124,698 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Risk assessment of buried natural gas pipelines. Critical aspects of event tree analysis
No full textThe safety aspects of pipelines conveying hazardous materials are not included neither under the umbrella of Seveso Directives aiming at preventing major accidents at industrial facilities, nor in other EU legislation such as the Pressure Equipment Directive (PED). A review of relevant past accidents can provide statistical evidence on the extent to which pipelines present a risk potentially comparable to that of Seveso installations and on the degree to which the pipeline hazards are adequately controlled. Starting from evidence that in the last decades, the international natural gas market has been growing at a very high rate and continues to exhibit an increasing trend, in this paper we focus on consequences deriving from accidents on high pressure buried Natural Gas Pipelines (NGP) and related probabilities of the various outcomes. The paper focuses on a novel Event Tree framework, to overcome the limitations of the amply applied over-conservative IP UKOOA approach. In order to evidence the capability of the approach, the use of refined PET is exemplified by means of a real case-study of a high pressure buried NG pipeline, contrasting the actual results with those obtained by conventional methods, in terms of evolving scenario probability and damage. Conclusions are drawn about the effective application of the framework within risk assessment and related uncertainties in pipeline accident modelling
Critical aspects of natural gas pipelines risk assessments. A case-study application on buried layout
No full textThe safety aspects of pipelines conveying hazardous materials are included neither under the umbrella of Seveso Directives aiming at preventing major accidents at industrial facilities, nor in other EU legislations, such as the Pressure Equipment Directive (PED). Starting from evidence that in the last decades the international natural gas market has been growing at a very high rate and continues to exhibit an increasing trend, in this paper we focus on consequences deriving from accidents on high pressure buried Natural Gas Pipelines (NGP) and related probabilities of the various outcomes. A survey on historical accidents occurred on NG pipelines in the USA, Canada and EU allowed the attainment of significant statistics concerning the main factors responsible for the accident evolution, namely failure mode, immediate and root cause, evolving scenario, degree of confinement produced by the surroundings and ignition timing. In this paper, we focus on a refined Event Tree framework, to overcome the limitations of the amply applied over-conservative IP UKOOA approach. In order to evidence the capability of the approach, the use of refined PET is exemplified by means of a real case-study of a high pressure buried NG pipeline, contrasting the actual results with those obtained by conventional methods, in terms of evolving scenario probability and damage. Conclusions are drawn about the effective application of the framework within risk assessment and the uncertainties and sensitivities in the pipeline accident modelling
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Proteomic insights into oligogalacturonide signalling in plant defence and development
No full textOligogalacturonides (OGs) are fragments derived from the hydrolysis of plant cell wall homogalacturonan by fungal endo-polygalacturonases and are well known damage-associated molecular patterns (DAMPs). In Arabidopsis thaliana, perception of OGs triggers an intracellular signaling cascade that initiates defense against pathogens. OGs may also work as regulators of plant growth and development mainly through their antagonism with auxin (IAA). However, most of the mechanism by which the OG signal is transduced is not yet known.
In this study, quantitative phosphoproteomics was applied to investigate the initial signaling events specifically activated by OG signaling. Analysis of quantitative changes in the proteome and phosphoproteome, determined by dimethyl labelling and LC/MSMS analysis in a membrane-enriched fraction, revealed rapid phosphorylation changes, with no substantial changes in overall protein abundance after a 10 min treatment with OGs.
We also analyzed the changes in the nuclear proteome in response to IAA, OGs or a IAA/OG co-treatment, to identify regulatory elements that mediate the inhibition of the auxin-induced responses by OGs. The analysis of proteomic and transcriptomic data suggests that changes in abundance of nuclear proteins in response to OGs/IAA may arise not only from enhanced or reduced expression but also from post-translational modifications, degradation and/or translocation of proteins to different compartments. Some interesting candidates in OG/IAA antagonism have been identified and their functional role is under study
Proteomic analysis of endoplasmic reticulum and golgi proteins during tomato fruit ripening
No full textPragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
Congenital and acquired ADAMTS13 deficiency: two mechanisms, one patient
No full textThrombotic thrombocytopenic purpura (TTP) is a life-threatening microangiopathy with a heterogeneous and largely unpredictable course. It is caused by ADAMTS13 deficiency, that can be either congenital or due to anti-ADAMTS13 autoantibodies development. ADAMTS13 deficiency is necessary but not always sufficient to cause acute clinical manifestations and trigger factors may be needed. We report the case of a woman diagnosed with congenital TTP in her adulthood, presenting with anti-ADAMTS13 autoantibodies in acute phase during ticlopidine consumption. Noteworthy, the two ADAMTS13 mutations identified in this patient are novel: one is a splice-site mutation located in intron 11 (c.1308+2_5delTAGG) and the other is a point missense mutation in exon 29 (c.4184T>C leading to p.Leu1395Pro substitution). Since congenital TTP is an extremely rare disease and drug-induced TTP is an uncommon side effect of treatment with ticlopidine, the simultaneous occurrence of both mechanisms of disease in one patient is exceptional. This case represents TTP as a multifactorial disease, with ADAMTS13 genetic abnormality and environmental exposures acting together in determining individual clinical phenotype
Dr. Edwin Wright Collection: Author Unknown
No full textNotes - The author relates several short stories about his neighbours including Alex McDonell, homesteading and life around Meanook and Athabasca (1 page
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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