patients. Interestingly, among the different genes involved in the IFN-α receptor pathway, the expression levels of JAK1, together with spleen volume and platelet count, were selected by the stepwise multivariate analysis as the variables that independently correlate with IFN-α response. We used the relative HRs and the optimal cut-offs for response calculated for each variable by the ROC analysis to develop a prognostic score able to predict IFN-α response. This score has an overall 87% diagnostic efficiency in discriminating IFN-α response and unambiguously identifies the response to IFN-α in most patients, avoiding treatment in those with no probability of gaining benefit from this therapy.
In addition, this score is able to identify unambiguously the response to IFN in a sizeable proportion of patients: an IFN-R score of 3 or 4 (31 patients, corresponding to 70.4% of the Good-R) indicates a 100% odd to obtain CHR, while a score of 0 indicates no chance of achieving a response.
Conclusion.
In conclusion, this study shows for the first time that the use of three simples parameters predicts the response to IFN in ET patients
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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