1,720,994 research outputs found
Predictive factors of tmj involvement in 230 consecutive jia patients regularly screened from 2000 to 2014 in a single pediatric rheumatology centre
No full textBackground: Juvenile Idiopathic Arthritis (JIA) has been shown to involve frequently the temporo-mandibular joint (TMJ). An important prognostic aspect is to diagnose and treat it promptly.
Objectives: To evaluate in a consecutive JIA patients (pts) cohort, regularly screened from year 2000 to 2014, the predictive factors of the TMJ involvement.
Methods: 230 consecutive pts (152 females, 78 males) affected by JIA according to ILAR classification, 164 oligoarthritis, 4 polyarthritis rheumatoid factor (RF) +, 34 polyarthritis RF-, 22 systemic onset JIA (soJIA), 4 enthesitis-related arthritis (ERA) HLA B27+, and 2 psoriatic arthritis were included in a retrospective evaluation. Mean disease onset age was 6.5 yrs (range 1-16), mean disease duration 12.7 yrs (range 0.2-46.2).
We analyzed the correlation between TMJ involvement with the following items: ILAR categories, age at onset, gender, pattern of articular involvement (large joints, small ones, hips, cervical spine).
Results: 88/230 patients (38.3%), 36.8% of females and 41% of males showed a clinical TMJ involvement. Mean age at onset (or diagnosis) of TMJ involvement was 8.3 yrs. 62/88 pts (70.5%) had a bilateral clinical signs of condylar alteration.
The involvement of TMJ was observed in 38.3% of the whole population (54.5% of oligoarthritis, 27.3% polyarthritis RF negative, 2.3% polyarthritis RF positive, 9.1% soJIA, 4.5% ERA and 2.3% juvenile psoriatic arthritis)
3 cases (2 females and 1 male) presented with an involvement of TMJ at the diagnosis of JIA.
The rate of TMJ involvement was higher in the pts with an early onset of the disease (52.3% in the 0-6 yrs group, vs 36.4% in 7-12 yrs group and 11.3% in 13-16 yrs group).
In 56/88 pts (63.3%) TMJ disease was associated with an involvement of large joints, in 4/88 (4.54%) with small joints, in 24/88 (27.7%) with hips and in 18/88 (20.45%) with cervical spine.
Conclusions: An early onset of JIA, the oligoarticular ILAR category and a pattern of large joints involvement seem correlated with a higher rate of TMJ disease. Predictive factors of TMJ involvement should be confirmed in a larger JIA population and may be useful for clinicians to adopt appropriate prevention strategies of TMJ disease
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
IMPAIRED ABCG1-MEDIATED SERUM CHOLESTEROL EFFLUX CAPACITY IN PATIENTS WITH RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS.
No full textAim: Accelerated atherosclerosis associated with autoimmune diseases is partly due to immune system dysregulation aggravating cardiovascular damage, but little is known on lipid metabolism derangement in this condition. Serum capacity to promote cholesterol efflux from macrophages (CEC) is the first limiting step of the atheroprotective reverse cholesterol transfer process, mainly reflects HDL function and inversely correlates to subclinical atherosclerosis in vivo. We intend verifying whether CEC is altered in rheumatoid arthritis (AR) and systemic lupus erithematosus (SLE) patients. Methods: CEC is measured by a validated ex vivo system using H3-cholesterol in 30 AR and 30 SLE patients, and in 30 age and sex-matched healthy subjects. ABCG1-mediated CEC tests were completed, SR-BI-mediated CEC was determined in AR patients and in control subjects so far, and ABCA1 is under evaluation. Results: ABCG1-mediated CEC in AR and SLE patients is significantly lower than in control subjects (6.045±0.195, 5.74±0.327, 7.13±0.195, respectively, p<0.005 AR vs controls, p<0.0003 SLE vs controls). Correlation between ABCG1-mediated CEC and serum HDL, present in controls (p=0.02), is absent in autoimmune patients. SLE patients as a group showed the lowest ABCG1-mediated CEC in spite of the highest HDL serum level (p=0.0001 vs controls). SR-BI-mediated CEC did not differ between AR and controls. Conclusions: the selective impairment of ABCG1-mediated CEC, independent of HDL serum levels, found in AR and SLE patients is the first demonstration of dysfunction and loss of atheroprotective activity of HDL in these disorders and may represent a tool to better understand accelerated atherosclerosis in autoimmune diseases
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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